Prostaglandin E2 induces hypoxia-inducible factor-1α stabilization and nuclear localization in a human prostate cancer cell line

Journal of Biological Chemistry

Volumn 277, Issue 51, 2002, Pages 50081-50086

  Liu, Xin Hua ^a   Kirschenbaum, Alexander ^a   Lu, Min ^a   Yao, Shen ^a   Dosoretz, Amy ^a   Holland, James F ^a   Levine, Alice C ^a  

^a MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL CULTURE; ENZYME INHIBITION; ENZYMES; GENES; GROWTH KINETICS; MUTAGENESIS; PROTEINS; TUMORS;

NUCLEAR LOCALIZATION;

BIOCHEMISTRY;

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MELOXICAM; MESSENGER RNA; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; PROSTAGLANDIN E2; ARACHIDONIC ACID; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ENDOTHELIAL CELL GROWTH FACTOR; ENZYME INHIBITOR; FLAVONOID; GREEN FLUORESCENT PROTEIN; HIF1A PROTEIN, HUMAN; ISOENZYME; LYMPHOKINE; MEMBRANE PROTEIN; N-(2-CYCLOHEXYLOXY-4-NITROPHENYL)METHANESULFONAMIDE; NITROBENZENE DERIVATIVE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOTOPROTEIN; PROSTAGLANDIN; PROSTAGLANDIN SYNTHASE; PROSTAGLANDIN SYNTHASE INHIBITOR; PTGS2 PROTEIN, HUMAN; SIGNAL PEPTIDE; SULFONAMIDE; THIAZINE DERIVATIVE; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR; VASCULOTROPIN; VASCULOTROPIN A;

ARTICLE; CANCER CELL CULTURE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSOL; DRUG ACTIVITY; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; HYPOXIA; NEOVASCULARIZATION (PATHOLOGY); NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN STABILITY; TIME; ACTIVE TRANSPORT; ANOXIA; CATALYSIS; CELL CULTURE; CELL NUCLEUS; CULTURE MEDIUM; IMMUNOBLOTTING; MALE; METABOLISM; PATHOLOGY; PROSTATE TUMOR; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ACTIVE TRANSPORT, CELL NUCLEUS; ANOXIA; ARACHIDONIC ACID; CATALYSIS; CELL NUCLEUS; CULTURE MEDIA, SERUM-FREE; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; CYTOSOL; DINOPROSTONE; ENDOTHELIAL GROWTH FACTORS; ENZYME INHIBITORS; FLAVONOIDS; GREEN FLUORESCENT PROTEINS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOBLOTTING; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; ISOENZYMES; LUMINESCENT PROTEINS; LYMPHOKINES; MALE; MAP KINASE SIGNALING SYSTEM; MEMBRANE PROTEINS; NITROBENZENES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROSTAGLANDINS; PROSTATIC NEOPLASMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SULFONAMIDES; THIAZINES; THIAZOLES; TIME FACTORS; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TUMOR CELLS, CULTURED; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0037146555     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M201095200     Document Type: Article

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