Recombinant human interleukin (IL)-1β-mediated regulation of hypoxia-inducible factor-1α (HIF-1α) stabilization, nuclear translocation and activation requires an antioxidant/reactive oxygen species (ROS)-sensitive mechanism

European Cytokine Network

Volumn 13, Issue 2, 2002, Pages 250-260

  Haddad, John J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Airway epithelium; Antioxidant; Cytokine; HIF 1 ; IL 1 ; Mitochondria; Oxygen sensing; Reactive oxygen species

Indexed keywords

ACETOPHENONE DERIVATIVE; ANTIOXIDANT; APOCYNIN; CYTOKINE; DIMETHYL SULFOXIDE; DIMETHYLTHIOUREA; DIPHENYLIODONIUM SALT; HYDROGEN PEROXIDE; HYDROXYL RADICAL; HYPOXIA INDUCIBLE FACTOR 1ALPHA; INTERLEUKIN 1; POTASSIUM CYANIDE; REACTIVE OXYGEN METABOLITE; RECOMBINANT INTERLEUKIN 1BETA; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SCAVENGER; SUPEROXIDE; TRANSCRIPTION FACTOR; UBIQUINONE; HIF1A PROTEIN, HUMAN; RECOMBINANT PROTEIN;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CELL NUCLEUS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DOSE RESPONSE; ENZYME INHIBITION; FETUS; HYPOXIA; LUNG ALVEOLUS EPITHELIUM; MITOCHONDRION; NONHUMAN; PROTEIN STABILITY; RAT; RECEPTOR UPREGULATION; REGULATORY MECHANISM; RESPIRATORY CHAIN; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; ANIMAL; CELL CULTURE; DRUG EFFECT; HUMAN; KINETICS; LUNG ALVEOLUS; METABOLISM; PHYSIOLOGY; RESPIRATORY TRACT MUCOSA; SPRAGUE DAWLEY RAT;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMAL; ANTIOXIDANTS; CELLS, CULTURED; FETUS; HUMAN; INTERLEUKIN-1; KINETICS; PULMONARY ALVEOLI; RATS; RATS, SPRAGUE-DAWLEY; REACTIVE OXYGEN SPECIES; RECOMBINANT PROTEINS; RESPIRATORY MUCOSA; SUPPORT, NON-U.S. GOV'T; TRANSCRIPTION FACTORS; ANIMALS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT;

EID: 0035991511     PISSN: 11485493     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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