메뉴 건너뛰기




Volumn 6, Issue 7, 2004, Pages 642-647

HIF activation by pH-dependent nucleolar sequestration of VHL

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROTON; VON HIPPEL LINDAU PROTEIN;

EID: 3242725198     PISSN: 14657392     EISSN: None     Source Type: Journal    
DOI: 10.1038/ncb1144     Document Type: Article
Times cited : (228)

References (30)
  • 1
    • 0034663989 scopus 로고    scopus 로고
    • HIF-1 and human disease: One highly involved factor
    • Semenza, G. L. HIF-1 and human disease: one highly involved factor. Genes Dev. 14, 1983-1991(2000).
    • (2000) Genes Dev. , vol.14 , pp. 1983-1991
    • Semenza, G.L.1
  • 2
    • 0033587146 scopus 로고    scopus 로고
    • The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
    • Maxwell, P. H. et al . The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 399, 271-275 (1999).
    • (1999) Nature , vol.399 , pp. 271-275
    • Maxwell, P.H.1
  • 3
    • 0035917808 scopus 로고    scopus 로고
    • 2-regulated prolyl hydroxylation
    • 2-regulated prolyl hydroxylation. Science 292, 468-472 (2001).
    • (2001) Science , vol.292 , pp. 468-472
    • Jaakkola, P.1
  • 4
    • 0033574594 scopus 로고    scopus 로고
    • Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex
    • Shou, W. et al. Exit from mitosis is triggered by Tem1-dependent release of the protein phosphatase Cdc14 from nucleolar RENT complex. Cell 97, 233-244 (1999).
    • (1999) Cell , vol.97 , pp. 233-244
    • Shou, W.1
  • 5
    • 0033614303 scopus 로고    scopus 로고
    • Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus
    • Visintin, R., Hwang, E. S. & Amon, A. Cfi1 prevents premature exit from mitosis by anchoring Cdc14 phosphatase in the nucleolus. Nature 398, 818-823 (1999).
    • (1999) Nature , vol.398 , pp. 818-823
    • Visintin, R.1    Hwang, E.S.2    Amon, A.3
  • 7
    • 0036894648 scopus 로고    scopus 로고
    • A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells
    • Tsai, R. Y. & McKay, R. D. A nucleolar mechanism controlling cell proliferation in stem cells and cancer cells, Genes Dev. 16, 2991-3003 (2002).
    • (2002) Genes Dev. , vol.16 , pp. 2991-3003
    • Tsai, R.Y.1    McKay, R.D.2
  • 8
    • 0035574141 scopus 로고    scopus 로고
    • Skeletal muscle angiogenesis. A possible role for hypoxia
    • Wagner, P. D. Skeletal muscle angiogenesis. A possible role for hypoxia. Adv. Exp. Med. Biol. 502, 21-38 (2001).
    • (2001) Adv. Exp. Med. Biol. , vol.502 , pp. 21-38
    • Wagner, P.D.1
  • 9
    • 0036718539 scopus 로고    scopus 로고
    • Molecular basis of the VHL hereditary cancer syndrome
    • Kaelin, W. G., Jr. Molecular basis of the VHL hereditary cancer syndrome. Nature Rev. Cancer 2, 673-682 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 673-682
    • Kaelin Jr., W.G.1
  • 10
    • 0036359548 scopus 로고    scopus 로고
    • Hypoxia - A key regulatory factor in tumour growth
    • Harris, A. L. Hypoxia - a key regulatory factor in tumour growth. Nature Rev. Cancer 2 , 38-47 (2002).
    • (2002) Nature Rev. Cancer , vol.2 , pp. 38-47
    • Harris, A.L.1
  • 11
    • 0026027873 scopus 로고
    • Protection by acidotic pH against anoxic cell killing in perfused rat liver: Evidence for a pH paradox
    • Currin, R. T., Gores, G. J., Thurman, R. G. & Lemasters, J. J. Protection by acidotic pH against anoxic cell killing in perfused rat liver: evidence for a pH paradox. Faseb J. 5, 207-210 (1991).
    • (1991) Faseb J. , vol.5 , pp. 207-210
    • Currin, R.T.1    Gores, G.J.2    Thurman, R.G.3    Lemasters, J.J.4
  • 12
    • 0027179773 scopus 로고
    • Neuroprotective effects of glutamate antagonists and extracellular acidity
    • Kaku, D. A., Giffard, R. G. & Choi, D. W. Neuroprotective effects of glutamate antagonists and extracellular acidity. Science 260, 1516-1518 (1993).
    • (1993) Science , vol.260 , pp. 1516-1518
    • Kaku, D.A.1    Giffard, R.G.2    Choi, D.W.3
  • 13
    • 0025129130 scopus 로고
    • Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures
    • Giffard, R. G., Monyer, H., Christine, C. W. & Choi, D. W. Acidosis reduces NMDA receptor activation, glutamate neurotoxicity, and oxygen-glucose deprivation neuronal injury in cortical cultures. Brain Res. 506, 339-342 (1990).
    • (1990) Brain Res. , vol.506 , pp. 339-342
    • Giffard, R.G.1    Monyer, H.2    Christine, C.W.3    Choi, D.W.4
  • 14
    • 0030980723 scopus 로고    scopus 로고
    • Extracellular acidosis delays cell death against glucose-oxygen deprivation in neuroblastoma x glioma hybrid cells
    • Morimoto, Y., Kemmotsu, O. & Alojado, E. S. Extracellular acidosis delays cell death against glucose-oxygen deprivation in neuroblastoma x glioma hybrid cells. Crit. Care Med. 25, 841-847 (1997).
    • (1997) Crit. Care Med. , vol.25 , pp. 841-847
    • Morimoto, Y.1    Kemmotsu, O.2    Alojado, E.S.3
  • 15
    • 0035476873 scopus 로고    scopus 로고
    • Protective effects of lactic acid on force production in rat skeletal muscle
    • Nielsen, O. B., de Paoli, F. & Overgaard, K. Protective effects of lactic acid on force production in rat skeletal muscle. J. Physiol. 536, 161-166 (2001).
    • (2001) J. Physiol. , vol.536 , pp. 161-166
    • Nielsen, O.B.1    de Paoli, F.2    Overgaard, K.3
  • 16
    • 0344026345 scopus 로고    scopus 로고
    • Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein
    • Lee, S. et al. Transcription-dependent nuclear-cytoplasmic trafficking is required for the function of the von Hippel-Lindau tumor suppressor protein. Mol. Cell Biol. 19, 1486-1497 (1999).
    • (1999) Mol. Cell Biol. , vol.19 , pp. 1486-1497
    • Lee, S.1
  • 17
    • 0036314978 scopus 로고    scopus 로고
    • Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein
    • Groulx, I. & Lee, S. Oxygen-dependent ubiquitination and degradation of hypoxia-inducible factor requires nuclear-cytoplasmic trafficking of the von Hippel-Lindau tumor suppressor protein. Mol. Cell Biol. 22, 5319-5336 (2002).
    • (2002) Mol. Cell Biol. , vol.22 , pp. 5319-5336
    • Groulx, I.1    Lee, S.2
  • 18
    • 0029147430 scopus 로고
    • Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C
    • Kibel, A., Iliopoulos, O., DeCaprio, J. A. & Kaelin, W. G., Jr. Binding of the von Hippel-Lindau tumor suppressor protein to Elongin B and C. Science 269, 1444-1446 (1995).
    • (1995) Science , vol.269 , pp. 1444-1446
    • Kibel, A.1    Iliopoulos, O.2    DeCaprio, J.A.3    Kaelin Jr., W.G.4
  • 19
    • 0030948396 scopus 로고    scopus 로고
    • Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues
    • Corless, C. L., Kilbel, A. S., Iliopoulos, O. & Kaelin, W. G., Jr. Immunostaining of the von Hippel-Lindau gene product in normal and neoplastic human tissues. Hum. Pathol. 28, 459-464 (1997).
    • (1997) Hum. Pathol. , vol.28 , pp. 459-464
    • Corless, C.L.1    Kilbel, A.S.2    Iliopoulos, O.3    Kaelin Jr., W.G.4
  • 21
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. On the origin of cancer cells. Science 123, 309-314 (1956).
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 22
    • 0024281372 scopus 로고
    • Cell and environment interactions in tumor microregions: The multicell spheroid model
    • Sutherland, R. M. Cell and environment interactions in tumor microregions: the multicell spheroid model. Science 240, 177-184 (1988).
    • (1988) Science , vol.240 , pp. 177-184
    • Sutherland, R.M.1
  • 23
    • 0029090338 scopus 로고
    • Tumour suppression by the human von Hippel-Lindau gene product
    • Iliopoulos, O., Kibel, A., Gray, S. & Kaelin, W. G., Jr. Tumour suppression by the human von Hippel-Lindau gene product. Nature Med. 1, 822-826 (1995).
    • (1995) Nature Med. , vol.1 , pp. 822-826
    • Iliopoulos, O.1    Kibel, A.2    Gray, S.3    Kaelin Jr., W.G.4
  • 24
    • 0030953635 scopus 로고    scopus 로고
    • The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins
    • Pause, A. et al. The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins. Proc. Natl Acad. Sci. USA 94, 2156-2161 (1997).
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 2156-2161
    • Pause, A.1
  • 25
    • 0034682783 scopus 로고    scopus 로고
    • Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein
    • Cockman, M. E. et al. Hypoxia inducible factor-alpha binding and ubiquitylation by the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 275, 25733-25741 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 25733-25741
    • Cockman, M.E.1
  • 26
    • 0035847050 scopus 로고    scopus 로고
    • Role of exon 2-encoded beta - Domain of the von Hippel-Lindau tumor suppressor protein
    • Bonicalzi, M. E., Groulx, I., de Paulsen, N. & Lee, S. Role of exon 2-encoded beta - domain of the von Hippel-Lindau tumor suppressor protein. J. Biol. Chem. 276, 1407-1416 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 1407-1416
    • Bonicalzi, M.E.1    Groulx, I.2    de Paulsen, N.3    Lee, S.4
  • 27
    • 0242581718 scopus 로고    scopus 로고
    • -/-) renal cell carcinoma cells
    • -/-) renal cell carcinoma cells. J. Biol. Chem. 278, 44966-44974 (2003).
    • (2003) J. Biol. Chem. , vol.278 , pp. 44966-44974
    • Gunaratnam, L.1
  • 28
    • 0037109768 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: Potential role of insulin-like growth factor-1
    • Chavez, J. C. & LaManna, J. C. Activation of hypoxia-inducible factor-1 in the rat cerebral cortex after transient global ischemia: potential role of insulin-like growth factor-1. J. Neurosci. 22, 8922-8931 (2002).
    • (2002) J. Neurosci. , vol.22 , pp. 8922-8931
    • Chavez, J.C.1    LaManna, J.C.2
  • 29
    • 0041743159 scopus 로고    scopus 로고
    • VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia
    • Sun, Y. et al. VEGF-induced neuroprotection, neurogenesis, and angiogenesis after focal cerebral ischemia. J. Clin. Invest. 111, 1843-1851 (2003).
    • (2003) J. Clin. Invest. , vol.111 , pp. 1843-1851
    • Sun, Y.1
  • 30
    • 0033614348 scopus 로고    scopus 로고
    • Mitotic treasures in the nucleolus
    • Bachant, J. B. & Elledge, S. J. Mitotic treasures in the nucleolus. Nature 398, 757-758 (1999).
    • (1999) Nature , vol.398 , pp. 757-758
    • Bachant, J.B.1    Elledge, S.J.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.