The Transcription Factors Hypoxia-Inducible Factor 1α and Ets-1 Colocalize in the Hypoxic Synovium of Inflamed Joints in Adjuvant-Induced Arthritis

Arthritis and Rheumatism

Volumn 50, Issue 1, 2004, Pages 291-296

  Peters, C L ^a   Morris, C J ^a   Mapp, P I ^a   Blake, D R ^a   Lewis, C E ^b   Winrow, V R ^a  

^a UNIVERSITY OF BATH   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT; CELL MARKER; HYPOXIA INDUCIBLE FACTOR 1ALPHA; MONOCLONAL ANTIBODY; PIMONIDAZOLE; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ETS 1;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; FEMALE; HYPOXIA; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; RAT; RAT STRAIN; RHEUMATOID ARTHRITIS; SCORING SYSTEM; SYNOVIUM;

ANIMALS; ANOXIA; ARTHRITIS, EXPERIMENTAL; DISEASE MODELS, ANIMAL; FEMALE; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; PROTO-ONCOGENE PROTEIN C-ETS-1; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-ETS; RATS; RATS, INBRED LEW; SYNOVIAL MEMBRANE; SYNOVITIS; TRANSCRIPTION FACTORS;

EID: 0347719258     PISSN: 00043591     EISSN: None     Source Type: Journal    
DOI: 10.1002/art.11473     Document Type: Article

References (15)

1. Stevens CR, Blake DR, Merry P, Revell PA, Levick JR. A comparative study by morphometry of the microvasculature in normal and rheumatoid synovium. Arthritis Rheum 1991;34:1508-13.
2. Steinbrech DS, Longaker MT, Mehrara BJ, Saadeh PB, Chin GS, Gerrets RP, et al. Fibroblast response to hypoxia: the relationship between angiogenesis and matrix regulation. J Surg Res 1999;84:127-33.
3. Wernert N, Gilles F, Fafeur V, Bouali F, Raes MB, Pyke C. Stromal expression of c-Ets1 transcription factor correlates with tumor invasion. Cancer Res 1994;54:5683-8.
4. Wernert N, Justen HP, Rothe M, Behrens P, Dreschers S, Neuhaus T, et al. The Ets 1 transcription factor is upregulated during inflammatory angiogenesis in rheumatoid arthritis. J Mol Med 2002;80:258-66.
5. Hollander AP, Corke KP, Freemont AJ, Lewis CE. Expression of hypoxia-inducible factor 1α by macrophages in the rheumatoid synovium: implications for targeting of therapeutic genes to the inflamed joint. Arthritis Rheum 2001;44:1540-4.
6. Luttun A, Tjwa M, Moons L, Wu Y, Angelillo-Scherrer A, Liao F, et al. Revascularization of ischemic tissues by P1GF treatment, and inhibition of tumor angiogenesis, arthritis and atherosclerosis by anti-Flt1. Nat Med 2002;8:831-40.
7. Arteel GE, Thurman RG, Raleigh JA. Reductive metabolism of the hypoxia marker pimonidazole is regulated by oxygen tension independent of the pyridine nucleotide redox state. Eur J Biochem 1998;253:743-50.
8. Kennedy AS, Raleigh JA, Perez GM, Calkins DP, Thrall DE, Novotny DB, et al. Proliferation and hypoxia in human squamous cell carcinoma of the cervix: first report of combined immunohistochemical assays. Int J Radiat Oncol Biol Phys 1997;37:897-905.
9. Andrews FJ, Morris CJ, Kondratowicz G, Blake DR. Effect of iron chelation on inflammatory joint disease. Ann Rheum Dis 1987;46:327-33.
10. Pogue BW, Paulsen KD, O'Hara JA, Wilmot CM, Swartz HM. Estimation of oxygen distribution in RIF-1 tumors by diffusion model-based interpretation of pimonidazole hypoxia and Eppendorf measurements. Radiat Res 1995;155:15-25.
11. Hitchon C, Wong K, Ma G, Reed J, Lyttle D, El-Gabalawy H. Hypoxia-induced production of stromal cell-derived factor 1 (CXCL12) and vascular endothelial growth factor by synovial fibroblasts. Arthritis Rheum 2002;46:2587-97.
12. Oikawa M, Abe M, Kurosawa H, Hida W, Shirato K, Sato Y. Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1. Biochem Biophys Res Commun 2001; 289:39-43.
13. Lelievre E, Lionneton F, Soncin F, Vandenbunder B. The Ets family contains transcriptional activators and repressors involved in angiogenesis. Int J Biochem Cell Biol 2001;4:391-407.
14. Klimiuk PA, Sierakowski S, Latosiewicz R, Cylwik B, Skowronski J, Chwiecko J. Serum matrix metalloproteinases and tissue inhibitors of metalloproteinases in different histological variants of rheumatoid synovitis. Rheumatology (Oxford) 2002;41:78-87.
15. Wiesener MS, Turley H, Allen WE, Willam C, Eckardt KU, Talks KL, et al. Induction of endothelial PAS domain protein-1 by hypoxia: characterization and comparison with hypoxia-inducible factor-1alpha. Blood 1998;92:2260-8.