HIF-1 and AP-1 cooperate to increase gene expression in hypoxia: Role of MAP kinases

IUBMB Life

Volumn 52, Issue 1-2, 2001, Pages 49-53

  Michiels, C ^a   Minet, E ^a   Michel, G ^a   Mottet, D ^a   Piret, J P ^a   Raes, M ^a  

^a UNIVERSITY OF NAMUR   (Belgium)

Author keywords

AP 1; HIF 1; Hypoxia; MAP kinases; VEGF

Indexed keywords

ERYTHROPOIETIN; GLUCOSE TRANSPORTER; GLYCOLYTIC ENZYME; HYPOXIA INDUCIBLE FACTOR 1; TRANSCRIPTION FACTOR AP 1; VASCULOTROPIN;

CONFERENCE PAPER; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME INHIBITION; ENZYME REGULATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; HYPOXIA; PROTEIN FAMILY;

ANIMALS; ANOXIA; DNA-BINDING PROTEINS; ENDOTHELIAL GROWTH FACTORS; GENE EXPRESSION REGULATION; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; LYMPHOKINES; MITOGEN-ACTIVATED PROTEIN KINASES; NUCLEAR PROTEINS; TRANSCRIPTION FACTOR AP-1; TRANSCRIPTION FACTORS; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS;

EID: 0036139795     PISSN: 15216543     EISSN: None     Source Type: Journal    
DOI: 10.1080/15216540252774766     Document Type: Conference Paper

References (47)

1. Oxygen(e)s and the hypoxia-inducible factor-1
2. HIF-1: Mediator of physiological and pathological responses to hypoxia
3. Hypoxia response element in the aldolase A, enolase 1, and lactate deshydrogenase A promoters contain essential binding sites for hypoxia-inducible factor 1
4. Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
5. Regulation of gene expression for tyrosine hydroxylase in oxygen sensitive cells by hypoxia
6. Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1
7. Endothelial cell responses to hypoxic stress
8. 2 tension
9. Hypoxia-inducible factor 1a (HIF-1a) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions
10. 2-dependent degradation domain via the ubiquitin-proteasome pathway
11. Regulation of the hypoxia-inducible transcription factor 1alpha by the ubiquitin-proteasome pathway
12. Efficient translation of mouse hypoxia-inducible factor-1alpha under normoxic and hypoxic conditions
13. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
14. Ubiquitination of hypoxia-inducible factor requires direct binding to the beta-domain of the von Hippel-Lindau protein
15. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
16. Mechanism of regulation of the hypoxia-inducible factor-1 alpha by the von Hippel-Lindau tumor suppressor protein
17. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
18. The von Hippel-Lindau tumor suppressor protein
19. 2 sensing
20. 2-regulated prolyl hydroxylation
21. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
22. Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
23. Loss of PTEN facilitates HIF-1-mediated gene expression
24. Molecular mechanisms of transcription activation by HLF and HIF1alpha in response to hypoxia: Their stabilization and redox signal-induced interaction with CBP/p300
25. Hypoxia-induced activation of HIF-1: Role of HIF-1alpha-Hsp90 interaction
26. Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
27. Redox-regulated recruitment of the transcriptional coactivators CREB-binding protein and SRC-1 to hypoxia-inducible factor 1alpha
28. Effect of protein kinase and phosphatase inhihitors on expression of hypoxia-inducible factor 1
29. Complex role of protein phosphorylation in gene activation by hypoxia
30. ERK activation upon hypoxia: Involvement in HIF-1 activation
31. p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1alpha (HIF-1alpha) and enhance the transcriptional activity of HIF-1
32. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
33. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK
34. AP-1: One switch for many signals
35. The regulation of AP-1 activity by mitogen-activated protein kinase
36. The stress-activated protein kinase subfamily of c-Jun kinases
37. Selective activation of p38alpha and p38gamma by hypoxia
38. Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types
39. Hypoxia-induced apoptosis in human hepatocellular carcinoma cells: A possible involvement of the 6-TG-sensitive protein kinase(s)-dependent signaling pathway
40. The genomic response of tumor cells to hypoxia and reoxygenation: Differential activation of transcription factor AP-1 and NF-κB
41. Regulation of c-jun expression during hypoxic and low-glucose stress
42. Hypoxia-induced bFGF gene expression is mediated through the JNK signal transduction pathway
43. Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway
44. c-JUN gene induction and AP-1 activity is regulated by a JNK-dependent pathway in hypoxic HepG2 cells
45. Activator-protein-1 binding potentiates the hypoxia-inducible factor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells
46. 2+ and PKC