Current paradigms in cellular oxygen sensing

Advances in Experimental Medicine and Biology

Volumn 543, Issue , 2003, Pages 57-71

  Schumacker, Paul T ^a  

^a NONE

Author keywords

Hypoxia, mitochondria, NAD(P)H oxidase; Reactive oxygen species

Indexed keywords

ANTIMYCIN A1; CYANIDE; MYXOTHIAZOL; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; ROTENONE; SUPEROXIDE;

CAROTID BODY; CELL ORGANELLE; CONFERENCE PAPER; ELECTRON TRANSPORT; EMBRYO DEVELOPMENT; HUMAN; HYPOXIA; MITOCHONDRIAL RESPIRATION; MODEL; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; REGULATORY MECHANISM; SIGNAL TRANSDUCTION; SURVIVAL;

EID: 0842334756     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4419-8997-0_5     Document Type: Conference Paper

References (84)

1. Abdalla S and Will JA. Potentiation of the hypoxic contraction of guinea-pig isolated pulmonary arteries by two inhibitors of superoxide dismutase. Gen Pharmacol 26: 785-792, 1995.
2. Ali MH, Schlidt SA, Chandel NS, Hynes KL, Schumacker PT and Gewertz BL. Endothelial permeability and IL-6 production during hypoxia: role of ROS in signal transduction. Am J Physiol 277: L1057-L1065, 1999.
3. Archer S and Michelakis E. The mechanism(s) of hypoxic pulmonary vasoconstriction: potassium channels, redox O(2) sensors, and controversies. News Physiol Sci 17: 131-137, 2002.
4. 2 sensor in rat pulmonary vasculature. Circ Res 73: 1100-1112, 1993.
5. 2 sensing is preserved in mice lacking the gp91 phox subunit of NADPH oxidase. Proc Natl Acad Sci U S A 96: 7944-7949, 1999.
6. Aslund F, Zheng M, Beckwith J and Storz G. Regulation of the OxyR transcription factor by hydrogen peroxide and the cellular thiol - disulfide status. Proc Natl Acad Sci USA 96: 6161-6165, 1999.
7. Babior BM, Lambeth JD and Nauseef W. The neutrophil NADPH oxidase. Arch Biochem Biophys 397: 342-344, 2002.
8. Boveris A, Oshino N and Chance B. The cellular production of hydrogen peroxide. Biochem J 128: 617-630, 1972.
9. Bunn HF and Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Reviews 76: 839-885, 1996.
10. Burke TM and Wolin MS. Hydrogen peroxide elicits pulmonary arterial relaxation and guanylate cyclase activation. Am J Physiol 252: H721-H732, 1987.
11. Chandel NS, Budinger GRS and Schumacker PT. Molecular oxygen modulates cytochrome c oxidase function. J Biol Chem 271: 18672-18677, 1996.
12. Chandel NS, Maltepe E, Goldwasser E, Mathieu CE, Simon MC and Schumacker PT. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription. Proc Natl Acad Sci USA 95: 11715-11720, 1998.
13. 2 sensing. J Biol Chem 275: 25130-25138, 2000.
14. Chandel NS, Trzyna WC, McClintock DS and Schumacker PT. Role of Oxidants in NF-kappaB Activation and TNF-alpha Gene Transcription Induced by Hypoxia and Endotoxin. J Immunol 165: 1013-1021, 2000.
15. Chandel NS, Vander Heiden MG, Thompson CB and Schumacker PT. Redox regulation of p53 during hypoxia. Oncogene 19: 3840-3848, 2000.
16. Cooper CE. The steady-state kinetics of cytochrome c oxidation by cytochrome oxidase. Bioch Biophys Act 1017: 187-203, 1990.
17. Duranteau J, Chandel NS, Kulisz A, Shao Z and Schumacker PT. Intracellular signaling by reactive oxygen species during hypoxia in cardiomyocytes. J Biol Chem 273: 11619-11624, 1998.
18. Dusi S, Della B, V, Grzeskowiak M and Rossi F. Relationship between phosphorylation and translocation to the plasma membrane of p47phox and p67phox and activation of the NADPH oxidase in normal and Ca(2+)-depleted human neutrophils. Biochem J 290 (Pt 1): 173-178, 1993.
19. Epstein AC, Gleadle JM, McNeill LA, Hewitson KS, O'Rourke J, Mole DR, Mukherji M, Metzen E, Wilson MI, Dhanda A, Tian YM, Masson N, Hamilton DL, Jaakkola P, Barstead R, Hodgkin J, Maxwell PH, Pugh CW, Schofield CJ and Ratcliffe PJ. C. elegans EGL-9 and Mammalian Homologs Define a Family of Dioxygenases that Regulate HIF by Prolyl Hydroxylation. Cell 107: 43-54, 2001.
20. Forsythe JA, Jiang BH, Iyer NV, Agani F, Leung SW, Koos RD and Semenza GL. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Molecular & Cellular Biology 16: 4604-4613, 1996.
21. Freeman BA and Crapo JD. Hyperoxia increases oxygen radical production in rat lungs and lung mitochondria. J Biol Chem 256: 10986-10992, 1981.
22. Fu XW, Wang DS, Nurse CA, Dinauer MC and Cutz E. NADPH oxidase is an O2 sensor in airway chemoreceptors: Evidence from K+ current modulation in wild-type and oxidase-deficient mice. Proc Natl Acad Sci USA 97: 4374-4379, 2000.
23. Gilbert HF. Molecular and cellular aspects of thiol-disulfide exchange. Adv Enzymol Relat Areas Mol Biol 63: 69-172, 1990.
24. Gillespie MN, Killilea DW, Solomon M, Babal P, LeDoux SP and Wilson GL. Hypoxia causes oxidant lesions in the rat pulmonary artery smooth muscle cell VEGF gene - Potential link to VEGF mRNA expression. Chest 114: 45S, 1998.
25. Gorlach A, Holtermann G, Jelkmann W, Hancock JT, Jones SA, Jones OT and Acker H. Photometric characteristics of haem proteins in erythropoietin- producing hepatoma cells (HepG2). Biochem J 290: 771-776, 1993.
26. Griendling KK, Minieri CA, Ollerenshaw JD and Alexander RW. Angiotensin II stimulates NADH and NADPH oxidase activity in cultured vascular smooth muscle cells. Circ Res 74: 1141-1148, 1994.
27. Griendling KK, Sorescu D and Ushio-Fukai M. NAD(P)H oxidase - Role in cardiovascular biology and disease. Circ Res 86: 494-501, 2000.
28. Grishko V, Solomon M, Breit JF, Killilea DW, LeDoux SP, Wilson GL and Gillespie MN. Hypoxia promotes oxidative base modifications in the pulmonary artery endothelial cell VEGF gene. FASEB J 15: 1267-1269, 2001.
29. Grishko V, Solomon M, Wilson GL, LeDoux SP and Gillespie MN. Oxygen radical-induced mitochondrial DNA damage and repair in pulmonary vascular endothelial cell phenotypes. Am J Physiol Lung Cell Mol Physiol 280: L1300-L1308, 2001.
30. Han D, Antunes F, Daneri F and Cadenas E. Mitochondrial superoxide anion production and release into intermembrane space. Methods Enzymol 349:271-280: 271-280, 2002.
31. 2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA 95: 7987-7992, 1998.
32. Ivan M, Haberberger T, Gervasi DC, Michelson KS, Guenzler V, Kondo K, Yang HF, Sorokina I, Conaway RC, Conaway JW and Kaelin WG, Jr. Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor. Proc Natl Acad Sci USA 99: 13459-13464, 2002.
33. 2 sensing. Science 292: 464-468, 2001.
34. 2-regulated prolyl hydroxylation. Science 292: 468-472, 2001.
35. Jakob U, Muse W, Eser M and Bardwell JC. Chaperone activity with a redox switch. Cell 96: 341-352, 1999.
36. Jin N, Packer CS and Rhoades RA. Reactive oxygen-mediated contraction in pulmonary arterial smooth muscle: cellular mechanisms. Can J Physiol Pharmacol 69: 383-388, 1991.
37. Jones RD, Hancock JT and Morice AH. NADPH oxidase: a universal oxygen sensor? Free Radic Biol Med 29: 416-424, 2000.
38. Jones RD, Thompson JS and Morice AH. The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries. Physiol Res 49: 587-596, 2000.
39. phox homologues in vascular smooth muscle cells - Nox1 mediates angiotensin II-induced superoxide formation and redox-sensitive signaling pathways. Circ Res 88: 888-894, 2001.
40. Lauweryns JM, Cokelaere M, Deleersynder M and Liebens M. Intrapulmonary neuro-epithelial bodies in newborn rabbits. Influence of hypoxia, hyperoxia, hypercapnia, nicotine, reserpine, L-DOPA and 5-HTP. Cell Tissue Res 182: 425-440, 1977.
41. Leach RM, Hill HM, Snetkov VA, Robertson TP and Ward JPT. Divergent roles of glycolysis and the mitochondrial electron transport chain in hypoxic pulmonary vasoconstriction of the rat: identity of the hypoxic sensor. J Physiol (Lond) 536: 211-224, 2001.
42. Lebovitz RM, Zhang H, Vogel H, Cartwright J, Jr., Dionne L, Lu N, Huang S and Matzuk MM. Neurodegeneration, myocardial injury, and perinatal death in mitochondrial superoxide dismutase-deficient mice. Proc Natl Acad Sci U S A 93: 9782-9787, 1996.
43. Li Y, Huang TT, Carlson EJ, Melov S, Ursell PC, Olson JL, Noble LJ, Yoshimura MP, Berger C, Chan PH and . Dilated cardiomyopathy and neonatal lethality in mutant mice lacking manganese superoxide dismutase. Nat Genet 11: 376-381, 1995.
44. Liu JQ, Sham JS, Shimoda LA, Kuppusamy P and Sylvester JT. Hypoxic constriction and reactive oxygen species in porcine distal pulmonary arteries. Am J Physiol Lung Cell Mol Physiol 2003 (in press).
45. Marshall C, Mamary AJ, Verhoeven AJ and Marshall BE. Pulmonary artery NADPH-oxidase is activated in hypoxic pulmonary vasoconstriction. Am J Resp Cell Molec Biol 15: 633-644, 1996.
46. Maxwell PH, Pugh CW and Ratcliffe PJ. Inducible operation of the erythropoietin 3′ enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. Proc Natl Acad Sci U S A 90: 2423-2427, 1993.
47. Maxwell PH, Wiesener MS, Chang GW, Clifford SC, Vaux EC, Cockman ME, Wykoff CC, Pugh CW, Maher ER and Ratcliffe PJ. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature 20;399: 271-275, 1999.
48. Michelakis ED, Hampl V, Nsair A, Wu XC, Harry G, Haromy A, Gurtu R and Archer SL. Diversity in mitochondrial function explains differences in vascular oxygen sensing. Circ Res 90: 1307-1315, 2002.
49. 2-elicited responses. Am J Physiol 269: L637-L644, 1995.
50. O'Kelly I, Peers C and Kemp PJ. O2-sensitive K+ channels in neuroepithelial body-derived small cell carcinoma cells of the human lung. Am J Physiol Lung Cell Mol Physiol 275: L709-L716, 1998.
51. 2-sensitive K+ current in a human neuroepithelial body-derived cell line. Am J Physiol Lung Cell Mol Physiol 276: L96-L104, 1999.
52. 2-induced channel activation are on luminal side of ryanodine receptors. Am J Physiol 274: C914-C921, 1998.
53. Ostergaard H, Henriksen A, Hansen FG and Winther JR. Shedding light on disulfide bond formation: engineering a redox switch in green fluorescent protein. EMBO J 20: 5853-5862, 2001.
54. Prabhakar NR. Oxygen sensing by the carotid body chemoreceptors. J Appl Physiol 88: 2287-2295, 2000.
55. Ravi R, Mookerjee B, Bhujwalla ZM, Sutter CH, Artemov D, Zeng QW, Dillehay LE, Madan A, Semenza GL and Bedi A. Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha. Genes Dev 14: 34-44, 2000.
56. Reeve HL, Tolarova S, Nelson DP, Archer S and Weir EK. Redox control of oxygen sensing in the rabbit ductus arteriosus. J Physiol (Lond) 533: 253-261, 2001.
57. + channel activity and tone in rat vascular tissue. Exp Physiol 80: 825-834, 1995.
58. Rhoades RA, Packer CS and Meiss RA. Pulmonary vascular smooth muscle contractility. Effect of free radicals. Chest 93: 94S-95S, 1988.
59. Rhoades RA, Packer CS, Roepke DA, Jin N and Meiss RA. Reactive oxygen species alter contractile properties of pulmonary arterial smooth muscle. Can J Physiol Pharmacol 68: 1581-1589, 1990.
60. Rumsey WL, Schlosser C, Nuutinen EM, Robiolio M and Wilson DF. Cellular energetics and the oxygen dependence of respiration in cardiac myocytes isolated from adult rat. J Biol Chem 265: 15392-15399, 1990.
61. Schroedl C, McClintock DS, Budinger GRS and Chandel NS. Hypoxic but not anoxic stabilization of HIF-1alpha requires mitochondrial reactive oxygen species. Am J Physiol Lung Cell Mol Physiol 283: L922-L931, 2002.
62. 2 sensing: the search continues. Am J Physiol Lung Cell Mol Physiol 283: L918-L921, 2002.
63. Schumacker PT and Cain SM. The concept of a critical oxygen delivery. Intensive Care Med 13: 223-229, 1987.
64. Semenza GL. Perspectives on oxygen sensing. Cell 98: 281-284, 1999.
65. 2, and the 3 PHDs: How animal cells signal hypoxia to the nucleus. Cell 107: 1-3, 2001.
66. Semenza GL and Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Molec Cell Biol 12: 5447-5454, 1992.
67. Seshiah PN, Weber DS, Rocic P, Valppu L, Taniyama Y and Griendling KK. Angiotensin II stimulation of NAD(P)H oxidase activity - Upstream mediators. Circ Res 91: 406-413, 2002.
68. Sham JSK. Hypoxic pulmonary vasoconstriction - Ups and downs of reactive oxygen species. Circ Res 91: 649-651, 2002.
69. Suh YA, Arnold RS, Lassegue B, Shi J, Xu X, Sorescu D, Chung AB, Griendling KK and Lambeth JD. Cell transformation by the superoxide-generating oxidase Mox1. Nature 401: 79-82, 1999.
70. Tan CC and Ratcliffe PJ. Effect of inhibitors of oxidative phosphorylation on erythropoietin mRNA in isolated perfused rat kidneys. Am J Physiol 261: F982-F987, 1991.
71. Thomas HM, III, Carson RC, Fried ED and Novitch RS. Inhibition of hypoxic pulmonary vasoconstriction by diphenyleneiodonium. Biochem Pharmacol 42: R9-12, 1991.
72. Thompson JS, Jones RD, Rogers TK, Hancock J and Morice AH. Inhibition of hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries by diphenyleneiodonium (DPI). Pulm Pharmacol Ther 11: 71-75, 1998.
73. Turrens JF, Alexandre A and Lehninger AL. Ubisemiquinone is the electron donor for superoxide formation by complex III of heart mitochondria. Arch Biochem Biophys 237: 408-414, 1985.
74. + channels by hydrogen peroxide. Biochem Biophys Res Commun 186: 1681-1687, 1992.
75. Waypa GB, Chandel NS and Schumacker PT. Model for hypoxic pulmonary vasoconstriction involving mitochondrial oxygen sensing. Circ Res 88: 1259-1266, 2001.
76. Waypa GB, Marks JD, Mack MM, Boriboun C, Mungai PT and Schumacker PT. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res 91: 719-726, 2002.
77. Waypa GB, Marks JD, Mack MM, Boriboun C, Mungai PT and Schumacker PT. Mitochondrial reactive oxygen species trigger calcium increases during hypoxia in pulmonary arterial myocytes. Circ Res 91: 719-726, 2002.
78. Waypa GB and Schumacker PT. O(2) sensing in hypoxic pulmonary vasoconstriction: the mitochondrial door re-opens. Respir Physiolo Neurobiol 132: 81-91, 2002.
79. Weir EK and Archer SL. The mechanism of acute hypoxic pulmonary vasoconstriction: a tale of two channels. FASEB J 9: 183-189, 1995.
80. Weir EK, Reeve HL, Peterson DA, Michelakis ED, Nelson DP and Archer SL. Pulmonary vasoconstriction, oxygen sensing, and the role of ion channels - Thomas A. Neff Lecture. Chest 114: 17S-22S, 1998.
81. Wilson DF, Rumsey WL, Green TJ and Vanderkooi JM. The oxygen dependence of mitochondrial oxidative phosphorylation measured by a new optical method for measuring oxygen concentration. J Biol Chem 263: 2712-2718, 1988.
82. 2-sensing protein (NADPH oxidase) in chemoreceptor cells. Microsc Res Tech 37: 101-106, 1997.
83. Youngson C, Nurse C, Yeger H and Cutz E. Oxygen sensing in airway chemoreceptors. Nature 365: 153-155, 1993.
84. Zhu H and Bunn HF. Signal transduction - How do cells sense oxygen? Science 20;292: 449-451, 2001.