Hypoxia-inducible factor 2α binds to cobalt in vitro

Biochemical and Biophysical Research Communications

Volumn 288, Issue 4, 2001, Pages 849-854

  Yuan, Y ^a   Beitner Johnson, D ^a   Millhorn, D E ^a  

^a UNIVERSITY OF CINCINNATI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COBALT; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 2ALPHA; IRON; OXYGEN; PROTEASOME; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DNA RESPONSIVE ELEMENT; GENE EXPRESSION; GENE MUTATION; GENETIC TRANSCRIPTION; HYPOXIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STABILITY;

EID: 0035834566     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.5835     Document Type: Article

References (22)

1. Exploiting the hypoxic cancer cell: Mechanisms and therapeutic strategies
2. Erythropoietin: Structure, control of production, and function
3. Similarities between the oxygen-sensing mechanisms regulating the expression of vascular endothelial growth factor and erythropoietin
4. Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia
5. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
6. 2 homeostasis by hypoxia-inducible factor 1
7. Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension
8. Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its alpha subunit
9. Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
10. Induction of endothelial PAS domain protein-1 by hypoxia: Characterization and comparison with hypoxia-inducible factor-1alpha
11. Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3′-untranslated region of rat tyrosine hydroxylase mRNA
12. EPAS1 trans-activation during hypoxia requires p42/p44 MAPK
13. Oxygen-regulated and transactivating domains in endothelial PAS protein 1: Comparison with hypoxia-inducible factor-1alpha
14. Regulation of the erythropoietin gene: Evidence that the oxygen sensor is a heme protein
15. Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
16. Erythropoietin induction in Hep3B cells is not affected by inhibition of heme biosynthesis
17. Mitochondrial reactive oxygen species trigger hypoxia-induced transcription
18. Carcinogenic metals induce hypoxia-inducible factor-stimulated transcription by reactive oxygen species-independent mechanism
19. Reactive oxygen species generated at mitochondrial complex III stabilize hypoxia-inducible factor-1alpha during hypoxia: A mechanism of O2 sensing
20. Comparative resistance of the 20S and 26S proteasome to oxidative stress
21. Phosphorylation-dependent targeting of cAMP response element binding protein to the ubiquitin/proteasome pathway in hypoxia
22. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis