-
1
-
-
0030690459
-
Molecular aspects of oxygen sensing in physiological adaptation to hypoxia
-
Czyzyk-Krzeska MF. Molecular aspects of oxygen sensing in physiological adaptation to hypoxia. Respir Physiol. 1997;110:99-111.
-
(1997)
Respir Physiol
, vol.110
, pp. 99-111
-
-
Czyzyk-Krzeska, M.F.1
-
2
-
-
0029842459
-
Oxygen sensing and molecular adaptation to hypoxia
-
Bunn HF, Poyton RO. Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev. 1996;76:839-885.
-
(1996)
Physiol Rev
, vol.76
, pp. 839-885
-
-
Bunn, H.F.1
Poyton, R.O.2
-
3
-
-
8044253996
-
Structural and functional analysis of hypoxia-inducible factor 1
-
Semenza GL, Agani F, Booth G, et al. Structural and functional analysis of hypoxia-inducible factor 1. Kidney Int. 1997;51:553-555.
-
(1997)
Kidney Int
, vol.51
, pp. 553-555
-
-
Semenza, G.L.1
Agani, F.2
Booth, G.3
-
4
-
-
0026468180
-
A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
-
Semenza GL, Wang GL. A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Mol Cell Biol. 1992;12:5447-5454.
-
(1992)
Mol Cell Biol
, vol.12
, pp. 5447-5454
-
-
Semenza, G.L.1
Wang, G.L.2
-
5
-
-
0028816847
-
Purification and characterization of hypoxia-inducible factor 1
-
Wang GL, Semenza GL. Purification and characterization of hypoxia-inducible factor 1. J Biol Chem. 1995;270:1230-1237.
-
(1995)
J Biol Chem
, vol.270
, pp. 1230-1237
-
-
Wang, G.L.1
Semenza, G.L.2
-
6
-
-
0029944965
-
Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
-
Jiang BH, Rue E, Wang GL, Roe R, Semenza GL. Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. J Biol Chem. 1996;271:17771-17778.
-
(1996)
J Biol Chem
, vol.271
, pp. 17771-17778
-
-
Jiang, B.H.1
Rue, E.2
Wang, G.L.3
Roe, R.4
Semenza, G.L.5
-
7
-
-
0030787469
-
Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension
-
Jiang BH, Zheng JZ, Leung SW, Roe R, Semenza GL. Transactivation and inhibitory domains of hypoxia-inducible factor 1alpha. Modulation of transcriptional activity by oxygen tension. J Biol Chem. 1997;272:19253-19260.
-
(1997)
J Biol Chem
, vol.272
, pp. 19253-19260
-
-
Jiang, B.H.1
Zheng, J.Z.2
Leung, S.W.3
Roe, R.4
Semenza, G.L.5
-
8
-
-
0032538797
-
Signal transduction in hypoxic cells: Inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha
-
Kallio PJ, Okamoto K, O'Brien S, et al. Signal transduction in hypoxic cells: inducible nuclear translocation and recruitment of the CBP/p300 coactivator by the hypoxia-inducible factor-1alpha. EMBO J. 1998;17:6573-6586.
-
(1998)
EMBO J
, vol.17
, pp. 6573-6586
-
-
Kallio, P.J.1
Okamoto, K.2
O'Brien, S.3
-
9
-
-
0032493368
-
Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway
-
Huang LE, Gu J, Schau M, Bunn HF. Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway. Proc Natl Acad Sci USA. 1998;95:7987-7992.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 7987-7992
-
-
Huang, L.E.1
Gu, J.2
Schau, M.3
Bunn, H.F.4
-
10
-
-
0035834409
-
A conserved family of prolyl-4-hydroxylases that modify HIF
-
Bruick RK, McKnight SL. A conserved family of prolyl-4-hydroxylases that modify HIF. Science. 2001;294:1337-1340.
-
(2001)
Science
, vol.294
, pp. 1337-1340
-
-
Bruick, R.K.1
McKnight, S.L.2
-
11
-
-
17944375360
-
C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation
-
Epstein AC, Gleadle JM, McNeill LA, et al. C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation. Cell. 2001;107:43-54.
-
(2001)
Cell
, vol.107
, pp. 43-54
-
-
Epstein, A.C.1
Gleadle, J.M.2
McNeill, L.A.3
-
12
-
-
0035917313
-
HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: Implications for O2 sensing
-
Ivan M, Kondo K, Yang H, et al. HIFalpha targeted for VHL-mediated destruction by proline hydroxylation: implications for O2 sensing. Science. 2001;292:464-468.
-
(2001)
Science
, vol.292
, pp. 464-468
-
-
Ivan, M.1
Kondo, K.2
Yang, H.3
-
14
-
-
0035903468
-
Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation
-
Masson N, Willam C, Maxwell PH, Pugh CW, Ratcliffe PJ. Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation. EMBO J. 2001;20:5197-5206.
-
(2001)
EMBO J
, vol.20
, pp. 5197-5206
-
-
Masson, N.1
Willam, C.2
Maxwell, P.H.3
Pugh, C.W.4
Ratcliffe, P.J.5
-
15
-
-
0034641615
-
Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex
-
Kamura T, Sato S, Iwai K, Czyzyk-Krzeska M, Conaway RC, Conaway JW. Activation of HIF1alpha ubiquitination by a reconstituted von Hippel-Lindau (VHL) tumor suppressor complex. Proc Natl Acad Sci USA. 2000;97:10430-10435.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 10430-10435
-
-
Kamura, T.1
Sato, S.2
Iwai, K.3
Czyzyk-Krzeska, M.4
Conaway, R.C.5
Conaway, J.W.6
-
16
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell PH, Wiesener MS, Chang GW, et al. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature. 1999;399:271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
-
17
-
-
18744375998
-
Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation
-
Jeong JW, Bae MK, Ahn MY, et al. Regulation and destabilization of HIF-1alpha by ARD1-mediated acetylation. Cell. 2002;111:709-720.
-
(2002)
Cell
, vol.111
, pp. 709-720
-
-
Jeong, J.W.1
Bae, M.K.2
Ahn, M.Y.3
-
18
-
-
0036469038
-
Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch
-
Lando D, Peet DJ, Whelan DA, Gorman JJ, Whitelaw ML. Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch. Science. 2002;295:858-861.
-
(2002)
Science
, vol.295
, pp. 858-861
-
-
Lando, D.1
Peet, D.J.2
Whelan, D.A.3
Gorman, J.J.4
Whitelaw, M.L.5
-
19
-
-
0035887011
-
FIH-1: A novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
-
Mahon PC, Hirota K, Semenza GL. FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity. Genes Dev. 2001;15:2675-2686.
-
(2001)
Genes Dev
, vol.15
, pp. 2675-2686
-
-
Mahon, P.C.1
Hirota, K.2
Semenza, G.L.3
-
20
-
-
18544386401
-
Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family
-
Hewitson KS, McNeill LA, Riordan MV, et al. Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family. J Biol Chem. 2002;277:26351-26355.
-
(2002)
J Biol Chem
, vol.277
, pp. 26351-26355
-
-
Hewitson, K.S.1
McNeill, L.A.2
Riordan, M.V.3
-
21
-
-
0037097861
-
FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor
-
Lando D, Peet DJ, Gorman JJ, Whelan DA, Whitelaw ML, Bruick RK. FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor. Genes Dev. 2002;16:1466-1471.
-
(2002)
Genes Dev
, vol.16
, pp. 1466-1471
-
-
Lando, D.1
Peet, D.J.2
Gorman, J.J.3
Whelan, D.A.4
Whitelaw, M.L.5
Bruick, R.K.6
-
22
-
-
0026846928
-
The role of angiogenesis in tumor growth
-
Folkman J. The role of angiogenesis in tumor growth. Semin Cancer Biol. 1992;3:65-71.
-
(1992)
Semin Cancer Biol
, vol.3
, pp. 65-71
-
-
Folkman, J.1
-
23
-
-
0036216692
-
HIF-1 and tumor progression: Pathophysiology and therapeutics
-
Semenza GL. HIF-1 and tumor progression: pathophysiology and therapeutics. Trends Mol Med. 2002;8:S62-S67.
-
(2002)
Trends Mol Med
, vol.8
-
-
Semenza, G.L.1
-
24
-
-
0034654174
-
Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
-
Zhong H, Chiles K, Feldser D, et al. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res. 2000;60:1541-1545.
-
(2000)
Cancer Res
, vol.60
, pp. 1541-1545
-
-
Zhong, H.1
Chiles, K.2
Feldser, D.3
-
25
-
-
0035012605
-
HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: Novel mechanism for HIF-1-mediated vascular endothelial growth factor expression
-
Laughner E, Taghavi P, Chiles K, Mahon PC, Semenza GL. HER2 (neu) signaling increases the rate of hypoxia-inducible factor 1alpha (HIF-1alpha) synthesis: novel mechanism for HIF-1-mediated vascular endothelial growth factor expression. Mol Cell Biol. 2001;21:3995-4004.
-
(2001)
Mol Cell Biol
, vol.21
, pp. 3995-4004
-
-
Laughner, E.1
Taghavi, P.2
Chiles, K.3
Mahon, P.C.4
Semenza, G.L.5
-
26
-
-
0037008770
-
Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
-
Treins C, Giorgetti-Peraldi S, Murdaca J, Semenza GL, Van Obberghen E. Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway. Biol Chem. 2002;277:27975-27981.
-
(2002)
Biol Chem
, vol.277
, pp. 27975-27981
-
-
Treins, C.1
Giorgetti-Peraldi, S.2
Murdaca, J.3
Semenza, G.L.4
Van Obberghen, E.5
-
27
-
-
12244267687
-
Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells
-
Park JH, Kim TY, Jong HS, et al. Gastric epithelial reactive oxygen species prevent normoxic degradation of hypoxia-inducible factor-1alpha in gastric cancer cells. Clin Cancer Res. 2003;9:433-440.
-
(2003)
Clin Cancer Res
, vol.9
, pp. 433-440
-
-
Park, J.H.1
Kim, T.Y.2
Jong, H.S.3
-
28
-
-
0033571682
-
Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases
-
Zhong H, De Marzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1alpha in common human cancers and their metastases. Cancer Res. 1999;59:5830-5835.
-
(1999)
Cancer Res
, vol.59
, pp. 5830-5835
-
-
Zhong, H.1
De Marzo, A.M.2
Laughner, E.3
-
29
-
-
0034213146
-
Expression of hypoxia-inducible factor 1alpha in brain tumors: Association with angiogenesis, invasion, and progression
-
Zagzag D, Zhong H, Scalzitti JM, Laughner E, Simons JW, Semenza GL. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 2000;88:2606-2618.
-
(2000)
Cancer
, vol.88
, pp. 2606-2618
-
-
Zagzag, D.1
Zhong, H.2
Scalzitti, J.M.3
Laughner, E.4
Simons, J.W.5
Semenza, G.L.6
-
30
-
-
0034282518
-
Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer
-
Birner P, Schindl M, Obermair A, Plank C, Breitenecker G, Oberhuber G. Overexpression of hypoxia-inducible factor 1alpha is a marker for an unfavorable prognosis in early-stage invasive cervical cancer. Cancer Res. 2000;60:4693-4696.
-
(2000)
Cancer Res
, vol.60
, pp. 4693-4696
-
-
Birner, P.1
Schindl, M.2
Obermair, A.3
Plank, C.4
Breitenecker, G.5
Oberhuber, G.6
-
31
-
-
0035925072
-
Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis
-
Bos R, Zhong H, Hanrahan CF, et al. Levels of hypoxia-inducible factor-1 alpha during breast carcinogenesis. J Natl Cancer Inst. 2001;93:309-314.
-
(2001)
J Natl Cancer Inst
, vol.93
, pp. 309-314
-
-
Bos, R.1
Zhong, H.2
Hanrahan, C.F.3
-
32
-
-
0035300410
-
Expression of hypoxia-inducible factor-1alpha: A novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer
-
Aebersold DM, Burri P, Beer KT, et al. Expression of hypoxia-inducible factor-1alpha: a novel predictive and prognostic parameter in the radiotherapy of oropharyngeal cancer. Cancer Res. 2001;61:2911-2916.
-
(2001)
Cancer Res
, vol.61
, pp. 2911-2916
-
-
Aebersold, D.M.1
Burri, P.2
Beer, K.T.3
-
33
-
-
0030816109
-
Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
-
Maxwell PH, Dachs GU, Gleadle JM, et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc Natl Acad Sci USA. 1997;94:8104-8109.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8104-8109
-
-
Maxwell, P.H.1
Dachs, G.U.2
Gleadle, J.M.3
-
34
-
-
0035159670
-
HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia
-
Stroka DM, Burkhardt T, Desbaillets I, et al. HIF-1 is expressed in normoxic tissue and displays an organ-specific regulation under systemic hypoxia. FASEB J. 2001;15:2445-2453.
-
(2001)
FASEB J
, vol.15
, pp. 2445-2453
-
-
Stroka, D.M.1
Burkhardt, T.2
Desbaillets, I.3
-
35
-
-
18444380862
-
Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys
-
Rosenberger C, Mandriota S, Jurgensen JS, et al. Expression of hypoxia-inducible factor-1alpha and -2alpha in hypoxic and ischemic rat kidneys. J Am Soc Nephrol. 2002;13:1721-1732.
-
(2002)
J Am Soc Nephrol
, vol.13
, pp. 1721-1732
-
-
Rosenberger, C.1
Mandriota, S.2
Jurgensen, J.S.3
-
36
-
-
0033435198
-
Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain
-
Bergeron M, Yu AY, Solway KE, Semenza GL, Sharp FR. Induction of hypoxia-inducible factor-1 (HIF-1) and its target genes following focal ischaemia in rat brain. Eur J Neurosci. 1999;11:4159-4170.
-
(1999)
Eur J Neurosci
, vol.11
, pp. 4159-4170
-
-
Bergeron, M.1
Yu, A.Y.2
Solway, K.E.3
Semenza, G.L.4
Sharp, F.R.5
-
37
-
-
0034594876
-
Early expression of angiogenesis factors in acute myocardial ischemia and infarction
-
Lee SH, Wolf PL, Escudero R, Deutsch R, Jamieson SW, Thistlethwaite PA. Early expression of angiogenesis factors in acute myocardial ischemia and infarction. N Engl J Med. 2000;342:626-633.
-
(2000)
N Engl J Med
, vol.342
, pp. 626-633
-
-
Lee, S.H.1
Wolf, P.L.2
Escudero, R.3
Deutsch, R.4
Jamieson, S.W.5
Thistlethwaite, P.A.6
-
38
-
-
0344705115
-
VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis
-
Li J, Brown LF, Hibberd MG, Grossman JD, Morgan JP, Simons M. VEGF, flk-1, and flt-1 expression in a rat myocardial infarction model of angiogenesis. Am J Physiol. 1996;270: H1803-H1811.
-
(1996)
Am J Physiol
, vol.270
-
-
Li, J.1
Brown, L.F.2
Hibberd, M.G.3
Grossman, J.D.4
Morgan, J.P.5
Simons, M.6
-
39
-
-
0013199207
-
Early expression of myocardial HIF-1alpha in response to mechanical stresses: Regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway
-
Kim CH, Cho YS, Chun YS, Park JW, Kim MS. Early expression of myocardial HIF-1alpha in response to mechanical stresses: regulation by stretch-activated channels and the phosphatidylinositol 3-kinase signaling pathway. Circ Res. 2002;90:E25-E33.
-
(2002)
Circ Res
, vol.90
-
-
Kim, C.H.1
Cho, Y.S.2
Chun, Y.S.3
Park, J.W.4
Kim, M.S.5
-
40
-
-
0036150703
-
Hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta
-
Kuwahara F, Kai H, Tokuda K, et al. Hypoxia-inducible factor-1alpha/vascular endothelial growth factor pathway for adventitial vasa vasorum formation in hypertensive rat aorta. Hypertension. 2002;39:46-50.
-
(2002)
Hypertension
, vol.39
, pp. 46-50
-
-
Kuwahara, F.1
Kai, H.2
Tokuda, K.3
-
41
-
-
0033104847
-
Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha
-
Yu AY, Shimoda LA, Iyer NV, et al. Impaired physiological responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1alpha. J Clin Invest. 1999;103:691-696.
-
(1999)
J Clin Invest
, vol.103
, pp. 691-696
-
-
Yu, A.Y.1
Shimoda, L.A.2
Iyer, N.V.3
-
42
-
-
0034282388
-
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells
-
Richard DE, Berra E, Pouyssegur J. Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1alpha in vascular smooth muscle cells. J Biol Chem. 2000;275:26765-26771.
-
(2000)
J Biol Chem
, vol.275
, pp. 26765-26771
-
-
Richard, D.E.1
Berra, E.2
Pouyssegur, J.3
-
43
-
-
0024179069
-
Maternal mortality at the University of Nigeria Teaching Hospital, Enugu: A 10-year survey
-
Chukudebelu WO, Ozumba BC. Maternal mortality at the University of Nigeria Teaching Hospital, Enugu: a 10-year survey. Trop J Obstet Gynaecol. 1988;1:23-26.
-
(1988)
Trop J Obstet Gynaecol
, vol.1
, pp. 23-26
-
-
Chukudebelu, W.O.1
Ozumba, B.C.2
-
44
-
-
0025861266
-
Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia
-
Roberts JM, Taylor RN, Goldfien A. Clinical and biochemical evidence of endothelial cell dysfunction in the pregnancy syndrome preeclampsia. Am J Hypertens. 1991;4:700-708.
-
(1991)
Am J Hypertens
, vol.4
, pp. 700-708
-
-
Roberts, J.M.1
Taylor, R.N.2
Goldfien, A.3
-
45
-
-
0027178149
-
Pre-eclampsia: More than pregnancy-induced hypertension
-
Roberts JM, Redman CW. Pre-eclampsia: more than pregnancy-induced hypertension. Lancet. 1993;341:1447-1451.
-
(1993)
Lancet
, vol.341
, pp. 1447-1451
-
-
Roberts, J.M.1
Redman, C.W.2
-
46
-
-
0025909958
-
Placental bed spiral arteries in the hypertensive disorders of pregnancy
-
Pijnenborg R, Anthony J, Davey DA, Rees A, Tiltman AL, Van Assche FA. Placental bed spiral arteries in the hypertensive disorders of pregnancy. Br J Obstet Gynaecol. 1991;98:648-655.
-
(1991)
Br J Obstet Gynaecol
, vol.98
, pp. 648-655
-
-
Pijnenborg, R.1
Anthony, J.2
Davey, D.A.3
Rees, A.4
Tiltman, A.L.5
Van Assche, F.A.6
-
47
-
-
0030935503
-
Placental cytokines and the pathogenesis of preeclampsia
-
Conrad KP, Benyo DF. Placental cytokines and the pathogenesis of preeclampsia. Am J Reprod Immunol. 1997;37:240-249.
-
(1997)
Am J Reprod Immunol
, vol.37
, pp. 240-249
-
-
Conrad, K.P.1
Benyo, D.F.2
-
48
-
-
0030943123
-
Hypoxia stimulates cytokine production by villous explants from the human placenta
-
Benyo DF, Miles TM, Conrad KP. Hypoxia stimulates cytokine production by villous explants from the human placenta. J Clin Endocrinol Metab. 1997;82:1582-1588.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 1582-1588
-
-
Benyo, D.F.1
Miles, T.M.2
Conrad, K.P.3
-
49
-
-
0038710247
-
Impaired oxygen-dependent reduction of HIF-1alpha and -2alpha proteins in pre-eclamptic placentae
-
Rajakumar A, Doty K, Daftary A, Harger G, Conrad KP. Impaired oxygen-dependent reduction of HIF-1alpha and -2alpha proteins in pre-eclamptic placentae. Placenta. 2003;24:199-208.
-
(2003)
Placenta
, vol.24
, pp. 199-208
-
-
Rajakumar, A.1
Doty, K.2
Daftary, A.3
Harger, G.4
Conrad, K.P.5
-
50
-
-
10644283807
-
Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: Oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies - A review
-
Caniggia I, Winter JL. Adriana and Luisa Castellucci Award lecture 2001. Hypoxia inducible factor-1: oxygen regulation of trophoblast differentiation in normal and pre-eclamptic pregnancies - a review. Placenta. 2002;23:S47-S57.
-
(2002)
Placenta
, vol.23
-
-
Caniggia, I.1
Winter, J.L.2
-
51
-
-
0037423948
-
HIF-1alpha is essential for myeloid cell-mediated inflammation
-
Cramer T, Yamanishi Y, Clausen BE, et al. HIF-1alpha is essential for myeloid cell-mediated inflammation. Cell. 2003;112:645-657.
-
(2003)
Cell
, vol.112
, pp. 645-657
-
-
Cramer, T.1
Yamanishi, Y.2
Clausen, B.E.3
-
52
-
-
0142154635
-
Oxygen-dependent and -independent regulation of HIF-1alpha
-
Chun YS, Kim MS, Park JW. Oxygen-dependent and -independent regulation of HIF-1alpha. J Korean Med Sci. 2002;17:581-588.
-
(2002)
J Korean Med Sci
, vol.17
, pp. 581-588
-
-
Chun, Y.S.1
Kim, M.S.2
Park, J.W.3
-
53
-
-
0034629304
-
Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha
-
Gothie E, Richard DE, Berra E, Pages G, Pouyssegur J. Identification of alternative spliced variants of human hypoxia-inducible factor-1alpha. J Biol Chem. 2000;275:6922-6927.
-
(2000)
J Biol Chem
, vol.275
, pp. 6922-6927
-
-
Gothie, E.1
Richard, D.E.2
Berra, E.3
Pages, G.4
Pouyssegur, J.5
-
54
-
-
0035205085
-
A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses
-
Chun YS, Choi E, Yeo EJ, Lee JH, Kim MS, Park JW. A new HIF-1 alpha variant induced by zinc ion suppresses HIF-1-mediated hypoxic responses. J Cell Sci. 2001;114:4051-4061.
-
(2001)
J Cell Sci
, vol.114
, pp. 4051-4061
-
-
Chun, Y.S.1
Choi, E.2
Yeo, E.J.3
Lee, J.H.4
Kim, M.S.5
Park, J.W.6
-
55
-
-
0037083845
-
A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene
-
Chun YS, Choi E, Kim TY, Kim MS, Park JW. A dominant-negative isoform lacking exons 11 and 12 of the human hypoxia-inducible factor-1alpha gene. Biochem J. 2002;362:71-79.
-
(2002)
Biochem J
, vol.362
, pp. 71-79
-
-
Chun, Y.S.1
Choi, E.2
Kim, T.Y.3
Kim, M.S.4
Park, J.W.5
-
56
-
-
0035969508
-
Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression
-
Makino Y, Cao R, Svensson K, et al. Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression. Nature. 2001;414:550-554.
-
(2001)
Nature
, vol.414
, pp. 550-554
-
-
Makino, Y.1
Cao, R.2
Svensson, K.3
-
57
-
-
0037031808
-
Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus
-
Makino Y, Kanopka A, Wilson WJ, Tanaka H, Poellinger L. Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus. J Biol Chem. 2002;277:32405-32408.
-
(2002)
J Biol Chem
, vol.277
, pp. 32405-32408
-
-
Makino, Y.1
Kanopka, A.2
Wilson, W.J.3
Tanaka, H.4
Poellinger, L.5
-
58
-
-
0031565271
-
YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice
-
Teng CM, Wu CC, Ko FN, Lee FY, Kuo SC. YC-1, a nitric oxide-independent activator of soluble guanylate cyclase, inhibits platelet-rich thrombosis in mice. Eur J Pharmacol. 1997;320:161-166.
-
(1997)
Eur J Pharmacol
, vol.320
, pp. 161-166
-
-
Teng, C.M.1
Wu, C.C.2
Ko, F.N.3
Lee, F.Y.4
Kuo, S.C.5
-
59
-
-
0346643472
-
Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity
-
Galle J, Zabel U, Hubner U, et al. Effects of the soluble guanylyl cyclase activator, YC-1, on vascular tone, cyclic GMP levels and phosphodiesterase activity. Br J Pharmacol. 1999;127:195-203.
-
(1999)
Br J Pharmacol
, vol.127
, pp. 195-203
-
-
Galle, J.1
Zabel, U.2
Hubner, U.3
-
60
-
-
0035871942
-
Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells
-
Chun YS, Yeo EJ, Choi E, et al. Inhibitory effect of YC-1 on the hypoxic induction of erythropoietin and vascular endothelial growth factor in Hep3B cells. Biochem Pharmacol. 2001;61:947-954.
-
(2001)
Biochem Pharmacol
, vol.61
, pp. 947-954
-
-
Chun, Y.S.1
Yeo, E.J.2
Choi, E.3
-
61
-
-
0037414180
-
YC-1: A potential anticancer drug targeting hypoxia-inducible factor 1
-
Yeo EJ, Chun YS, Cho YS, et al. YC-1: a potential anticancer drug targeting hypoxia-inducible factor 1. J Natl Cancer Inst. 2003;95:516-525.
-
(2003)
J Natl Cancer Inst
, vol.95
, pp. 516-525
-
-
Yeo, E.J.1
Chun, Y.S.2
Cho, Y.S.3
-
62
-
-
10744231706
-
2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF
-
Mabjeesh NJ, Escuin D, LaVallee TM, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3:363-375.
-
(2003)
Cancer Cell
, vol.3
, pp. 363-375
-
-
Mabjeesh, N.J.1
Escuin, D.2
LaVallee, T.M.3
-
63
-
-
0036682284
-
Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway
-
Rapisarda A, Uranchimeg B, Scudiero DA, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 2002;62:4316-4324.
-
(2002)
Cancer Res
, vol.62
, pp. 4316-4324
-
-
Rapisarda, A.1
Uranchimeg, B.2
Scudiero, D.A.3
-
64
-
-
0034892432
-
Hsp90: Chaperoning signal transduction
-
Richter K, Buchner J. Hsp90: chaperoning signal transduction. J Cell Physiol. 2001;188:281-290.
-
(2001)
J Cell Physiol
, vol.188
, pp. 281-290
-
-
Richter, K.1
Buchner, J.2
-
66
-
-
0032749463
-
Hypoxia-induced activation of HIF-1: Role of HIF-1alpha-Hsp90 interaction
-
Minet E, Mottet D, Michel G, Roland I, Raes M, Remacle J, Michiels C. Hypoxia-induced activation of HIF-1: role of HIF-1alpha-Hsp90 interaction. FEBS Lett. 1999;460:251-256.
-
(1999)
FEBS Lett
, vol.460
, pp. 251-256
-
-
Minet, E.1
Mottet, D.2
Michel, G.3
Roland, I.4
Raes, M.5
Remacle, J.6
Michiels, C.7
-
67
-
-
0037119415
-
Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway
-
Isaacs JS, Jung YJ, Mimnaugh EG, Martinez A, Cuttitta F, Neckers LM. Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway. J Biol Chem. 2002;277:29936-29944.
-
(2002)
J Biol Chem
, vol.277
, pp. 29936-29944
-
-
Isaacs, J.S.1
Jung, Y.J.2
Mimnaugh, E.G.3
Martinez, A.4
Cuttitta, F.5
Neckers, L.M.6
-
68
-
-
0036569704
-
Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells
-
Mabjeesh NJ, Post DE, Willard MT, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res. 2002;62:2478-2482.
-
(2002)
Cancer Res
, vol.62
, pp. 2478-2482
-
-
Mabjeesh, N.J.1
Post, D.E.2
Willard, M.T.3
-
69
-
-
0036841843
-
Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol
-
Hur E, Kim HH, Choi SM, et al. Reduction of hypoxia-induced transcription through the repression of hypoxia-inducible factor-1alpha/aryl hydrocarbon receptor nuclear translocator DNA binding by the 90-kDa heat-shock protein inhibitor radicicol. Mol Pharmacol. 2002;62:975-982.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 975-982
-
-
Hur, E.1
Kim, H.H.2
Choi, S.M.3
-
70
-
-
0034925041
-
Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1
-
Jiang BH, Jiang G, Zheng JZ, Lu Z, Hunter T, Vogt PK. Phosphatidylinositol 3-kinase signaling controls levels of hypoxia-inducible factor 1. Cell Growth Differ. 2001;12:363-369.
-
(2001)
Cell Growth Differ
, vol.12
, pp. 363-369
-
-
Jiang, B.H.1
Jiang, G.2
Zheng, J.Z.3
Lu, Z.4
Hunter, T.5
Vogt, P.K.6
-
71
-
-
0032169214
-
Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1 alpha/ARNT
-
Zelzer E, Levy Y, Kahana C, Shilo BZ, Rubinstein M, Cohen B. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1 alpha/ARNT. EMBO J. 1998;17:5085-5094.
-
(1998)
EMBO J
, vol.17
, pp. 5085-5094
-
-
Zelzer, E.1
Levy, Y.2
Kahana, C.3
Shilo, B.Z.4
Rubinstein, M.5
Cohen, B.6
-
72
-
-
0033566693
-
Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
-
Feldser D, Agani F, Iyer NV, Pak B, Ferreira G, Semenza GL. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res. 1999;59:3915-3918.
-
(1999)
Cancer Res
, vol.59
, pp. 3915-3918
-
-
Feldser, D.1
Agani, F.2
Iyer, N.V.3
Pak, B.4
Ferreira, G.5
Semenza, G.L.6
-
73
-
-
0037070223
-
Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway
-
Stiehl DP, Jelkmann W, Wenger RH, Hellwig-Burgel T. Normoxic induction of the hypoxia-inducible factor 1alpha by insulin and interleukin-1beta involves the phosphatidylinositol 3-kinase pathway. FEBS Lett. 2002;512:157-162.
-
(2002)
FEBS Lett
, vol.512
, pp. 157-162
-
-
Stiehl, D.P.1
Jelkmann, W.2
Wenger, R.H.3
Hellwig-Burgel, T.4
-
74
-
-
0033965962
-
Assessment of HER2 status in breast cancer: Why, when and how?
-
Dowsett M, Cooke T, Ellis I, et al. Assessment of HER2 status in breast cancer: why, when and how? Eur J Cancer. 2000;36:170-176.
-
(2000)
Eur J Cancer
, vol.36
, pp. 170-176
-
-
Dowsett, M.1
Cooke, T.2
Ellis, I.3
|