메뉴 건너뛰기




Volumn 15, Issue 1, 2005, Pages 49-62

RNA as a target for small-molecule therapeutics

Author keywords

Aminoglycosides; HIV; Ribosome; RNase P; X ray crystallography

Indexed keywords

2 AMINOPYRIDINE DERIVATIVE; 2 AMINOQUINOLINE; 2 DEOXYSTREPTAMINE; 4 HYDROXY 2 QUINOLONE 3 CARBOXYLIC ACID AMIDE; AMIDINOHYDRAZONE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIINFECTIVE AGENT; BACTERIAL RNA; BETA CARBOLINE DERIVATIVE; CHLORAMPHENICOL; ERYTHROMYCIN; ESTERASE INHIBITOR; FRAMYCETIN; KANAMYCIN DERIVATIVE; KETOLIDE; LINEZOLID; MACROLIDE; N (AMINOETHYL) 4 METHYL 2 AMINOPYRIDINE; NEAMINE; OXAZOLIDINEDIONE DERIVATIVE; PAROMOMYCIN; PROFLAVINE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; REV PROTEIN; RIBONUCLEASE P; TELITHROMYCIN; TETRACYCLINE DERIVATIVE; THIOSTREPTON; TREHALOSE; UNCLASSIFIED DRUG; UNINDEXED DRUG; VIRUS RNA;

EID: 13544264777     PISSN: 13543776     EISSN: None     Source Type: Journal    
DOI: 10.1517/13543776.15.1.49     Document Type: Review
Times cited : (51)

References (104)
  • 1
    • 0031933080 scopus 로고    scopus 로고
    • RNA as a drug target: Chemical, modelling and evolutionary tools
    • HERMANN T, WESTHOF E: RNA as a drug target: chemical, modelling and evolutionary tools. Curr. Opin. Biotechnol. (1998) 9:66-73.
    • (1998) Curr. Opin. Biotechnol. , vol.9 , pp. 66-73
    • Hermann, T.1    Westhof, E.2
  • 2
    • 0034595705 scopus 로고    scopus 로고
    • Strategies for the design of drugs targeting RNA and RNA-protein complexes
    • HERMANN T: Strategies for the design of drugs targeting RNA and RNA-protein complexes. Angew. Chem. Int. Ed. (2000) 39 1890-1904.
    • (2000) Angew. Chem. Int. Ed. , vol.39 , pp. 1890-1904
    • Hermann, T.1
  • 3
    • 0142011647 scopus 로고    scopus 로고
    • Targeting RNA with small molecules
    • TOR Y: Targeting RNA with small molecules. Chembiochem (2003) 4:998-1007.
    • (2003) Chembiochem. , vol.4 , pp. 998-1007
    • Tor, Y.1
  • 5
    • 0346687595 scopus 로고    scopus 로고
    • The riboswitch control of bacterial metabolism
    • NUDLER E, MIRONOV AS: The riboswitch control of bacterial metabolism. Trends Biochem. Sci. (2004) 29:11-17.
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 11-17
    • Nudler, E.1    Mironov, A.S.2
  • 7
    • 0041836268 scopus 로고    scopus 로고
    • Chemical and functional diversity of small molecule ligands for RNA
    • HERMANN T: Chemical and functional diversity of small molecule ligands for RNA. Biopolymers (2003) 70:4-18.
    • (2003) Biopolymers , vol.70 , pp. 4-18
    • Hermann, T.1
  • 8
    • 0036737560 scopus 로고    scopus 로고
    • RNA-targeted therapeutics: Prospects and promise
    • GRIFFEY RH, SWAYZE EE: RNA-targeted therapeutics: prospects and promise. Expert Opin. Ther. Patents (2002) 12:1367-1374.
    • (2002) Expert Opin. Ther. Patents , vol.12 , pp. 1367-1374
    • Griffey, R.H.1    Swayze, E.E.2
  • 9
    • 0142106950 scopus 로고    scopus 로고
    • RNA as a drug target: The case of aminoglycosides
    • VICENS Q, WESTHOF E: RNA as a drug target: the case of aminoglycosides. Chembiochem (2003) 4:1018-1023.
    • (2003) Chembiochem. , vol.4 , pp. 1018-1023
    • Vicens, Q.1    Westhof, E.2
  • 10
    • 0037303518 scopus 로고    scopus 로고
    • Macrolide antibiotic interaction and resistance on the bacterial ribosome
    • POEHLSGAARD J, DOUTHWAITE S: Macrolide antibiotic interaction and resistance on the bacterial ribosome. Curr. Opin. Investig. Drugs (2003) 4:140-148.
    • (2003) Curr. Opin. Investig. Drugs , vol.4 , pp. 140-148
    • Poehlsgaard, J.1    Douthwaite, S.2
  • 12
    • 0037012422 scopus 로고    scopus 로고
    • Design of novel antibiotics that bind to the ribosomal acyltransferase site
    • HADDAD J, KOTRA LP, LLANO-SOLETO B et al.: Design of novel antibiotics that bind to the ribosomal acyltransferase site. J. Am. Chem. Soc. (2002) 124:3229-3237.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 3229-3237
    • Haddad, J.1    Kotra, L.P.2    Llano-Soleto, B.3
  • 13
    • 0037467430 scopus 로고    scopus 로고
    • The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography
    • RUSSELL RJ, MURRAY JB, LENTZEN G, HADDAD J, MOBASHERY S: The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography. J. Am. Chem. Soc. (2003) 125:3410-3411.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 3410-3411
    • Russell, R.J.1    Murray, J.B.2    Lentzen, G.3    Haddad, J.4    Mobashery, S.5
  • 14
    • 0142106443 scopus 로고    scopus 로고
    • A new class of branched aminoglycosides: Pseudopentasaccharide dervatives of beomycin B
    • FRIDMAN M, BELAKHOV V, YARON S, BAASOV T: A new class of branched aminoglycosides: pseudopentasaccharide dervatives of beomycin B. Org. Lett. (2003) 5:3575-3578.
    • (2003) Org. Lett. , vol.5 , pp. 3575-3578
    • Fridman, M.1    Belakhov, V.2    Yaron, S.3    Baasov, T.4
  • 15
    • 0035979090 scopus 로고    scopus 로고
    • An efficient synthesis of mimetics of neamine for RNA recognition
    • DING Y, HOFSTADLER SA, SWAYZE EE, GRIFFEY RH: An efficient synthesis of mimetics of neamine for RNA recognition. Org. Lett. (2001) 3:1621-1623.
    • (2001) Org. Lett. , vol.3 , pp. 1621-1623
    • Ding, Y.1    Hofstadler, S.A.2    Swayze, E.E.3    Griffey, R.H.4
  • 16
    • 0042074617 scopus 로고    scopus 로고
    • Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay
    • DING Y, HOFSTADLER SA, SWAYZE EE, RISEN L, GRIFFEY RH: Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay. Angew. Chem. Int. Ed. (2003) 42:3409-3412.
    • (2003) Angew. Chem. Int. Ed. , vol.42 , pp. 3409-3412
    • Ding, Y.1    Hofstadler, S.A.2    Swayze, E.E.3    Risen, L.4    Griffey, R.H.5
  • 17
    • 2942588958 scopus 로고    scopus 로고
    • Glyco-optimization of aminoglycosides: New aminoglycosides as novel anti-infective agents
    • YAO S, SGARBI PW, MARBY KA et al.: Glyco-optimization of aminoglycosides: new aminoglycosides as novel anti-infective agents. Bioorg. Med. Chem. Lett. (2004) 14:3733-3738.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 3733-3738
    • Yao, S.1    Sgarbi, P.W.2    Marby, K.A.3
  • 18
    • 17444444927 scopus 로고    scopus 로고
    • Novel 2,5-dideoxystreptamine derivatives taregting the ribosomal decoding site RNA
    • VOURLOUMIS D, TAKAHASHI M, WINTERS GC et al.: Novel 2,5-dideoxystreptamine derivatives taregting the ribosomal decoding site RNA. Bioorg. Med. Chem. Lett. (2002) 12:3367-3372.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 3367-3372
    • Vourloumis, D.1    Takahashi, M.2    Winters, G.C.3
  • 19
    • 12244280014 scopus 로고    scopus 로고
    • Novel paromamine derivatives exploring shallow-groove recognition of ribosomal-decoding-site RNA
    • SIMONSEN KB, AYIDA BK, VOURLOUMIS D et al.: Novel paromamine derivatives exploring shallow-groove recognition of ribosomal-decoding-site RNA. Chembiochem (2002) 3:1223-1228.
    • (2002) Chembiochem. , vol.3 , pp. 1223-1228
    • Simonsen, K.B.1    Ayida, B.K.2    Vourloumis, D.3
  • 20
    • 0141733704 scopus 로고    scopus 로고
    • Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site
    • VOURLOUMIS D, WINTERS GC, TAKAHASHI M et al.: Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site. Chembiochem (2003) 4:879-885.
    • (2003) Chembiochem. , vol.4 , pp. 879-885
    • Vourloumis, D.1    Winters, G.C.2    Takahashi, M.3
  • 21
    • 0141733703 scopus 로고    scopus 로고
    • Piperidine glycosides targeting the ribosomal decoding site
    • SIMONSEN KB, AYIDA BK, VOURLOUMIS D et al.: Piperidine glycosides targeting the ribosomal decoding site. Chembiochem (2003) 4:886-890.
    • (2003) Chembiochem. , vol.4 , pp. 886-890
    • Simonsen, K.B.1    Ayida, B.K.2    Vourloumis, D.3
  • 22
    • 1642534330 scopus 로고    scopus 로고
    • Rational design of azepane-glycoside antibiotics targteing the bacterial ribosome
    • BARLUENGA S, SIMONSEN KB, LITTLEFIELD ES et al.: Rational design of azepane-glycoside antibiotics targteing the bacterial ribosome. Bioorg. Med. Chem. Lett. (2004) 14:713-718.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 713-718
    • Barluenga, S.1    Simonsen, K.B.2    Littlefield, E.S.3
  • 23
    • 0142106950 scopus 로고    scopus 로고
    • Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: An analysis of X-ray crystal structures
    • VICENS Q, WESTHOF E: Molecular recognition of aminoglycoside antibiotics by ribosomal RNA and resistance enzymes: an analysis of X-ray crystal structures. Chembiochem (2003) 4:1018-1023.
    • (2003) Chembiochem. , vol.4 , pp. 1018-1023
    • Vicens, Q.1    Westhof, E.2
  • 24
    • 0242348721 scopus 로고    scopus 로고
    • Synthesis of linked carbohydrates and evaluation of their binding for 16S RNA by mass spectrometry
    • WU B, YANG J, ROBINSON D et al.: Synthesis of linked carbohydrates and evaluation of their binding for 16S RNA by mass spectrometry. Bioorg. Med. Chem. Lett. (2003) 13:3915-3918.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 3915-3918
    • Wu, B.1    Yang, J.2    Robinson, D.3
  • 26
    • 1342332906 scopus 로고    scopus 로고
    • Regioselective glycosylation of neamine core: A facile entry to kanamycin B related analogues
    • CHOU CH, WU CS, CHEN CH et al.: Regioselective glycosylation of neamine core: a facile entry to kanamycin B related analogues. Org. Lett. (2004) 6:585-588.
    • (2004) Org. Lett. , vol.6 , pp. 585-588
    • Chou, C.H.1    Wu, C.S.2    Chen, C.H.3
  • 27
    • 1642534336 scopus 로고    scopus 로고
    • Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry
    • HE Y, YANG J, WU B et al.: Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry. Bioorg. Med. Chem. Lett. (2004) 14:695-699.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 695-699
    • He, Y.1    Yang, J.2    Wu, B.3
  • 28
    • 0037194620 scopus 로고    scopus 로고
    • SAR by MS: A ligand based technique for drug lead discovery against structured RNA targets
    • SWAYZE EE, JEFFERSON EA, SANNES-LOWERY KA et al.: SAR by MS: A ligand based technique for drug lead discovery against structured RNA targets. J. Med. Chem. (2002) 45:3816-3819.
    • (2002) J. Med. Chem. , vol.45 , pp. 3816-3819
    • Swayze, E.E.1    Jefferson, E.A.2    Sannes-Lowery, K.A.3
  • 29
    • 0037448895 scopus 로고    scopus 로고
    • Discovery of aminoglycoside mimetics by NMR-based screening of Escherichia coli A-site RNA
    • YU L, OOST TK, SCHKERYANTZ JM, YANG J, JANOWICK D, FESIK SW: Discovery of aminoglycoside mimetics by NMR-based screening of Escherichia coli A-site RNA. J. Am. Chem. Soc. (2003) 125 4444-4450.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 4444-4450
    • Yu, L.1    Oost, T.K.2    Schkeryantz, J.M.3    Yang, J.4    Janowick, D.5    Fesik, S.W.6
  • 31
    • 1342343126 scopus 로고    scopus 로고
    • A structure-based strategy to identify new molecular scaffolds targeting the bacterial ribosomal A-site
    • FOLOPPE N, CHEN I-J, DAVIS B, HOLD A, MORLEY D, HOWES R: A structure-based strategy to identify new molecular scaffolds targeting the bacterial ribosomal A-site. Bioorg. Med. Chem. (2004) 12 935-947.
    • (2004) Bioorg. Med. Chem. , vol.12 , pp. 935-947
    • Foloppe, N.1    Chen, I.-J.2    Davis, B.3    Hold, A.4    Morley, D.5    Howes, R.6
  • 32
    • 3142756547 scopus 로고    scopus 로고
    • Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins
    • DISNEY MD, SEEBERGER PH: Aminoglycoside microarrays to explore interactions of antibiotics with RNAs and proteins. Chemistry (2004) 10:3308-3314.
    • (2004) Chemistry , vol.10 , pp. 3308-3314
    • Disney, M.D.1    Seeberger, P.H.2
  • 33
    • 1642347123 scopus 로고    scopus 로고
    • Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: Comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences
    • KAUL M, BARBIERI CM, PILCH DS: Fluorescence-based approach for detecting and characterizing antibiotic-induced conformational changes in ribosomal RNA: comparing aminoglycoside binding to prokaryotic and eukaryotic ribosomal RNA sequences. J. Am. Chem. Soc. (2004) 126:3447-3453.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 3447-3453
    • Kaul, M.1    Barbieri, C.M.2    Pilch, D.S.3
  • 34
    • 4544340867 scopus 로고    scopus 로고
    • Monitoring molecular recognition of the ribosomal decoding site
    • SHANDRICK S, ZHAO Q, HAN Q et al.: Monitoring molecular recognition of the ribosomal decoding site. Angew. Chem. Int. Ed. (2004) 43:3177-3182.
    • (2004) Angew. Chem. Int. Ed. , vol.43 , pp. 3177-3182
    • Shandrick, S.1    Zhao, Q.2    Han, Q.3
  • 35
    • 0033032414 scopus 로고    scopus 로고
    • Ribosomal RNA is the target for oxazolidinones, a novel class of translation inhibitors
    • MATASSOVA NB, RODNINA MV, ENDERMANN R et al.: Ribosomal RNA is the target for oxazolidinones, a novel class of translation inhibitors. RNA (1999) 5:939-946.
    • (1999) RNA , vol.5 , pp. 939-946
    • Matassova, N.B.1    Rodnina, M.V.2    Endermann, R.3
  • 37
    • 0036210596 scopus 로고    scopus 로고
    • Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes
    • AOKI H, KE L, POPPE SM et al.: Oxazolidinone antibiotics target the P site on Escherichia coli ribosomes. Antimicrob. Agents Chemother. (2002) 46:1080-1085.
    • (2002) Antimicrob. Agents Chemother. , vol.46 , pp. 1080-1085
    • Aoki, H.1    Ke, L.2    Poppe, S.M.3
  • 39
    • 0042415065 scopus 로고    scopus 로고
    • Structural basis for contrasting activities of ribosome binding thiazole antibiotics
    • LENTZEN G, KLINCK R, MATASSOVA N, ABOUL-ELA F: Structural basis for contrasting activities of ribosome binding thiazole antibiotics. Chem. Biol. (2003) 10:769-778.
    • (2003) Chem. Biol. , vol.10 , pp. 769-778
    • Lentzen, G.1    Klinck, R.2    Matassova, N.3    Aboul-Ela, F.4
  • 40
    • 0038309315 scopus 로고    scopus 로고
    • Structure-based design of agents targeting the bacterial ribosome
    • BOWER J, DRYSDALE M, HEBDON R et al.: Structure-based design of agents targeting the bacterial ribosome. Bioorg. Med. Chem. Lett. (2003) 13:2455-2458.
    • (2003) Bioorg. Med. Chem. Lett. , vol.13 , pp. 2455-2458
    • Bower, J.1    Drysdale, M.2    Hebdon, R.3
  • 41
    • 1242319523 scopus 로고    scopus 로고
    • An approach to enhance specificity against RNA targets using heteroconjugates of aminoglycosides and chloramphenicol (or linezolid)
    • LEE J, KWON M, LEE KH et al.: An approach to enhance specificity against RNA targets using heteroconjugates of aminoglycosides and chloramphenicol (or linezolid). J. Am. Chem. Soc. (2004) 126 1956-1957.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 1956-1957
    • Lee, J.1    Kwon, M.2    Lee, K.H.3
  • 42
    • 0036794070 scopus 로고    scopus 로고
    • Inhibition of protein synthesis by aminoglycoside-argirinine conjugates
    • CARRIERE M, VIJAYABASKAR V, APPLEFIEID D et al.: Inhibition of protein synthesis by aminoglycoside-argirinine conjugates. RNA (2002) 8:1267-1279.
    • (2002) RNA , vol.8 , pp. 1267-1279
    • Carriere, M.1    Vijayabaskar, V.2    Applefieid, D.3
  • 44
    • 0036682411 scopus 로고    scopus 로고
    • New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles
    • JEFFERSON EA, ARAKAWA S, BLYN LB et al.: New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles. J. Med. Chem. (2002) 45:3430-3439.
    • (2002) J. Med. Chem. , vol.45 , pp. 3430-3439
    • Jefferson, E.A.1    Arakawa, S.2    Blyn, L.B.3
  • 45
    • 2442470467 scopus 로고    scopus 로고
    • A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen
    • PRATT SD, DAVID CA, BLACK-SCHAEFER C et al.: A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen. J. Biomol. Screen. (2004) 9:3-11.
    • (2004) J. Biomol. Screen. , vol.9 , pp. 3-11
    • Pratt, S.D.1    David, C.A.2    Black-Schaefer, C.3
  • 46
    • 2442503394 scopus 로고    scopus 로고
    • Novel inhibitors of bacterial protein synthesis: Structure-activity relationships for 1,8-naphtyridine derivatives incorporating position 3 and 4 variants
    • CLARK RF, WANG S, MA, Z et al.: Novel inhibitors of bacterial protein synthesis: structure-activity relationships for 1,8-naphtyridine derivatives incorporating position 3 and 4 variants. Bioorg. Med Chem. Lett. (2004) 14:3299-3302.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 3299-3302
    • Clark, R.F.1    Wang, S.2    Ma, Z.3
  • 47
    • 0036682411 scopus 로고    scopus 로고
    • New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles
    • JEFFERSON EA, ARAKAWA S, BLYN LB et al.: New inhibitors of bacterial protein synthesis from a combinatorial library of macrocycles.J. Med. Chem. (2002) 45:3430-3439.
    • (2002) J. Med. Chem. , vol.45 , pp. 3430-3439
    • Jefferson, E.A.1    Arakawa, S.2    Blyn, L.B.3
  • 48
    • 0037458197 scopus 로고    scopus 로고
    • Trans-translation and protein synthesis inhibitors
    • VIOQUE A, DE LA CRUZ J: Trans-translation and protein synthesis inhibitors. FEMS Microbiol. Lett. (2003) 218:9-14.
    • (2003) FEMS Microbiol. Lett. , vol.218 , pp. 9-14
    • Vioque, A.1    De La Cruz, J.2
  • 49
    • 0038351953 scopus 로고    scopus 로고
    • Inhibition of transfer messenger RNA aminoacylation and trans-translation by aminoglycoside antibiotics
    • CORVAISIER S, BORDEAU V, FELDEN B: Inhibition of transfer messenger RNA aminoacylation and trans-translation by aminoglycoside antibiotics. J. Biol. Chem. (2003) 278 14788-14797.
    • (2003) J. Biol. Chem. , vol.278 , pp. 14788-14797
    • Corvaisier, S.1    Bordeau, V.2    Felden, B.3
  • 50
    • 0042847384 scopus 로고    scopus 로고
    • Various effects of paromomycin on tmRNA-directed trans-translation
    • TAKAHASHI T, KONNO T, MUTO A, HIMENO H: Various effects of paromomycin on tmRNA-directed trans-translation. J. Biol. Chem. (2003) 278:27672-27680.
    • (2003) J. Biol. Chem. , vol.278 , pp. 27672-27680
    • Takahashi, T.1    Konno, T.2    Muto, A.3    Himeno, H.4
  • 51
    • 3442899924 scopus 로고    scopus 로고
    • A minimum structure of aminoglycosides that causes an initiation shift trans-translation
    • KONNO T, TAKAHASHI T, KURITA D, MUTO A, HIMENO H: A minimum structure of aminoglycosides that causes an initiation shift trans translation. Nucleic Acids Res. (2004) 32:4119-4126.
    • (2004) Nucleic Acids Res. , vol.32 , pp. 4119-4126
    • Konno, T.1    Takahashi, T.2    Kurita, D.3    Muto, A.4    Himeno, H.5
  • 55
    • 0027370433 scopus 로고
    • Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production
    • ZAPP ML, STERN S, GREEN MR: Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. Cell (1993) 74:969-978.
    • (1993) Cell , vol.74 , pp. 969-978
    • Zapp, M.L.1    Stern, S.2    Green, M.R.3
  • 56
    • 0030087981 scopus 로고    scopus 로고
    • A non-canonical base pair within the human immunodeficiency virus revresponsive element is involved in both rev and small molecule recognition
    • WERSTUCK G, ZAPP ML, GREEN MR: A non-canonical base pair within the human immunodeficiency virus revresponsive element is involved in both rev and small molecule recognition. Chem. Biol. (1996) 3 129-137.
    • (1996) Chem. Biol. , vol.3 , pp. 129-137
    • Werstuck, G.1    Zapp, M.L.2    Green, M.R.3
  • 57
    • 0031005114 scopus 로고    scopus 로고
    • Discovery of selective, small-molecule inhibitors of RNA complexes I. The Tat protein/TAR RNA complexes required for HIV-1 transcription
    • MEI HY, MACK DP, GALAN AA et al.: Discovery of selective, small-molecule inhibitors of RNA complexes I. The Tat protein/TAR RNA complexes required for HIV-1 transcription. Bioorg. Med. Chem. (1997) 5:1173-1184.
    • (1997) Bioorg. Med. Chem. , vol.5 , pp. 1173-1184
    • Mei, H.Y.1    Mack, D.P.2    Galan, A.A.3
  • 59
    • 0742299457 scopus 로고    scopus 로고
    • RNA as a target for drug design, the example of Tat-TAR interaction
    • FROEYEN M, HERDEWIJN P: RNA as a target for drug design, the example of Tat-TAR interaction. Curr. Top. Med. Chem. (2002) 2 1123-1145.
    • (2002) Curr. Top. Med. Chem. , vol.2 , pp. 1123-1145
    • Froeyen, M.1    Herdewijn, P.2
  • 60
    • 2942615518 scopus 로고    scopus 로고
    • Inhibitors of HIV-1 gene expression and transcription
    • BABA M: Inhibitors of HIV-1 gene expression and transcription. Curr. Top. Med. Chem. (2004) 4:871-882.
    • (2004) Curr. Top. Med. Chem. , vol.4 , pp. 871-882
    • Baba, M.1
  • 61
    • 0041836262 scopus 로고    scopus 로고
    • Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors
    • LUEDTKE NW, TOR Y: Fluorescence-based methods for evaluating the RNA affinity and specificity of HIV-1 Rev-RRE inhibitors. Biopolymers (2003) 70:103-119.
    • (2003) Biopolymers , vol.70 , pp. 103-119
    • Luedtke, N.W.1    Tor, Y.2
  • 62
    • 0141483331 scopus 로고    scopus 로고
    • RNA-ligand interactions: Affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element
    • LUEDTKE NW, LIU Q, TOR Y: RNA-ligand interactions: affinity and specificity of aminoglycoside dimers and acridine conjugates to the HIV-1 Rev response element. Biochemistry (2003) 42 11391-11403.
    • (2003) Biochemistry , vol.42 , pp. 11391-11403
    • Luedtke, N.W.1    Liu, Q.2    Tor, Y.3
  • 63
    • 0242361200 scopus 로고    scopus 로고
    • Synthesis, photophysical properties, and nucleic acid binding of phenanthridinium derivatives based on ethidium
    • LUEDTKE NW, LIU Q, TOR Y: Synthesis, photophysical properties, and nucleic acid binding of phenanthridinium derivatives based on ethidium. Chembiochem (2003) 11:5235-5247.
    • (2003) Chembiochem. , vol.11 , pp. 5235-5247
    • Luedtke, N.W.1    Liu, Q.2    Tor, Y.3
  • 65
    • 0141954275 scopus 로고    scopus 로고
    • Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine
    • LUEDTKE NW, CARMICHAEL P, TOR Y: Cellular uptake of aminoglycosides, guanidinoglycosides, and poly-arginine. J. Am. Chem. Soc. (2003) 125:12374-12375.
    • (2003) J. Am. Chem. Soc. , vol.125 , pp. 12374-12375
    • Luedtke, N.W.1    Carmichael, P.2    Tor, Y.3
  • 66
    • 0034731571 scopus 로고    scopus 로고
    • Synthesis and anti-HIV activity of guanidinoglycosides
    • BAKER TJ, LUEDTKE NW, TOR Y, GOODMAN M: Synthesis and anti-HIV activity of guanidinoglycosides. J. Org. Chem. (2000) 65:9054-9058.
    • (2000) J. Org. Chem. , vol.65 , pp. 9054-9058
    • Baker, T.J.1    Luedtke, N.W.2    Tor, Y.3    Goodman, M.4
  • 67
    • 0034674040 scopus 로고    scopus 로고
    • Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy
    • LACOURCIERE KA, STIVERS JT, MARINO JP: Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy. Biochemistry (2000) 39:5630-5641.
    • (2000) Biochemistry , vol.39 , pp. 5630-5641
    • Lacourciere, K.A.1    Stivers, J.T.2    Marino, J.P.3
  • 68
    • 0038047131 scopus 로고    scopus 로고
    • Proflavine as a Rev inhibitor by targeting the high-affinity Reb binding site of the Rev responsive element of HIV-1
    • DEJONG ES, CHANG C, GILSON MK, MARINO JP: Proflavine as a Rev inhibitor by targeting the high-affinity Reb binding site of the Rev responsive element of HIV-1. Biochemistry (2003) 42 8035-8046.
    • (2003) Biochemistry , vol.42 , pp. 8035-8046
    • Dejong, E.S.1    Chang, C.2    Gilson, M.K.3    Marino, J.P.4
  • 69
    • 0036227966 scopus 로고    scopus 로고
    • Small molecule modulators of HIV Rev/Rev response element interaction identified by random screening
    • CHAPMAN RL, STANLEY TB, HAZEN R, GARVEY EP: Small molecule modulators of HIV Rev/Rev response element interaction identified by random screening Antiviral Res. (2002) 54:149-162.
    • (2002) Antiviral Res. , vol.54 , pp. 149-162
    • Chapman, R.L.1    Stanley, T.B.2    Hazen, R.3    Garvey, E.P.4
  • 70
    • 0026589545 scopus 로고
    • Specific binding of arginine to TAR RNA
    • TAO J, FRANKEL AD: Specific binding of arginine to TAR RNA. Proc. Natl. Acad. Sci. USA (1992) 89:2723-2726.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 2723-2726
    • Tao, J.1    Frankel, A.D.2
  • 71
    • 0141905902 scopus 로고    scopus 로고
    • Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding
    • BLOUNT KF, TOR Y: Using pyrene-labeled HIV-1 TAR to measure RNA-small molecule binding. Nucleic Acids Res. (2003) 31 5490-5500.
    • (2003) Nucleic Acids Res. , vol.31 , pp. 5490-5500
    • Blount, K.F.1    Tor, Y.2
  • 72
    • 4344579386 scopus 로고    scopus 로고
    • Ligand-induced changes in 2-aminopurine fluorescence as a probe for small molecule binding to HIV-1 TAR RNA
    • BRADICK TD, MARINO JP: Ligand-induced changes in 2-aminopurine fluorescence as a probe for small molecule binding to HIV-1 TAR RNA. RNA (2004) 10:1459-1468.
    • (2004) RNA , vol.10 , pp. 1459-1468
    • Bradick, T.D.1    Marino, J.P.2
  • 73
    • 0034984277 scopus 로고    scopus 로고
    • Merged screening for human immunodeficiency virus Tat and Rev inhibitors
    • HAMY F, FELDER E, LIPSON K, KLIMKAIT T: Merged screening for human immunodeficiency virus Tat and Rev inhibitors. J. Biomol. Screen. (2001) 6:179-187.
    • (2001) J. Biomol. Screen. , vol.6 , pp. 179-187
    • Hamy, F.1    Felder, E.2    Lipson, K.3    Klimkait, T.4
  • 74
    • 1942502683 scopus 로고    scopus 로고
    • α,α-Trehalose derivatives bearing guanidino groups as inhibitors to HIV-1 Tat-TAR RNA interaction in human cells
    • WANG M, XU Z, TU P, YU X, XIA S, YANG M: α,α-Trehalose derivatives bearing guanidino groups as inhibitors to HIV-1 Tat-TAR RNA interaction in human cells. Bioorg. Med. Chem. Lett. (2004) 14 2585-2588.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2585-2588
    • Wang, M.1    Xu, Z.2    Tu, P.3    Yu, X.4    Xia, S.5    Yang, M.6
  • 75
    • 2442421847 scopus 로고    scopus 로고
    • Synthesis and biological evaluation of novel α-carboline derivatives as Tat-TAR interaction inhibitors
    • YU X, LIN W, LI J, YANG M: Synthesis and biological evaluation of novel α-carboline derivatives as Tat-TAR interaction inhibitors. Bioorg. Med. Chem. Lett. (2004) 14:3127-3130.
    • (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 3127-3130
    • Yu, X.1    Lin, W.2    Li, J.3    Yang, M.4
  • 76
    • 0032532765 scopus 로고    scopus 로고
    • Exploration of metal ion binding sites in RNA folds by Brownian-dynamics simulations
    • HERMANN T, WESTHOF E: Exploration of metal ion binding sites in RNA folds by Brownian-dynamics simulations. Structure (1998) 6:1303-1314.
    • (1998) Structure , vol.6 , pp. 1303-1314
    • Hermann, T.1    Westhof, E.2
  • 77
    • 0033535566 scopus 로고    scopus 로고
    • Docking of cationic antibiotics to negatively charged pockets in RNA folds
    • HERMANN T, WESTHOF E: Docking of cationic antibiotics to negatively charged pockets in RNA folds. J. Med. Chem. (1999) 42 1250-1261.
    • (1999) J. Med. Chem. , vol.42 , pp. 1250-1261
    • Hermann, T.1    Westhof, E.2
  • 78
    • 9144274314 scopus 로고    scopus 로고
    • Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic 'hot spots'
    • DAVIS B, AFSHAR M, VARANI G et al.: Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic 'hot spots'. J. Mol. Biol. (2004) 336:343-356.
    • (2004) J. Mol. Biol. , vol.336 , pp. 343-356
    • Davis, B.1    Afshar, M.2    Varani, G.3
  • 79
    • 10744222241 scopus 로고    scopus 로고
    • Structure-based drug design targeting an inactive RNA conformation: Exploiting the flexibility of HIV-1 TAR RNA
    • MURCHIE AIH, DAVIS B, ISEL C et al.: Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA. J. Mol. Biol. (2004) 336 625-638.
    • (2004) J. Mol. Biol. , vol.336 , pp. 625-638
    • Murchie, A.I.H.1    Davis, B.2    Isel, C.3
  • 80
    • 0036761206 scopus 로고    scopus 로고
    • Rational ligand design for RNA: The role of static structure and conformational flexibility in target recognition
    • HERMANN T: Rational ligand design for RNA: the role of static structure and conformational flexibility in target recognition. Biochimie (2002) 84:869-875.
    • (2002) Biochimie , vol.84 , pp. 869-875
    • Hermann, T.1
  • 81
    • 0036008846 scopus 로고    scopus 로고
    • Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA
    • LIND KE, DU Z, FUJINAGA K, PETERLIN BM, JAMES TL: Structure-based computational database screening, in vitro assay, and NMR assessment of compounds that target TAR RNA. Chem. Biol. (2002) 9:185-193.
    • (2002) Chem. Biol. , vol.9 , pp. 185-193
    • Lind, K.E.1    Du, Z.2    Fujinaga, K.3    Peterlin, B.M.4    James, T.L.5
  • 82
    • 0035986695 scopus 로고    scopus 로고
    • Structure of TAR RNA complexed with a Tat-TAR interaction nanomolar inhibitor that was identified by computational screening
    • DU Z, LIND KE, JAMES TL: Structure of TAR RNA complexed with a Tat-TAR interaction nanomolar inhibitor that was identified by computational screening. Chem. Biol. (2002) 9:707-712.
    • (2002) Chem. Biol. , vol.9 , pp. 707-712
    • Du, Z.1    Lind, K.E.2    James, T.L.3
  • 83
    • 1842450536 scopus 로고    scopus 로고
    • NMR-based characterization of phenothiazines as a RNA binding scaffold
    • MAYER M, JAMES TL: NMR-based characterization of phenothiazines as a RNA binding scaffold. J. Am. Chem. Soc. (2004) 126:4453-4460.
    • (2004) J. Am. Chem. Soc. , vol.126 , pp. 4453-4460
    • Mayer, M.1    James, T.L.2
  • 85
    • 0037152424 scopus 로고    scopus 로고
    • Inhibition of the U1A-RNA complex by an aminoacridine derivative
    • GAYLE AY, BARANGER AM: Inhibition of the U1A-RNA complex by an aminoacridine derivative. Bioorg. Med. Chem. Lett. (2002) 12 2839-2842.
    • (2002) Bioorg. Med. Chem. Lett. , vol.12 , pp. 2839-2842
    • Gayle, A.Y.1    Baranger, A.M.2
  • 86
    • 0034609799 scopus 로고    scopus 로고
    • 6-Aminoquinolones as new potential anti-HIV agents
    • CECCHETTI V, PAROLIN C, MORO S et al.: 6-Aminoquinolones as new potential anti-HIV agents. J. Med. Chem. (2000) 43:3799-3802.
    • (2000) J. Med. Chem. , vol.43 , pp. 3799-3802
    • Cecchetti, V.1    Parolin, C.2    Moro, S.3
  • 88
    • 2142753038 scopus 로고    scopus 로고
    • Inhibition of human inummodeficiency virus Type 1 Tat-trans-activation-responsive region interaction by an antiviral quinolone derivative
    • RICHTER S, PAROLIN C, GATTO B et al.: Inhibition of human inummodeficiency virus Type 1 Tat-trans-activation-responsive region interaction by an antiviral quinolone derivative. Antimicrob. Agents Chemother. (2004) 48:1895-1899.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 1895-1899
    • Richter, S.1    Parolin, C.2    Gatto, B.3
  • 90
    • 0037462818 scopus 로고    scopus 로고
    • HIV-1 RNA dimerization initiation site is structurally similar to the ribosomal A site and binds aminoglycoside antibiotics
    • ENNIFAR E, PAILLART JC, MARQUET R et al.: HIV-1 RNA dimerization initiation site is structurally similar to the ribosomal A site and binds aminoglycoside antibiotics. J. Biol. Chem. (2003) 278:2723-2730.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2723-2730
    • Ennifar, E.1    Paillart, J.C.2    Marquet, R.3
  • 91
    • 0036837080 scopus 로고    scopus 로고
    • Footprinting and circular dichroism studies on paromomycin binding to the packaging region of human immunodeficiency virus type-1
    • MCPIKE MP, GOODISMAN J, DABROWIAK JC: Footprinting and circular dichroism studies on paromomycin binding to the packaging region of human immunodeficiency virus type-1. Bioorg. Med. Chem. (2002) 10:3663-3672.
    • (2002) Bioorg. Med. Chem. , vol.10 , pp. 3663-3672
    • Mcpike, M.P.1    Goodisman, J.2    Dabrowiak, J.C.3
  • 92
    • 1642461680 scopus 로고    scopus 로고
    • Specificity of neomycin analogues bound to the packaging region of human immunodficiency virus type 1 RNA
    • MCPIKE MP, GOODISMAN J, DABROWIAK JC: Specificity of neomycin analogues bound to the packaging region of human immunodficiency virus type 1 RNA. Bioorg. Med. Chem. (2004) 12:1835-1843.
    • (2004) Bioorg. Med. Chem. , vol.12 , pp. 1835-1843
    • Mcpike, M.P.1    Goodisman, J.2    Dabrowiak, J.C.3
  • 93
    • 13544277790 scopus 로고    scopus 로고
    • Chiron stakes out its teritory
    • COHEN J: Chiron stakes out its teritory. Science (1999) 285:28.
    • (1999) Science , vol.285 , pp. 28
    • Cohen, J.1
  • 94
    • 0036545533 scopus 로고    scopus 로고
    • The hepatitis C virus internal ribosome-entry site: A new target for antiviral research
    • GALLEGO J, VARANI G: The hepatitis C virus internal ribosome-entry site: a new target for antiviral research. Biochem. Soc. Trans. (2002) 30:140-145.
    • (2002) Biochem. Soc. Trans. , vol.30 , pp. 140-145
    • Gallego, J.1    Varani, G.2
  • 95
    • 0037301437 scopus 로고    scopus 로고
    • Targeting hepatitis C virus translation: Stopping HCV where its starts
    • JUBIN R: Targeting hepatitis C virus translation: stopping HCV where its starts. Curr. Opin. Investig. Drugs (2003) 4 162-167.
    • (2003) Curr. Opin. Investig. Drugs , vol.4 , pp. 162-167
    • Jubin, R.1
  • 96
    • 0035831269 scopus 로고    scopus 로고
    • Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit
    • SPAHN CM, KIEFT JS, GRASSUCI RA et al.: Hepatitis C virus IRES RNA-induced changes in the conformation of the 40S ribosomal subunit. Science (2001) 291:1959-1962.
    • (2001) Science , vol.291 , pp. 1959-1962
    • Spahn, C.M.1    Kieft, J.S.2    Grassuci, R.A.3
  • 97
    • 0033744387 scopus 로고    scopus 로고
    • A potential RNA drug target in the hepatitis C virus internal ribosome entry site
    • KLINCK R, WESTHOF E, WALKER S, AFSHAR M, COLLIER A, ABOUL-ELA F: A potential RNA drug target in the hepatitis C virus internal ribosome entry site. RNA (2000) 6:1423-1431.
    • (2000) RNA , vol.6 , pp. 1423-1431
    • Klinck, R.1    Westhof, E.2    Walker, S.3    Afshar, M.4    Collier, A.5    Aboul-Ela, F.6
  • 98
    • 0033673387 scopus 로고    scopus 로고
    • Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function
    • LUKAVSKY PJ, OTTO GA, LANCASTER AM, SARNOW P, PUGLISI JD: Structures of two RNA domains essential for hepatitis C virus internal ribosome entry site function. Nat. Struct. Biol. (2000) 7 1105-1110.
    • (2000) Nat. Struct. Biol. , vol.7 , pp. 1105-1110
    • Lukavsky, P.J.1    Otto, G.A.2    Lancaster, A.M.3    Sarnow, P.4    Puglisi, J.D.5
  • 99
    • 0036237981 scopus 로고    scopus 로고
    • Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation
    • KIEFT JS, ZHOU K, GRECH A, JUBIN R, DOUDNA JA: Crystal structure of an RNA tertiary domain essential to HCV IRES-mediated translation initiation. Nat. Struct. Biol. (2002) 9:370-374.
    • (2002) Nat. Struct. Biol. , vol.9 , pp. 370-374
    • Kieft, J.S.1    Zhou, K.2    Grech, A.3    Jubin, R.4    Doudna, J.A.5
  • 100
    • 0037077562 scopus 로고    scopus 로고
    • NMR study of 100 kDa HCV IRES RNA using segmental isotope labeling
    • KIM I, LUKAVSKY PJ, PUGLISI JD: NMR study of 100 kDa HCV IRES RNA using segmental isotope labeling. J. Am. Chem. Soc. (2002) 124:9338-9339.
    • (2002) J. Am. Chem. Soc. , vol.124 , pp. 9338-9339
    • Kim, I.1    Lukavsky, P.J.2    Puglisi, J.D.3
  • 102
    • 2442615084 scopus 로고    scopus 로고
    • High throughput screening of library compounds against an oligonucleotide substructure of an RNA target
    • GOODING KB, HIGGS R, HODGE B et al.: High throughput screening of library compounds against an oligonucleotide substructure of an RNA target. J. Am. Soc. Mass Spectrom. (2004) 15:884-892.
    • (2004) J. Am. Soc. Mass Spectrom. , vol.15 , pp. 884-892
    • Gooding, K.B.1    Higgs, R.2    Hodge, B.3
  • 103
  • 104
    • 4444295503 scopus 로고    scopus 로고
    • Seeing is believing: The impact of structural genomics on antimicrobial drug discovery
    • SCHMID MB: Seeing is believing: the impact of structural genomics on antimicrobial drug discovery. Nat. Rev. Microbiol. (2004) 2:739-746.
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 739-746
    • Schmid, M.B.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.