2 RNA as a Drug Target

Progress in Medicinal Chemistry

Volumn 39, Issue C, 2002, Pages 73-119

  Drysdale, Martin J ^a   Lentzen, Georg ^a   Matassova, Natalia ^a   Murchie, Alastair I H ^a   Aboul Ela, Fareed ^a   Afshar, Mohammad ^a  

^a Ribo Targets Ltd   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIINFECTIVE AGENT; BACTERIAL RNA; PROTEIN SYNTHESIS INHIBITOR; RIBOSOME RNA; VIRUS RNA;

ANIMAL; CHEMISTRY; CONFORMATION; DRUG DESIGN; DRUG EFFECT; HUMAN; REVIEW; RIBOSOME; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTI-HIV AGENTS; DRUG DESIGN; HUMANS; NUCLEIC ACID CONFORMATION; PROTEIN SYNTHESIS INHIBITORS; RIBOSOMES; RNA, BACTERIAL; RNA, RIBOSOMAL; RNA, VIRAL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0036987832     PISSN: 00796468     EISSN: None     Source Type: Book Series    
DOI: 10.1016/S0079-6468(08)70069-9     Document Type: Article

References (169)

1. Pearson N.D., and Prescott C.D. Chem. Biol. 4 (1997) 409-414
2. Hermann T.E., and Westhof E. Curr. Opin. Biotechnol. 9 (1998) 66-73
3. Michael K., and Tor Y. Chem.-Eur. J. 4 (1998) 2091-2098
4. Afshar M., Prescott C.D., and Varani G. Curr. Opin. Biotechnol. 10 (1999) 59-63
5. Tor Y. Angew. Chem. Int. Ed. 38 (1999) 1579-1582
6. Ecker D.J., and Griffey. Drug Discovery Today 4 (1999) 420-429
7. Hermann T. Angew. Chem. Int. Ed. 39 (2000) 1890-1905
8. Ferre-D'Amare A.R., and Doudna J.A. Ann. Rev. Biophys. Biomol. Struct. 28 (1999) 57-73
9. Moore P.B. Ann. Rev. Biochem. 67 (1999) 287-300
10. Batey R.T., Rambo J.A., and Doudna J.A. Angew. Chem. Int. Ed. 38 (1999) 2326-2343
11. Hermann T., and Patel D.J. J. Mol. Biol. 294 (1999) 829-849
12. Klinck R., Westhof E., Walker S., Afshar M., Collier A., and Aboul-Ela F. RNA 10 (2000) 1423-1431
13. Wimberly B.T., Brodersen D.E., Clemons Jr. W.M., Morgan-Warren R.J., Carter A.P., Vonrhein C., Hartsch T., and Ramakrishnan V. Nature (London) 407 (2000) 327-339
14. Carter A.P., Clemons Jr., Brodersen W.M.D.E., Morgan-Warren R.J., Wimberly B.T., and Ramakrishnan V. Nature (London) 407 (2000) 340-348
15. Schluenzen F., Tocilj A., Zarivach R., Harms J., Gluehmann M., Janell D., Bashan A., Bartels H., Agmon I., Franceschi F., and Yonath A. Cell 102 (2000) 615-623
16. Ban N., Nissen P., Hansen J., Moore P.B., and Steitz T.A. Science (Washington, D.C.) 289 (2000) 905-920
17. Nissen P., Hansen J., Ban N., Moore P.B., and Steitz T.A. Science (Washington, D.C.) 289 (2000) 920-929
18. Lucas G.M., Chaisson R.E., and Moore R.D. Ann. Intern. Med. 131 (1999) 81-87
19. Yerly S., Kaiser L., Race E., Bru J.-P., Clavel F., and Perrin L. Lancet 354 (1999) 729-733
20. Karn J., Gait M.J., Churcher M.J., Mann D.A., Mikaelian I., and Pritchard C. In: Nagai K., and Mattaj I.W. (Eds). RNA Protein Interactions (1994), Oxford University Press 213-220
21. Jones K., and Peterlin B.M. Ann. Rev. Biochem. 63 (1994) 717-743
22. Bogerd H.P., Fridell R.A., Madore S., and Cullen B.R. Cell 82 (1995) 485-494
23. Fischer U., Huber J., Boelens W.C., Mattej I.W., and Luhrmann R. Cell 82 (1995) 475-483
24. Fritz C.C., Zapp M.L., and Green M.R. Nature (London) 376 (1995) 530-533
25. Stutz F., Neville M., and Rosbash M. Cell 82 (1995) 495-506
26. Lazinski D., Grzadienska E., and Das A. Cell 59 (1989) 207-218
27. Colvin R.A., and Garcia-Blanco M.A. J. Virol. 66 (1992) 930-935
28. Tao J., and Frankel A.D. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 2723-2726
29. Loret E.P., Georgel P., Johnson W.C.J., and Ho P.S. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 9734-9738
30. Aboul-Ela F., Karn J., and Varani G. J. Mol. Biol. 253 (1995) 313-332
31. Puglisi J.D., Tan R., Canlan B.J., Frankel A.D., and Williamson J.R. Science (Washington D.C.) 257 (1992) 76-80
32. Puglisi J.D., Chen L., Frankel A.D., and Williamson J.R. Proc. Natl. Acad. Sci. U.S.A. 90 (1993) 3680-3684
33. Hamy F., Felder E.R., Heizmann G., Lazdins J., Aboul-Ela F., Varani G., Karn J., and Klimkait T. Proc. Natl. Acad. Sci. U.S.A. 94 (1997) 3548-3553
34. Hamy F., Brondani V., Florsheimer A., Stark W., Blommers M.J.J., and Klimkait T. Biochemistry 37 (1998) 5086-5095
35. Gelus N., Bailly C., Hamy F., Klimkait T., Wilson W.D., and Boykin D.W. Bioorg. Med. Chem. 7 (1999) 1089-1096
36. Trent J.O., Clark G.R., Kumar A., Wilson W.D., Boykin D.W., Hall J.E., Tidwell R.R., Blagburn B.L., and Neidle S. J. Med. Chem. 39 (1996) 4554-4562
37. Rakhit, S. and Slassi, A. (1995) PCT Int. Appl. WO 95 29926.
38. Chem. Abstr. 124 (1996) 202940w
39. Mei H.-Y., Mack D.P., Galan A.A., Halem N.S., Heldsinger A., Loo J.A., Moreland D.W., Sannes-Lowery K.A., Sharmeen L., Truong H.N., and Czarnik A.W. Bioorg. Med. Chem. 5 (1997) 1173-1184
40. Mei H.-Y., Cui M., Heldsinger A., Lemrow S.M., Loo J.A., Sannes-Lowery K.A., Sharmeen L., and Czarnik A.W. Biochemistry 37 (1998) 14202-14212
41. An H., Haly B.D., and Cook P.D. Bioorg. Med. Chem. Lett. 8 (1998) 2345-2350
42. Wang T., An H., Vickers T.A., Bharadwaj R., and Cook P.D. Tetrahedron 54 (1998) 7955-7976
43. Dassonneville L., Hamy F., Colson P., Houssier C., and Bailly C. Nucleic Acids Res. 25 (1997) 4487-4492
44. Olsen H.S., Cochrane A.W., Dillon P.J., Nalin C.M., and Rosen C.A. Genes & Dev. 4 (1990) 1357-1364
45. Zapp M.L., Hope T.J., Parslow M.R., and Green M.R. Proc. Natl. Acad. Sci. U.S.A. 88 (1991) 7734-7738
46. Cook K.S., Fisk G.J., Hauber J., Usman N., Daly T.J., and Rusche J.R. Nucleic Acids Res. 19 (1991) 1577-1583
47. Tiley L.S., Malim M.H., Tewary H.K., Stockley P.G., and Cullen B.R. Proc. Natl. Acad. Sci. U.S.A. 89 (1992) 758-762
48. Hendrix M., Priestley E.S., Joyce G.F., and Wong C.-H. J. Am. Chem. Soc. 119 (1997) 3641-3648
49. Hamasaki K., Woo M.-C., and Ueno A. Tetrahedron Lett. 41 (2000) 8327-8332
50. Kirk S.R., Luedtke N.W., and Tor Y. J. Am. Chem. Soc. 122 (2000) 980-981
51. Ratmeyer L., Zapp M.L., Green M.R., Vinayak R., Kumar A., Boykin D.W., and Wilson W.D. Biochemistry 35 (1996) 13689-13696
52. Li K., Xiao G., Rigl T., Kumar A., Boykin D.W., and Wilson W.D. In: Sarma R.H., and Sarma M.H. (Eds). Structure, Motion, Interaction and Expression of Biological Macromolecules (1998), Adenine Press 137-145
53. Zapp M.L., Stern S., and Green M.R. Cell 74 (1993) 969-978
54. Li K., Davis T.M., Bailly C., Kumar A., Boykin D.W., and Wilson W.D. Biochemistry 40 (2001) 1150-1158
55. M.A. Wuonola Z. Li U.S. Pat. Appl. 5 668 1997 165
56. May R.P., Nowotny V., Nowotny P., Voss H., and Nierhaus K.H. EMBO J. 11 (1992) 373-378
57. Frank J., and Agrawal R.K. Nature (London) 406 (2000) 318-322
58. Willumeit R., Forthmann S., Beckmann J., Diedrich G., Ratering R., Stuhrmann H.B., and Nierhaus K.H. J. Mol. Biol. 305 (2001) 167-177
59. Van Loock M.S., Agrawal R.K., Gabashvili I.S., Qi L., Frank J., and Harvey S.C. J. Mol. Biol. 304 (2000) 507-515
60. van Heel M. Curr. Opin. Struct. Biol. 10 (2000) 252-264
61. Green R., and Noller H.F. Annu. Rev. Biochem. 66 (1997) 679-716
62. Rinke-Appel J., Junke N., Osswald M., and Brimacombe R. RNA 1 (1995) 1018-1028
63. Yusupov, M.M., Yusupova, G.Zh., Baucom, A., Lieberman, K., Earnest, T.N., Cate, J.H.D and Noller, H.F. (2001) Published online March, 29, 10.1126/science. 1060089 (Science Express Research Articles).
64. Cate J.H., Yusupov M.M., Yusupova G.Z., Earnest T.N., and Noller H.F. Science (Washington, D.C.) 285 (1999) 2095-2104
65. Clemons Jr. W.M., May J.L., Wimberly B.T., McCutcheon J.P., Capel M.S., and Ramakrishnan V. Nature (London) 400 (1999) 833-840
66. Ban N., Nissen P., Hansen J., Capel M., Moore P.B., and Steitz T.A. Nature (London) 400 (1999) 841-847
67. Brodersen D.E., Clemons Jr. W.M., Carter A.P., Morgan-Warren R.J., Wimberly B.T., and Ramakrishnan V. Cell 103 (2001) 1143-1154
68. Carter A.P., Clemons Jr. W.M., Brodersen D.E., Morgan-Warren R.J., Hartsch T., Wimberly B.T., and Ramakrishnan V. Science (Washington, D.C.) 291 (2001) 498-501
69. Mueller F., Sommer I., Baranov P., Matadeen R., Stoldt M., Wohnert J., Gorlach M., van Heel M., and Brimacombe R. J. Mol. Biol. 298 (2000) 35-59
70. Stark H., Rodnina M.V., Wieden H.J., van Heel M., and Wintermeyer W. Cell 100 (2000) 301-309
71. Frank J., Verschoor A., Li Y., Zhu J., Lata R.K., Radermacher M., Penczek P., Grassucci R., Agrawal R.K., and Srivastava S. Biochem. Cell Biol. 73 (1995) 757-765
72. Frank J., Penczek P., Agrawal R.K., Grassucci R.A., and Heagle A.B. Methods Enzymol 317 (2000) 276-291
73. Cundliffe E. In: Hardesty I.B. (Ed). Structure, Function and Genetics of Ribosomes (1986), Springer-Verlag, New York 586-604
74. Shine J., and Dalgarno L. Eur. J. Biochem. 57 (1975) 221-230
75. Wintermeyer W., and Gualerzi C. Biochemistry 22 (1983) 690-694
76. Gualerzi, C.O. and Wintermeyer, W. (1986) FEBS Lett. 202, 1-6.
77. La Teana, A., Pon, C.L. and Gualerzi, CO. (1996) J. Mol. Biol. 256, 667-675.
78. Grunberg-Manago M., Dessen P., Pantaloni D., Godefroy-Colburn T., Wolfe A.D., and Dondon J. J. Mol. Biol. 94 (1975) 461-478
79. Hershey J.W.B. In: Neidhardt F.C., Ingraham J.L., Brooks Low K., Magasanik B., Schaechter M., and Umbarger H.E. (Eds). Escherischia coli and Salmonella typhimurium. Cellular and Molecular Biology (1987), American Society for Microbiology, Washington, D.C. 613-647
80. Gualerzi C.O., and Pon C.L. Biochemistry 29 (1990) 5881-5889
81. Gualerzi C.O., Brandi L., Caserta E., La Teana A., Spurio R., Tomsic J., and Pon C.L. In: Garrett R.A., Douthwaite S.R., Liljas A., Matheson A.T., Moore P.B., and Noller H.F. (Eds). The Ribosome: Structure, Function, Antibiotics and Cellular Interactions (2000), ASM Press, Washington, D.C. 477-494
82. Rodnina M.V., Pape T., Savelsbergh A., Mohr D., Matassova N., and Wintermeyer W. in Ref. 59 (2000) 301-317
83. Rodnina M.V., and Wintermeyer W. Trends Biochem. Sci. 26 (2001) 124-130
84. Semenkov Y.P., Rodnina M.V., and Wintermeyer W. Nat. Struct. Biol. 7 (2000) 1027-1031
85. Rodnina M.V., Stark H., Savelsbergh A., Wieden H.J., Mohr D., Matassova N.B., Peske F., Daviter T., Gualerzi C.O., and Wintermeyer W. Biol. Chem. 381 (2000) 377-387
86. Rodnina M.V., Savelsbergh A., Matassova N.B., Katunin V.I., Semenkov Y.P., and Wintermeyer W. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 9586-9590
87. Peske F., Matassova N.B., Savelsbergh A., Rodnina M.V., and Wintermeyer W. Mol. Cell 6 (2000) 501-505
88. Savelsbergh A., Matassova N.B., Rodnina M.V., and Wintermeyer W. J. Mol. Biol. 300 (2000) 951-961
89. Noller H.F. FASEB J. 7 (2000) 87-89
90. Green R., Samaha R.R., and Noller H.F. J. Mol. Biol. 266 (1997) 40-50
91. Green R., Switzer C., and Noller H.F. Science (Washington, D.C.) 280 (1998) 286-289
92. Crick F.H. J. Mol. Biol. 383 (1968) 67-79
93. Rodnina M.V., Savelsbergh A., Matassova N.B., Katunin V.I., Semenkov Y.P., and Wintermeyer W. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 9586-9590
94. Rodnina M.V., Stark H., Savelsbergh A., Wieden H.-J., Mohr D., Matassova N., Peske F., and Wintermeyer W. Biol. Chem. 381 (2000) 377-387
95. Buckingham R.H., Grentzmann G., and Kisselev L. Mol. Microbiol. 24 (1997) 449-456
96. Janosi L., Mottagui-Tabar S., Isaksson L.A., Sekine Y., Ohtsubo E., Zhang S., Goon S., Nelken S., Shuda M., and Kaji A. EMBO J. 17 (1998) 1141-1151
97. Ganoza, M.C. (1966) Cold Spring Harb. Symp. Quant. Biol. 31, 273-278.
98. Freistroffer D.V., Pavlov M.Y., MacDougall J., Buckingham R.H., and Ehrenberg M. EMBO J. 16 (1997) 4126-4133
99. Fourmy D., Recht M.I., Blanchard S.C., and Puglisi J.D. Science (Washington, D.C.) 274 (1996) 1367-1371
100. Pape T., Wintermeyer W., and Rodnina M.V. Nat. Struct. Biol. 7 (2000) 104-107
101. Lodmell J.S., and Dahlberg A.E. Science (Washington, D.C.) 277 (1997) 1262-1267
102. Bilgin N., Richter A.A., Ehrenberg M., Dahlberg A.E., and Kurland C.G. EMBO J. 9 (1990) 735-739
103. Chopra I., Hawkey P.M., and Hinton M. J. Antimicrob. Chemother. 29 (1992) 245-277
104. Gale E.F., Cundliffe E., Reynolds P.E., Richmond M.H., and Waring M.J. The Molecular Basis of Antibiotic Action (1981), Wiley, London
105. Epe B., Woolley P., and Hornig H. FEBS Lett. 213 (1987) 443-447
106. Kolesnikov I.V., Protasova N.Y., and Gudkov A.T. Biochimie 78 (1996) 868-873
107. Moazed D., and Noller H.F. Nature (London) 327 (1987) 389-394
108. Cohen L.B., Goldberg I.H., and Herner A.E. Biochemistry 8 (1969) 1327-1335
109. Moazed D., Samaha R.R., Gualerzi C., and Noller H.F. J. Mol. Biol. 248 (1995) 207-210
110. Woodcock J., Moazed D., Cannon M., Davies J., and Noller H.F. EMBO J. 10 (1991) 3099-3103
111. Vila-Sanjurjo A., Squires C.L., and Dahlberg A.E. J. Mol. Biol. 293 (1999) 1-8
112. Douthwaite S. Nucleic Acids Res. 20 (1992) 4120-4717
113. Rodriguez-Fonseca C., Amils R., and Garrett R.A. J. Mol. Biol. 247 (1995) 224-235
114. Leviev I.G., Rodriguez-Fonseca C., Phan H., Garrett R.A., Heilek G., Noller H.F., and Mankin A.S. EMBO J. 13 (1994) 1682-1686
115. Xiong L., Shah S., Mauvais P., and Mankin A.S. Mol. Microbiol. 31 (1999) 633-639
116. Porse B.T., and Garrett R.A. J. Mol. Biol. 286 (1999) 375-387
117. Kirillov S.V., Porse B.T., and Garrett R.A. RNA 5 (1999) 1003-1013
118. Kuechler E., Steiner G., and Barta A. Methods Enzymol. 164 (1988) 361-372
119. Poulsen S.M., Kofoed C., and Vester B. J. Mol. Biol. 304 (2000) 471-481
120. Menninger J.R., and Otto D.P. Antimicrob. Agents Chemother. 21 (1982) 811-818
121. In: Bryskier A.J., Butzler J.-P., Neu H.C., and Tulkens P.M. (Eds). Macrolides: Chemistry, Pharmacology and Clinical Uses (1993), Arnette Blackwell, Paris
122. In: Neu H.C., Young L.S., Zinner S.H., and Acar J.F. (Eds). New Macrolides, Azalides and Streptogramins in Clinical Practice (1995), Marcel Dekker, New York
123. Chu D.T.W. Exp. Opin. Invest. Drugs 4 (1995) 65
124. Lartey P.A., and Perun T. In: Rahman A. (Ed). Studies in Natural Products Chemistry (1993), Elsevier Science, Amsterdam 155-185
125. Acar J.F., and Goldstein F.W. in Ref. 93 b (1995) 41-49
126. Shah P.M., and Bryskier A.J. in Ref. 93 b (1993) 143-166
127. Neu H.C. Science (Washington, D.C.) 257 (1992) 1064-1073
128. Appelbaum P.C. Clin. Infect. Dis. 15 (1992) 77-83
129. Friedland I.R., and McCracken G.H. New Engl. J. Med. 331 (1994) 377-382
130. Goldstein F.W., and Acar J.F. J. Antimicrob. Che-mother. 38 (1996) 71-84
131. Hardy D.J., Hensey D.M., Beyer J.M., Vojtko C., McDonald E.J., and Fernandes P.B. Antimicrob. Agents Chemother. 32 (1988) 1710-1719
132. Fernandes P.B., Baker W.R., Freiberg L.A., Hardy D.J., and McDonald E.J. Antimicrob. Agents Chemother. 33 (1989) 78-81
133. Agouridas C., Denis A., Auger J.-M., Benedetti Y., Bonnefoy A., Bretin F., Chantot J.-F., Dussarat A., Fromentin C., Gouin D'Ambrieres S., Lachaud S., Laurin P., Le Martret O., Loyau V., and Tessot N. J. Med. Chem. 41 (1998) 4080-4100
134. Bertho G., Gharbi-Benarous J., Delaforge M., Lang C., Parent A., and Girault J.-P. J. Med. Chem. 41 (1998) 3373-3386
135. Denis A., Agouridas C., Auger J.-M., Benedetti Y., Bonnefoy A., Bretin F., Chantot J.-F., Dussarat A., Fromentin C., Gouin D'Ambrieres S., Lachaud S., Laurin P., Le Martret O., Loyau V., Tessot N., Pejac J.-M., and Perron S. Bioorg. Med. Chem. Lett. 9 (1999) 3075-3080
136. Evrard-Todeschi N., Gharbi-Benarous J., Gaillet C., Verdier L., Bertho G., Lang C., Parent A., and Girault J.-P. Bioorg. Med. Chem. 8 (2000) 1579-1597
137. Or Y.S., Clark R.F., Wang S., Chu D.T.W., Nilius A.M., Flamm R.K., Mitten M., Ewing P., Alder J., and Ma Z. J. Med. Chem. 43 (2000) 1045-1049
138. Cao, Z., Hammond, R., Pratt, S., Saiki, A., Lemer, C. and Zhong, P. (1999) 39th Intersci. Conf. Antimicrob. Agents Chemother., Abstr. 2135.
139. Copobianco J.O., Cao Z., Shortridge V.D., Ma Z., Flamm R.K., and Zhong P. Antimicrob. Agents Chemother. 44 (2000) 1562-1567
140. Phan L.T., Clark R.F., Rupp M., Or Y.S., Chu D.T.W., and Ma Z. Org. Lett. 2 (2000) 2951-2954
141. Wimberly B.T., Guymon R., McCutcheon J.P., White S.W., and Ramakrishnan V.A. Cell 97 (1999) 491-502
142. Conn G.L., Draper D.E., Lattman E.E., and Gittis A.G. Science (Washington, D.C.) 284 (1999) 1171-1174
143. Cundliffe E., and Thompson J. Eur. J. Biochem. 118 (1981) 47-52
144. Moazed D., and Noller H.F. Biochimie 69 (1987) 879-884
145. Merryman C., Moazed D., Daubresse G., and Noller H.F. J. Mol. Biol. 285 (1999) 107-113
146. Belova L., Tenson T., Xiong L., McNicholas P.M., and Mankin A.S. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 3726-3731
147. Barrett J.F. Curr. Opin. Investig. Drugs 1 (2000) 181-187
148. French G. Int. J. Clin. Pract. 55 (2001) 59-63
149. Matassova N.B., Rodnina M.V., Endermann R., Kroll H.P., Pleiss U., Wild H., and Wintermeyer W. RNA 5 (1999) 939-946
150. Tucker J.A., Allwine D.A., Grega K.C., Barbachyn M.R., Klock J.L., Adamski J.L., Brickner S.J., Hutchison D.K., Ford C.W., Zurenko G.E., Conradi R.A., Burton P.S., and Jensen R.M. J. Med. Chem. 41 (1998) 3727-3735
151. Xiong L., Kloss P., Douthwaite S., Andersen N.M., Swaney S., Shinabarger D.L., and Mankin A.S. J. Bacteriol. 182 (2000) 5325-5331
152. Nurse, K., Sterner, T., Ferguson, D., Takle, A., Davies, S., Ham, P., Dean, D., Hunt, E., Woodnutt, G., King, F., Meek, T. and Hegg, L. (1999) Nucleic Acids Symposium Series 41, 11-12.
153. Egger H., and Reinshagen H. J. Antibiot. 29 (1976) 915-922
154. Egger H., and Reinshagen H. J. Antibiot. 29 (1976) 923-927
155. Hinks, J., Takle, A. and Hunt, E. (1997) PCT Int. Appl. WO 97 25309.
156. Chem. Abstr. 127 (1997) 161997m
157. Takle, A., Hunt, E. and Naylor, A. (1998) PCT Int. Appl. WO 98 05659.
158. Chem. Abstr. 128 (1998) 154256m
159. Berry, V., Dabbs, S., Frydrych, C.H., Hunt, E., Woodnutt, G. and Sanderson, F.D. (1999) PCT Int. Appl. WO 99 21855.
160. Chem. Abstr. 130 (1999) 338272m
161. Dean, D., Howard, S., Naylor, A., and Takle, A. (2000) PCT Int. Appl. WO 00 73287.
162. Berry, V., Brooks, G., Dabbs, S., Davies, S., Dean, D., Frydrych, C.H., Hunt, E., King, F., Rittenhouse, S., Sattersfield, J., Singley, C., Takle, A., Turconi, S. and Woodnutt, G. (2000) 3rd International Symposium on Recent Advances In The Medicinal Chemistry of Anti-Infective Agents: New Targets and Opportunities, Cambridge U.K., Poster 8.
163. Tackle, A. (2000) 3rd International Symposium on Recent Advances In The Medicinal Chemistry of Anti-Infective Agents: New Targets and Opportunities, Cambridge, U.K.
164. Hansen L.H., Mauvais P., and Douthwaite S. Mol. Microbiol. 31 (1999) 623-631
165. Hogenauer G., and Ruf C. Antimicrob. Agents Chemother. 19 (1999) 260-265
166. Cannon M., Amin M., Mirza A., and Brown P.R. Biochem. Soc. Trans. 22 (1994) 449S
167. Rosendahl G., and Douthwaite S. Nucleic Acids Res. 22 (1994) 357-363
168. Egdeberg J., and Garrett R.A. Biochimie 73 (1991) 1145-1149
169. Aargaard C., Phan H., Trevisanato S., and Garrett R. J. Bact. 24 (1994) 7744-7747