Design and synthesis of paromomycin-related heterocycle-substituted aminoglycoside mimetics based on a mass spectrometry RNA-binding assay

Angewandte Chemie - International Edition

Volumn 42, Issue 29, 2003, Pages 3409-3412

  Ding, Yili ^a   Hofstadler, Steven A ^b   Swayze, Eric E ^b   Risen, Lisa ^b   Griffey, Richard H ^b  

^a Isis Pharmaceuticals Inc ^*  (United States)

^b ISIS PHARMACEUTICALS   (United States)

Author keywords

Aminoglycosides; Antibiotics; Heterocycles; Mass spectrometry; Synthesis design

Indexed keywords

MASS SPECTROMETRY; RNA; SYNTHESIS (CHEMICAL);

BACTERICIDAL COMPOUNDS;

BACTERIA;

AMINOGLYCOSIDE ANTIBIOTIC AGENT; BACTERICIDE; HETEROCYCLIC COMPOUND; PAROMOMYCIN; RNA;

ARTICLE; BINDING AFFINITY; DISSOCIATION CONSTANT; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; MASS SPECTROMETRY; STRUCTURE ANALYSIS;

AMINOGLYCOSIDES; BINDING, COMPETITIVE; CARBOHYDRATE SEQUENCE; DRUG DESIGN; LIGANDS; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MOLECULAR STRUCTURE; PAROMOMYCIN; RNA, RIBOSOMAL, 16S; RNA, RIBOSOMAL, 18S; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY;

EID: 0042074617     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351354     Document Type: Article

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15. abstract
16. The MS RNA-binding data were obtained from the assay described in reference [4], and paromomycin was used as the standard compound.