Small molecule modulators of HIV Rev/Rev response element interaction identified by random screening

Antiviral Research

Volumn 54, Issue 3, 2002, Pages 149-162

  Chapman, Richard L ^a   Stanley, Thomas B ^a   Hazen, Richard ^a   Garvey, Edward P ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

High throughput screening (HTS); Human immunodeficiency virus (HIV); Protein RNA interaction; Rev, Rev response element (RRE)

Indexed keywords

BLOCKING AGENT; REV PROTEIN;

ANALYTIC METHOD; ARTICLE; BIOTINYLATION; DNA RESPONSIVE ELEMENT; HUMAN IMMUNODEFICIENCY VIRUS; IC 50; MOLECULAR INTERACTION; MOLECULAR WEIGHT; NONHUMAN; PRIORITY JOURNAL; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; PROTEIN RNA BINDING; PROTEIN STRUCTURE; REGULATORY MECHANISM; SCINTILLATION; STRUCTURE ACTIVITY RELATION; SURFACE PLASMON RESONANCE;

AMINO ACID SEQUENCE; ANTIVIRAL AGENTS; BINDING, COMPETITIVE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE PRODUCTS, REV; GENES, ENV; HIV; HUMANS; INHIBITORY CONCENTRATION 50; MOLECULAR SEQUENCE DATA; RNA, VIRAL; SCINTILLATION COUNTING; STRUCTURE-ACTIVITY RELATIONSHIP; SURFACE PLASMON RESONANCE;

HUMAN IMMUNODEFICIENCY VIRUS;

EID: 0036227966     PISSN: 01663542     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0166-3542(01)00222-4     Document Type: Article

References (31)

1. Alpha helix-RNA major groove recognition in an HIV-1 rev peptide-RRE RNA complex
2. Solution oligomerization of the rev protein of HIV-1: Implications for function
3. 5-Chloro-2′,3′-dideoxy-3′-fluorouridine (935U83), a selective anti-human immunodeficiency virus agent with an improved metabolic and toxicological profile
4. Determination of the refractive index increments of small molecules for correction of surface plasmon resonance data
5. Potent inhibition of human immunodeficiency virus type 1 replication by an intracellular anti-Rev single-chain antibody
6. The molecular weight of avidin
7. NMR-based discovery of lead inhibitors that block DNA binding of the human papillomavirus E2 protein
8. HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element region
9. The ins and outs of HIV Rev
10. Recognition of the high affinity binding site in rev-response element RNA by the human immunodeficiency virus type-1 rev protein
11. Specific binding of a basic peptide from HIV-1 Rev
12. Neomycin-acridine conjugate: A potent inhibitor of Rev-RRE binding
13. Mechanism of neomycin and Rev peptide binding to the Rev responsive element of HIV-1 as determined by fluorescence and NMR spectroscopy
14. A computer screening approach to immunoglobulin superfamily structures and interactions: Discovery of small non-peptidic CD4 inhibitors as novel immunotherapeutics
15. Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication
16. A molecular rheostat. Co-operative rev binding to stem I of the rev-response element modulates human immunodeficiency virus type-1 late gene expression
17. Inhibitors of protein-RNA complexation that target the RNA: Specific recognition of human immunodeficiency virus type 1 TAR RNA by small organic molecules
18. Mimicking dominant negative inhibition of prion replication through structure-based drug design
19. Incidence and impact of resistance against approved antiretroviral drugs
20. Niruriside, a new HIV Rev/RRE binding inhibitor from Phyllanthus niruri
21. Binding site of brefeldin A at the interface between the small G protein ADP-ribosylation factor 1 (ARF1) and the nucleotide-exchange factor Sec7 domain
22. Inhibition of HIV replication by immunoliposomal antisense oligonucleotide
23. The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating
24. Construction of a cell-based high-flux assay for the rev protein of HIV-1
25. Real-time kinetics of HIV-1 Rev-Rev response element interactions
26. Antiretroviral therapy: State of the HAART
27. Specificity of aminoglycoside binding to RNA constructs derived from the 16S rRNA decoding region and the HIV-RRE activator region
28. Binding kinetics and bioassay of RRE mRNA fragments to a peptide containing the recognition domain of HIV-1 Rev
29. A chimeric human immunodeficiency virus type 1 (HIV-1) minimal Rev response element-ribozyme molecule exhibits dual antiviral function and inhibits cell-cell transmission of HIV-1
30. Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production
31. Modulation of the Rev-RRE interaction by aromatic heterocyclic compounds