A strategy for discovery of novel broad-spectrum antibacterials using a high-throughput Streptococcus pneumoniae transcription/translation screen

Journal of Biomolecular Screening

Volumn 9, Issue 1, 2004, Pages 3-11

  Pratt, Steven D ^a   David, Caroline A ^a   Black Schaefer, Candace ^a   Dandliker, Peter J ^a   Xuei, Xiaoling ^a,b   Warrior, Usha ^a   Burns, David J ^a   Zhong, Ping ^a,c   Cao, Zhensheng ^a   Saiki, Anne Y C ^a,d   Lerner, Claude G ^a   Chovan, Linda E ^a   Soni, Niru B ^a   Nilius, Angela M ^a   Wagenaar, Frank L ^a   Merta, Philip J ^a   Traphagen, Linda M ^a   Beutel, Bruce A ^a  

^a ABBOTT LABORATORIES   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Givaudan Roure Corporation   (United States)

^d AMGEN INC   (United States)

Author keywords

Antibacterial; Screen; Streptococcus; Transcription; Translation

Indexed keywords

A 209106; A 58012; A 72310; A 84655; A 85123; A 91664; ANTIBIOTIC AGENT; BLASTICIDIN S; CHLORAMPHENICOL; CYCLOHEXIMIDE; ERYTHROMYCIN; LINCOMYCIN; LINEZOLID; LUCIFERASE; RIFAMPICIN; STREPTOMYCIN; TETRACYCLINE; UNCLASSIFIED DRUG; ANTIINFECTIVE AGENT; BACTERIAL DNA;

ANIMAL CELL; ARTICLE; ARTIFACT; DRUG SPECIFICITY; DRUG STRUCTURE; ENZYME INHIBITION; ESCHERICHIA COLI; GENETIC TRANSCRIPTION; HIGH THROUGHPUT SCREENING; NONHUMAN; PRIORITY JOURNAL; REPORTER GENE; RETICULOCYTE; RNA TRANSLATION; STREPTOCOCCUS PNEUMONIAE; WHOLE CELL; DRUG EFFECT; GENETICS; HUMAN; METHODOLOGY; MICROBIOLOGICAL EXAMINATION; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PROTEIN SYNTHESIS; TUMOR CELL LINE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; MAMMALIA; ORYCTOLAGUS CUNICULUS; STREPTOCOCCUS; STREPTOCOCCUS PNEUMONIAE;

ANTI-BACTERIAL AGENTS; BASE SEQUENCE; CELL LINE, TUMOR; DNA, BACTERIAL; GENES, REPORTER; HUMANS; LUCIFERASES; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; PROTEIN BIOSYNTHESIS; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION, GENETIC;

EID: 2442470467     PISSN: 10870571     EISSN: None     Source Type: Journal    
DOI: 10.1177/1087057103260876     Document Type: Article

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