Novel acyclic deoxystreptamine mimetics targeting the ribosomal decoding site

ChemBioChem

Volumn 4, Issue 9, 2003, Pages 879-885

  Vourloumis, Dionisios ^a   Winters, Geoffrey C ^a   Takahashi, Masayuki ^a   Simonsen, Klaus B ^a   Ayida, Benjamin K ^a   Shandrick, Sarah ^a   Zhao, Qiang ^a   Hermann, Thomas ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

Aminoglycosides; Antibiotics; Drug design; Medicinal chemistry; RNA recognition

Indexed keywords

2 DEOXYSTREPTAMINE; AMINOGLYCOSIDE ANTIBIOTIC AGENT; FRAMYCETIN; GLUCOSAMINE DERIVATIVE; HYDROXYLAMINE; PAROMOMYCIN; PIPERIDINE DERIVATIVE; RNA;

ANTIMICROBIAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DESIGN; DRUG SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; PHARMACOPHORE; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; RNA TRANSCRIPTION; RNA TRANSLATION; STAPHYLOCOCCUS AUREUS; STEREOCHEMISTRY; STRUCTURE ACTIVITY RELATION;

AMINOGLYCOSIDES; ANTI-BACTERIAL AGENTS; BINDING SITES; ESCHERICHIA COLI; HEXOSAMINES; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RNA, BACTERIAL; RNA, RIBOSOMAL; STAPHYLOCOCCUS AUREUS; STRUCTURE-ACTIVITY RELATIONSHIP;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 0141733704     PISSN: 14394227     EISSN: None     Source Type: Journal    
DOI: 10.1002/cbic.200300688     Document Type: Article

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