The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography

Journal of the American Chemical Society

Volumn 125, Issue 12, 2003, Pages 3410-3411

  Russell, Rupert J M ^a   Murray, James B ^a   Lentzen, Georg ^a   Haddad, Jalal ^b   Mobashery, Shahriar ^b  

^a RiboTargets Ltd   (United Kingdom)

^b WAYNE STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMIKACIN; AMINOACYL TRANSFER RNA; AMINOGLYCOSIDE ANTIBIOTIC AGENT; ANTIBIOTIC AGENT; MESSENGER RNA; NEAMINE; PAROMOMYCIN; RIBOSOME RNA;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ANTICODON; ARTICLE; BASE PAIRING; CODON; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; MOLECULAR INTERACTION; MOLECULAR RECOGNITION; NONHUMAN; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN STRUCTURE; RIBOSOME SUBUNIT; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANTI-BACTERIAL AGENTS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; ESCHERICHIA COLI; NUCLEIC ACID CONFORMATION; PAROMOMYCIN; PROTEIN BIOSYNTHESIS; RNA, RIBOSOMAL;

EID: 0037467430     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja029736h     Document Type: Article

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