Synthesis and evaluation of novel bacterial rRNA-binding benzimidazoles by mass spectrometry

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 3, 2004, Pages 695-699

  He, Yun ^a,b   Yang, Jun ^a   Wu, Baogen ^a   Robinson, Dale ^a   Sprankle, Kelly ^a   Kung, Pei Pei ^a   Lowery, Kristin ^a   Mohan, V ^a   Hofstadler, Steve ^a   Swayze, Eric E ^a   Griffey, Rich ^a  

^a ISIS PHARMACEUTICALS   (United States)

^b GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

Author keywords

Benzimidazoles; Mass spectrometry; rRNA

Indexed keywords

BACTERIAL RNA; BENZIMIDAZOLE DERIVATIVE; RIBOSOME RNA;

ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG BINDING; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; MASS SPECTROMETRY; NONHUMAN; RNA BINDING; SOLID; STRUCTURE ACTIVITY RELATION; TECHNIQUE;

BACTERIA (MICROORGANISMS);

EID: 1642534336     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.031     Document Type: Article

References (38)

1. Ecker D.J., Griffey R.H. Drug Discovery Today. 4:1999;420.
2. Hermann T. Angew. Chem., Int. Ed. 39:2000;1891.
3. Tor Y. Angew. Chem., Int. Ed. 38:1999;1579.
4. Afshar M., Precott C.D., Varani G. Curr. Opin. Biotechnol. 10:1999;59.
5. Hofstadler S.A., Griffey R.H. Curr. Opin. Drug. Discovery Dev. 3:2000;423.
6. Hofstadler S.A., Griffey R.H. Chem. Rev. 101:2001;377.
7. Xavier K.A., Eder P.S., Giordano T. Trends Biotechnol. 18:2000;349.
8. Xiong Y.-Q., Yeaman M.R., Bayer Arnold S. Drugs of Today. 36:2000;631.
9. Griffey R.H., Greig M.J., An H., Sasmor H., Manalili S. J. Am. Chem. Soc. 121:1999;474.
10. Sannes-Lowery K.A., Griffey R.H., Hofstadler S.A. Anal. Biochem. 280:2000;264.
11. Griffey R.H., Sannes-Lowery K.A., Drader J.J., Mohan V., Swayze E.E., Hofstadler S.A. J. Am. Chem. Soc. 122:2000;9933.
12. Griffey R.H., Hofstadler S.A., Sannes-Lowery K.A., Ecker D.J., Crooke S.T. Proc. Natl. Acad. Sci. U.S.A. 96:1999;10129.
13. Yusupov M.M., Yusupova G.Z., Baucom A., Lieberman K., Earnest T.N., Cate J.H., Noller H.F. Science. 292:2001;883.
14. Vicens Q., Westhof E. Structure. 9:2001;647.
15. Ogle J.M., Brodersen D.E., Clemons W.M. Jr., Tarry M.J., Carter A.P., Ramakrishnan V. Science. 292:2001;897.
16. Hyun Ryu D., Rando R.R. Bioorg. Med. Chem. 9:2001;2601.
17. Carter A.P., Clemons W.M. Jr., Brodersen D.E., Morgan-Warren R.J., Hartsch T., Wimberly B.T., Ramakrishnan V. Science. 291:2001;498.
18. Carter A.P., Clemons W.M., Brodersen D.E., Morgan-Warren R.J., Wimberly B.T., Ramakrishnan V. Nature. 407:2000;340.
19. Wong C.-H., Hendrix M., Priestley E.S., Greenberg W.A. Chem. Biol. 5:1998;397.
20. Wagner R., Gassen H.G., Ehresmann C., Stiegler P., Ebel J.P. FEBS Lett. 67:1976;312.
21. Tok J.B.H., Fenker J. Bioog. Med. Chem. Lett. 11:2001;2987.
22. Tok J.B.-H., Dunn L.J., De Jean R.C. Bioog. Med. Chem. Lett. 11:2001;1127.
23. Tatsuta K. Curr. Org. Chem. 5:2001;207.
24. Hamasaki K., Ueno A. Bioorg. Med. Chem. Lett. 11:2001;591.
25. Cashman D.J., Rife J.P., Kellogg G.E. Bioorg. Med. Chem. Lett. 11:2001;119.
26. Wilson W.D., Li K. Curr. Med. Chem. 7:2000;73.
27. Sucheck S.J., Wong A.L., Koeller K.M., Boehr D.D., Draker K.-A., Sears P., Wright G.D., Wong C.-H. J. Am. Chem. Soc. 122:2000;5230.
28. Ding Y., Swayze E.E., Hofstadler S.A., Griffey R.H. Tetrahedron Lett. 41:2000;4049.
29. Hamasaki K., Woo M.-C., Ueno A. Tetrahedron Lett. 41:2000;8327.
30. Wong C.-H. Acc. Chem. Res. 32:1999;376.
31. Wong C.-H., Hendrix M., Manning D.D., Rosenbohm C., Greenberg W.A. J. Am. Chem. Soc. 120:1998;8319.
32. Wang H., Tor Y. Angew. Chem., Int. Ed. 37:1998;109.
33. Alper P.B., Hendrix M., Sears P., Wong C.-H. J. Am. Chem. Soc. 120:1998;1965.
34. Hendrix M., Alper P.B., Priestley E.S., Wong C.-H. Angew. Chem., Int. Ed. 36:1997;95.
35. Park W.K.C., Auer M., Jaksche H., Wong C.-H. J. Am. Chem., Soc. 118:1996;10150.
36. Zaske D.E. Infectious Disease and Therapy. 9:1994;183.
37. Kim M., Nicolau D.P. Infectious Disease and Therapy. 28:2002;125.
38. Tok J.B.-H., Bi L. Curr. Top. Med. Chem. 3:2003;1001.