Proflavine acts as a Rev inhibitor by targeting the high-affinity Rev binding site of the Rev responsive element of HIV-1

Biochemistry

Volumn 42, Issue 26, 2003, Pages 8035-8046

  DeJong, Eric S ^a   Chang, Chia En ^a   Gilson, Michael K ^a   Marino, John P ^a  

^a UNIVERSITY OF MARYLAND BIOTECHNOLOGY INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

VIRAL REPLICATION;

BIOASSAY; FLUORESCENCE; GENES; NUCLEAR MAGNETIC RESONANCE;

PROTEINS;

2 AMINOPURINE; AMINOGLYCOSIDE; ARGININE; HETEROCYCLIC COMPOUND; PROFLAVINE; PURINE; REV PROTEIN; REV RESPONSIVE ELEMENT; UNCLASSIFIED DRUG; VIRUS PROTEIN; VIRUS RNA;

AMINO ACID SEQUENCE; ARTICLE; BASE PAIRING; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; COMPLEX FORMATION; DRUG DESIGN; ENVELOPE GENE; FLUORESCENCE; HUMAN IMMUNODEFICIENCY VIRUS 1; LATENT PERIOD; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; PROTEIN TARGETING; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; TITRIMETRY; VIRUS GENOME; VIRUS REPLICATION;

2-AMINOPURINE; ANTI-INFECTIVE AGENTS, LOCAL; ANTIMETABOLITES; BINDING SITES; BINDING, COMPETITIVE; DIMERIZATION; FLUORESCENCE; GENE PRODUCTS, REV; GENES, ENV; HIV-1; HUMANS; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; NUCLEIC ACID CONFORMATION; PROFLAVINE; PROTEIN BINDING; RNA, VIRAL; SPECTROMETRY, FLUORESCENCE; THERMODYNAMICS;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

EID: 0038047131     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi034252z     Document Type: Article

References (59)

1. Daly, T. J., Cook, K. S., Gray, G. S., Maione, T. E., and Rusche, J. R. (1989) Nature 342, 816-819.
2. Felber, B. K., Hadzopouloucladaras, M., Cladaras, C., Copeland, T., and Pavlakis, G. N. (1989) Proc. Natl. Acad. Sci. U.S.A. 86, 1495-1499.
3. Malim, M. H., Hauber, J., Fenrick, R., and Cullen, B. R. (1988) Nature 335, 181-183.
4. Zapp, M. L., and Green, M. R. (1989) Nature 342, 714-716.
5. Cochrane, A. W., Chen, C. H., and Rosen, C. A. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 1198-1202.
6. Malim, M. H., Freimuth, W. W., Liu, J. S., Boyle, T. J., Lyerly, H. K., Cullen, B. R., and Nabel, G. J. (1992) J. Exp. Med. 176, 1197-1201.
7. Duan, L., Zhu, M., Ozaki, I., Zhang, H., Wei, D. L., and Pomerantz, R. J. (1997) Gene Ther. 4, 533-543.
8. Zapp, M. L., Stern, S., and Green, M. R. (1993) Cell 74, 969-978.
9. Hendrix, M., Priestley, E. S., Joyce, G. F., and Wong, C. H. (1997) J. Am. Chem. Soc. 119, 3641-3648.
10. Werstuck, G., Zapp, M. L., and Green, M. R. (1996) Chem. Biol. 3, 129-137.
11. Wang, Y., Hamasaki, K., and Rando, R. R. (1997) Biochemistry 36, 768-779.
12. Cho, J. H., and Rando, R. R. (1999) Biochemistry 38, 8548-8554.
13. Michael, K., Wang, H., and Tor, Y. (1999) Bioorg. Med. Chem. 7, 1361-1371.
14. Kirk, S. R., Luedtke, N. W., and Tor, Y. (2000) J. Am. Chem. Soc. 122, 980-981.
15. Sucheck, S. J., Greenberg, W. A., Tolbert, T. J., and Wong, C. H. (2000) Angew. Chem., Int. Ed. 39, 1080.
16. Wang, H., and Tor, Y. (1998) Angew. Chem., Int. Ed. 37, 109-111.
17. Xiao, G., Kumar, A., Li, K., Rigl, C. T., Bajic, M., Davis, T. M., Boykin, D. W., and Wilson, W. D. (2001) Bioorg. Med. Chem. 9, 1097-1113.
18. Zapp, M. L., Young, D. W., Kumar, A., Singh, R., Boykin, D. W., Wilson, W. D., and Green, M. R. (1997) Bioorg. Med. Chem. 5, 1149-1155.
19. Ratmeyer, L., Zapp, M. L., Green, M. R., Vinayak, R., Kumar, A., Boykin, D. W., and Wilson, W. D. (1996) Biochemistry 35, 13689-13696.
20. Li, K., Davis, T. M., Bailly, C., Kumar, A., Boykin, D. W., and Wilson, W. D. (2001) Biochemistry 40, 1150-1158.
21. Chapman, R. L., Stanley, T. B., Hazen, R., and Garvey, E. P. (2002) Antiviral Res. 54, 149-162.
22. Kjems, J., Frankel, A. D., and Sharp, P. A. (1991) Cell 67, 169-178.
23. Cook, K. S., Fisk, G. J., Hauber, J., Usman, N., Daly, T. J., and Rusche, J. R. (1991) Nucleic Acids Res. 19, 1577-1583.
24. Kjems, J., Calnan, B. J., Frankel, A. D., and Sharp, P. A. (1992) EMBO J. 11, 1119-1129.
25. Tan, R. Y., Chen, L., Buettner, J. A., Hudson, D., and Frankel, A. D. (1993) Cell 73, 1031-1040.
26. Tan, R. Y., and Frankel, A. D. (1994) Biochemistry 33, 14579-14585.
27. Battiste, J. L., Tan, R. Y., Frankel, A. D., and Williamson, J. R. (1994) Biochemistry 33, 2741-2747.
28. Battiste, J. L., Mao, H. Y., Rao, N. S., Tan, R. Y., Muhandiram, D. R., Kay, L. E., Frankel, A. D., and Williamson, J. R. (1996) Science 273, 1547-1551.
29. Peterson, R. D., Bartel, D. P., Szostak, J. W., Horvath, S. J., and Feigon, J. (1994) Biochemistry 33, 5357-5366.
30. Peterson, R. D., and Feigon, J. (1996) J. Mol. Biol. 264, 863-877.
31. Lacourciere, K. A., Stivers, J. T., and Marino, J. P. (2000) Biochemistry 39, 5630-5641.
32. Millar, D. P. (1996) Curr. Opin. Struct. Biol. 6, 322-326.
33. Rist, M. J., and Marino, J. P. (2001) Nucleic Acids Res. 29, 2401-2408.
34. Greenberg, W. A., Priestley, E. S., Sears, P. S., Alper, P. B., Rosenbohm, C., Hendrix, M., Hung, S. C., and Wong, C. H. (1999) J. Am. Chem. Soc. 121, 6527-6541.
35. Mei, H. Y., Galan, A. A., Halim, N. S., Mack, D. P., Moreland, D. W., Sanders, K. B., Truong, H. N., and Czarnik, A. W. (1995) Bioorg. Med. Chem. Lett. 5, 2755-2760.
36. Sannes-Lowery, K. A., Mei, H. Y., and Loo, J. A. (1999) Int. J. Mass Spectrom. 193, 115-122.
37. Mikkelsen, N. E., Johansson, K., Virtanen, A., and Kirsebom, L. A. (2001) Nat. Struct. Biol. 8, 510-514.
38. Gelus, N., Hamy, F., and Bailly, C. (1999) Bioorg. Med. Chem. 7, 1075-1079.
39. Cho, J., and Rando, R. R. (2000) Nucleic Acids Res. 28, 2158-2163.
40. Krey, A., and Hahn, F. (1975) Naturwissenschaften 62, 99-100.
41. Ciak, J., and Fiatin, F. (1967) Science 156, 655-656.
42. Milligan, J. F., and Uhlenbeck, O. C. (1989) Methods Enzymol. 180, 51.
43. Nikonowicz, E. P., Sirr, A., Legault, P., Jucker, F. M., Baer, L. M., and Pardi, A. (1992) Nucleic Acids Res. 20, 4507-4513.
44. Batey, R. T., Inada, M., Kujawinski, E., Puglisi, J. D., and Williamson, J. R. (1992) Nucleic Acids Res. 20, 4515-4523.
45. Kuzmic, P. (1996) Anal. Biochem. 237, 260-273.
46. Piotto, M., Saudek, V., and Sklenar, V. (1992) J. Biomol. NMR 2, 661-665.
47. Lippens, G., Dhalluin, C., and Wieruszeski, J. M. (1995) J. Biomol. NMR 5, 327-331.
48. Dingley, A. J., and Grzesiek, S. (1998) J. Am. Chem. Soc. 120, 8293-8297.
49. Delaglio, F., Grzesiek, S., Vuister, G. W., Zhu, G., Pfeifer, J., and Bax, A. (1995) J. Biomol. NMR 6, 277-293.
50. DeJong, E. S., Luy, B., and Marino, J. P. (2002) Curr. Top. Med. Chem. 2, 289-302.
51. Hermann, T. (2000) Angew. Chem., Int. Ed. 39, 1891-1905.
52. Hermann, T., and Westhof, E. (2000) Comb. Chem. High Throughput Screening 3, 219-234.
53. Xavier, K. A., Eder, P. S., and Giordano, T. (2000) Trends Biotechnol. 18, 349-356.
54. Schelhorn, T., Kretz, S., and Zimmermann, H. W. (1992) Cell. Mol. Biol. 38, 345-365.
55. Wilson, W. D., Ratmeyer, L., Cegla, M. T., Spychala, J., Boykin, D., Demeunynck, M., Lhomme, J., Krishnan, G., Kennedy, D., Vinayak, R., and Zon, G. (1994) New J. Chem. 18, 419-423.
56. Mei, H. Y., Cui, M., Heldsinger, A., Lemrow, S. M., Loo, J. A., Sannes-Lowery, K. A., Sharmeen, L., and Czarnik, A. W. (1998) Biochemistry 37, 14204-14212.
57. Gayle, A. Y., and Baranger, A. M. (2002) Bioorg. Med. Chem. Lett. 12, 2839-2842.
58. Woodson, S. A., and Crothers, D. M. (1988) Biochemistry 27, 8904-8914.
59. Neidle, S., Taylor, G., Sanderson, M., Shieh, H.-S., and Berman, H. (1978) Nucleic Acids Res. 5, 4417.