A structure-based strategy to identify new molecular scaffolds targeting the bacterial ribosomal A-site

Bioorganic and Medicinal Chemistry

Volumn 12, Issue 5, 2004, Pages 935-947

  Foloppe, Nicolas ^a   Chen, I Jen ^a   Davis, Ben ^a   Hold, Adam ^a   Morley, Dave ^a   Howes, Rob ^a  

^a Vernalis PLC   (United Kingdom)

Author keywords

A site; Drug design; FRET assay; Ribosome

Indexed keywords

LIGAND; PAROMOMYCIN; RNA;

ARTICLE; BACTERIUM; BINDING AFFINITY; BINDING ASSAY; BINDING SITE; CALIBRATION; CONTROLLED STUDY; DRUG BINDING; DRUG POTENCY; DRUG STRUCTURE; DRUG TARGETING; EXPERIMENT; FLUORESCENCE RESONANCE ENERGY TRANSFER; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; RIBOSOME; SCORING SYSTEM; SCREENING; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; VALIDATION PROCESS; X RAY ANALYSIS;

BACTERIA (MICROORGANISMS);

EID: 1342343126     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2003.12.023     Document Type: Article

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