Inhibition of protein synthesis by aminoglycoside-arginine conjugates

RNA

Volumn 8, Issue 10, 2002, Pages 1267-1279

  Carriere, Marjolaine ^a   Vijayabaskar, Veerappan ^a   Applefield, Drew ^a   Harvey, Isabelle ^a   Garneau, Philippe ^a   Lorsch, Jon ^a   Lapidot, Aviva ^a   Pelletier, Jerry ^a  

^a MCGILL UNIVERSITY   (Canada)

Author keywords

Aminoglycoside arginine conjugates; Peptidyl transferase inhibitor; Ribosome; Translation inhibition

Indexed keywords

AMINOGLYCOSIDE; ARGININE; GENTAMICIN; NEOMYCIN; RIBOSOME RNA; TRANSACTIVATOR PROTEIN;

ARTICLE; CONJUGATE; CONTROLLED STUDY; DRUG PROTEIN BINDING; EUKARYOTE; HUMAN IMMUNODEFICIENCY VIRUS; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; PROTEIN SYNTHESIS INHIBITION; RABBIT; RNA BINDING; RNA TRANSLATION; STRUCTURE ACTIVITY RELATION; XENOPUS LAEVIS;

EUKARYOTA; HUMAN IMMUNODEFICIENCY VIRUS; ORYCTOLAGUS CUNICULUS; PROKARYOTA; XENOPUS LAEVIS;

EID: 0036794070     PISSN: 13558382     EISSN: None     Source Type: Journal    
DOI: 10.1017/S1355838202029059     Document Type: Article

References (57)

1. Anderson CW, Straus JW, Dudock BS. 1983. Preparation of a cell-free protein-synthesizing system from wheat germ. In: Wu R, Grossman L, Moldave K, eds. Methods in enzymology. New York: Academic Press. pp 635-644.
2. Bauer C, Brass N, Diesinger I, Kayser K, Grasser FA, Meese E. 2002. Overexpression of the eukaryotic translation initiation factor 4G (elF4G-1) in squamous cell lung carcinoma. Int J Cancer 98:181-185.
3. Beckers CJ, Roos DS, Donald RG, Luft BJ, Schwab JC, Cao Y, Joiner KA. 1995. Inhibition of cytoplasmic and organellar protein synthesis in Toxoplasma gondii. Implications for the target of macrolide antibiotics. J Clin Invest 95:367-376.
4. Bottger EC, Springer B, Prammananan T, Kidan Y, Sander P. 2001. Structural basis for selectivity and toxicity of ribosomal antibiotics. EMBO Rep 2:318-323.
5. Brodersen DE, Clemons WM Jr, Carter AP, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. 2000. The structural basis for the action of the antibiotics tetracycline, pactamycin, and hygromycin B on the 30S ribosomal subunit. Cell 103:1143-1154.
6. Cabrera C, Gutierrez A, Barretina J, Blanco J, Litovchick A, Lapidot A, Clotet B, Este JA. 2002. Anti-HIV activity of a novel aminoglycoside-arginine conjugate. Antiviral Res 53:1-8.
7. Carter AP, Clemons WM, Brodersen DE, Morgan-Warren RJ, Wimberly BT, Ramakrishnan V. 2000. Functional insights from the structure of the 30S ribosomal subunit and its interactions with antibiotics. Nature 407:340-348.
8. Chen H-Z, Zubay G. 1983. Prokaryotic coupled transcriptiontranslation. In: Wu R, Grossman L, Moldave K, eds. Methods in enzymology. New York: Academic Press. pp 674-690.
9. Cheng AC, Calabro V, Frankel AD. 2001. Design of RNA-binding proteins and ligands. Curr Opin Struct Biol 11:478-484.
10. Colman A. 1984. Translation of eukaryotic messenger RNA in Xenopus oocytes. Transcription and translation. A practical approach. Oxford, England: IRL Press Ltd. pp 271-302.
11. Earnshaw DJ, Gait MJ. 1998. Hairpin ribozyme cleavage catalyzed by aminoglycoside antibiotics and the polyamine spermine in the absence of metal ions. Nucleic Acids Res 26:5551-5561.
12. Eckstein F, Kettler M, Parmeggiani A. 1971. Guanylylimidodiphosphate and its interaction with amino acid polymerization factors. Biochem Biophys Res Commun 45:1151-1158.
13. Eubank TD, Biswas R, Jovanovic M, Litovchick A, Lapidot A, Gopalan V. 2002. Inhibition of bacterial RNase P by aminoglycosidearginine conjugates. FEBS Lett 511:107-112.
14. Fersht A. 1999. Structure and mechanism in protein science. New York: W.H. Freeman and Company.
15. Gale EF, Cundliffe E, Reynolds PE, Richmond MH, Waring JM. 1981. The molecular basis of antibiotic action. New York: John Wiley and Sons.
16. Gold L, Polisky B, Uhlenbeck O, Yarus M. 1995. Diversity of oligonucleotide functions. Annu Rev Biochem 64:763-797.
17. Gorman C. 1985. High efficiency gene transfer into mammalian cells. DNA cloning II. A practical approach. Oxford, England: IRL Press Ltd. pp 143-190.
18. Harvey I, Garneau P, Pelletier J. 2002. Forced engagement of a RNA/protein complex by a chemical inducer of dimerization to modulate gene expression. Proc Natl Acad Sci USA 99:1882-1887.
19. Hausner TP, Geigenmuller U, Nierhaus KH. 1988. The allosteric three-site model for the ribosomal elongation cycle. New insights into the inhibition mechanisms of aminoglycosides, thiostrepton, and viomycin. J Biol Chem 263:13103-13111.
20. Hoch I, Berens C, Westhof E, Schroeder R. 1998. Antibiotic inhibition of RNA catalysis: Neomycin B binds to the catalytic core of the td group I intron displacing essential metal ions. J Mol Biol 282:557-569.
21. Jenne A, Hartig JS, Piganeau N, Tauer A, Samarsky DA, Green MR, Davies J, Famulok M. 2001. Rapid identification and characterization of hammerhead-ribozyme inhibitors using fluorescence-based technology. Nat Biotechnol 19:56-61.
22. Kurtz DI. 1974. Fidelity of protein synthesis with chicken embryo mitochondrial and cytoplasmic ribosomes. Biochemistry 13:572-577.
23. Litovchick A, Evdokimov AG, Lapidot A. 1999. Arginine-aminoglycoside conjugates that bind to HIV transactivation responsive element RNA in vitro. FEBS Lett 445:73-79.
24. Litovchick A, Evdokimov AG, Lapidot A. 2000. Aminoglycosidearginine conjugates that bind TAR RNA: Synthesis, characterization, and antiviral activity. Biochemistry 39:2838-2852.
25. Litovchick A, Lapidot A, Eisenstein M, Kalinkovich A, Borkow G. 2001. Neomycin B-arginine conjugate, a novel HIV-1 Tat antagonist: Synthesis and anti-H IV activities. Biochemistry 40:15612-15623.
26. Lorsch JR, Herschlag D. 1999. Kinetic dissection of fundamental processes of eukaryotic translation initiation in vitro. EMBO J 18:6705-6717.
27. Mehta R, Champney WS. 2002. 30S Ribosomal subunit assembly is a target for inhibition by aminoglycosides in Escherichia coli. Antimicrob Agents Chemother 46:1546-1549.
28. Mei HY, Mack DP, Galan AA, Halim NS, Heldsinger A, Loo JA, Moreland DW, Sannes-Lowery KA, Sharmeen L, Truong HN, Czarnik AW. 1997. Discovery of selective, small-molecule inhibitors of RNA complexes I. The Tat protein/TAR RNA complexes required for HIV-1 transcription. Bioorg Med Chem 5:1173-1184.
29. Merrick WC. 1983. Translation of exogenous mRNAs in reticulocyte lysates. In: Wu R, Grossman L, Moldave K, eds. Methods in enzymology. New York: Academic Press. pp 606-615.
30. Mikkelsen NE, Brannvall M, Virtanen A, Kirsebom LA. 1999. Inhibition of RNase P RNA cleavage by aminoglycosides. Proc Natl Acad Sci USA 96:6155-6160.
31. Nathan CA, Liu L, Li BD, Abreo FW, Nandy I, De Benedetti A. 1997. Detection of the proto-oncogene eIF4E in surgical margins may predict recurrence in head and neck cancer. Oncogene 15:579-584.
32. Noller HF. 1991. Ribosomal RNA and translation. Annu Rev Biochem 60:191-227.
33. Palacian E, Vazquez D. 1979. Interaction of arginine with the ribosomal peptidyl transferase centre. Eur J Biochem 101:469-473.
34. Palmer E, Wilhelm JM. 1978. Mistranslation in a eucaryotic organism. Cell 13:329-334.
35. Pelletier J, Sonenberg N. 1985. Insertion mutagenesis to increase secondary structure within the 5' noncoding region of a eukaryotic mRNA reduces translational efficiency. Cell 40:515-526.
36. Pestka S. 1977. Inhibitors of protein synthesis. In: Weissbach H, Pestka S, eds. Molecular mechanisms of protein synthesis. New York: Academic Press. pp 468-536.
37. Pioletti M, Schlunzen F, Harms J, Zarivach R, Gluhmann M, Avila H, Bashan A, Bartels H, Auerbach T, Jacobi C, Hartsch T, Yonath A, Franceschi F. 2001. Crystal structures of complexes of the small ribosomal subunit with tetracycline, edeine and IF3. EMBO J 20:1829-1839.
38. Puglisi JD, Chen L, Frankel AD, Williamson JR. 1993. Role of RNA structure in arginine recognition of TAR RNA. Proc Natl Acad Sci USA 90:3680-3684.
39. Puglisi JD, Tan R, Calnan BJ, Frankel AD, Williamson JR. 1992. Conformation of the TAR RNA-arginine complex by NMR spectroscopy. Science 257:76-80.
40. Rogers J, Chang AH, von Ahsen U, Schroeder R, Davies J. 1996. Inhibition of the self-cleavage reaction of the human hepatitis delta virus ribozyme by antibiotics. J Mol Biol 259:916-925.
41. Schlunzen F, Zarivach R, Harms J, Bashan A, Tocilj A, Albrecht R, Yonath A, Franceschi F. 2001. Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria. Nature 413:814-821.
42. Schroeder R, Waldsich C, Wank H. 2000. Modulation of RNA function by aminoglycoside antibiotics. EMBO J 19:1-9.
43. Sor F, Fukuhara H. 1984. Erythromycin and spiramycin resistance mutations of yeast mitochondria: Nature of the rib2 locus in the large ribosomal RNA gene. Nucleic Acids Res 12:8313-8318.
44. Stage TK, Hertel KJ, Uhlenbeck OC. 1995. Inhibition of the hammer-head ribozyme by neomycin. RNA 1:95-101.
45. Svitkin YV, Agol VI. 1978. Complete translation of encephalomyocarditis virus RNA and faithful cleavage of virus-specific proteins in a cell-free system from Krebs-2 cells. FEBS Lett 87:7-11.
46. Svitkin YV, Imataka H, Khaleghpour K, Kahvejian A, Liebig HD, Sonenberg N. 2001. Poly(A)-binding protein interaction with eIF4G stimulates picornavirus IRES-dependent translation. RNA 7:1743-1752.
47. Svitkin YV, Ovchinnikov LP, Dreyfuss G, Sonenberg N. 1996. General RNA binding proteins render translation cap dependent. EMBO J 15:7147-7155.
48. Szittner R, Meighen E. 1990. Nucleotide sequence, expression, and properties of luciferase coded by lux genes from a terrestrial bacterium. J Biol Chem 265:16581-16587.
49. Tao J, Frankel AD. 1992. Specific binding of arginine to TAR RNA. Proc Natl Acad Sci USA 89:2723-2726.
50. Tarbe N, Evtimova V, Burtscher H, Jarsch M, Alves F, Weidle UH. 2001. Transcriptional profiling of cell lines derived from an orthotopic pancreatic tumor model reveals metastasis-associated genes. Anticancer Res 21:3221-3228.
51. Vazquez D. 1979. Inhibitors of protein biosynthesis. New York: Springer-Verlag.
52. von Ahsen U, Davies J, Schroeder R. 1991. Antibiotic inhibition of group I ribozyme function. Nature 353:368-370.
53. Walter F, Putz J, Giege R, Westhof E. 2002. Binding of tobramycin leads to conformational changes in yeast tRNA(Asp) and inhibition of aminoacylation. EMBO J 21:760-768.
54. Walter F, Vicens Q, Westhof E. 1999. Aminoglycoside-RNA interactions. Curr Opin Chem Biol 3:694-704.
55. Wilhelm JM, Jessop JJ, Pettit SE. 1978a. Aminoglycoside antibiotics and eukaryotic protein synthesis: Stimulation of errors in the translation of natural messengers in extracts of cultured human cells. Biochemistry 17:1149-1153.
56. Wilhelm JM, Pettitt SE, Jessop JJ. 1978b. Aminoglycoside antibiotics and eukaryotic protein synthesis: Structure-function relationships in the stimulation of misreading with a wheat embryo system. Biochemistry 17:1143-1149.
57. Zapp ML, Stern S, Green MR. 1993. Small molecules that selectively block RNA binding of HIV-1 Rev protein inhibit Rev function and viral production. Cell 74:969-978.