Novel Antibacterial Class

Antimicrobial Agents and Chemotherapy

Volumn 47, Issue 12, 2003, Pages 3831-3839

  Dandliker, Peter J ^a   Pratt, Steve D ^a   Nilius, Angela M ^a   Black Schaefer, Candace ^a   Ruan, Xiaoan ^a   Towne, Danli L ^a   Clark, Richard F ^a   Englund, Erika E ^a   Wagner, Rolf ^a   Weitzberg, Moshe ^a   Chovan, Linda E ^a   Hickman, Robert K ^a   Daly, Melissa M ^a   Kakavas, Stephan ^a   Zhong, Ping ^a   Cao, Zhensheng ^a   David, Caroline A ^a   Xuei, Xiaoling ^a   Lerner, Claude G ^a   Soni, Niru B ^a   Bui, Mai ^a   Shen, Linus L ^a   Cai, Yingna ^a   Merta, Philip J ^a   Saiki, Anne Y C ^a   Beutel, Bruce A ^a   more..

^a ABBOTT LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

A 692345; A 72310; ANTIINFECTIVE AGENT; BACTERIAL PROTEIN; CHLORAMPHENICOL; CIPROFLOXACIN; CYCLOHEXIMIDE; ERYTHROMYCIN; LEVOFLOXACIN; LINCOMYCIN; LINEZOLID; MINOCYCLINE; NEAMINE; NORFLOXACIN; OXYTETRACYCLINE; PUROMYCIN; RIFAMPICIN; STREPTOMYCIN; TETRACYCLINE; THIOSTREPTON; UNCLASSIFIED DRUG;

ANTIBIOTIC RESISTANCE; ARTICLE; BACTERICIDAL ACTIVITY; BACTERIUM; CELL FREE SYSTEM; DNA MICROARRAY; DRUG CONFORMATION; DRUG DESIGN; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; GROWTH INHIBITION; HAEMOPHILUS INFLUENZAE; INTRACELLULAR KILLING; MORAXELLA CATARRHALIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RIBOSOME SUBUNIT; STAPHYLOCOCCUS AUREUS; STREPTOCOCCUS PNEUMONIAE; STRUCTURE ACTIVITY RELATION;

AMINO ACYL-TRNA SYNTHETASES; ANIMALS; ANTI-INFECTIVE AGENTS; BACILLUS SUBTILIS; BACTERIA; BETA-GALACTOSIDASE; DNA GYRASE; DRUG DESIGN; DRUG RESISTANCE, BACTERIAL; ESCHERICHIA COLI; EUKARYOTIC CELLS; GENES, REPORTER; INDICATORS AND REAGENTS; LUCIFERASES; MICROBIAL SENSITIVITY TESTS; PLASMIDS; RABBITS; RIBOSOMAL PROTEINS; RIBOSOMES; STREPTOCOCCUS PNEUMONIAE; TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC;

EID: 10744232512     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.47.12.3831-3839.2003     Document Type: Article

References (22)

1. Chen, D. K., A. McGeer, J. C. de Azavedo, and D. E. Low. 1999. Decreased susceptibility of Streptococcus pneumoniae to fluoroquinolones in Canada. N. Engl. J. Med. 341:233-239.
2. Chenoweth, C. E., S. Saint, F. Martinez, J. P. Lynch III, and A. M. Fendrick. 2000. Antimicrobial resistance in Streptococcus pneumoniae: implications for patients with community-acquired pneumonia. Mayo Clin. Proc. 75:1161-1168.
3. Claverys, J. P., A. Dintilhac, E. V. Pestova, B. Martin, and D. A. Morrison. 1995. Construction and evaluation of new drug-resistance cassettes for gene disruption mutagenesis in Streptococcus pneumoniae, using an ami test platform. Gene 164:123-128.
4. Doern, G. V., K. P. Heilmann, H. K. Huynh, P. R. Rhomberg, S. L. Coffman, and A. B. Brueggemann. 2001. Antimicrobial resistance among clinical isolates of Streptococcus pneumoniae in the United States during 1999-2000, including a comparison of resistance rates since 1994-1995. Antimicrob. Agents Chemother. 45:1721-1729.
5. Felmingham, D., R. R. Reinert, Y. Hirakata, and A. Rodloff. 2002. Increasing prevalence of antimicrobial resistance among isolates of Streptococcus pneumoniae from the PROTEKT surveillance study, and comparative in vitro activity of the ketolide, telithromycin. J. Antimicrob. Chemother. 50(Suppl. 1):25-37.
6. Gale, E. F., E. Cundliffe, P. E. Reynolds, M. H. Richmond, and M. J. Waring. 1981. Molecular basis of antibiotic action. John Wiley and Sons, London, United Kingdom.
7. Gmuender, H., K. Kuratli, K. Di Padova, C. P. Gray, W. Keck, and S. Evers. 2001. Gene expression changes triggered by exposure to Haemophilus influenzae to novobiocin or ciprofloxacin: combined transcription and translation analysis. Genome Res. 11:28-42.
8. Hoban, D. J., A. K. Wierzbowski, K. Nichol, and G. G. Zhanel. 2001. Macrolide-resistant Streptococcus pneumoniae in Canada during 1998-1999: Prevalence of mef(A) and erm(B) and susceptibilities to ketolides. Antimicrob. Agents Chemother. 45:2147-2150.
9. Knowles, D. J. C., N. Foloppe, N. B. Matassova, and A. I. Murchie. 2002. The bacterial ribosome, a promising focus for structure-based drug design. Curr. Opin. Pharmacol. 5:501-506.
10. Lacks, S. A., B. Greenberg, and A. G. Sabelnikov. 1995. Possible regulation of DNA methyltransferase expression by RNA processing in Streptococcus pneumoniae. Gene 157:209-212.
11. Lafontaine, D. L. J., and D. Tollervey. 2001. The function and synthesis of ribosomes. Nat. Rev. Mol. Cell Biol. 2:514-520.
12. Legault-Demare, L., and G. H. Chambliss. 1974. Natural messenger ribonucleic acid-directed cell-free protein-synthesizing system of Bacillus subtilis. J. Bacteriol. 120:1300-1307.
13. Mackie, G. A., C. Donly, and P. C. Wong. 1990. Coupled transcription/translation of ribosomal proteins, p. 191-211. In G. Spedding (ed.), Ribosomes and protein synthesis: A practical approach. Oxford University Press, New York, N.Y.
14. National Committee for Clinical Laboratory Standards. 1997. Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically. Document no. M7-A4. National Committee for Clinical Laboratory Standards, Wayne, Pa.
15. Ng, W. L., K. M. Kazmierczak, G. T. Robertson, R. Gilmour, and M. E. Winkler. 2003. Transcriptional regulation and signature patterns revealed by microarray analyses of Streptococcus pneumoniae R6 challenged with sublethal concentrations of translation inhibitors. J. Bacteriol. 185:359-370.
16. Pagé, B., M. Pagé, and C. Noël. 1993. A fluorometric assay for cytotoxicity measurements in vitro. Int. J. Oncol. 3:473-476.
17. Pestka, S. 1971. Inhibitors of ribosome functions. Annu. Rev. Microbiol. 25:487-562.
18. Saiki, A. Y. C., L. L. Shen, C.-M. Chen, J. Baranowski, and C. G. Lerner. 1999. DNA cleavage activities of Staphylococcus aureus gyrase and topoisomerase IV stimulated by quinolones and 2-pyridones. Antimicrob. Agents Chemother. 43:1574-1577.
19. Shen, L. L., W. E. Kohlbrenner, D. Weigl, and J. Baranowski. 1989. Mechanism of quinolone inhibition of DNA gyrase: appearance of unique norfloxacin binding sites in enzyme-DNA complexes. J. Biol. Chem. 264:2973-2978.
20. Spahn, C. M., and C. D. Prescott. 1996. Throwing a spanner in the works: antibiotics and the translation apparatus. J. Mol. Med. 74:423-439.
21. Vázquez, D. 1979. Inhibitors of protein sythesis. Springer-Verlag, New York, N.Y.
22. Whitney, C. G., M. M. Farley, J. Hadler, L. H. Harrison, C. Lexau, A. Reingold, L. Lefkowitz, P. R. Cieslak, M. Cetron, E. R. Zell, J. H. Jorgensen, A. Schuchat, R. R. Facklam, and N. M. Bennett. 2000. Increasing prevalence of multidrug-resistant Streptococcus pneumoniae in the United States. N. Engl. J. Med. 343:1917-1924.