Fluorescence-Based Approach for Detecting and Characterizing Antibiotic-Induced Conformational Changes in Ribosomal RNA: Comparing Aminoglycoside Binding to Prokaryotic and Eukaryotic Ribosomal RNA Sequences

Journal of the American Chemical Society

Volumn 126, Issue 11, 2004, Pages 3447-3453

  Kaul, Malvika ^a   Barbieri, Christopher M ^a   Pilch, Daniel S ^a  

^a RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALORIMETRY; CONFORMATIONS; ESCHERICHIA COLI; FLUORESCENCE; OLIGOMERS; RNA; SYNTHESIS (CHEMICAL);

CONFORMATIONAL CHANGES; DIFFERENTIAL AFFINITY;

ANTIBIOTICS;

ADENINE DERIVATIVE; AMINO ACID; AMINOGLYCOSIDE ANTIBIOTIC AGENT; OLIGONUCLEOTIDE; PAROMOMYCIN; RIBOSOME RNA;

ANTIMICROBIAL ACTIVITY; ARTICLE; BINDING SITE; CHEMICAL BINDING; CONFORMATIONAL TRANSITION; DRUG SPECIFICITY; ENTHALPY; ESCHERICHIA COLI; EUKARYOTE EVOLUTION; EVALUATION; FLUORESCENCE; LIGAND BINDING; NONHUMAN; NUCLEOTIDE SEQUENCE; PROKARYOTE; PROTEIN SYNTHESIS; QUANTUM MECHANICS; RNA BINDING; RNA CONFORMATION; RNA SEQUENCE;

2-AMINOPURINE; ANTI-BACTERIAL AGENTS; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; NUCLEIC ACID CONFORMATION; PAROMOMYCIN; RNA, RIBOSOMAL, 16S; SPECTROMETRY, FLUORESCENCE; SPECTROPHOTOMETRY, ULTRAVIOLET; SUBSTRATE SPECIFICITY; THERMODYNAMICS;

EID: 1642347123     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja030568i     Document Type: Article

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