Rational design of azepane-glycoside antibiotics targeting the bacterial ribosome

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 3, 2004, Pages 713-718

  Barluenga, Sofia ^a,b   Simonsen, Klaus B ^a   Littlefield, Ethel S ^a   Ayida, Benjamin K ^a   Vourloumis, Dionisios ^a   Winters, Geoffrey C ^a   Takahashi, Masayuki ^a   Shandrick, Sarah ^a   Zhao, Qiang ^a   Han, Qing ^a   Hermann, Thomas ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

^b UNIVERSITÉ LOUIS PASTEUR   (France)

Author keywords

Antibiotics; RNA; Structure based design

Indexed keywords

2 DEOXYSTREPTAMINE; ANTIBIOTIC AGENT; GLYCOSIDE; HETEROCYCLIC COMPOUND;

ANTIBACTERIAL ACTIVITY; ANTIBIOTIC RESISTANCE; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BINDING AFFINITY; CONTROLLED STUDY; DRUG BINDING; DRUG DESIGN; DRUG SYNTHESIS; DRUG TARGETING; NONHUMAN; RIBOSOME; RNA TRANSLATION; STAPHYLOCOCCUS AUREUS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; THREE DIMENSIONAL IMAGING;

BACTERIA (MICROORGANISMS); STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 1642534330     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.028     Document Type: Article

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