A unique PPARγ ligand with potent insulin-sensitizing yet weak adipogenic activity

Molecular Cell

Volumn 8, Issue 4, 2001, Pages 737-747

  Rocchi, Stéphane ^a   Picard, Frédéric ^a   Vamecq, Joseph ^b   Gelman, Laurent ^a   Potier, Noelle ^a   Zeyer, Denis ^a   Dubuquoy, Laurent ^b   Bac, Pierre ^b   Champy, Marie France ^a   Plunket, Kelli D ^c   Leesnitzer, Lisa M ^c   Blanchard, Steven G ^c   Desreumaux, Pierre ^b   Moras, Dino ^a   Renaud, Jean Paul ^a   Auwerx, Johan ^a  

^a INSTITUT DE GÉNÉTIQUE ET DE BIOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^b LILLE UNIVERSITY HOSPITAL   (France)

^c GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

9 FLUORENYLMETHYLOXYCARBONYLLEUCINE; AMINO ACID DERIVATIVE; DIMETHYL SULFOXIDE; INSULIN; LIGAND; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; UNCLASSIFIED DRUG; 2,4 THIAZOLIDINEDIONE DERIVATIVE; AMINO ACID; ANTIDIABETIC AGENT; CELL RECEPTOR; FLUORENE DERIVATIVE; HYBRID PROTEIN; LEUCINE; N(ALPHA) FLUORENYLMETHYLOXYCARBONYLAMINO ACIDS; N(ALPHA)-FLUORENYLMETHYLOXYCARBONYLAMINO ACIDS; THIAZOLE DERIVATIVE; TRANSCRIPTION FACTOR; TYROSINE;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; DRUG RECEPTOR BINDING; GENE ACTIVATION; GLUCOSE TOLERANCE; HUMAN; HUMAN CELL; INSULIN SENSITIVITY; LIGAND BINDING; MOUSE; NONHUMAN; ADIPOCYTE; ANIMAL; BINDING SITE; BODY WEIGHT; CELL DIFFERENTIATION; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; GENE EXPRESSION REGULATION; GENETICS; GLUCOSE BLOOD LEVEL; INSULIN RESISTANCE; MALE; METABOLISM; MOUSE STRAIN; PHYSIOLOGY; PROTEIN BINDING; PROTEIN CONFORMATION; REPORTER GENE;

ANIMALIA;

ADIPOCYTES; AMINO ACIDS; ANIMALS; BINDING SITES; BLOOD GLUCOSE; BODY WEIGHT; CELL DIFFERENTIATION; CELL LINE; DOSE-RESPONSE RELATIONSHIP, DRUG; FLUORENES; GENE EXPRESSION REGULATION; GENES, REPORTER; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; LEUCINE; LIGANDS; MALE; MICE; MICE, INBRED STRAINS; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS; TYROSINE;

EID: 2642557181     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(01)00353-7     Document Type: Article

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