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Volumn 4, Issue , 2003, Pages 257-291

The Inherited Basis of Diabetes Mellitus: Implications for the Genetic Analysis of Complex Traits

Author keywords

[No Author keywords available]

Indexed keywords

DIABETES MELLITUS; DISEASE CLASSIFICATION; GENE; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC HETEROGENEITY; GENETIC LINKAGE; GENETIC TRAIT; HERITABILITY; INHERITANCE; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN GENE; MATURITY ONSET DIABETES MELLITUS; MONOGENIC DISORDER; NON INSULIN DEPENDENT DIABETES MELLITUS; PHENOTYPE; REVIEW;

EID: 0242524453     PISSN: 15278204     EISSN: None     Source Type: Book Series    
DOI: 10.1146/annurev.genom.4.070802.110436     Document Type: Review
Times cited : (276)

References (196)
  • 1
    • 0036578783 scopus 로고    scopus 로고
    • AG-PAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34
    • Agarwal AK, Arioglu E, De Almeida S, Akkoc N, Taylor SI, et al. 2002. AG-PAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34. Nat. Genet. 31:21-23
    • (2002) Nat. Genet. , vol.31 , pp. 21-23
    • Agarwal, A.K.1    Arioglu, E.2    De Almeida, S.3    Akkoc, N.4    Taylor, S.I.5
  • 3
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARgamma Pro12A1a polymorphism is associated with decreased risk of type 2 diabetes
    • Altshuler D, Hirschhorn JN, Klannemark M, Lindgren CM, Vohl MC, et al. 2000. The common PPARgamma Pro12A1a polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26:76-80
    • (2000) Nat. Genet. , vol.26 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3    Lindgren, C.M.4    Vohl, M.C.5
  • 4
    • 0037112047 scopus 로고    scopus 로고
    • Projection of an immunological self shadow within the thymus by the Aire protein
    • Anderson MS, Venanzi ES, Klein L, Chen Z, Berzins SP, et al. 2002. Projection of an immunological self shadow within the thymus by the Aire protein. Science 298:1395-401
    • (2002) Science , vol.298 , pp. 1395-1401
    • Anderson, M.S.1    Venanzi, E.S.2    Klein, L.3    Chen, Z.4    Berzins, S.P.5
  • 5
    • 0034892915 scopus 로고    scopus 로고
    • Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion
    • Ardlie K, Liu-Cordero SN, Eberle MA, Daly M, Barrett J, et al. 2001. Lower-than-expected linkage disequilibrium between tightly linked markers in humans suggests a role for gene conversion. Am. J. Hum. Genet. 69:582-89
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 582-589
    • Ardlie, K.1    Liu-Cordero, S.N.2    Eberle, M.A.3    Daly, M.4    Barrett, J.5
  • 6
    • 0036071296 scopus 로고    scopus 로고
    • Testing for population subdivision and association in four case-control studies
    • Ardlie KG, Lunetta KL, Seielstad M. 2002. Testing for population subdivision and association in four case-control studies. Am. J. Hum. Genet 71:1478-80
    • (2002) Am. J. Hum. Genet. , vol.71 , pp. 1478-1480
    • Ardlie, K.G.1    Lunetta, K.L.2    Seielstad, M.3
  • 7
    • 0033797241 scopus 로고    scopus 로고
    • A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance
    • Baier LJ, Permana PA, Yang X, Pratley RE, Hanson RL, et al. 2000. A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance. J. Clin. Invest. 106:R69-73
    • (2000) J. Clin. Invest. , vol.106
    • Baier, L.J.1    Permana, P.A.2    Yang, X.3    Pratley, R.E.4    Hanson, R.L.5
  • 9
    • 0028808309 scopus 로고
    • Neurodegeneration and diabetes: UK nationwide study of Wolfram (DID-MOAD) syndrome
    • Barrett TG, Bundey SE, Macleod AF. 1995. Neurodegeneration and diabetes: UK nationwide study of Wolfram (DID-MOAD) syndrome. Lancet 346:1458-63
    • (1995) Lancet , vol.346 , pp. 1458-1463
    • Barrett, T.G.1    Bundey, S.E.2    Macleod, A.F.3
  • 10
    • 0032757985 scopus 로고    scopus 로고
    • Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q
    • Bektas A, Suprenant ME, Wogan LT, Plengvidhya N, Rich SS, et al. 1999. Evidence of a novel type 2 diabetes locus 50 cM centromeric to NIDDM2 on chromosome 12q. Diabetes 48:2246-51
    • (1999) Diabetes , vol.48 , pp. 2246-2251
    • Bektas, A.1    Suprenant, M.E.2    Wogan, L.T.3    Plengvidhya, N.4    Rich, S.S.5
  • 11
    • 0021343570 scopus 로고
    • A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus
    • Bell GI, Horita S, Karam JH. 1984. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes 33:176-83
    • (1984) Diabetes , vol.33 , pp. 176-183
    • Bell, G.I.1    Horita, S.2    Karam, J.H.3
  • 13
    • 0020080870 scopus 로고
    • The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences
    • Bell GI, Selby MJ, Rutter WJ. 1982. The highly polymorphic region near the human insulin gene is composed of simple tandemly repeating sequences. Nature 295:31-35
    • (1982) Nature , vol.295 , pp. 31-35
    • Bell, G.I.1    Selby, M.J.2    Rutter, W.J.3
  • 14
    • 0026032055 scopus 로고
    • Gene for non-insulin dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q
    • Bell GI, Xiang K, Newman MV, Wu SH, Wright LJ, et al. 1991. Gene for non-insulin dependent diabetes mellitus (maturity-onset diabetes of the young subtype) is linked to DNA polymorphism on human chromosome 20q. Proc. Natl. Acad. Sci. USA 88:1884-88
    • (1991) Proc. Natl. Acad. Sci. USA , vol.88 , pp. 1884-1888
    • Bell, G.I.1    Xiang, K.2    Newman, M.V.3    Wu, S.H.4    Wright, L.J.5
  • 15
    • 0035167967 scopus 로고    scopus 로고
    • The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3
    • Bennett CL, Christie J, Ramsdell F, Brunkow ME, Ferguson PJ, et al. 2001. The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3. Nat. Genet. 27:20-21
    • (2001) Nat. Genet. , vol.27 , pp. 20-21
    • Bennett, C.L.1    Christie, J.2    Ramsdell, F.3    Brunkow, M.E.4    Ferguson, P.J.5
  • 16
    • 0030444451 scopus 로고    scopus 로고
    • Human type 1 diabetes and the insulin gene: Principles of mapping polygenes
    • Bennett ST, Todd JA. 1996. Human type 1 diabetes and the insulin gene: principles of mapping polygenes. Annu. Rev. Genet. 30:343-70
    • (1996) Annu. Rev. Genet. , vol.30 , pp. 343-370
    • Bennett, S.T.1    Todd, J.A.2
  • 17
    • 0026558807 scopus 로고
    • Identification of genetic markers flanking the locus for maturity-onset diabetes of the young on human chromosome 20
    • Bowden DW, Gravius TC, Akots G, Fajans SS. 1992. Identification of genetic markers flanking the locus for maturity-onset diabetes of the young on human chromosome 20. Diabetes 41:88-92
    • (1992) Diabetes , vol.41 , pp. 88-92
    • Bowden, D.W.1    Gravius, T.C.2    Akots, G.3    Fajans, S.S.4
  • 18
    • 0030897631 scopus 로고    scopus 로고
    • Linkage of genetic markers on human chromosomes 20 and 12 to NIDDM in Caucasian sib pairs with a history of diabetic nephropathy
    • Bowden DW, Sale M, Howard TD, Qadri A, Spray BJ, et al. 1997. Linkage of genetic markers on human chromosomes 20 and 12 to NIDDM in Caucasian sib pairs with a history of diabetic nephropathy. Diabetes 46:882-86
    • (1997) Diabetes , vol.46 , pp. 882-886
    • Bowden, D.W.1    Sale, M.2    Howard, T.D.3    Qadri, A.4    Spray, B.J.5
  • 19
    • 18244373999 scopus 로고    scopus 로고
    • A genomewide search for type 2 diabetes susceptibility genes in indigenous Australians
    • Busfield F, Duffy DL, Resting JB, Walker SM, Lovelock PK, et al. 2002. A genomewide search for type 2 diabetes susceptibility genes in indigenous Australians. Am. J. Hum. Genet. 70:349-57
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 349-357
    • Busfield, F.1    Duffy, D.L.2    Resting, J.B.3    Walker, S.M.4    Lovelock, P.K.5
  • 20
    • 13344270899 scopus 로고    scopus 로고
    • Friedreich's ataxia: Autosomal recessive disease caused by an intronic GAA triplet repeat expansion
    • Campuzano V, Montermini L, Molto MD, Pianese L, Cossee M, et al. 1996. Friedreich's ataxia: autosomal recessive disease caused by an intronic GAA triplet repeat expansion. Science 271:1423-27
    • (1996) Science , vol.271 , pp. 1423-1427
    • Campuzano, V.1    Montermini, L.2    Molto, M.D.3    Pianese, L.4    Cossee, M.5
  • 21
    • 0034059075 scopus 로고    scopus 로고
    • Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy
    • Cao H, Hegele RA. 2000. Nuclear lamin A/C R482Q mutation in canadian kindreds with Dunnigan-type familial partial lipodystrophy. Hum. Mol. Genet. 9:109-12
    • (2000) Hum. Mol. Genet. , vol.9 , pp. 109-112
    • Cao, H.1    Hegele, R.A.2
  • 22
    • 0035257236 scopus 로고    scopus 로고
    • Association study designs for complex diseases
    • Cardon LR, Bell JI. 2001. Association study designs for complex diseases. Nat. Rev. Genet. 2:91-99
    • (2001) Nat. Rev. Genet. , vol.2 , pp. 91-99
    • Cardon, L.R.1    Bell, J.I.2
  • 23
    • 0036312406 scopus 로고    scopus 로고
    • Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians
    • Cassell PG, Jackson AE, North BV, Evans JC, Syndercombe-Court D, et al. 2002. Haplotype combinations of calpain 10 gene polymorphisms associate with increased risk of impaired glucose tolerance and type 2 diabetes in South Indians. Diabetes 51:1622-28
    • (2002) Diabetes , vol.51 , pp. 1622-1628
    • Cassell, P.G.1    Jackson, A.E.2    North, B.V.3    Evans, J.C.4    Syndercombe-Court, D.5
  • 24
    • 0242712510 scopus 로고    scopus 로고
    • Atlanta: S. Dep. Health Hum. Serv., PHS
    • CDC. 1999. Diabetes Surveillance Report. Atlanta: S. Dep. Health Hum. Serv., PHS
    • (1999) Diabetes Surveillance Report
  • 25
    • 0029962261 scopus 로고    scopus 로고
    • Liver-enriched transcription factors and hepatocyte differentiation
    • Cereghini S. 1996. Liver-enriched transcription factors and hepatocyte differentiation. FASEB J. 10:267-82
    • (1996) FASEB J. , vol.10 , pp. 267-282
    • Cereghini, S.1
  • 26
    • 0026681851 scopus 로고
    • A genetic marker at the glucokinase gene locus for type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles
    • Chiu KC, Province MA, Dowse GK, Zimmet PZ, Wagner G, et al. 1992. A genetic marker at the glucokinase gene locus for type 2 (non-insulin-dependent) diabetes mellitus in Mauritian Creoles. Diabetologia 35:632-38
    • (1992) Diabetologia , vol.35 , pp. 632-638
    • Chiu, K.C.1    Province, M.A.2    Dowse, G.K.3    Zimmet, P.Z.4    Wagner, G.5
  • 28
    • 17344372511 scopus 로고    scopus 로고
    • A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus
    • Concannon P, Gogolin-Ewens KJ, Hinds DA, Wapelhorst B, Morrison VA, et al. 1998. A second-generation screen of the human genome for susceptibility to insulin-dependent diabetes mellitus. Nat. Genet. 19:292-96
    • (1998) Nat. Genet. , vol.19 , pp. 292-296
    • Concannon, P.1    Gogolin-Ewens, K.J.2    Hinds, D.A.3    Wapelhorst, B.4    Morrison, V.A.5
  • 29
    • 0346599403 scopus 로고    scopus 로고
    • An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains
    • Consortium F-GA. 1997. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet. 17:399-403
    • (1997) Nat. Genet. , vol.17 , pp. 399-403
    • Consortium, F.-G.A.1
  • 30
    • 0028843482 scopus 로고
    • Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33
    • Copeman JB, Cucca F, Hearne CM, Cornall RJ, Reed PW, et al. 1995. Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31-q33. Nat. Genet. 9:80-85
    • (1995) Nat. Genet. , vol.9 , pp. 80-85
    • Copeman, J.B.1    Cucca, F.2    Hearne, C.M.3    Cornall, R.J.4    Reed, P.W.5
  • 31
    • 0032928542 scopus 로고    scopus 로고
    • Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans
    • Cox NJ, Frigge M, Nicolae DL, Concannon P, Hanis CL, et al. 1999. Loci on chromosomes 2 (NIDDM1) and 15 interact to increase susceptibility to diabetes in Mexican Americans. Nat. Genet. 21:213-15
    • (1999) Nat. Genet. , vol.21 , pp. 213-215
    • Cox, N.J.1    Frigge, M.2    Nicolae, D.L.3    Concannon, P.4    Hanis, C.L.5
  • 32
    • 0034821661 scopus 로고    scopus 로고
    • Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families
    • Cox NJ, Wapelhorst B, Morrison VA, Johnson L, Pinchuk L, et al. 2001. Seven regions of the genome show evidence of linkage to type 1 diabetes in a consensus analysis of 767 multiplex families. Am. J. Hum. Genet. 69:820-30
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 820-830
    • Cox, N.J.1    Wapelhorst, B.2    Morrison, V.A.3    Johnson, L.4    Pinchuk, L.5
  • 33
    • 72449200312 scopus 로고
    • Letter: HL-A antigens and diabetes mellitus
    • Cudworth AG, Woodrow JC. 1974. Letter: HL-A antigens and diabetes mellitus. Lancet 2:1153
    • (1974) Lancet , vol.2 , pp. 1153
    • Cudworth, A.G.1    Woodrow, J.C.2
  • 34
    • 18544380387 scopus 로고    scopus 로고
    • Parameters for reliable results in genetic association studies in common disease
    • Dahlman I, Eaves IA, Kosoy R, Morrison VA, Heward J, et al. 2002. Parameters for reliable results in genetic association studies in common disease. Nat. Genet. 30:149-50
    • (2002) Nat. Genet. , vol.30 , pp. 149-150
    • Dahlman, I.1    Eaves, I.A.2    Kosoy, R.3    Morrison, V.A.4    Heward, J.5
  • 35
    • 0036124605 scopus 로고    scopus 로고
    • Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese
    • Daimon M, Oizumi T, Saitoh T, Kameda W, Yamaguchi H, et al. 2002. Calpain 10 gene polymorphisms are related, not to type 2 diabetes, but to increased serum cholesterol in Japanese. Diabetes Res. Clin. Pract. 56:147-52
    • (2002) Diabetes Res. Clin. Pract. , vol.56 , pp. 147-152
    • Daimon, M.1    Oizumi, T.2    Saitoh, T.3    Kameda, W.4    Yamaguchi, H.5
  • 37
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12A1a substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • Deeb SS, Fajas L, Nemoto M, Pihlajamaki J, Mykkanen L, et al. 1998. A Pro12A1a substitution in PPARgamma2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat. Genet. 20:284-87
    • (1998) Nat. Genet. , vol.20 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3    Pihlajamaki, J.4    Mykkanen, L.5
  • 38
    • 16944367291 scopus 로고    scopus 로고
    • Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6
    • Delepine M, Pociot F, Habita C, Hashimoto L, Froguel P, et al. 1997. Evidence of a non-MHC susceptibility locus in type I diabetes linked to HLA on chromosome 6. Am. J. Hum. Genet. 60:174-87
    • (1997) Am. J. Hum. Genet. , vol.60 , pp. 174-187
    • Delepine, M.1    Pociot, F.2    Habita, C.3    Hashimoto, L.4    Froguel, P.5
  • 39
    • 0031014716 scopus 로고    scopus 로고
    • CTLA4 Alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus
    • Donner H, Rau H, Walfish PG, Braun J, Siegmund T, et al. 1997. CTLA4 Alanine-17 confers genetic susceptibility to Graves' disease and to type 1 diabetes mellitus. J. Clin. Endocrinol. Metab. 82:143-46
    • (1997) J. Clin. Endocrinol. Metab. , vol.82 , pp. 143-146
    • Donner, H.1    Rau, H.2    Walfish, P.G.3    Braun, J.4    Siegmund, T.5
  • 40
    • 0034745184 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: Association with type 2 diabetes and trait differences
    • Douglas JA, Erdos MR, Watanabe RM, Braun A, Johnston CL, et al. 2001. The peroxisome proliferator-activated receptor-gamma2 Pro12A1a variant: association with type 2 diabetes and trait differences. Diabetes 50:886-90
    • (2001) Diabetes , vol.50 , pp. 886-890
    • Douglas, J.A.1    Erdos, M.R.2    Watanabe, R.M.3    Braun, A.4    Johnston, C.L.5
  • 41
    • 0033365057 scopus 로고    scopus 로고
    • Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans
    • Duggirala R, Blangero J, Almasy L, Dyer TD, Williams KL, et al. 1999. Linkage of type 2 diabetes mellitus and of age at onset to a genetic location on chromosome 10q in Mexican Americans. Am. J. Hum. Genet. 64:1127-40
    • (1999) Am. J. Hum. Genet. , vol.64 , pp. 1127-1140
    • Duggirala, R.1    Blangero, J.2    Almasy, L.3    Dyer, T.D.4    Williams, K.L.5
  • 42
    • 0034100050 scopus 로고    scopus 로고
    • Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses
    • Eckenrode S, Marron MP, Nicholls R, Yang MCK, Yang JJ, et al. 2000. Fine-mapping of the type 1 diabetes locus (IDDM4) on chromosome 11q and evaluation of two candidate genes (FADD and GALN) by affected sibpair and linkage-disequilibrium analyses. Hum. Genet. 106:14-18
    • (2000) Hum. Genet. , vol.106 , pp. 14-18
    • Eckenrode, S.1    Marron, M.P.2    Nicholls, R.3    Yang, M.C.K.4    Yang, J.J.5
  • 43
    • 0033942075 scopus 로고    scopus 로고
    • Genomewide search for type 2 diabetes susceptibility genes in four American populations
    • Ehm MG, Karnoub MC, Sakul H, Gottschalk K, Holt DC, et al. 2000. Genomewide search for type 2 diabetes susceptibility genes in four American populations. Am. J. Hum. Genet. 66:1871-81
    • (2000) Am. J. Hum. Genet. , vol.66 , pp. 1871-1881
    • Ehm, M.G.1    Karnoub, M.C.2    Sakul, H.3    Gottschalk, K.4    Holt, D.C.5
  • 44
    • 0035676129 scopus 로고    scopus 로고
    • Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus
    • Ek J, Andersen G, Urhammer SA, Gæde PH, Drivsholm T, et al. 2001. Mutation analysis of peroxisome proliferator-activated receptor-γ coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia 44: 2220-26
    • (2001) Diabetologia , vol.44 , pp. 2220-2226
    • Ek, J.1    Andersen, G.2    Urhammer, S.A.3    Gæde, P.H.4    Drivsholm, T.5
  • 46
    • 0026564961 scopus 로고
    • Linkage analysis of GLUT1 (HepG2) and GLUT2 (liver/islet) genes in familial NIDDM
    • Elbein SC, Hoffman MD, Matsutani A, Permutt MA. 1992. Linkage analysis of GLUT1 (HepG2) and GLUT2 (liver/islet) genes in familial NIDDM. Diabetes 41:1660-67
    • (1992) Diabetes , vol.41 , pp. 1660-1667
    • Elbein, S.C.1    Hoffman, M.D.2    Matsutani, A.3    Permutt, M.A.4
  • 47
    • 0032910599 scopus 로고    scopus 로고
    • A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians
    • Elbein SC, Hoffman MD, Teng K, Leppert MF, Hasstedt SJ. 1999. A genome-wide search for type 2 diabetes susceptibility genes in Utah Caucasians. Diabetes 48:1175-82
    • (1999) Diabetes , vol.48 , pp. 1175-1182
    • Elbein, S.C.1    Hoffman, M.D.2    Teng, K.3    Leppert, M.F.4    Hasstedt, S.J.5
  • 48
    • 0034894047 scopus 로고    scopus 로고
    • Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom
    • Evans JC, Frayling TM, Cassell PG, Saker PJ, Hitman GA, et al. 2001. Studies of association between the gene for calpain-10 and type 2 diabetes mellitus in the United Kingdom. Am. J. Hum. Genet. 69:544-52
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 544-552
    • Evans, J.C.1    Frayling, T.M.2    Cassell, P.G.3    Saker, P.J.4    Hitman, G.A.5
  • 49
    • 0035960122 scopus 로고    scopus 로고
    • Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young
    • Fajans SS, Bell GI, Polonsky KS. 2001. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N. Engl. J. Med. 345:971-80
    • (2001) N. Engl. J. Med. , vol.345 , pp. 971-980
    • Fajans, S.S.1    Bell, G.I.2    Polonsky, K.S.3
  • 50
    • 0002938144 scopus 로고
    • Tolbutamide-induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus
    • Fajans SS, Conn JW. 1960. Tolbutamide-induced improvement in carbohydrate tolerance of young people with mild diabetes mellitus. Diabetes 9:83
    • (1960) Diabetes , vol.9 , pp. 83
    • Fajans, S.S.1    Conn, J.W.2
  • 51
    • 9344224529 scopus 로고    scopus 로고
    • A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis
    • Feder J, Gnirke A, Thomas W, Tsuchihashi Z, Ruddy D, et al. 1996. A novel MHC class I-like gene is mutated in patients with hereditary haemochromatosis. Nat. Genet. 13:399-408
    • (1996) Nat. Genet. , vol.13 , pp. 399-408
    • Feder, J.1    Gnirke, A.2    Thomas, W.3    Tsuchihashi, Z.4    Ruddy, D.5
  • 53
    • 0036164731 scopus 로고    scopus 로고
    • Genetic linkage and association studies of type I diabetes: Challenges and rewards
    • Field LL. 2002. Genetic linkage and association studies of type I diabetes: challenges and rewards. Diabetologia 45:21-35
    • (2002) Diabetologia , vol.45 , pp. 21-35
    • Field, L.L.1
  • 54
    • 0027966026 scopus 로고
    • A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus
    • Field LL, Tobias R, Magnus T. 1994. A locus on chromosome 15q26 (IDDM3) produces susceptibility to insulin-dependent diabetes mellitus. Nat. Genet. 8:189-94
    • (1994) Nat. Genet. , vol.8 , pp. 189-194
    • Field, L.L.1    Tobias, R.2    Magnus, T.3
  • 55
    • 0029920402 scopus 로고    scopus 로고
    • Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31
    • Field LL, Tobias R, Thomson G, Plon S. 1996. Susceptibility to insulin-dependent diabetes mellitus maps to a locus (IDDM11) on human chromosome 14q24.3-q31. Genomics 33:1-8
    • (1996) Genomics , vol.33 , pp. 1-8
    • Field, L.L.1    Tobias, R.2    Thomson, G.3    Plon, S.4
  • 56
    • 0036316935 scopus 로고    scopus 로고
    • Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort
    • Fingerlin TE, Erdos MR, Watanabe RM, Wiles KR, Stringham HM, et al. 2002. Variation in three single nucleotide polymorphisms in the calpain-10 gene not associated with type 2 diabetes in a large Finnish cohort. Diabetes 51:1644-48
    • (2002) Diabetes , vol.51 , pp. 1644-1648
    • Fingerlin, T.E.1    Erdos, M.R.2    Watanabe, R.M.3    Wiles, K.R.4    Stringham, H.M.5
  • 57
    • 0026608764 scopus 로고
    • Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus
    • Froguel P, Vaxillaire M, Sun F, Velho G, Zouali H, et al. 1992. Close linkage of glucokinase locus on chromosome 7p to early-onset non-insulin-dependent diabetes mellitus. Nature 356:162-64
    • (1992) Nature , vol.356 , pp. 162-164
    • Froguel, P.1    Vaxillaire, M.2    Sun, F.3    Velho, G.4    Zouali, H.5
  • 58
    • 0027472126 scopus 로고
    • Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus
    • Froguel P, Zouali H, Vionnet N, Velho G, Vaxillaire M, et al. 1993. Familial hyperglycemia due to mutations in glucokinase. Definition of a subtype of diabetes mellitus. N. Engl. J. Med. 328:697-702
    • (1993) N. Engl. J. Med. , vol.328 , pp. 697-702
    • Froguel, P.1    Zouali, H.2    Vionnet, N.3    Velho, G.4    Vaxillaire, M.5
  • 59
    • 0036235796 scopus 로고    scopus 로고
    • Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus
    • Fullerton SM, Bartoszewicz A, Ybazeta G, Horikawa Y, Bell GI, et al. 2002. Geographic and haplotype structure of candidate type 2 diabetes susceptibility variants at the calpain-10 locus. Am. J. Hum. Genet. 70:1096-106
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 1096-1106
    • Fullerton, S.M.1    Bartoszewicz, A.2    Ybazeta, G.3    Horikawa, Y.4    Bell, G.I.5
  • 61
  • 62
    • 0033764737 scopus 로고    scopus 로고
    • The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes
    • Ghosh S, Watanabe RM, Valle TT, Hauser ER, Magnuson VL, et al. 2000. The Finland-United States investigation of non-insulin-dependent diabetes mellitus genetics (FUSION) study. I. An autosomal genome scan for genes that predispose to type 2 diabetes. Am. J. Hum. Genet. 67:1174-85
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 1174-1185
    • Ghosh, S.1    Watanabe, R.M.2    Valle, T.T.3    Hauser, E.R.4    Magnuson, V.L.5
  • 63
    • 0035043009 scopus 로고    scopus 로고
    • Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53)
    • Gloyn AL, Hashim Y, Ashcroft SJ, Ashfield R, Wiltshire S, Turner RC. 2001. Association studies of variants in promoter and coding regions of beta-cell ATP-sensitive K-channel genes SUR1 and Kir6.2 with Type 2 diabetes mellitus (UKPDS 53). Diabetes Med. 18:206-12
    • (2001) Diabetes Med. , vol.18 , pp. 206-212
    • Gloyn, A.L.1    Hashim, Y.2    Ashcroft, S.J.3    Ashfield, R.4    Wiltshire, S.5    Turner, R.C.6
  • 64
    • 0037317981 scopus 로고    scopus 로고
    • Large-scale association studies of variants in genes encoding the pancreatic {beta}-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes
    • Gloyn AL, Weedon MN, Owen KR, Turner MJ, Knight BA, et al. 2003. Large-scale association studies of variants in genes encoding the pancreatic {beta}-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52:568-72
    • (2003) Diabetes , vol.52 , pp. 568-572
    • Gloyn, A.L.1    Weedon, M.N.2    Owen, K.R.3    Turner, M.J.4    Knight, B.A.5
  • 65
    • 0029119111 scopus 로고
    • Mutation of the glucagon receptor gene and diabetes mellitus in the UK: Association or founder effect?
    • Gough SC, Saker PJ, Pritchard LE, Merriman TR, Merriman ME, et al. 1995. Mutation of the glucagon receptor gene and diabetes mellitus in the UK: association or founder effect? Hum. Mol. Genet. 4:1609-12
    • (1995) Hum. Mol. Genet. , vol.4 , pp. 1609-1612
    • Gough, S.C.1    Saker, P.J.2    Pritchard, L.E.3    Merriman, T.R.4    Merriman, M.E.5
  • 66
    • 0003408870 scopus 로고
    • NIH Publication No. 95-1468. Bethesda, MD: Natl. Inst. Diabetes Dig. Kidney Dis.
    • National Diabetes Data Group. 1995. Diabetes in America. NIH Publication No. 95-1468. Bethesda, MD: Natl. Inst. Diabetes Dig. Kidney Dis.
    • (1995) Diabetes in America
  • 67
    • 0028848010 scopus 로고
    • A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus
    • Hager J, Hansen L, Vaisse C, Vionnet N, Philippi A, et al. 1995. A missense mutation in the glucagon receptor gene is associated with non-insulin-dependent diabetes mellitus. Nat. Genet. 9:299-304
    • (1995) Nat. Genet. , vol.9 , pp. 299-304
    • Hager, J.1    Hansen, L.2    Vaisse, C.3    Vionnet, N.4    Philippi, A.5
  • 68
    • 0021052991 scopus 로고
    • Studies on mutant human insulin genes: Identification and sequence analysis of a gene encoding (ser-B24) insulin
    • Haneda M, Chan SJ, Kwok SCM, Rubenstein AH, Steiner DF. 1983. Studies on mutant human insulin genes: identification and sequence analysis of a gene encoding (ser-B24) insulin. Proc. Natl. Acad. Sci. USA 80:6366-70
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 6366-6370
    • Haneda, M.1    Chan, S.J.2    Kwok, S.C.M.3    Rubenstein, A.H.4    Steiner, D.F.5
  • 69
    • 0031773333 scopus 로고    scopus 로고
    • Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): A meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians
    • Hani EH, Boutin P, Durand E, Inoue H, Permutt MA, et al. 1998. Missense mutations in the pancreatic islet beta cell inwardly rectifying K+ channel gene (KIR6.2/BIR): a meta-analysis suggests a role in the polygenic basis of Type II diabetes mellitus in Caucasians. Diabetologia 41:1511-15
    • (1998) Diabetologia , vol.41 , pp. 1511-1515
    • Hani, E.H.1    Boutin, P.2    Durand, E.3    Inoue, H.4    Permutt, M.A.5
  • 70
    • 14444273653 scopus 로고    scopus 로고
    • Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians
    • Hani EH, Clement K, Velho G, Vionnet N, Hager J, et al. 1997. Genetic studies of the sulfonylurea receptor gene locus in NIDDM and in morbid obesity among French Caucasians. Diabetes 46:688-94
    • (1997) Diabetes , vol.46 , pp. 688-694
    • Hani, E.H.1    Clement, K.2    Velho, G.3    Vionnet, N.4    Hager, J.5
  • 71
    • 9044243415 scopus 로고    scopus 로고
    • A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2
    • Hanis CL, Boerwinkle E, Chakraborty R, Ellsworth DL, Concannon P, et al. 1996. A genome-wide search for human non-insulin-dependent (type 2) diabetes genes reveals a major susceptibility locus on chromosome 2 [see comments]. Nat. Genet. 13:161-66
    • (1996) Nat. Genet. , vol.13 , pp. 161-166
    • Hanis, C.L.1    Boerwinkle, E.2    Chakraborty, R.3    Ellsworth, D.L.4    Concannon, P.5
  • 72
    • 0031051534 scopus 로고    scopus 로고
    • Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose-and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM
    • Hansen L, Echwald SM, Hansen T, Urhammer SA, Clausen JO, Pedersen O. 1997. Amino acid polymorphisms in the ATP-regulatable inward rectifier Kir6.2 and their relationships to glucose-and tolbutamide-induced insulin secretion, the insulin sensitivity index, and NIDDM. Diabetes 46:508-12
    • (1997) Diabetes , vol.46 , pp. 508-512
    • Hansen, L.1    Echwald, S.M.2    Hansen, T.3    Urhammer, S.A.4    Clausen, J.O.5    Pedersen, O.6
  • 73
    • 0031925068 scopus 로고    scopus 로고
    • Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene
    • Hansen T, Echwald SM, Hansen L, Moller AM, Almind K, et al. 1998. Decreased tolbutamide-stimulated insulin secretion in healthy subjects with sequence variants in the high-affinity sulfonylurea receptor gene. Diabetes 47: 598-605
    • (1998) Diabetes , vol.47 , pp. 598-605
    • Hansen, T.1    Echwald, S.M.2    Hansen, L.3    Moller, A.M.4    Almind, K.5
  • 74
    • 0032231322 scopus 로고    scopus 로고
    • An autosomal genomic scan for loci linked to type II diabetes mellitus and bodymass index in Pima Indians
    • Hanson RL, Ehm MG, Pettitt DJ, Prochazka M, Thompson DB, et al. 1998. An autosomal genomic scan for loci linked to type II diabetes mellitus and bodymass index in Pima Indians. Am. J. Hum. Genet. 63:1130-38
    • (1998) Am. J. Hum. Genet. , vol.63 , pp. 1130-1138
    • Hanson, R.L.1    Ehm, M.G.2    Pettitt, D.J.3    Prochazka, M.4    Thompson, D.B.5
  • 75
    • 0034728762 scopus 로고    scopus 로고
    • The Pro12A1a polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes
    • Hara K, Okada T, Tobe K, Yasuda K, Mori Y, et al. 2000. The Pro12A1a polymorphism in PPAR gamma2 may confer resistance to type 2 diabetes. Biochem. Biophys. Res. Commun. 271:212-16
    • (2000) Biochem. Biophys. Res. Commun. , vol.271 , pp. 212-216
    • Hara, K.1    Okada, T.2    Tobe, K.3    Yasuda, K.4    Mori, Y.5
  • 76
    • 0031897103 scopus 로고    scopus 로고
    • Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults
    • Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, et al. 1998. Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults. Diabetes Care 21:518-24
    • (1998) Diabetes Care , vol.21 , pp. 518-524
    • Harris, M.I.1    Flegal, K.M.2    Cowie, C.C.3    Eberhardt, M.S.4    Goldstein, D.E.5
  • 77
    • 0033007968 scopus 로고    scopus 로고
    • Variants in the sulphonylurea receptor gene: Association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians
    • Hart LM, de Knijff P, Dekker JM, Stolk RP, Nijpels G, et al. 1999. Variants in the sulphonylurea receptor gene: association of the exon 16-3t variant with Type II diabetes mellitus in Dutch Caucasians. Diabetologia 42:617-20
    • (1999) Diabetologia , vol.42 , pp. 617-620
    • Hart, L.M.1    De Knijff, P.2    Dekker, J.M.3    Stolk, R.P.4    Nijpels, G.5
  • 78
    • 0028070552 scopus 로고
    • Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q
    • Hashimoto L, Habita C, Beressi JP, Delepine M, Besse C, et al. 1994. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature 371:161-64
    • (1994) Nature , vol.371 , pp. 161-164
    • Hashimoto, L.1    Habita, C.2    Beressi, J.P.3    Delepine, M.4    Besse, C.5
  • 79
    • 0035093082 scopus 로고    scopus 로고
    • Effect of the peroxisome proliferator-activated receptor-{gamma}2 Pro12A1a variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds
    • Hasstedt SJ, Ren Q-F, Teng K, Elbein SC. 2001. Effect of the peroxisome proliferator-activated receptor-{gamma}2 Pro12A1a variant on obesity, glucose homeostasis, and blood pressure in members of familial type 2 diabetic kindreds. J. Clin. Endocrinol. Metab. 86:536-41
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 536-541
    • Hasstedt, S.J.1    Ren, Q.-F.2    Teng, K.3    Elbein, S.C.4
  • 80
    • 0033857978 scopus 로고    scopus 로고
    • Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans
    • Hebinck J, Hardt C, Schols L, Vorgerd M, Briedigkeit L, et al. 2000. Heterozygous expansion of the GAA tract of the X25/frataxin gene is associated with insulin resistance in humans. Diabetes 49:1604-47
    • (2000) Diabetes , vol.49 , pp. 1604-1647
    • Hebinck, J.1    Hardt, C.2    Schols, L.3    Vorgerd, M.4    Briedigkeit, L.5
  • 82
    • 0035432297 scopus 로고    scopus 로고
    • Absence of association of type 2 diabetes with CAPN10 and PC-1 polymorphisms in Oji-Cree
    • Hegele RA, Harris SB, Zinman B, Hanley AJG, Cao H. 2001. Absence of association of type 2 diabetes with CAPN10 and PC-1 polymorphisms in Oji-Cree. Diabetes Care 24:1498-99
    • (2001) Diabetes Care , vol.24 , pp. 1498-1499
    • Hegele, R.A.1    Harris, S.B.2    Zinman, B.3    Hanley, A.J.G.4    Cao, H.5
  • 83
    • 0038049458 scopus 로고    scopus 로고
    • Genetic epidemiology of type 1 diabetes
    • In press
    • Hirschhorn JN. 2003. Genetic epidemiology of type 1 diabetes. Pediatr. Diabetes. In press
    • (2003) Pediatr. Diabetes
    • Hirschhorn, J.N.1
  • 84
    • 0036775432 scopus 로고    scopus 로고
    • Once and again-issues surrounding replication in genetic association studies
    • Hirschhorn JN, Altshuler D. 2002. Once and again-issues surrounding replication in genetic association studies. J. Clin. Endocrinol. Metab. 87:4438-41
    • (2002) J. Clin. Endocrinol. Metab. , vol.87 , pp. 4438-4441
    • Hirschhorn, J.N.1    Altshuler, D.2
  • 86
    • 0021847489 scopus 로고
    • Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11
    • Hitman GA, Tarn AC, Winter RM, Drummond V, Williams LG, et al. 1985. Type 1 (insulin-dependent) diabetes and a highly variable locus close to the insulin gene on chromosome 11. Diabetologia 28:218-22
    • (1985) Diabetologia , vol.28 , pp. 218-222
    • Hitman, G.A.1    Tarn, A.C.2    Winter, R.M.3    Drummond, V.4    Williams, L.G.5
  • 88
    • 0031453186 scopus 로고    scopus 로고
    • Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY
    • Horikawa Y, Iwasaki N, Hara M, Furuta H, Hinokio Y, et al. 1997. Mutation in hepatocyte nuclear factor-1 beta gene (TCF2) associated with MODY. Nat. Genet. 17:384-85
    • (1997) Nat. Genet. , vol.17 , pp. 384-385
    • Horikawa, Y.1    Iwasaki, N.2    Hara, M.3    Furuta, H.4    Hinokio, Y.5
  • 89
    • 0033772073 scopus 로고    scopus 로고
    • Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus
    • Horikawa Y, Oda N, Cox NJ, Li X, Orho-Melander M, et al. 2000. Genetic variation in the gene encoding calpain-10 is associated with type 2 diabetes mellitus. Nat. Genet. 26:163-75
    • (2000) Nat. Genet. , vol.26 , pp. 163-175
    • Horikawa, Y.1    Oda, N.2    Cox, N.J.3    Li, X.4    Orho-Melander, M.5
  • 90
    • 0031942841 scopus 로고    scopus 로고
    • Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes
    • Imperatore G, Hanson RL, Pettitt DJ, Kobes S, Bennett PH, Knowler WC. 1998. Sib-pair linkage analysis for susceptibility genes for microvascular complications among Pima Indians with type 2 diabetes. Diabetes 47:821-30
    • (1998) Diabetes , vol.47 , pp. 821-830
    • Imperatore, G.1    Hanson, R.L.2    Pettitt, D.J.3    Kobes, S.4    Bennett, P.H.5    Knowler, W.C.6
  • 91
    • 15144338831 scopus 로고    scopus 로고
    • Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: Identification and lack of role in Caucasian patients with NIDDM
    • Inoue H, Ferrer J, Warren-Perry M, Zhang Y, Millns H, et al. 1997. Sequence variants in the pancreatic islet beta-cell inwardly rectifying K+ channel Kir6.2 (Bir) gene: identification and lack of role in Caucasian patients with NIDDM. Diabetes 46:502-7
    • (1997) Diabetes , vol.46 , pp. 502-507
    • Inoue, H.1    Ferrer, J.2    Warren-Perry, M.3    Zhang, Y.4    Millns, H.5
  • 92
    • 15844366738 scopus 로고    scopus 로고
    • Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians
    • Inoue H, Ferrer J, Welling CM, Elbein SC, Hoffman M, et al. 1996. Sequence variants in the sulfonylurea receptor (SUR) gene are associated with NIDDM in Caucasians. Diabetes 45:825-31
    • (1996) Diabetes , vol.45 , pp. 825-831
    • Inoue, H.1    Ferrer, J.2    Welling, C.M.3    Elbein, S.C.4    Hoffman, M.5
  • 93
    • 17344362695 scopus 로고    scopus 로고
    • A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)
    • Inoue H, Tanizawa Y, Wasson J, Behn P, Kalidas K, et al. 1998. A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome). Nat. Genet. 20:143-48
    • (1998) Nat. Genet. , vol.20 , pp. 143-148
    • Inoue, H.1    Tanizawa, Y.2    Wasson, J.3    Behn, P.4    Kalidas, K.5
  • 94
    • 0030949271 scopus 로고    scopus 로고
    • Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene
    • Jackson RS, Creemers JWM, Ohagi S, Raffin-Sanson M-L, Sanders L, et al. 1997. Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene. Nat. Genet. 16:303-6
    • (1997) Nat. Genet. , vol.16 , pp. 303-306
    • Jackson, R.S.1    Creemers, J.W.M.2    Ohagi, S.3    Raffin-Sanson, M.-L.4    Sanders, L.5
  • 97
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H. 1994. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 371:606-9
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 98
    • 0023896248 scopus 로고
    • Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance
    • Kadowaki T, Bevins CL, Cama A, Ojamaa K, Marcus-Samuels B, et al. 1988. Two mutant alleles of the insulin receptor gene in a patient with extreme insulin resistance. Science 240:787-90
    • (1988) Science , vol.240 , pp. 787-790
    • Kadowaki, T.1    Bevins, C.L.2    Cama, A.3    Ojamaa, K.4    Marcus-Samuels, B.5
  • 100
    • 0029128706 scopus 로고
    • Concordance rates of insulin dependent diabetes mellitus: A population based study of young Danish twins
    • Kyvik KO, Green A, Beck-Nielsen H. 1995. Concordance rates of insulin dependent diabetes mellitus: a population based study of young Danish twins. Br. Med. J. 311:913-17
    • (1995) Br. Med. J. , vol.311 , pp. 913-917
    • Kyvik, K.O.1    Green, A.2    Beck-Nielsen, H.3
  • 101
    • 0028877463 scopus 로고
    • Genetic dissection of complex traits: Guidelines for interpreting and reporting linkage results
    • Lander E, Kruglyak L. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat. Genet. 11:241-47
    • (1995) Nat. Genet. , vol.11 , pp. 241-247
    • Lander, E.1    Kruglyak, L.2
  • 102
    • 0033787614 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma 2 Pro12A1a gene variant is strongly associated with larger body mass in the Taiwanese
    • Lei HH, Chen MH, Yang WS, Chiu MC, Chen MC, et al. 2000. Peroxisome proliferator-activated receptor gamma 2 Pro12A1a gene variant is strongly associated with larger body mass in the Taiwanese. Metabolism 49:1267-70
    • (2000) Metabolism , vol.49 , pp. 1267-1270
    • Lei, H.H.1    Chen, M.H.2    Yang, W.S.3    Chiu, M.C.4    Chen, M.C.5
  • 103
    • 7144256518 scopus 로고    scopus 로고
    • Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery
    • Lepretre F, Vionnet N, Budhan S, Dina C, Powell KL, et al. 1998. Genetic studies of polymorphisms in ten non-insulin-dependent diabetes mellitus candidate genes in Tamil Indians from Pondichery. Diabetes Metab. 24:244-50
    • (1998) Diabetes Metab. , vol.24 , pp. 244-250
    • Lepretre, F.1    Vionnet, N.2    Budhan, S.3    Dina, C.4    Powell, K.L.5
  • 104
    • 0023759159 scopus 로고
    • Association of genetic variant of the glucose transporter with non-insulin-dependent diabetes mellitus
    • Li SR, Baroni MG, Oelbaum RS, Stock J, Galton DJ. 1988. Association of genetic variant of the glucose transporter with non-insulin-dependent diabetes mellitus. Lancet 2:368-70
    • (1988) Lancet , vol.2 , pp. 368-370
    • Li, S.R.1    Baroni, M.G.2    Oelbaum, R.S.3    Stock, J.4    Galton, D.J.5
  • 105
    • 18244399128 scopus 로고    scopus 로고
    • Genomewide search for type 2 diabetes susceptibility loci in Finnish families: The Botnia study
    • Lindgren CM, Mahtani MM, Widén E, McCarthy MI, Daly MJ, et al. 2002. Genomewide search for type 2 diabetes susceptibility loci in Finnish families: The Botnia study. Am. J. Hum. Genet. 70:509-16
    • (2002) Am. J. Hum. Genet. , vol.70 , pp. 509-516
    • Lindgren, C.M.1    Mahtani, M.M.2    Widén, E.3    McCarthy, M.I.4    Daly, M.J.5
  • 106
    • 0037312921 scopus 로고    scopus 로고
    • Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease
    • Lohmueller K, Pearce CL, Pike M, Lander ES, Hirschhorn JN. 2003. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33:177-82
    • (2003) Nat. Genet. , vol.33 , pp. 177-182
    • Lohmueller, K.1    Pearce, C.L.2    Pike, M.3    Lander, E.S.4    Hirschhorn, J.N.5
  • 107
    • 0037064057 scopus 로고    scopus 로고
    • The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyl-transferase I gene expression by cAMP in combination with HNF4alpha and cAMP-response element-binding protein (CREB)
    • Louet J-F, Hayhurst G, Gonzalez FJ, Girard J, Decaux J-F. 2002. The coactivator PGC-1 is involved in the regulation of the liver carnitine palmitoyl-transferase I gene expression by cAMP in combination with HNF4alpha and cAMP-response element-binding protein (CREB). J. Biol. Chem. 277:37991-8000
    • (2002) J. Biol. Chem. , vol.277 , pp. 37991-38000
    • Louet, J.-F.1    Hayhurst, G.2    Gonzalez, F.J.3    Girard, J.4    Decaux, J.-F.5
  • 108
    • 9244244764 scopus 로고    scopus 로고
    • Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8
    • Luo D-F, Buzzetti R, Rotter JI, Maclaren NK, Raffel LJ, et al. 1996. Confirmation of three susceptibility genes to insulin-dependent diabetes mellitus: IDDM4, IDDM5 and IDDM8. Hum. Mol. Genet. 5:693-98
    • (1996) Hum. Mol. Genet. , vol.5 , pp. 693-698
    • Luo, D.-F.1    Buzzetti, R.2    Rotter, J.I.3    Maclaren, N.K.4    Raffel, L.J.5
  • 109
    • 0035058351 scopus 로고    scopus 로고
    • A genome-wide search for type II diabetes susceptibility genes in Chinese Hans
    • Luo TH, Zhao Y, Li G, Yuan WT, Zhao JJ, et al. 2001. A genome-wide search for type II diabetes susceptibility genes in Chinese Hans. Diabetologia 44:501-6
    • (2001) Diabetologia , vol.44 , pp. 501-506
    • Luo, T.H.1    Zhao, Y.2    Li, G.3    Yuan, W.T.4    Zhao, J.J.5
  • 110
    • 0036097653 scopus 로고    scopus 로고
    • Variation in the calpain-10 gene affects blood glucose levels in the British population
    • Lynn S, Evans JC, White C, Frayling TM, Hattersley AT, et al. 2002. Variation in the calpain-10 gene affects blood glucose levels in the British population. Diabetes 51:247-50
    • (2002) Diabetes , vol.51 , pp. 247-250
    • Lynn, S.1    Evans, J.C.2    White, C.3    Frayling, T.M.4    Hattersley, A.T.5
  • 111
    • 0034941121 scopus 로고    scopus 로고
    • Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13
    • Magre J, Delepine M, Khallouf E, Gedde-Dahl TJ, Van Maldergem L, et al. 2001. Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13. Nat. Genet. 28:365-70
    • (2001) Nat. Genet. , vol.28 , pp. 365-370
    • Magre, J.1    Delepine, M.2    Khallouf, E.3    Gedde-Dahl, T.J.4    Van Maldergem, L.5
  • 112
    • 16044374799 scopus 로고    scopus 로고
    • Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families
    • Mahtani MM, Widen E, Lehto M, Thomas J, McCarthy M, et al. 1996. Mapping of a gene for type 2 diabetes associated with an insulin secretion defect by a genome scan in Finnish families. Nat. Genet. 14:90-94
    • (1996) Nat. Genet. , vol.14 , pp. 90-94
    • Mahtani, M.M.1    Widen, E.2    Lehto, M.3    Thomas, J.4    McCarthy, M.5
  • 113
    • 0032700272 scopus 로고    scopus 로고
    • Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus
    • Malecki MT, Jhala US, Antonellis A, Fields L, Doria A, et al. 1999. Mutations in NEUROD1 are associated with the development of type 2 diabetes mellitus. Nat. Genet. 23:323-28
    • (1999) Nat. Genet. , vol.23 , pp. 323-328
    • Malecki, M.T.1    Jhala, U.S.2    Antonellis, A.3    Fields, L.4    Doria, A.5
  • 114
    • 0036099118 scopus 로고    scopus 로고
    • Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population
    • Malecki MT, Moczulski DK, Klupa T, Wanic K, Cyganek K, et al. 2002. Homozygous combination of calpain 10 gene haplotypes is associated with type 2 diabetes mellitus in a Polish population. Eur. J. Endocrinol. 146:695-99
    • (2002) Eur. J. Endocrinol. , vol.146 , pp. 695-699
    • Malecki, M.T.1    Moczulski, D.K.2    Klupa, T.3    Wanic, K.4    Cyganek, K.5
  • 115
    • 0033060302 scopus 로고    scopus 로고
    • Pro12A1a substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes
    • Mancini FP, Vaccaro O, Sabatino L, Tufano A, Rivellese AA, et al. 1999. Pro12A1a substitution in the peroxisome proliferator-activated receptor-gamma2 is not associated with type 2 diabetes. Diabetes 48:1466-68
    • (1999) Diabetes , vol.48 , pp. 1466-1468
    • Mancini, F.P.1    Vaccaro, O.2    Sabatino, L.3    Tufano, A.4    Rivellese, A.A.5
  • 116
    • 8544274482 scopus 로고    scopus 로고
    • Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups
    • Marron MP, Raffel LJ, Garchon H-J, Jacob CO, Serrano Rios M, et al. 1997. Insulin-dependent diabetes mellitus (IDDM) is associated with CTLA4 polymorphisms in multiple ethnic groups. Hum. Mol. Genet. 6:1275-82
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1275-1282
    • Marron, M.P.1    Raffel, L.J.2    Garchon, H.-J.3    Jacob, C.O.4    Serrano Rios, M.5
  • 117
    • 0034049641 scopus 로고    scopus 로고
    • Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33
    • Marron MP, Zeidler A, Raffel LJ, Eckenrode SE, Yang JJ, et al. 2000. Genetic and physical mapping of a type 1 diabetes susceptibility gene (IDDM12) to a 100-kb phagemid artificial chromosome clone containing D2S72-CTLA4-D2S105 on chromosome 2q33. Diabetes 49:492-99
    • (2000) Diabetes , vol.49 , pp. 492-499
    • Marron, M.P.1    Zeidler, A.2    Raffel, L.J.3    Eckenrode, S.E.4    Yang, J.J.5
  • 118
    • 0028218909 scopus 로고
    • Glucokinase gene polymorphisms: A genetic marker for glucose intolerance in a cohort of elderly Finnish men
    • McCarthy MI, Hitman GA, Hitchins M, Riikonen A, Stengard J, et al. 1994. Glucokinase gene polymorphisms: a genetic marker for glucose intolerance in a cohort of elderly Finnish men. Diabetes Med. 11:198-204
    • (1994) Diabetes Med. , vol.11 , pp. 198-204
    • McCarthy, M.I.1    Hitman, G.A.2    Hitchins, M.3    Riikonen, A.4    Stengard, J.5
  • 119
    • 17144452354 scopus 로고    scopus 로고
    • A search for type 1 diabetes susceptibility genes in families from the United Kingdom
    • Mein CA, Esposito L, Dunn MG, Johnson GC, Timms AE, et al. 1998. A search for type 1 diabetes susceptibility genes in families from the United Kingdom. Nat. Genet. 19:297-300
    • (1998) Nat. Genet. , vol.19 , pp. 297-300
    • Mein, C.A.1    Esposito, L.2    Dunn, M.G.3    Johnson, G.C.4    Timms, A.E.5
  • 120
    • 0001491179 scopus 로고    scopus 로고
    • Impact of the peroxisome proliferator activated receptor gamma2 Pro12A1a polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus
    • Meirhaeghe A, Fajas L, Helbecque N, Cottel D, Auwerx J, et al. 2000. Impact of the peroxisome proliferator activated receptor gamma2 Pro12A1a polymorphism on adiposity, lipids and non-insulin-dependent diabetes mellitus. Int. J. Obes. Relat. Metab. Disord. 24: 195-99
    • (2000) Int. J. Obes. Relat. Metab. Disord. , vol.24 , pp. 195-199
    • Meirhaeghe, A.1    Fajas, L.2    Helbecque, N.3    Cottel, D.4    Auwerx, J.5
  • 121
    • 0035370562 scopus 로고    scopus 로고
    • Impact of sulfonylurea receptor 1 genetic variability on non-insulin-dependent diabetes mellitus prevalence and treatment: A population study
    • Meirhaeghe A, Helbecque N, Cottel D, Arveiler D, Ruidavets JB, et al. 2001. Impact of sulfonylurea receptor 1 genetic variability on non-insulin-dependent diabetes mellitus prevalence and treatment: a population study. Am. J. Hum. Genet. 101:4-8
    • (2001) Am. J. Hum. Genet. , vol.101 , pp. 4-8
    • Meirhaeghe, A.1    Helbecque, N.2    Cottel, D.3    Arveiler, D.4    Ruidavets, J.B.5
  • 122
    • 0035152589 scopus 로고    scopus 로고
    • Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases
    • Merriman TR, Cordell HJ, Eaves IA, Danoy PA, Coraddu F, et al. 2001. Suggestive evidence for association of human chromosome 18q12-q21 and its orthologue on rat and mouse chromosome 18 with several autoimmune diseases. Diabetes 50:184-94
    • (2001) Diabetes , vol.50 , pp. 184-194
    • Merriman, T.R.1    Cordell, H.J.2    Eaves, I.A.3    Danoy, P.A.4    Coraddu, F.5
  • 123
    • 0035403064 scopus 로고    scopus 로고
    • Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy
    • Moczulski DK, Grzelczak Z, Gawlik B. 2001. Role of hemochromatosis C282Y and H63D mutations in HFE gene in development of type 2 diabetes and diabetic nephropathy. Diabetes Care 24:1187-91
    • (2001) Diabetes Care , vol.24 , pp. 1187-1191
    • Moczulski, D.K.1    Grzelczak, Z.2    Gawlik, B.3
  • 124
    • 0024272188 scopus 로고
    • Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type a insulin resistance)
    • Moller DE, Flier JS. 1988. Detection of an alteration in the insulin-receptor gene in a patient with insulin resistance, acanthosis nigricans, and the polycystic ovary syndrome (type A insulin resistance). N. Engl. J. Med. 319:1526-29
    • (1988) N. Engl. J. Med. , vol.319 , pp. 1526-1529
    • Moller, D.E.1    Flier, J.S.2
  • 125
    • 0038054341 scopus 로고    scopus 로고
    • PGC-1alpha responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes
    • In press
    • Mootha VK, Lindgren CM, Eriksson K-F, Subramanian A, Sihag S, et al. PGC-1alpha responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. In press
    • Nat. Genet.
    • Mootha, V.K.1    Lindgren, C.M.2    Eriksson, K.-F.3    Subramanian, A.4    Sihag, S.5
  • 126
    • 0035132568 scopus 로고    scopus 로고
    • Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele
    • Morahan G, Huang D, Ymer SI, Cancilia MR, Stephen K, et al. 2001. Linkage disequilibrium of a type 1 diabetes susceptibility locus with a regulatory IL12B allele. Nat. Genet. 27:218-21
    • (2001) Nat. Genet. , vol.27 , pp. 218-221
    • Morahan, G.1    Huang, D.2    Ymer, S.I.3    Cancilia, M.R.4    Stephen, K.5
  • 127
    • 0034745185 scopus 로고    scopus 로고
    • The Pro12 → A1a substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: Possible involvement in impairment of insulin secretion in individuals with type 2 diabetes
    • Mori H, Ikegami H, Kawaguchi Y, Seino S, Yokoi N, et al. 2001. The Pro12 → A1a substitution in PPAR-gamma is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes. Diabetes 50:891-94
    • (2001) Diabetes , vol.50 , pp. 891-894
    • Mori, H.1    Ikegami, H.2    Kawaguchi, Y.3    Seino, S.4    Yokoi, N.5
  • 128
    • 0036230486 scopus 로고    scopus 로고
    • Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p
    • Mori Y, Otabe S, Dina C, Yasuda K, Populaire C, et al. 2002. Genome-wide search for type 2 diabetes in Japanese affected sib-pairs confirms susceptibility genes on 3q, 15q, and 20q and identifies two new candidate loci on 7p and 11p. Diabetes 51:1247-55
    • (2002) Diabetes , vol.51 , pp. 1247-1255
    • Mori, Y.1    Otabe, S.2    Dina, C.3    Yasuda, K.4    Populaire, C.5
  • 133
    • 0037312864 scopus 로고    scopus 로고
    • The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes
    • Nielsen E-MD, Hansen L, Carstensen B, Echwald SM, Drivsholm T, et al. 2003. The E23K variant of Kir6.2 associates with impaired post-OGTT serum insulin response and increased risk of type 2 diabetes. Diabetes 52:573-77
    • (2003) Diabetes , vol.52 , pp. 573-577
    • Nielsen, E.-M.D.1    Hansen, L.2    Carstensen, B.3    Echwald, S.M.4    Drivsholm, T.5
  • 135
    • 0034186496 scopus 로고    scopus 로고
    • Significance of Pro12A1a mutation in peroxisome proliferator-activated receptor-{gamma}2 in Korean diabetic and obese subjects
    • Oh EY, Min KM, Chung JH, Min Y-K, Lee M-S, et al. 2000. Significance of Pro12A1a mutation in peroxisome proliferator-activated receptor-{gamma}2 in Korean diabetic and obese subjects. J. Clin. Endocrinol. Metab. 85:1801-4
    • (2000) J. Clin. Endocrinol. Metab. , vol.85 , pp. 1801-1804
    • Oh, E.Y.1    Min, K.M.2    Chung, J.H.3    Min, Y.-K.4    Lee, M.-S.5
  • 136
    • 0031915309 scopus 로고    scopus 로고
    • Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM
    • Ohta Y, Tanizawa Y, Inoue H, Hosaka T, Ueda K, et al. 1998. Identification and functional analysis of sulfonylurea receptor 1 variants in Japanese patients with NIDDM. Diabetes 47:476-81
    • (1998) Diabetes , vol.47 , pp. 476-481
    • Ohta, Y.1    Tanizawa, Y.2    Inoue, H.3    Hosaka, T.4    Ueda, K.5
  • 137
    • 0035120347 scopus 로고    scopus 로고
    • A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11
    • Parker A, Meyer J, Lewitzky S, Rennich JS, Chan G, et al. 2001. A gene conferring susceptibility to type 2 diabetes in conjunction with obesity is located on chromosome 18p11. Diabetes 50:675-80
    • (2001) Diabetes , vol.50 , pp. 675-680
    • Parker, A.1    Meyer, J.2    Lewitzky, S.3    Rennich, J.S.4    Chan, G.5
  • 138
    • 0035119822 scopus 로고    scopus 로고
    • A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population
    • Permutt MA, Wasson JC, Suarez BK, Lin J, Thomas J, et al. 2001. A genome scan for type 2 diabetes susceptibility loci in a genetically isolated population. Diabetes 50:681-85
    • (2001) Diabetes , vol.50 , pp. 681-685
    • Permutt, M.A.1    Wasson, J.C.2    Suarez, B.K.3    Lin, J.4    Thomas, J.5
  • 139
    • 0037026745 scopus 로고    scopus 로고
    • Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus
    • Petersen KF, Shulman GI. 2002. Pathogenesis of skeletal muscle insulin resistance in type 2 diabetes mellitus. Am. J. Cardiol. 90:11G-8G
    • (2002) Am. J. Cardiol. , vol.90
    • Petersen, K.F.1    Shulman, G.I.2
  • 140
    • 0019455384 scopus 로고
    • HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus
    • Platz P, Jakobsen BK, Morling N, Ryder LP, Svejgaard A, et al. 1981. HLA-D and -DR antigens in genetic analysis of insulin dependent diabetes mellitus. Diabetologia 21:108-15
    • (1981) Diabetologia , vol.21 , pp. 108-115
    • Platz, P.1    Jakobsen, B.K.2    Morling, N.3    Ryder, L.P.4    Svejgaard, A.5
  • 141
    • 10244227968 scopus 로고    scopus 로고
    • Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations
    • Pontiroli AE, Capra F, Veglia F, Ferrari M, Xiang KS, et al. 1996. Genetic contribution of polymorphism of the GLUT1 and GLUT4 genes to the susceptibility to type 2 (non-insulin-dependent) diabetes mellitus in different populations. Acta Diabetologica 33:193-97
    • (1996) Acta Diabetologica , vol.33 , pp. 193-197
    • Pontiroli, A.E.1    Capra, F.2    Veglia, F.3    Ferrari, M.4    Xiang, K.S.5
  • 142
    • 0032953097 scopus 로고    scopus 로고
    • Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study
    • Poulsen P, Kyvik KO, Vaag A, Beck-Nielsen H. 1999. Heritability of type II (non-insulin-dependent) diabetes mellitus and abnormal glucose tolerance-a population-based twin study. Diabetologia 42:139-45
    • (1999) Diabetologia , vol.42 , pp. 139-145
    • Poulsen, P.1    Kyvik, K.O.2    Vaag, A.3    Beck-Nielsen, H.4
  • 143
    • 18244421874 scopus 로고    scopus 로고
    • The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes
    • Pugliese A, Zeller M, Fernandez AJ, Zalcberg LJ, Bartlett RJ, et al. 1997. The insulin gene is transcribed in the human thymus and transcription levels correlated with allelic variation at the INS VNTR-IDDM2 susceptibility locus for type 1 diabetes. Nat. Genet. 15:293-97
    • (1997) Nat. Genet. , vol.15 , pp. 293-297
    • Pugliese, A.1    Zeller, M.2    Fernandez, A.J.3    Zalcberg, L.J.4    Bartlett, R.J.5
  • 144
    • 0032549811 scopus 로고    scopus 로고
    • A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis
    • Puigserver P, Wu Z, Park CW, Graves R, Wright M, Spiegelman BM. 1998. A cold-inducible coactivator of nuclear receptors linked to adaptive thermogenesis. Cell 92:829-39
    • (1998) Cell , vol.92 , pp. 829-839
    • Puigserver, P.1    Wu, Z.2    Park, C.W.3    Graves, R.4    Wright, M.5    Spiegelman, B.M.6
  • 145
    • 0036895104 scopus 로고    scopus 로고
    • Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians
    • Rasmussen SK, Urhammer SA, Berglund L, Jensen JN, Hansen L, et al. 2002. Variants within the calpain-10 gene on chromosome 2q37 (NIDDM1) and relationships to type 2 diabetes, insulin resistance, and impaired acute insulin secretion among Scandinavian Caucasians. Diabetes 51:3561-67
    • (2002) Diabetes , vol.51 , pp. 3561-3567
    • Rasmussen, S.K.1    Urhammer, S.A.2    Berglund, L.3    Jensen, J.N.4    Hansen, L.5
  • 147
    • 8544270861 scopus 로고    scopus 로고
    • Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11
    • Reed P, Cucca F, Jenkins S, Merriman M, Wilson A, et al. 1997. Evidence for a type 1 diabetes susceptibility locus (IDDM10) on human chromosome 10p11-q11. Hum. Mol. Genet. 6:1011-16
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1011-1016
    • Reed, P.1    Cucca, F.2    Jenkins, S.3    Merriman, M.4    Wilson, A.5
  • 148
    • 0033582258 scopus 로고    scopus 로고
    • Pro12A1a missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus
    • Ringel J, Engeli S, Distler A, Sharma AM. 1999. Pro12A1a missense mutation of the peroxisome proliferator activated receptor gamma and diabetes mellitus. Biochem. Biophys. Res. Commun. 254:450-53
    • (1999) Biochem. Biophys. Res. Commun. , vol.254 , pp. 450-453
    • Ringel, J.1    Engeli, S.2    Distler, A.3    Sharma, A.M.4
  • 149
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K. 1996. The future of genetic studies of complex human diseases. Science 273:1516-17
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 150
    • 0033625771 scopus 로고    scopus 로고
    • Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin
    • Rissanen J, Markkanen A, Karkkainen P, Pihlajamaki J, Kekalainen P, et al. 2000. Sulfonylurea receptor 1 gene variants are associated with gestational diabetes and type 2 diabetes but not with altered secretion of insulin. Diabetes Care 23:70-73
    • (2000) Diabetes Care , vol.23 , pp. 70-73
    • Rissanen, J.1    Markkanen, A.2    Karkkainen, P.3    Pihlajamaki, J.4    Kekalainen, P.5
  • 152
    • 0020692126 scopus 로고
    • HLA genotypic study of insulin-dependent diabetes the excess of DR3/DR4 heterozygotes allows rejection of the recessive hypothesis
    • Rotter JI, Anderson CE, Rubin R, Congleton JE, Terasaki PI, Rimoin DL. 1983. HLA genotypic study of insulin-dependent diabetes the excess of DR3/DR4 heterozygotes allows rejection of the recessive hypothesis. Diabetes 32:169-74
    • (1983) Diabetes , vol.32 , pp. 169-174
    • Rotter, J.I.1    Anderson, C.E.2    Rubin, R.3    Congleton, J.E.4    Terasaki, P.I.5    Rimoin, D.L.6
  • 153
    • 0029740428 scopus 로고    scopus 로고
    • Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: No association with NIDDM in white Caucasian subjects or evidence of abnormal function when expressed in vitro
    • Sakura H, Wat N, Horton V, Millns H, Turner RC, Ashcroft FM. 1996. Sequence variations in the human Kir6.2 gene, a subunit of the beta-cell ATP-sensitive K-channel: no association with NIDDM in white Caucasian subjects or evidence of abnormal function when expressed in vitro. Diabetologia 39:1233-36
    • (1996) Diabetologia , vol.39 , pp. 1233-1236
    • Sakura, H.1    Wat, N.2    Horton, V.3    Millns, H.4    Turner, R.C.5    Ashcroft, F.M.6
  • 154
    • 0034709699 scopus 로고    scopus 로고
    • Role of C282Y mutation in haemochromatosis gene in development of type 2 diabetes in healthy men: Prospective cohort study
    • Salonen JT, Tuomainen TP, Kontula K. 2000. Role of C282Y mutation in haemochromatosis gene in development of type 2 diabetes in healthy men: prospective cohort study. Br. Med. J. 320:1706-7
    • (2000) Br. Med. J. , vol.320 , pp. 1706-1707
    • Salonen, J.T.1    Tuomainen, T.P.2    Kontula, K.3
  • 155
    • 0036314298 scopus 로고    scopus 로고
    • KIR6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K+ channels
    • Schwanstecher C, Meyer U, Schwanstecher M. 2002. KIR6.2 polymorphism predisposes to type 2 diabetes by inducing overactivity of pancreatic beta-cell ATP-sensitive K+ channels. Diabetes 51:875-79
    • (2002) Diabetes , vol.51 , pp. 875-879
    • Schwanstecher, C.1    Meyer, U.2    Schwanstecher, M.3
  • 157
    • 0031713870 scopus 로고    scopus 로고
    • Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q
    • Shaw JT, Lovelock PK, Resting JB, Cardinal J, Duffy D, et al. 1998. Novel susceptibility gene for late-onset NIDDM is localized to human chromosome 12q. Diabetes 47:1793-96
    • (1998) Diabetes , vol.47 , pp. 1793-1796
    • Shaw, J.T.1    Lovelock, P.K.2    Resting, J.B.3    Cardinal, J.4    Duffy, D.5
  • 158
    • 0024560413 scopus 로고
    • A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles
    • Sheehy MJ, Scharf SJ, Rowe JR, Neme de Gimenez MH, Meske LM, et al. 1989. A diabetes-susceptible HLA haplotype is best defined by a combination of HLA-DR and -DQ alleles. J. Clin. Invest. 83:830-35
    • (1989) J. Clin. Invest. , vol.83 , pp. 830-835
    • Sheehy, M.J.1    Scharf, S.J.2    Rowe, J.R.3    Neme De Gimenez, M.H.4    Meske, L.M.5
  • 159
    • 0015883122 scopus 로고
    • Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus
    • Singal DP, Blajchman MA. 1973. Histocompatibility (HL-A) antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes 22:429-32
    • (1973) Diabetes , vol.22 , pp. 429-432
    • Singal, D.P.1    Blajchman, M.A.2
  • 160
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM. 1998. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47:507-14
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.M.1
  • 161
    • 0019226693 scopus 로고
    • Gene dosage and suceptibility to insulin-dependent diabetes
    • Spielman RS, Baker L, Zmijewski CM. 1980. Gene dosage and suceptibility to insulin-dependent diabetes. Ann. Hum. Genet. 44:135-50
    • (1980) Ann. Hum. Genet. , vol.44 , pp. 135-150
    • Spielman, R.S.1    Baker, L.2    Zmijewski, C.M.3
  • 162
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman RS, McGinnis RE, Ewens WJ. 1993. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52:506-16
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 163
    • 0035984095 scopus 로고    scopus 로고
    • Is a Pro12A1a polymorphism of the PPAR{gamma}2 gene related to obesity and type 2 diabetes mellitus in the Czech population?
    • Sramkova D, Kunesova M, Hainer V, Hill M, Vcelak J, Bendlova B. 2002. Is a Pro12A1a polymorphism of the PPAR{gamma}2 gene related to obesity and type 2 diabetes mellitus in the Czech population? Ann. NY Acad. Sci. 967:265-73
    • (2002) Ann. NY Acad. Sci. , vol.967 , pp. 265-273
    • Sramkova, D.1    Kunesova, M.2    Hainer, V.3    Hill, M.4    Vcelak, J.5    Bendlova, B.6
  • 164
  • 165
    • 0031031571 scopus 로고    scopus 로고
    • Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence
    • Stoffers DA, Zinkin NT, Stanojevic V, Clarke WL, Habener JF. 1997. Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence. Nat. Genet. 15:106-10
    • (1997) Nat. Genet. , vol.15 , pp. 106-110
    • Stoffers, D.A.1    Zinkin, N.T.2    Stanojevic, V.3    Clarke, W.L.4    Habener, J.F.5
  • 166
    • 0036255811 scopus 로고    scopus 로고
    • Opinion: Candidate-gene approaches for studying complex genetic traits: Practical considerations
    • Tabor HK, Risch NJ, Myers RM. 2002. Opinion: Candidate-gene approaches for studying complex genetic traits: practical considerations. Nat. Rev. Genet. 3:391-97
    • (2002) Nat. Rev. Genet. , vol.3 , pp. 391-397
    • Tabor, H.K.1    Risch, N.J.2    Myers, R.M.3
  • 167
    • 0028229319 scopus 로고
    • Early-onset type 2 (non-insulin-dependent) diabetes mellitus is associated with glucokinase locus, but not with adenosine deaminase locus, in the Japanese population
    • Takekawa K, Ikegami H, Fukuda M, Ueda H, Kawaguchi Y, et al. 1994.Early-onset type 2 (non-insulin-dependent) diabetes mellitus is associated with glucokinase locus, but not with adenosine deaminase locus, in the Japanese population. Diabetes Res. Clin. Pract. 23:141-46
    • (1994) Diabetes Res. Clin. Pract. , vol.23 , pp. 141-146
    • Takekawa, K.1    Ikegami, H.2    Fukuda, M.3    Ueda, H.4    Kawaguchi, Y.5
  • 168
    • 0029095432 scopus 로고
    • HepG2/erythrocyte glucose transporter (GLUT1) gene in NIDDM: A population association study and molecular scanning in Japanese subjects
    • Tao T, Tanizawa Y, Matsutani A, Matsubara A, Kaneko T, Kaku K. 1995. HepG2/erythrocyte glucose transporter (GLUT1) gene in NIDDM: a population association study and molecular scanning in Japanese subjects. Diabetologia 38:942-47
    • (1995) Diabetologia , vol.38 , pp. 942-947
    • Tao, T.1    Tanizawa, Y.2    Matsutani, A.3    Matsubara, A.4    Kaneko, T.5    Kaku, K.6
  • 169
    • 0029021696 scopus 로고
    • Mutations in the sulfonylurea receptor gene in familial hyperinsulinemic hypoglycemia of infancy
    • Thomas PM, Cote GJ, Wohlik N, Haddad B, Mathew PM, et al. 1995. Mutations in the sulfonylurea receptor gene in familial hyperinsulinemic hypoglycemia of infancy. Science 268:426-29
    • (1995) Science , vol.268 , pp. 426-429
    • Thomas, P.M.1    Cote, G.J.2    Wohlik, N.3    Haddad, B.4    Mathew, P.M.5
  • 170
    • 0023252262 scopus 로고
    • β gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus
    • β gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature 329:599-604
    • (1987) Nature , vol.329 , pp. 599-604
    • Todd, J.A.1    Bell, J.I.2    McDevitt, H.O.3
  • 171
    • 0024510601 scopus 로고
    • Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping
    • Todd JA, Mijovic C, Fletcher J, Jenkins D, Bradwell AR, Barnett AH. 1989. Identification of susceptibility loci for insulin-dependent diabetes mellitus by trans-racial gene mapping. Nature 338:587-89
    • (1989) Nature , vol.338 , pp. 587-589
    • Todd, J.A.1    Mijovic, C.2    Fletcher, J.3    Jenkins, D.4    Bradwell, A.R.5    Barnett, A.H.6
  • 172
    • 0035205377 scopus 로고    scopus 로고
    • Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: No evidence of association
    • Tsai HJ, Sun G, Weeks DE, Kaushal R, Wolujewicz M, et al. 2001. Type 2 diabetes and three calpain-10 gene polymorphisms in Samoans: no evidence of association. Am. J. Hum. Genet. 69: 1236-44
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 1236-1244
    • Tsai, H.J.1    Sun, G.2    Weeks, D.E.3    Kaushal, R.4    Wolujewicz, M.5
  • 173
    • 0037648405 scopus 로고    scopus 로고
    • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease
    • doi:10.1038/nature01621
    • 171a. Ueda H, Howson JMM, Esposito L, Heward J, Snook H, et al. 2003. Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. Nature doi:10.1038/nature01621
    • (2003) Nature
    • Ueda, H.1    Howson, J.M.M.2    Esposito, L.3    Heward, J.4    Snook, H.5
  • 175
    • 0031018819 scopus 로고    scopus 로고
    • Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus
    • Vafiadis P, Bennett ST, Todd JA, Nadeau J, Grabs R, et al. 1997. Insulin expression in human thymus is modulated by INS VNTR alleles at the IDDM2 locus. Nat. Genet. 15:289-92
    • (1997) Nat. Genet. , vol.15 , pp. 289-292
    • Vafiadis, P.1    Bennett, S.T.2    Todd, J.A.3    Nadeau, J.4    Grabs, R.5
  • 176
    • 0034891347 scopus 로고    scopus 로고
    • Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes
    • Vafiadis P, Ounissi-Benkalha H, Palumbo M, Grabs R, Rousseau M, et al. 2001. Class III alleles of the variable number of tandem repeat insulin polymorphism associated with silencing of thymic insulin predispose to type 1 diabetes. J. Clin. Endocrinol. Metab. 86:3705-10
    • (2001) J. Clin. Endocrinol. Metab. , vol.86 , pp. 3705-3710
    • Vafiadis, P.1    Ounissi-Benkalha, H.2    Palumbo, M.3    Grabs, R.4    Rousseau, M.5
  • 177
    • 0026906885 scopus 로고
    • Mutation in mitochondrial tRNA(Leu)(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness
    • van den Ouweland JM, Lemkes HH, Ruitenbeek W, Sandkuijl LA, de Vijlder MF, et al. 1992. Mutation in mitochondrial tRNA(Leu)(UUR) gene in a large pedigree with maternally transmitted type II diabetes mellitus and deafness. Nat. Genet. 1:368-71
    • (1992) Nat. Genet. , vol.1 , pp. 368-371
    • Van Den Ouweland, J.M.1    Lemkes, H.H.2    Ruitenbeek, W.3    Sandkuijl, L.A.4    De Vijlder, M.F.5
  • 178
  • 179
    • 0029791677 scopus 로고    scopus 로고
    • The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: Affected-sib-pair analysis and association studies
    • Veijola R, Knip M, Puukka R, Reijonen H, Cox DW, Ilonen J. 1997. The immunoglobulin heavy-chain variable region in insulin-dependent diabetes mellitus: affected-sib-pair analysis and association studies. Am. J. Hum. Genet. 59:462-70
    • (1997) Am. J. Hum. Genet. , vol.59 , pp. 462-470
    • Veijola, R.1    Knip, M.2    Puukka, R.3    Reijonen, H.4    Cox, D.W.5    Ilonen, J.6
  • 180
    • 0032532064 scopus 로고    scopus 로고
    • Evidence for oligogenic inheritance of type 1 diabetes in a large bedouin arab family
    • Verge CF, Vardi P, Babu S, Bao F, Erlich HA, et al. 1998. Evidence for oligogenic inheritance of type 1 diabetes in a large bedouin arab family. J. Clin. Invest. 102:1569-75
    • (1998) J. Clin. Invest. , vol.102 , pp. 1569-1575
    • Verge, C.F.1    Vardi, P.2    Babu, S.3    Bao, F.4    Erlich, H.A.5
  • 181
    • 0033652271 scopus 로고    scopus 로고
    • Genomewide search for type 2 diabetes-susceptibility genes in French whites: Evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24
    • Vionnet N, Hani El H, Dupont S, Gallina S, Francke S, et al. 2000. Genomewide search for type 2 diabetes-susceptibility genes in French whites: evidence for a novel susceptibility locus for early-onset diabetes on chromosome 3q27-qter and independent replication of a type 2-diabetes locus on chromosome 1q21-q24. Am. J. Hum. Genet. 67:1470-80
    • (2000) Am. J. Hum. Genet. , vol.67 , pp. 1470-1480
    • Vionnet, N.1    Hani El, H.2    Dupont, S.3    Gallina, S.4    Francke, S.5
  • 182
    • 0036275761 scopus 로고    scopus 로고
    • Counterpoint: Bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer
    • Wacholder S, Rothman N, Caporaso N. 2002. Counterpoint: bias from population stratification is not a major threat to the validity of conclusions from epidemiological studies of common polymorphisms and cancer. Cancer Epidemiol. Biomark. Prev. 11:513-20
    • (2002) Cancer Epidemiol. Biomark. Prev. , vol.11 , pp. 513-520
    • Wacholder, S.1    Rothman, N.2    Caporaso, N.3
  • 183
    • 0036723768 scopus 로고    scopus 로고
    • Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in Northern European Caucasians
    • Wang H, Chu W, Das SK, Ren Q, Hasstedt SJ, Elbein SC. 2002. Liver pyruvate kinase polymorphisms are associated with type 2 diabetes in Northern European Caucasians. Diabetes 51: 2861-65
    • (2002) Diabetes , vol.51 , pp. 2861-2865
    • Wang, H.1    Chu, W.2    Das, S.K.3    Ren, Q.4    Hasstedt, S.J.5    Elbein, S.C.6
  • 184
    • 0035163909 scopus 로고    scopus 로고
    • X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy
    • Wildin RS, Ramsdell F, Peake J, Faravelli F, Casanova JL, et al. 2001. X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy. Nat. Genet. 27:18-20
    • (2001) Nat. Genet. , vol.27 , pp. 18-20
    • Wildin, R.S.1    Ramsdell, F.2    Peake, J.3    Faravelli, F.4    Casanova, J.L.5
  • 185
    • 0034893106 scopus 로고    scopus 로고
    • A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): Analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q
    • Wiltshire S, Hattersley AT, Hitman GA, Walker M, Levy JC, et al. 2001. A genomewide scan for loci predisposing to type 2 diabetes in a U.K. population (the Diabetes UK Warren 2 Repository): Analysis of 573 pedigrees provides independent replication of a susceptibility locus on chromosome 1q. Am. J. Hum. Genet. 69:553-69
    • (2001) Am. J. Hum. Genet. , vol.69 , pp. 553-569
    • Wiltshire, S.1    Hattersley, A.T.2    Hitman, G.A.3    Walker, M.4    Levy, J.C.5
  • 187
    • 0033538473 scopus 로고    scopus 로고
    • Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1
    • Wu Z, Puigserver P, Andersson U, Zhang C, Adelmant G, et al. 1999. Mechanisms controlling mitochondrial biogenesis and respiration through the thermogenic coactivator PGC-1. Cell 98:115-24
    • (1999) Cell , vol.98 , pp. 115-124
    • Wu, Z.1    Puigserver, P.2    Andersson, U.3    Zhang, C.4    Adelmant, G.5
  • 188
    • 10544236911 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1)
    • Yamagata K, Furuta H, Oda N, Kaisaki PJ, Menzel S, et al. 1996. Mutations in the hepatocyte nuclear factor-4alpha gene in maturity-onset diabetes of the young (MODY1). Nature 384:458-60
    • (1996) Nature , vol.384 , pp. 458-460
    • Yamagata, K.1    Furuta, H.2    Oda, N.3    Kaisaki, P.J.4    Menzel, S.5
  • 189
    • 10544249874 scopus 로고    scopus 로고
    • Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
    • Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, et al. 1996. Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3). Nature 384:455-58
    • (1996) Nature , vol.384 , pp. 455-458
    • Yamagata, K.1    Oda, N.2    Kaisaki, P.J.3    Menzel, S.4    Furuta, H.5
  • 190
    • 0031434409 scopus 로고    scopus 로고
    • CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese
    • Yanagawa T, Taniyama M, Enomoto S, Gomi K, Maruyama H, et al. 1997. CTLA4 gene polymorphism confers susceptibility to Graves' disease in Japanese. Thyroid 7:843-46
    • (1997) Thyroid , vol.7 , pp. 843-846
    • Yanagawa, T.1    Taniyama, M.2    Enomoto, S.3    Gomi, K.4    Maruyama, H.5
  • 191
    • 0035855858 scopus 로고    scopus 로고
    • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1
    • Yoon JC, Puigserver P, Chen G, Donovan J, Wu Z, et al. 2001. Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. Nature 413:131-38
    • (2001) Nature , vol.413 , pp. 131-138
    • Yoon, J.C.1    Puigserver, P.2    Chen, G.3    Donovan, J.4    Wu, Z.5
  • 192
    • 0028895749 scopus 로고
    • A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans
    • Yoshida K, Furihata K, Takeda S, Nakamura A, Yamamoto K, et al. 1995. A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans. Nat. Genet. 9:267-72
    • (1995) Nat. Genet. , vol.9 , pp. 267-272
    • Yoshida, K.1    Furihata, K.2    Takeda, S.3    Nakamura, A.4    Yamamoto, K.5
  • 193
    • 0023886838 scopus 로고
    • Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing
    • Yoshimasa Y, Seino S, Whittaker J, Kakehi T, Kosaki A, et al. 1988. Insulin-resistant diabetes due to a point mutation that prevents insulin proreceptor processing. Science 240:784-87
    • (1988) Science , vol.240 , pp. 784-787
    • Yoshimasa, Y.1    Seino, S.2    Whittaker, J.3    Kakehi, T.4    Kosaki, A.5
  • 195
    • 0036066280 scopus 로고    scopus 로고
    • A genome-wide scan for obesity in African-Americans
    • Zhu X, Cooper RS, Luke A, Chen G, Wu X, et al. 2002. A genome-wide scan for obesity in African-Americans. Diabetes 51:541-44
    • (2002) Diabetes , vol.51 , pp. 541-544
    • Zhu, X.1    Cooper, R.S.2    Luke, A.3    Chen, G.4    Wu, X.5
  • 196
    • 0030766446 scopus 로고    scopus 로고
    • A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene
    • Zouali H, Haiti EH, Philippi A, Vionnet N, Beckmann JS, et al. 1997. A susceptibility locus for early-onset non-insulin dependent (type 2) diabetes mellitus maps to chromosome 20q, proximal to the phosphoenolpyruvate carboxykinase gene. Hum. Mol. Genet. 6:1401-8
    • (1997) Hum. Mol. Genet. , vol.6 , pp. 1401-1408
    • Zouali, H.1    Haiti, E.H.2    Philippi, A.3    Vionnet, N.4    Beckmann, J.S.5


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