A potent antidiabetic thiazolidinedione with unique peroxisome proliferator-activated receptor γ-activating properties

Journal of Biological Chemistry

Volumn 273, Issue 49, 1998, Pages 32679-32684

  Reginato, Mauricio J ^a,c   Bailey, Shannon T ^a   Krakow, Samuel L ^a   Minami, Chieko ^b   Ishii, Shinichi ^b   Tanaka, Hideho ^b   Lazar, Mitchell A ^a,d  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b MITSUBISHI CHEMICAL CORPORATION   (Japan)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ANTIDIABETIC AGENT; GLUCOSE; NETOGLITAZONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PIOGLITAZONE; ROSIGLITAZONE; THIAZOLIDINE DERIVATIVE; TROGLITAZONE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG RECEPTOR BINDING; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; MALE; MOUSE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN DNA BINDING; STRUCTURE ACTIVITY RELATION; TRANSCRIPTION REGULATION;

3T3 CELLS; ADIPOCYTES; ANIMALS; CELL DIFFERENTIATION; GENE EXPRESSION REGULATION; HYPOGLYCEMIC AGENTS; INSULIN RESISTANCE; MALE; MICE; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECOMBINANT FUSION PROTEINS; THIAZOLES; THIAZOLIDINEDIONES; TRANSCRIPTION FACTORS;

ANIMALIA;

EID: 0032484224     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.49.32679     Document Type: Article

References (45)

1. Mangelsdorf, D. J., Thummel, C., Beato, M., Herrlich, P., Schutz, G., Umesono, K., Blumberg, B., Kastner, P., Mark, M., Chambon, P., and Evans, R. M. (1995) Cell 83, 835-839
2. Jordan, V. C. (1995) Breast Cancer Res. Treat. 36, 267-285
3. Dorkin, T. J., and Neal, D. E. (1997) Semin. Cancer. Biol. 8, 21-27
4. Casini, T., Grignani, F., and Pelicci, P. G. (1997) Int. J. Cancer 70, 473-474
5. Refetoff, S., Weiss, R. E., and Usala, S. J. (1993) Endocr. Rev. 14, 348-399
6. Henry, R. R. (1997) Endocrinol. Metab. Clin. North Am. 26, 553-573
7. Yu, K., Bayona, W., Kallen, C. B., Harding, H. P., Ravera, C., McMahon, G., Brown, M., and Lazar, M. A. (1995) J. Biol. Chem. 270, 23975-23983
8. Kliewer, S. A., Lenhard, J. M., Willson, T. M., Patel, I., Morris, D. C., and Lehmann, J. M. (1995) Cell 83, 813-819
9. Forman, B. M., Tontonoz, P., Chen, J., Brun, R. P., Spiegelman, B. M., and Evans, R. M. (1995) Cell 83, 803-812
10. Lehmann, J. M., Moore, L. B., Smith-Oliver, T. A., Wilkison, W. O., Willson, T. M., and Kliewer, S. A. (1995) J. Biol. Chem. 270, 12953-12956
11. Willson, T. M., Cobb, J. E., Cowan, D. J., Wiethe, R. W., Correa, I. D., Prakash, S. R., Beck, K. D., Moore, L. B., Kliewer, S. A., and Lehmann, J. M. (1996) J. Med. Chem. 39, 665-668
12. Berger, J., Bailey, P., Biswas, C., Cullinan, C. A., Doebber, T. W., Hayes, N. S., Saperstein, R., Smith, R. G., and Leibowitz, M. D. (1996) Endocrinology 137, 4189-4195
13. Chawla, A., Schwarz, E. J., Dimaculangan, D. D., and Lazar, M. A. (1994) Endocrinology 135, 798-800
14. Tontonoz, P., Hu, E., Graves, R. A., Budavari, A. I., and Spiegelman, B. M. (1994) Genes Dev. 8, 1224-1234
15. Chawla, A., and Lazar, M. A. (1993) J. Biol. Chem. 268, 16265-16269
16. Adams, M., Reginato, M. J., Shao, D., Lazar, M. A., and Chatterjee, V. K. (1997) J. Biol. Chem. 272, 5128-5132
17. Harding, H. P., and Lazar, M. A. (1995) Mol. Cell. Biol. 15, 4791-4802
18. Krey, G., Braissant, O., L'Horset, F., Kalkhoven, E., Perroud, M., Parker, M. G., and Wahli, W. (1997) Mol. Endocrinol. 11, 779-791
19. Shao, D., and Lazar, M. A. (1997) J. Biol. Chem. 272, 21473-21478
20. Ishii, S., Wasaki, M., Ohe, T., Ueno, H., and Tanaka, H. (1996) Diabetes 45, Suppl. 2, 141A (abstr.)
21. Wurtz, J. M., Bourguet, W., Renaud, J. P., Vivat, V., Chambon, P., Moras, D., and Gronemeyer, H. (1996) Nat. Struct. Biol. 3, 87-94
22. Glass, C. K., Rose, D. W., and Rosenfeld, M. G. (1997) Curr. Opin. Cell Biol. 9, 222-232
23. Halachmi, S., Marden, E., Martin, G., MacKay, H., Abbondanza, C., and Brown, M. (1994) Science 264, 1455-1458
24. LeDouarin, B., vomBaur, E., Zechel, C., Heery, D., Heine, M., Vivat, V., Gronemeyer, H., Losson, R., and Chambon, P. (1996) Philos. Trans. R. Soc. Lond. B Biol. Sci. 351, 569-578
25. Chrivia, J. C., Kwok, R. P., Lamb, N., Hagiwara, M., Montminy, M. R., and Goodman, R. H. (1993) Nature 365, 855-859
26. Onate, S. A., Tsai, S. Y., Tsai, M.-J., and O'Malley, B. W. (1995) Science 270, 1354-1357
27. Cavailles, V., Dauvois, S., Danielian, P. S., and Parker, M. G. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 10009-10013
28. McDonnell, D. P., Dana, S. L., Hoener, P. A., Lieberman, B. A., Imhof, M. O., and Stein, R. B. (1995) Ann. N. Y. Acad. Sci. 761, 121-137
29. Jackson, T. A., Richer, J. K., Bain, D. L., Takimoto, G. S., Tung, L., and Horwitz, K. B. (1997) Mol. Endocrinol. 11, 693-705
30. Lavinsky, R. M., Kristen, J., Thorsten, H., Torchia, J., Mullen, T.-M., Schiff, R., Del-Rio, A. L., Ricote, M., Ngo, S., Gemsch, J., Hilsenbeck, S. G., Osborne, C. K., Glass, C. K., and Rosenfeld, M. G. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2920-2925
31. Smith, C. L., Nawaz, Z., and O'Malley, B. W. (1998) Mol. Endocrinol. 11, 657-666
32. Zhang, X., Jeyakumar, M., Petukhov, S., and Bagchi, M. K. (1998) Mol. Endocrinol. 12, 513-524
33. Zamir, I., Zhang, J., and Lazar, M. A. (1997) Genes Dev. 11, 835-846
34. Kletzien, R. F., Clarke, S. D., and Ulrich, R. G. (1992) Mol. Pharmacol. 41, 393-398
35. Tontonoz, P., Hu, E., and Spiegelman, B. M. (1994) Cell 79, 1147-1156
36. Kallen, C. B., and Lazar, M. A. (1996) Proc. Natl. Acad. Sci. U. S. A. 93, 5793-5796
37. DeVos, P., Lefebvre, A. M., Miller, S. G., Guerre-Millo, M., Wong, K., Saladin, R., Hamann, L. G., Staels, B., Briggs, M. R., and Auwerx, J. (1996) J. Clin. Invest. 98, 1004-1009
38. Hollenberg, A. N., Susulic, V. S., Madura, J. P., Zhang, B., Moller, D. E., Tontonoz, P., Sarraf, P., Spiegelman, B. M., and Lowell, B. B. (1997) J. Biol. Chem. 272, 5283-5290
39. Zhang, B., Graziano, M. P., Doebber, T. W., Leibowitz, M. D., White-Carrington, S., Szalkowski, D. M., Hey, P. J., Wu, M., Cullinan, C. A., Bailey, P., Lollmann, B., Frederich, R., Flier, J. S., Strader, C. D., and Smith., R. G. (1996) J. Biol. Chem. 271, 9455-9459
40. Peraldi, P., Xu, M., and Spiegelman, B. M. (1997) J. Clin. Invest. 100, 1863-1869
41. Martin, G., Schoonjans, K., Lefebvre, A.-M., Staels, B., and Auwerx, J. (1997) J. Biol. Chem. 272, 28210-28217
42. Parks, K. S., Ciaraldi, T. P., Abrams-Carter, L., Mudaliar, S., Nikoulina, S. E., and Henry, R. R. (1997) Diabetes 46, 1230-1234
43. Blanco, J. C., Minucci, S., Lu, J., Yang, X. J., Walker, K. K., Chen, H., Evans, R. M., Nakatani, Y., and Ozato, K. (1998) Genes Dev. 12, 1638-1651
44. Korzus, E., Torchia, J., Rose, D. W., Xu, L., Kurokawa, R., McInerney, E. M., Mullen, T. M., Glass, C. K., and Rosenfeld, M. G. (1998) Science 279, 703-707
45. Zhang, J., Zamir, I., and Lazar, M. A. (1997) Mol. Cell. Biol. 17, 6887-6897