Regulation of Bone Mass in Mice by the Lipoxygenase Gene Alox15

Science

Volumn 303, Issue 5655, 2004, Pages 229-232

  Klein, Robert F ^a,b   Allard, John ^c   Avnur, Zafrira ^c   Nikolcheva, Tania ^c   Rotstein, David ^c   Carlos, Amy S ^a,b   Shea, Marie ^a   Waters, Ruth V ^c   Belknap, John K ^a,b   Peltz, Gary ^c   Orwoll, Eric S ^a,b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b PORTLAND VA MEDICAL CENTER   (United States)

^c Roche Palo Alto ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; DRUG THERAPY; ENZYME INHIBITION; GENETIC ENGINEERING; PHARMACODYNAMICS;

BIOCHEMICAL PATHWAYS; PHARMACOLOGY;

BIOMEDICAL ENGINEERING;

LIPOXYGENASE; LIPOXYGENASE INHIBITOR;

BONE; GENE; MASS; RODENT;

ALOX15 GENE; ANIMAL CELL; ARTICLE; BONE DENSITY; BONE DEVELOPMENT; BONE MASS; BONE MINERAL; CONTROLLED STUDY; DRUG TARGETING; ENVIRONMENTAL FACTOR; GENE; GENE CONTROL; GENOMICS; HEREDITY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; OSTEOPOROSIS; PRIORITY JOURNAL;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; BONE DENSITY; BONE MARROW CELLS; CELL DIFFERENTIATION; CELLS, CULTURED; CROSSES, GENETIC; ENZYME INHIBITORS; FEMALE; FLUORENES; GENE EXPRESSION PROFILING; KIDNEY; LINKAGE (GENETICS); MALE; MICE; MICE, INBRED C57BL; MICE, INBRED STRAINS; MICE, KNOCKOUT; MICE, TRANSGENIC; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; OSTEOBLASTS; OSTEOGENESIS; OSTEOPOROSIS; POLYMORPHISM, GENETIC; QUANTITATIVE TRAIT LOCI; RATS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; STROMAL CELLS; TRANSCRIPTION FACTORS;

ANIMALIA; RODENTIA;

EID: 9144272249     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1090985     Document Type: Article

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