Novel chemical strategies for thymidylate synthase inhibition

Current Medicinal Chemistry

Volumn 12, Issue 2, 2005, Pages 191-202

  Gmeiner, W H ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

Author keywords

5FU; Antifolates; Cancer chemotherapy; Structure based drug design; Thymidylate synthase

Indexed keywords

10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; 2 DEAMINO 2 METHYL 10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; 2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; ANTINEOPLASTIC AGENT; ANTISENSE OLIGODEOXYNUCLEOTIDE; CAPECITABINE; CLOXURIDINE; DRUG METABOLITE; FLOXURIDINE; FLOXURIDINE DERIVATIVE; FLOXURIDINE PHOSPHATE; FLUOROURACIL; FOLIC ACID; FOLIC ACID ANTAGONIST; FOLINIC ACID; GLYCERALDEHYDE 3 PHOSPHATE; GS 7904L; GW 1843; LIPOSOME; MESSENGER RNA; METESIND GLUCURONATE; METHOTREXATE; METHYLENETETRAHYDROFOLIC ACID; N [4 [N [(3,4 DIHYDRO 2,7 DIMETHYL 4 OXO 6 QUINAZOLINYL)METHYL] N (2 PROPYNYL)AMINO] 2 FLUOROBENZOYL]GLUTAMIC ACID; NOLATREXED; OLIGODEOXYNUCLEOTIDE; PEMETREXED; PLEVITREXED; PRODRUG; PYRIDOXAL 5 PHOSPHATE; RALTITREXED; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER; CANCER CHEMOTHERAPY; CATALYSIS; CELL DESTRUCTION; CLINICAL TRIAL; COMPLEX FORMATION; COVALENT BOND; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG EFFICACY; DRUG FORMULATION; DRUG METABOLISM; DRUG PENETRATION; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SYNTHESIS; DRUG TRANSPORT; ENZYME INHIBITION; ENZYME REGULATION; GASTROINTESTINAL TOXICITY; HUMAN; LIVER TOXICITY; NEPHROTOXICITY; NONHUMAN; PROTEIN TARGETING; REDUCTION; REVIEW; TUMOR CELL;

EID: 11844276615     PISSN: 09298673     EISSN: None     Source Type: Journal    
DOI: 10.2174/0929867053363432     Document Type: Review

References (151)

1. Chu, E.; Callender, M.A.; Farrell, M.P.; Schmitz, J.C. Cancer Chemother. Pharmacol., 2003, 52 (suppl l), S80.
2. Danenberg, P.V.; Malli, H.; Swenson, S. Semin. Oncol. 2001,3 26, 621.
3. Rustum, Y.M.; Harstrick, A.; Cao, S.; Vanhoefer, U.; Yin, M.B.; Wilke, H; Seeber, S. J. Clin. Oncol., 2003, 15, 389.
4. Touroutoglou, N.; Pazdur, R. Clin. Cancer Res., 1996 2, 227.
5. Heidelberger, C.; Chaudhuri, N.K.; Danenberg, P.; Mooren, D.; Griesbach, L.; Duschinsky, R.; Schnitzer, R.J.; Pleven, E.; Schreiner, J. Nature, 1957, 179, 663.
6. Grem, J. Invest. New Drugs, 2000, 18, 299.
7. Longley, D.B.; Harkin, D.P.; Johnston, P.G. Nature Cancer 2003, 3, 330.
8. Jackman, A.L.; Theti, D.S.; Gibbs, D.D. Adv. Drug Deliv. Rev., 2004, 56, 1111.
9. Bavetsias, V; Jackman, A.L. Curr. Med. Chem., 1998 5, 265.
10. Jackman, A.L.; Melin, C.J.; Kimbell, R.; Brunton, L.; Aherne, G.W.; Theti, D.S.; Walton, M. Biochim. Biophys. Acta, 2002, 1587, 215.
11. Ju, J.; Kane, S.E.; Lenz, H.J.; Danenberg, K.D.; Chu, E.; Danenberg, P.V. Clin. Cancer Res., 1998, 4, 2229.
12. Berg, R.W.; Ferguson, P.J.; Vincent, M.D.; Koropatnick, D.J. Cancer Gene Ther., 2003, 10, 278.
13. Lin, S.B.; Ts'o, P.O.; Sun, S.K.; Choo, K.B.; Yang, F.Y.; Lim, Y.P.; Tsai, H.L.; Au, L.C. Mol. Pharmacol., 2001, 60 474.
14. Gmeiner, W.H. Cancer Watch, 1995, 4, 120.
15. Gmeiner, W.H.; Sahasrabudhe, P.; Pon, R.T.; Sonntag, J.; Srinivasan, S.; Iversen, P.L. Nucl. Nuct., 1995, 14, 243.
16. Liu, C.; Willingham, M.; Liu, J.; Gmeiner, W.H. Intl. J. Oncol., 2002, 21, 303.
17. Liu, J.; Skradis, A.; Kolar, C.; Kolath, J.; Anderson, J.; Lawson, T.; Talmadge, J.; Gmeiner, W.H. Nucl. Nuct., 1999, 18, 1789.
18. Liu, J.; Kolath, J.; Anderson, J.; Kolar, C.; Lawson, T.; Talmadge, J.; Gmeiner, W.H. Antisense Nucl. Acid Drug Des., 1999 9, 481-485.
19. Liu, J.; Kolar, C.; Lawson, T.A.; Gmeiner, W.H. J. Org. Chem., 2001, 66, 5655.
20. Carreras, C.W.; Santi, D.V. Annu. Rev. Biochem., 1995, 64, 721.
21. Mathews, C.K.; van Holde, K.E. Biochemistry. Benjamin/Cummings: Redwood City, CA, 1990.
22. Hatse, S.; De Clercq, E.; Balzarini, J. Biochem. Pharm. 1999, 58, 539.
23. van Triest, B.; Pinedo, H.M.; Giaccone, G.; Peters, G.J. Ann. Oncol., 2000, 11, 385.
24. Costi, M.P.; Tondi, D.; Rinaldi, M.; Barlocco, D.; Pecorari, P.; Soragni, F.; Venturelli, A.; Stroud, R.M. Biochim. Biophys. Acta 2002, 1587, 206.
25. Deng, T.L.; Li, D.W.; Jenh, C.H.; Johnson, L.F. J. Biol. Chem., 1986, 261, 16000.
26. Davisson, V.J.; Sirawaraporn, W.; Santi, D.V.; J. Biol. Chem., 1989, 264, 9145.
27. Anderson, A.C.; Perry, K.M.; Freymann, D.M.; Stroud, R.M. J. Mol. Biol., 2000, 297, 645.
28. Anderson, A.C.; O'Neil, R.H.; DeLano, W.L.; Stroud, R.M. Biochemistry, 1999, 38, 13829.
29. Maley, F.; Pedersen-Lane, J.; Changchian, L. Biochemistry 1995, 34, 1469.
30. Stroud, R.M.; Finer-Moore, J.S. Biochemistry, 2003 42, 239.
31. Liu, Y.; Barrett, J.E.; Schultz, P.G.; Santi, D.V. Biochemistry, 1999, 38, 848.
32. Ahmad, S.I.; Kirk, S.H.; Eisenstark, A. Annu. Rev. Microbiol., 1998, 52, 591.
33. Sat, B.; Reches, M.; Engelberg-Kulka, H. J. Bacteriology 2003, 185, 1803.
34. Houghton, J.A.; Harwood, F.G.; Tillman, D.M. Proc. Natl. Acad. Sci. USA, 1997, 94, 8144.
35. Tillman, D.M.; Petak, I.; Houghton, J.A. Clin. Cancer Res. 1999, 5, 425.
36. Petak, I.; Tillman, D.M.; Harwood, F.G.; Mihalik, R.; Houghton, J.A. Cancer Res., 2000, 60, 2643.
37. Ladner, R.D. Curr. Protein Pep. Sci., 2001, 2 361.
38. Dinner, A.R.; Blackburn, G.M.; Karplus, M. Nature, 2001, 413, 752.
39. Ingraham, H.A.; Dickey, L.; Goulian, M. Biochemistry, 1986, 25, 3225.
40. Valerie, K.; Povirk, L.F. Oncogene, 2003, 22 5792.
41. Myllykallio, H.; Lipowski, G.; Leduc, D.; Filee, J.; Forterre, P.; Liebl, U. Science, 2002, 297, 105.
42. Sotelo-Mundo, R.R.; Ciesla, J.; Dzik, J.M.; Rode, W.; Maley, F.; Maley, G.F.; Hardy, L.W.; Montfort, W.R. Biochemistry, 1999 38, 1087.
43. Santi, D.V.; McHenry, C.S. Proc. Natl. Acad. Sci. USA, 1972, 69, 1855.
44. Santi, D.V.; McHenry, C.S.; Sommer, H. Biochemistry, 1974, 13, 471.
45. Danenberg, P.V.; Danenberg, K.D. Biochemistry, 1978 17, 4018.
46. Danenberg, K.D.; Danenberg, P.V. Evidence for a sequential interaction of the subunits of thymidylate synthetase. J. Biol. Chem. 1979, 254, 4345.
47. Jackman, A.L.; Boyle, F.T.; Harrap, K.R. Invest. New Drugs 1996, 14, 305.
48. Jackson, R.C.; Jackman, A.L.; Calvert, A.H. Biochem. Pharmacol., 1983, 32, 3783.
49. Bird, O.D.; Vaitkus, J.W.; Clarke, J. Mol. Pharm., 1970, 6, 573.
50. Hynes, J.B.; Eason, D.E.; Garret, C.M.; Colvin Jr., P.L., Shores, K.E.; Freisheim, J.H. J. Med. Chem., 1977, 20, 588.
51. Calvert, A.H.; Alison, D.L.; Harland, S.J.; Robinson, B.A.; Jackman, A.L.; Jones, T.R.; Newell, D.R.; Siddik, Z.H.; Wiltshaw, E.; McElwain, T.J.; Smith, I.E.; Harrap, K.R. J. Clin. Oncol., 1986 4, 1245.
52. Jones, T.R.; Thornton, T.J.; Flinn, A.; Jackman, A.L.; Newell, D.R.; Calvert, A.H. J. Med. Chem., 1989, 32, 847.
53. Hughes, L.R.; Jackman, A.L.; Oldfield, J.; Smith, R.C.; Burrows, K.D.; Marsham, P.R.; Bishop, J.A.; Jones, T.R.; O'Connor, B.M.; Calvert, A.H. J. Med. Chem., 1990, 33, 3060.
54. Jackman, A.L.; Taylor, G.A.; O'Connor, B.M.; Bishop, J.A.; Moran, R.G.; Calvert, A.H. Cancer Res., 1990, 50, 5212.
55. Jackman, A.L.; Newell, D.R.; Gibson, W.; Jodrell, D.I.; Taylor, G.A.; Bishop, J.A.; Hughes, L.R.; Calvert, A.H. Biochem. Pharm., 1991, 42, 1885.
56. Jackman, A.L.; Marsham, P.R.; Moran, R.G.; Kimbell, R.; O'Connor, B.M.; Hughes, L.R.; Calvert, A.H. Adv. Enzyme Regul., 1991, 31, 13.
57. Jackman, A.L.; Farrugia, D.C.; Gibson, W.; Kimbell, R.; Harrap, K.R.; Stephens, T.C.; Azab, M.; Boyle, F.T. Eur. J. Cancer, 1995, 31, 1277.
58. Farrugia, D.C.; Aherne, G.W.; Brunton, L.; Clarke, S.J. Jackman, A.L. Clin. Cancer Res., 2000, 6, 3646.
59. Jackman, A.L.; Kimbell, R.; Aherne, G.W.; Brunton, L.; Jansen, G.; Stephens, T.C.; Smith, M.N.; Wardleworth, J.M.; Boyle, F.T. Clin. Cancer Res., 1997, 3, 911.
60. Rhee, M.S.; Wang, Y.; Nair, M.G.; Galivan, J. Acquisition of resistance to antifolates caused by enhanced gamma-glutamyl hydrolase activities. Cancer Res., 1993, 53, 2227.
61. Worm, J.; Kirkin, A.F.; Dzhandzhugazyan, K.N.; Guldberg, P. J. Biol. Chem., 2001, 276, 39990.
62. Cole, P.D.; Kamen, B.A.; Gorlick, R.; Banerjee, D.; Smith, A.K.; Magill, E.; Bertino, J.R. Cancer Res., 2001, 61, 4599.
63. Liani, E.; Rothem, L.; Bunni, M.A.; Smith, C.A.; Jansen, G.; Assaraf, Y.G. Int. J. Cancer, 2003, 103, 587.
64. Tse, A.; Moran, R.G. J. Biol. Chem., 1998, 273 25944.
65. Bavetsias, V.; Jackman, A.; Kimbell, R.; Gibson, W.; Boyle, F.T.; Bisset, G.M.F. J. Med. Chem., 1996, 39, 73.
66. Bisset, G.M.F.; Bavetsias, V.; Thornton, T.J.; Pawelczak, K.; Calvert, A.H.; Hughes, L.R.; Jackman, A. J. Med. Chem., 1994, 37, 3294.
67. deJonge, M.J.A.; Punt, C.J.A.; Sparreboom, A.; Planting, A.S.T.; Peters, M.E.W.J.; van de Schraaf, J.; Jackman, A.; de Mulder, H.M.; Verweij, J. J. Clin. Oncol., 2002, 20, 1923.
68. Marsham, P.R.; Wardleworth, J.M.; Boyle, F.T.; Hennequin, L.F.; Kimbell, R.; Brown, M.; Jackman, A.L. J. Med. Chem., 1999 42, 3809.
69. Marsham, P.R.; Jackman, A.L.; Barker, A.J.; Boyle, F.T.; Pegg, S.J.; Wardleworth, J.M.; Kimbell, R.; O'Connor, B.M.; Calvert, A.H.; Hughes, L.R. J. Med. Chem., 1995, 38, 994.
70. Matthews, D.A.; Appelt, K.; Oatley, S.J.; Xuong, N.H. J. Mol. Biol., 1990, 214, 923.
71. Montfort, W.R.; Perry, K.M.; Fauman, E.B.; Finer-Moore, J.S.; Maley, G.F.; Hardy, L.; Maley, F.; Stroud, R.M. Biochemistry, 1990, 29, 6964.
72. Bavetsias, V.; Marriott, J.H.; Melin, C.; Kimbell, R.; Matusiak, Z.S.; Boyle, F.T.; Jackman, A.L. J. Med. Chem., 2000 43, 1910.
73. Appelt, K.; Bacquet, R.J.; Bartlett, C.A. ; Booth, C.L.J. ; Freer, S.T.; Fuhry, M.A.M.; Gehring, M.R.; Herrmann, S.M.; Howland, E.F.; Janson, C.A.; Jones, T.R.; Kan, C-C.; Kathardekar, V.; Lewis, K.K.; Marzoni, G.P.; Matthews, D.A.; Mohr, C.; Moomaw, E.W.; Morse, C.A.; Oatley, S.J.; Ogden, R.C.; Rami Reddy, M.; Reich, S.H.; Schoetllin, W.S.; Smith, W.W.; Varney, M.D.; Villafranca, J.E.; Ward, R.W.; Webber, S.; Webber, S.E.; Welsh, K.M.; White, J. J. Med. Chem., 1991, 34, 1925.
74. O'Dwyer, P.J.; Laub, P.B.; DeMaria, D.; Qian, M.; Reilly, D.; Giantonio, B.; Johnston, A.L.; Wu, E.Y.; Bauman, L.; Clendeninn, N.J.; Gallo, J.M. Clin. Cancer Res., 1996, 2, 1685.
75. Webber, S.E.; Bleckman, T.M.; Attard, J.; Deal, J.G.; Kathardekar, V.; Welsh, K.M; Webber, S.; Janson, C.A.; Matthews, D.M.; Smith, W.W.; Freer, S.T.; Jordan, S.R.; Bacquet, R.J.; Howland, E.F.; Booth, C.L.J.: Ward, R.W.; Hermann, S.M.; White, J.; Morse, C.A.; Hilliard, J.A.; Bartlett, C.A. J. Med. Chem., 1993, 36, 733.
76. Webber, S.; Bartlett, C.A.; Boritzki, T.J.; Hilliard, J.A.; Howland, E.F.; Johnston, A.L; Kosa, M; Margosiak, S.A.; Morse, C.A.; Shetty, B.V. Cancer Chemother. Pharmacol., 1996, 37, 509.
77. Stewart, K.; Tessitore, J.; Rudy, J.; Clendennin, N.; Johnston, A. Cancer, 1999, 86, 410.
78. Tondi, D.; Slomczynska, U.; Costi, M.P.; Watterson, D.M.; Ghelli, S.; Shoichet, B.K. Chem. Biol., 1999, 6, 319.
79. Kim, S-G.; Yoon, C-J.; Kim, S-H.; Cho, Y-J.; Kang, D-I. Bioorg. Med. Chem., 2000, 8, 11.
80. Schiffer, C.; Clifton, I.; Davisson, V.J.; Santi, D.V.; Stroud, R.M. Biochemistry, 1995, 34, 16279.
81. Almog, R.; Waddling, C.A.; Maley, F.; Maley, G.F.; van Roey, P. Protein Sci., 2001, 10, 988.
82. Phan, J.; Koli, S.; Minor, W.; Dunlap, R.B.; Berger, S.; Lebioda, L. Biochemistry, 2001, 40, 1897.
83. Tong, Y.; Liu-Chen, X.; Ercikan-Abali, E.A.; Zhao, S-C.; Banerjee, D.; Maley, F.; Bertino, J.R. J. Biol. Chem., 1998, 273, 31209.
84. Fantz, C.; Shaw, D.; Jennings, W.; Forsthoetel, A.; Kitchens, M.; Phan, J.; Minor, W.; Lebioda, L.; Berger, F.G.; Spencer, H.T. Mol. Pharm., 2000, 57, 359.
85. Sapse, D.S.; Tong, Y.; Bertino, J.R.; Sapse, A-M. Cancer Invest., 1999, 17, 396.
86. Gangjee, A.; Vidwans, A.; Elzein, E.; McGuire, J.J.; Queener, S.F.; Kisliuk. J. Med. Chem., 2001, 44, 1993.
87. Gangjee, A.; Yu, J.; J.J.McGuire, J.J.; Cody, V.; Galitsky, N.; Kisliuk, R.L.; Queener, S.F. J. Med. Chem., 2000, 43 3837.
88. John, W.; Picus, J.; Blanke, C.D.; Clark, J.W.; Schulman, L.N.; Rowinsky, E.K., Thornton, D.E.; Loehrer, P.L. Cancer, 2000 88, 1807.
89. Sigmond, J.; Backus, H.H.; Wouters, D.; Temmink, O.H.; Jansen, G.; Peters, G.J. Biochem. Pharmacol., 2003, 66, 431.
90. Wang, Y.; Zhao, R.; Goldman, I.D. Biochem. Pharmacol., 2003, 65, 1163.
91. Pendergast, W.; Dickerson, S.H.; Johnson, J.V.; Dev, I.K.; Ferone, R.; Duch, D.S.; Smith, G.K. J. Med. Chem., 1993, 36, 3464.
92. Pendergast, W.; Dickerson, S.H.; Dev, I.K.; Ferone, R.; Duch, D.S.; Smith, G.K. J. Med. Chem., 1994, 37, 838.
93. Hanlon, M.H.; Ferone, R. Cancer Res., 1996, 56 3301.
94. Duch, D.S.; Banks, S.; Dev, I.K.; Dickerson, S.H.; Ferone, R.: Heath, L.S.; Humphreys, J.; Knick, V.; Pendergast, W.; Singer, S. Cancer Res., 1993, 53, 4810.
95. Weichsel, A.; Montfort, W.R.; Ciesla, J.; Maley, F. Proc. Natl. Acad. Sci. USA, 1995, 92, 3493.
96. [96]Chen, C-H.; Davis, R.A.; Maley, F. Biochemistry, 1996, 35, 8786.
97. Banks, S.D.; Waters, K.A.; Barrett, L.L.; Dickerson, S.; Pendergast, W.; Smith, G.K. Cancer Chemother. Pharmacol., 1994 33, 455.
98. [98]Kalman, T.I. Biochem. Biophys. Res. Commun., 1972, 49, 1007.
99. Kalman, T.I.; Nie, Z. Nucl. Nuct. Nucl. Acids, 2000 19, 357.
100. Stroud, R.M.; Finer-Moore, J.S. FASEB J., 1993, 7, 671.
101. Phan, J.; Mahdavian, E.; Nivens, M.C.; Wladek, M.; Berger, S.; Spencer, H.T.; Dunlap, R.B.; Lebioda, L. Biochemistry, 2000 39, 6969.
102. Montfort, W.R.; Weichsel, A. Pharmacol. Ther., 1997 76, 29.
103. Wataya, Y.; Santi, D.V. J. Am. Chem. Soc., 1977, 99, 4534.
104. Brandon, M.L.; Mi, L-J.; Chaung, W.; Teebor, G.; Boorstein, R.J. Mutation Res., 2000, 459, 161.
105. Garrett, C.; Wataya, Y.; Santi, D.V. Biochemistry, 1979, 18, 2798.
106. Matsuda, A.; Wataya, Y.; Santi, D.V. Biochem. Biophys. Res. Commun., 1978, 84, 654.
107. van der Wilt, C.L.; Smid, K.; Peters, G.J. Biochem. Pharm. 2002, 64, 669.
108. Eckstein, J.W.; Foster, P.G.; Finer-Moore, J.; Wataya, Y.; Santi, D.V. Biochemistry, 1994, 33, 15086.
109. Danenberg, P.V.; Heidelberger, C. J. Med. Chem., 1973, 16, 712.
110. Fujiwara, W.; Oki, T.; Heidelberger, C. Mol. Pharmacol. 1970, 6, 281.
111. Barr, P.J.; Robins, M.J.; Santi, D.V. Biochemistry, 1983, 22, 1696.
112. Barr, P.J.; Nolan, P.A.; Santi, D.V.; Robins. M.J. J. Med. Chem., 1981, 24, 1385.
113. Danenberg, P.V.; Bhatt, R.S.; Kundu, N.G.; Danenberg, K.; Heidelberger, C. J. Med. Chem., 1981, 24, 1537.
114. Barr, P.J.; Oppenheimer, N.J.; Santi, D.V. J. Biol. Chem. 1983, 258, 13627.
115. Li, Q.; Boyer, C.; Lee, J.Y.; Shepard, H.M. Mol. Pharm. 2001, 59, 446.
116. Kalman, T.I.; Nie, Z.; Kamat, A. Bioorg. Med. Chem. Lett. 2000, 10, 391.
117. Saxl, R.L.; Reston, J.; Nie, Z.; Kalman, T.I.; Maley, F. Biochemistry, 2003, 42, 4544.
118. Liu, L.; Santi, D.V. Biochim. Biophys. Acta, 1994 1209, 89.
119. Jarmula, A.; Anulewicz, R.; Les, A.; Cyranski, M.K.; Adamowicz, L.; Bretner, M.; Felczak, K.; Kulikowski, T.; Krygowski, T.M; Rode, W. Biochim. Biophys. Acta, 1998, 1382, 277.
120. Santi, D.V.; Ouyang, T.M.; Tan, A.K.; Gregory, D.H.; Scanlan, T.; Carreras, C.W. Biochemistry, 1993, 32, 11819.
121. Bures, A.K.; Daron, H.H.; Aull, J.L. Int. J. Biochem., 1991, 23, 733.
122. Phelps, M.E.; Woodman, P.W.; Danenberg, P.V. J. Med. Chem. 1980, 23, 1229.
123. Tobias, S.C.; Borch, R.F. J. Med. Chem., 2001, 44, 4475.
124. Freel Meyers, C.L.; Hong, L.; Joswig, C.; Borch, R.F. J. Med. Chem., 2000, 43, 4313.
125. Farquhar, D.; Chen, R.; Khan, S. J. Med. Chem., 1995 38, 488.
126. Tosqullas, G.; Alvarez, K.; Dell'Aquilla, C.; Morvan, F. ; Vasseur, J.J.; Imbach, J.L.; Rayner, B. Nucl. Acids Res., 1998 26, 2069.
127. Mummenbrauer, T.; Janus, F.; Muller, B.; Weismuller, L.; Deppert, W.; Grosse, F. Cell, 1996, 85, 1089.
128. Mazur, D.J.; Perrino, F.W. J. Biol. Chem., 2001, 276, 17022.
129. Gmeiner, W.H.; Trump, E.; Wei, C. Nucl. Nuct. Nucl. Acids 2004, 23, 401.
130. Liao, Z-Y.; Sordet, O.; Zhang, H-L.; Kohlhagen, G.; Antony, S.; Gmeiner, W.H.; Pommier, Y. Submitted.
131. Paff, M.T.; Baccanari, D.P.; Davis, S.T.; Cao, S.; Tansik, R.L.; Rustum, Y.M.; Spector, T. Invest. New Drugs, 2000, 18, 365.
132. Pritchard, D.M.; Watson, A.J.M.; Potten, C.S.; Jackman, A.L.; Hickman, J.A. Proc. Natl. Acad. Sci. USA, 1997, 94, 1795.
133. Tiraby, M.; Cazaux, C.; Baron, M.; Drocourt, D.; Reynes, F.P.; Tiraby, G. FEMS Microbial Lett., 1998, 167, 41.
134. Ren, Q.; van Groeningen, J.V.; Hardcastle, A.; Aherne, G.W.; Geoffrey, F.; Allegra, C.J.; Johnston, P.G.; Grem, J.L. Oncology Res. 1997, 9, 77.
135. Hoff, P.M. Semin. Oncol., 2003, 30, 88.
136. Uchida, M.; Brown, N.; Ho, D.H.W. Anticancer Res., 1990, 10, 779.
137. Ikemoto, S.; Sugimura, K.; Yoshida, N.; Kuratsukuri, K.; Wada, S.; Nakatani, T. Anticancer Res., 2002, 22, 4023.
138. Malet-Martino, M.; Martino, R. Oncologist, 2002, 7, 288.
139. Rohlff, C.; Watson, S.A.; Morris, T.M.; Skelton, L.; Jackman, A.L.; Page, M.J. Cancer Res., 1999, 59, 1268.
140. Matsuoka, K.; Tsukuda, K.; Suda, M.; Kobayashi, K.; Ota, T.; Okita, A.; Watanabe, K.; Suzuki, E.; Murikami, M.; Doihara, H.; Shimizu, N. Int. J. Oncol., 2004, 24, 217.
141. Berg, R.W.; Ferguson, P.J.; Vincent, M.D.; Koropatnick, D.J. Cancer Gene Ther., 2003, 10, 278.
142. Ferguson, P.J.; DeMoor, J.M.; Vincent, M.D.; Koropatnick, J. Br. J. Pharm., 2001, 134, 1437.
143. Lin, S.B.; Ts'o, P.O.; Sun, S.K.; Choo, K.B.; Yang, F.Y.; Lim, Y.P.; Tsai, H.L.; Au, L.C. Mol. Pharmacol., 2001, 60 474.
144. Schmitz, J.C.; Yu, D.; Agrawal, S.; Chu, E. Nucl. Acids Res., 2001, 29, 415.
145. Ju, J.; Kane, S.E.; Lenz, H.J.; Danenberg, K.D.; Chu, E.; Danenberg, P.V. Clin. Cancer Res., 1998, 4, 2229.
146. Chu, J.; Dolnick, B.J. Biochim. Biophys. Acta, 2002 1587, 183.
147. Powell, C.M.H.; Rudge, T.L.; Zhu, Q.; Johnson, L.F.; Hansen, U. EMBO J., 2000, 19, 4665.
148. Wu, Q.; Dolnick, B.J. Mol. Pharm., 2003, 63 167.
149. Erlanson, D.A.; Braisted, A.C.; Raphael, D.R.; Randal, M. Stroud, R.M.; Gordon, E.M.; Wells, J.A. Proc. Natl. Acad. Sci. USA, 2000, 97, 9367.
150. Bal, G. CA Cancer J. Clin., 2001, 51, 11.
151. Rahman, L.; Voeller, D.; Rahman, M.; Lipkowitz, S.; Allegra, C.; Barrett, J.C.; Kaye, F.J.; Zajac-Kaye, M. Cancer Cell, 2004 5, 341.