Synthesis and biological studies of novel nucleoside phosphoramidate prodrugs

Journal of Medicinal Chemistry

Volumn 44, Issue 25, 2001, Pages 4475-4480

  Tobias, S C ^a   Borch, R F ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1,4 NAPHTHOQUINONE DERIVATIVE; 5 FLUORO 2' DEOXYURIDYL 2 (1,4 NAPHTHOQUINONYL)METHYL N METHYL N (4 CHLOROBUTYL)PHOSPHORAMIDATE; 5 FLUORO 2' DEOXYURIDYL 5 NITROFURFURYL N METHYL N (4 CHLOROBUTYL)PHOSPHORAMIDATE; ANTINEOPLASTIC AGENT; FLOXURIDINE PHOSPHATE; NITROFURAN DERIVATIVE; NUCLEOSIDE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; THYMIDINE KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; CYCLIZATION; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; IC 50; LEUKEMIA CELL LINE; MOUSE; NONHUMAN; STRUCTURE ACTIVITY RELATION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL DIVISION; CELL LINE; DRUG SCREENING ASSAYS, ANTITUMOR; ENZYME INHIBITORS; FLOXURIDINE; FLUORODEOXYURIDYLATE; MAGNETIC RESONANCE SPECTROSCOPY; MICE; PRODRUGS; THYMIDINE KINASE; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED; URIDINE MONOPHOSPHATE;

EID: 0035818889     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm010337r     Document Type: Article

References (16)

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