Human thymidylate synthase is in the closed conformation when complexed with dUMP and raltitrexed, an antifolate drug

Biochemistry

Volumn 40, Issue 7, 2001, Pages 1897-1902

  Phan, J ^a   Koli, S ^a   Minor, W ^b   Dunlap, R B ^a   Berger, S H ^a   Lebioda, L ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE PHOSPHATE; FOLIC ACID ANTAGONIST; RALTITREXED; THIOPHENE; THYMIDYLATE SYNTHASE;

ARTICLE; COLORECTAL CANCER; COMPLEX FORMATION; COVALENT BOND; CRYSTAL STRUCTURE; DRUG STRUCTURE; ENZYME CONFORMATION; ESCHERICHIA COLI; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN TARGETING;

BINDING SITES; COMPUTER SIMULATION; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; DIMERIZATION; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; LIGANDS; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; PROTEIN CONFORMATION; QUINAZOLINES; THIOPHENES; THYMIDYLATE SYNTHASE;

ESCHERICHIA COLI;

EID: 0035916215     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi002413i     Document Type: Article

References (26)