Probing the folate-binding site of human thymidylate synthase by site- directed mutagenesis: Generation of mutants that confer resistance to raltitrexed, Thymitaq, and BW1843U89

Journal of Biological Chemistry

Volumn 273, Issue 47, 1998, Pages 31209-31214

  Tong, Youzhi ^b   Liu Chen, Xinyue ^b   Ercikan Abali, Emine A ^a   Zhao, Shi Cheng ^a   Banerjee, Debabrata ^a   Maley, Frank ^c   Bertino, Joseph R ^a,b,d  

^a Department of Population Medicine and Diagnostic Sciences   (United States)

^b Graduate School of Medical Sciences   (United States)

^c State of New York Department of Health   (United States)

^d MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; ANTINEOPLASTIC AGENT; FLOXURIDINE; FOLIC ACID; FOLIC ACID ANTAGONIST; ISOLEUCINE; LEUCINE; METESIND GLUCURONATE; MUTANT PROTEIN; NOLATREXED; PHENYLALANINE; RALTITREXED; THYMIDYLATE SYNTHASE;

ANIMAL CELL; ARTICLE; BONE MARROW CELL; CANCER CHEMOTHERAPY; CATALYSIS; COLONY FORMING UNIT GM; CONTROLLED STUDY; DRUG BINDING SITE; DRUG CYTOTOXICITY; DRUG RESISTANCE; ENZYME KINETICS; GENE TRANSFER; HEMATOPOIETIC STEM CELL; HUMAN; HUMAN CELL; HYDROPHOBICITY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BINDING SITES; BONE MARROW CELLS; DRUG RESISTANCE; FOLIC ACID; FOLIC ACID ANTAGONISTS; GRANULOCYTES; HUMANS; INDOLES; ISOLEUCINE; KINETICS; MACROPHAGES; MICE; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; QUINAZOLINES; RECOMBINANT PROTEINS; STEM CELLS; THIOPHENES; THYMIDYLATE SYNTHASE;

ANIMALIA;

EID: 0032553309     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.47.31209     Document Type: Article

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