Crystal structures of rat thymidylate synthase inhibited by Tomudex, a potent anticancer drug

Biochemistry

Volumn 38, Issue 3, 1999, Pages 1087-1094

  Sotelo Mundo, Rogerio R ^a   Ciesla, Joanna ^b   Dzik, Jolanta M ^b   Rode, Wojciech ^b   Maley, Frank ^c   Maley, Gladys F ^c   Hardy, Larry W ^d,e   Montfort, William R ^a  

^a University of Arizona   (United States)

^b NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^c WADSWORTH CENTER   (United States)

^d UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^e ARQULE INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYSTEINE; RALTITREXED; THYMIDYLATE SYNTHASE; URIDINE PHOSPHATE;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME CONFORMATION; ENZYME INHIBITION; HYDROGEN BOND; LIGAND BINDING; PRIORITY JOURNAL;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BACTERIAL PROTEINS; CARCINOMA, HEPATOCELLULAR; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN CONFORMATION; QUINAZOLINES; RATS; RECOMBINANT PROTEINS; THIOPHENES; THYMIDYLATE SYNTHASE; TUMOR CELLS, CULTURED;

ESCHERICHIA COLI; MAMMALIA;

EID: 0033579809     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi981881d     Document Type: Article

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