Structure-based discovery and in-parallel optimization of novel competitive inhibitors of thymidylate synthase

Chemistry and Biology

Volumn 6, Issue 5, 1999, Pages 319-331

  Tondi, Donatella ^a,b   Slomczynska, Ursula ^a,c   Costi, M Paola ^b   Watterson, D Martin ^a   Ghelli, Stefano ^b   Shoichet, Brian K ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^c MetaPhore Pharmaceuticals   (United States)

Author keywords

Computer based inhibitor design; Enzyme specificity; In parallel synthesis; Structure based drug design

Indexed keywords

LACTOBACILLUS CASEI;

EID: 0033133969     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1074-5521(99)80077-5     Document Type: Article

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