Increased cytotoxicity and decreased in vivo toxicity of FdUMP[10] relative to 5-FU

Nucleosides and Nucleotides

Volumn 18, Issue 8, 1999, Pages 1789-1802

  Liu, Jinqian ^a   Skradis, Alan ^a   Kolar, Carol ^a   Kolath, Jeff ^a   Anderson, James ^a   Lawson, Terrence ^a   Talmadge, James ^a   Gmeiner, William H ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

FLOXURIDINE PHOSPHATE; FLUOROURACIL; FOLINIC ACID; RALTITREXED; THYMIDYLATE SYNTHASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CANCER INHIBITION; CELL PROLIFERATION; COLORECTAL TUMOR; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG STRUCTURE; GENE OVEREXPRESSION; MAXIMUM PERMISSIBLE DOSE; MOUSE; NONHUMAN;

ANIMALIA;

EID: 0032866247     PISSN: 07328311     EISSN: None     Source Type: Journal    
DOI: 10.1080/07328319908044843     Document Type: Article

References (25)

1. Cancer Facts and Figures, American Cancer Society, 1996.
2. Wolmark, N., Fisher, B., Rockette H., Redmond, C., Deutsch, M., Wickerham, D.L., Fisher, E.R., Caplan, R., Jones, J., Lerner, H., Lawrence, W., Prager, D., Wexler, M., Evans, J., Cruz, A., Dimitrov, N., Jochimsen, P. and other NSABP investigators. J. Natl. Cancer Inst. 1992, 80, 30-36.
3. Moertel, C.G., Fleming, T.R., Macdonald, J.S., Haller, D.G., Laurie, J.A., Goodman, P.J., Ungerleider, J.S., Emerson, W.A., Tormey, D.C., Glick, J.H., Veeder, M.H. and Mailliard, J.A. N. Eng. J. Med. 1990 322, 352-358.
4. Moertel, C.G., Fleming, T.R., Macdonald, J.S., Haller, D.G., Laurie, J.A., Tangen, C.M., Ungerleider, J.S., Emerson, W.A., Tormey, D.C., Glick, J.H., Veeder, M.H. and Mailliard, J.A. Ann. Int. Med. 1995, 122, 321-326.
5. Wolmark, N., Rockette, H., Fisher, B., Wickerham, D.L., Redmond, C., Fisher, E.R., Jones, J., Mamounas, E.P., Ore, L., Petrelli, N.J., Spurr, C.L., Dimitrov, N., Romond, E.H., Sutherland, C.M., Kardinal, C.G., Defusco, P.A. and Jochimsen, P. J. Clin. Oncol. 1993, 11, 1879-1887.
6. Brown, M.L., Nayfield, S.G., and Shibley, L.M. J. Natl. Canc. Inst. 1994, 86, 424-430.
7. Santi, D.V. and McHenry, C.S. Proc. Natl. Acad. Sci. USA 1972, 69, 1855-1857.
8. Houghton, J. A., Harwood, F.G., and Houghton, P.J. Cancer Res. 1994 54, 4967-4973.
9. Weckbecker, G. Pharmac. Ther. 1991, 50, 367-424.
10. Copur, S., Aiba, K., Drake, J.C., Allegra, C.J., and Chu, E. Biochem. Pharmacol. 1995 49, 1419-1426.
11. Jackman, A.L., Kelland, L.R., Kimbell, R., Brown, M., Gibson, W., Aherne, G.W., Hardcastle, A., and Boyle, F.T. Br. J. Cancer 1995, 71, 914-924.
12. Duch, D.S., Banks, S., Dev, I.K., Dickerson, S.H., Ferone, R., Heath, L.S., Humphreys, J., Knick, V., Pendergast, W., Singer, S., Smith, G.K., Waters, K. And Wilson, H.R. Cancer Res. 1993 53, 810-818.
13. Perigaud, C., Gosselin, G., Lefebvre, I., Giardet, J.-L., Benzaria, S., Barner, I. and Imbach, J.-L. Bioorg. Med. Chem. Lett 1993., 3, 2521-2526.
14. Giardet, J-L. "Prodrugues mononucleotidiques: Concept, synthese et potentialities e chimo-therapies antitumorale et antivirale" Thesis, University of Montpellier, Montpellier, France, 1995.
15. Fries, K.M., Joswig, C., and Borch, R.F. J. Med. Chem. 1995, 38, 2672-2680.
16. Montgomery, J.A., Thomas, H.J., Kisliuk, R.L., and Gaumont, Y. J. Med. Chem. 1978, 22, 109-111.
17. Gmeiner, W.H., Sahasrabudhe, P., Pon, R.T., Sonntag, J., Srinivasan, S., and Iversen, P.L. Nucl. Nuct. 1995, 14, 243-253.
18. Gmeiner, W.H. Cancer Watch 1995, 4, 120-121.
19. Gmeiner, W.H., Saharabudhe, P.V., and Pon, R.T. J. Org. Chem. 1994, 59, 5779-5783.
20. Damha, M.J., Giannaris, P.A., Zabarylo, S.V. Nucl. Acids Res. 1990, 18, 3813-3821.
21. Mulkins, M.A., Heidelberger, C. Cancer Res. 1982 42, 965-973.
22. Park, J-G., Oie, H.K., Sugarbaker, P.H., Henslee, J.G., Chen, T-R., Johnson, B.E., and Gazdar, A. Cancer Res. 1987 47, 6710-6718.
23. Senderoff, R.I., Weber, P.A., Smith, D.R., and Sokoloski, T.D. Invest. Opthamol. Vis. Sci. 1990, 31, 2572-2578.
24. Houghton, J.A., Weiss, K.D., Williams, L.G., Torrance, P.M. & Houghton, P.J. Biochem. Pharmacol. 1986, 35 ,1351-1358.
25. Tew, K.D., Houghton, P.J., and Houghton, J.A. "Preclinical and clinical modulation of anticancer drugs." CRC Press, Boca Raton, 1991.