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Volumn 17, Issue 6, 1999, Pages 396-401

Ab initio studies of some amino acid residue complexes with 4- mercaptopyridine as a model for Thymitaq (AG337), an inhibitor of thymidylate synthase

Author keywords

[No Author keywords available]

Indexed keywords

4 MERCAPTOPYRIDINE; ALANINE; GLYCINE; ISOLEUCINE; ISOPENTANE; METESIND GLUCURONATE; NOLATREXED; RALTITREXED; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0032813224     PISSN: 07357907     EISSN: None     Source Type: Journal    
DOI: 10.3109/07357909909021431     Document Type: Article
Times cited : (5)

References (8)
  • 1
    • 0029036377 scopus 로고
    • The catalytic mechanism and structure of thymidylate synthase
    • Carreras CW, Santi DV: The catalytic mechanism and structure of thymidylate synthase. Annu Rev Biochem 64:721-762, 1995.
    • (1995) Annu Rev Biochem , vol.64 , pp. 721-762
    • Carreras, C.W.1    Santi, D.V.2
  • 2
    • 0028853821 scopus 로고
    • Folate-based thymidylate synthase inhibitors as anticancer drug
    • Jackman AL, Calvert AH: Folate-based thymidylate synthase inhibitors as anticancer drug. Ann Oncol 6:931-971, 1995.
    • (1995) Ann Oncol , vol.6 , pp. 931-971
    • Jackman, A.L.1    Calvert, A.H.2
  • 3
    • 0025737742 scopus 로고
    • Design of enzyme inhibitors using iterative protein crystallographic analysis
    • Appelt, K, Bacquet RJ, Bartlett CA, et al: Design of enzyme inhibitors using iterative protein crystallographic analysis. J Med Chem 34:1925-1934, 1991.
    • (1991) J Med Chem , vol.34 , pp. 1925-1934
    • Appelt, K.1    Bacquet, R.J.2    Bartlett, C.A.3
  • 4
    • 0026554077 scopus 로고
    • Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase
    • Varney MD, Marzoni GP, Palmer CL, et al: Crystal-structure-based design and synthesis of benz[cd]indole-containing inhibitors of thymidylate synthase. J Med Chem 35:663-676, 1992.
    • (1992) J Med Chem , vol.35 , pp. 663-676
    • Varney, M.D.1    Marzoni, G.P.2    Palmer, C.L.3
  • 5
    • 0026589385 scopus 로고
    • Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis
    • Reich SH, Fuhry MAM, Pino MJ, et al: Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis. J Med Chem 35:847-858, 1992.
    • (1992) J Med Chem , vol.35 , pp. 847-858
    • Reich, S.H.1    Fuhry, M.A.M.2    Pino, M.J.3
  • 6
    • 9044239673 scopus 로고    scopus 로고
    • AG337, a novel lipophilic thymidylate synthase inhibitor: In vitro and in vivo preclinical studies
    • Webber SE, Bartlett CA. Boritzki TJ, et al: AG337, a novel lipophilic thymidylate synthase inhibitor: in vitro and in vivo preclinical studies. Cancer Chemother Pharmacol 37:509-517, 1996.
    • (1996) Cancer Chemother Pharmacol , vol.37 , pp. 509-517
    • Webber, S.E.1    Bartlett, C.A.2    Boritzki, T.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.