Conformational dynamics along an enzymatic reaction pathway: Thymidylate synthase, "the movie"

Biochemistry

Volumn 42, Issue 2, 2003, Pages 239-247

  Stroud, Robert M ^a   Finer Moore, Janet S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THYMIDYLATE SYNTHASE;

AMINO ACID SEQUENCE; ARTICLE; CATALYSIS; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; ENZYME CONFORMATION; ENZYME MECHANISM; ESCHERICHIA COLI; HUMAN; LACTOBACILLUS CASEI; LIGAND BINDING; MOLECULAR DYNAMICS; NONHUMAN; PRIORITY JOURNAL; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI PROTEINS; KINETICS; MODELS, MOLECULAR; PROTEIN CONFORMATION; THERMODYNAMICS; THYMIDYLATE SYNTHASE;

ESCHERICHIA COLI; LACTOBACILLUS CASEI;

EID: 0037457982     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi020598i     Document Type: Article

References (54)

1. Montfort, W. R., Perry, K. M., Fauman, E. B., Finer-Moore, J. S., Maley, G. F., Hardy, L., Maley, F., and Stroud, R. M. (1990) Biochemistry 29, 6964-6977.
2. Finer-Moore, J. S., Montfort, W. R., and Stroud, R. M. (1990) Biochemistry 29, 6977-6986.
3. Santi, D. V., McHenry, C. S., Raines, R. T., and Ivanetich, K. M. (1987) Biochemistry 26, 8606-8613.
4. Spencer, H. T., Villafranca, J. E., and Appleman, J. R. (1997) Biochemistry 36, 4212-4222.
5. Hardy, L. W., Finer-Moore, J. S., Montfort, W. R., Jones, M. O., Santi, D. V., and Stroud, R. M. (1987) Science 235, 448-455.
6. Matthews, D. A., Appelt, K., and Oatley, S. J. (1989) J. Mol. Biol. 205, 449-454.
7. Stout, T. J., Sage, C. R., and Stroud, R. M. (1998) Structure 6, 839-848.
8. Birdsall, D. L., Finer-Moore, J., and Stroud, R. M. (1996) J. Mol. Biol. 255, 522-535.
9. Poe, M., Jackman, L. M., and Benkovic, S. J. (1979) Biochemistry 18, 5527-5530.
10. Sage, C. R., Rutenber, E. E., Stout, T. J., and Stroud, R. M. (1996) Biochemistry 35, 16270-16281.
11. Sage, C. R., Michelitsch, M. D., Stout, T. J., Biermann, D., Nissen, R., Finer-Moore, J., and Stroud, R. M. (1998) Biochemistry 37, 13893-13901.
12. Jones, T. R., Calvert, A. H., Jackman, A. L., Brown, S. J., Jones, M., and Harrap, K. R. (1981) Eur. J. Cancer 17, 11-19.
13. Fritz, T. A., Liu, L., Finer-Moore, J. S., and Stroud, R. M. (2002) Biochemistry 41, 7021-7029.
14. Carreras, C. W., Naber, N., Cooke, R., and Santi, D. V. (1994) Biochemistry 33, 2071-2077.
15. Danenberg, P. V., Langenbach, R. J., and Heidelberger, C. (1974) Biochemistry 13, 926-933.
16. Santi, D. V., McHenry, C. S., and Sommer, H. (1974) Biochemistry 13, 471-481.
17. Donato, H., Jr., Aull, J. L., Lyon, J. A., Reinsch, J. W., and Dunlap, R. B. (1976) J. Biol. Chem. 251, 1303-1310.
18. Lockshin, A., and Danenberg, P. V. (1980) Biochemistry 19, 4244-4251.
19. Kamb, A., Finer-Moore, J. S., and Stroud, R. M. (1992) Biochemistry 31, 12876-12884.
20. Fauman, E. B. (1995) Conformational Change and Catalysis in Thymidylate Synthase, Ph.D. Thesis, pp 118-122, University of California, San Francisco.
21. Ghose, C., Oleinick, R., Matthews, R. G., and Dunlap, R. B. (1990) in Chemistry and Biology of Pteridines (Curtius, H.-C., Ghisla, S., and Blau, N., Eds.) pp 860-865, Walter de Gruyter and Co., Berlin.
22. Matthews, D. A., Villafranca, J. E., Janson, C. A., Smith, W. W., Welsh, K., and Freer, S. (1990) J. Mol. Biol. 214, 937-948.
23. Slieker, L. J., and Benkovic, S. J. (1984) J. Am. Chem. Soc. 106, 1833-1838.
24. Barrett, J. E., Lucero, C. M., and Schultz, P. G. (1999) J. Am. Chem. Soc. 121, 7965-7966.
25. Hyatt, D. C., Maley, F., and Montfort, W. R. (1997) Biochemistry 36, 4585-4594.
26. Fauman, E. B., Rutenber, E. E., Maley, G. F., Maley, F., and Stroud, R. M. (1994) Biochemistry 33, 1502-1511.
27. Huang, W., and Santi, D. V. (1997) Biochemistry 36, 1869-1873.
28. Bruice, T. W., and Santi, D. V. (1982) Biochemistry 21, 6703-6709.
29. Dev, I. K., Dallas, W. S., Ferone, R., Hanlon, M., McKee, D. D., and Yates, B. B. (1994) J. Biol. Chem. 269, 1873-1882.
30. Variath, P., Liu, Y., Lee, T. T., Stroud, R. M., and Santi, D. V. (2000) Biochemistry 39, 2429-2435.
31. Maley, F., Pedersen-Lane, J., and Changchien, L. (1995) Biochemistry 34, 1469-1474.
32. Saxl, R. L., Changchien, L. M., Hardy, L. W., and Maley, F. (2001) Biochemistry 40, 5275-5282.
33. Anderson, A. C., O'Neil, R. H., DeLano, W. L., and Stroud, R. M. (1999) Biochemistry 38, 13829-13836.
34. Montfort, W. R., and Weichsel, A. (1997) Pharmacol. Ther. 76, 29-43.
35. Matthews, D. A., Appelt, K., Oatley, S. J., and Xuong, N. H. (1990) J. Mol. Biol. 214, 923-936.
36. Anderson, A. C., O'Neil, R. H., Surti, T. S., and Stroud, R. M. (2001) Chem. Biol. 8, 445-457.
37. Phan, J., Koli, S., Minor, W., Dunlap, R. B., Berger, S. H., and Lebioda, L. (2001) Biochemistry 40, 1897-1902.
38. Sayre, P. H., Finer-Moore, J. S., Fritz, T. A., Biermann, D., Gates, S. B., MacKellar, W. C., Patel, V. F., and Stroud, R. M. (2001) J. Mol. Biol. 313, 813-829.
39. Fox, K. M., Maley, F., Garibian, A., Changchien, L. M., and Van Roey, P. (1999) Protein Sci. 8, 538-544.
40. Knighton, D. R., Kan, C. C., Howland, E., Janson, C. A., Hostomska, Z., Welsh, K. M., and Matthews, D. A. (1994) Nat. Struct. Biol. 1, 186-194.
41. Perry, K. M., Fauman, E. B., Finer-Moore, J. S., Montfort, W. R., Maley, G. F., Maley, F., and Stroud, R. M. (1990) Proteins 8, 315-333.
42. Finer-Moore, J. S., Maley, G. F., Maley, F., Montfort, W. R., and Stroud, R. M. (1994) Biochemistry 33, 15459-15468.
43. Stout, T. J., Schellenberger, U., Santi, D. V., and Stroud, R. M. (1998) Biochemistry 37, 14736-14747.
44. Schiffer, C. A., Clifton, I. J., Davisson, V. J., Santi, D. V., and Stroud, R. M. (1995) Biochemistry 34, 16279-16287.
45. Jackman, A. L., Jodrell, D. I., Gibson, W., and Stephens, T. C. (1991) Adv. Exp. Med. Biol. 309A, 19-23.
46. Sotelo-Mundo, R. R., Ciesla, J., Dzik, J. M., Rode, W., Maley, F., Maley, G. F., Hardy, L. W., and Montfort, W. R. (1999) Biochemistry 38, 1087-1094.
47. Almog, R., Waddling, C. A., Maley, F., Maley, G. F., and Van Roey, P. (2001) Protein Sci. 10, 988-996.
48. Phan, J., Steadman, D. J., Koli, S., Ding, W. C., Minor, W., Dunlap, R. B., Berger, S. H., and Lebioda, L. (2001) J. Biol. Chem. 276, 14170-14177.
49. Weichsel, A., and Montfort, W. R. (1995) Nat. Struct. Biol. 2, 1095-1101.
50. Stout, T. J., Tondi, D., Rinaldi, M., Barlocco, D., Pecorari, P., Santi, D. V., Kuntz, I. D., Stroud, R. M., Shoichet, B. K., and Costi, M. P. (1999) Biochemistry 38, 1607-1617.
51. Stout, T. J., and Stroud, R. M. (1996) Structure 4, 67-77.
52. Fritz, T. A., Tondi, D., Finer-Moore, J. S., Costi, M. P., and Stroud, R. M. (2001) Chem. Biol. 8, 981-995.
53. Anderson, A. C., Perry, K. M., Freymann, D. M., and Stroud, R. M. (2000) J. Mol. Biol. 297, 645-657.
54. Kraulis, P. J. (1991) J. Appl. Crystallogr. 24, 946-950.