The crystal structure of thymidylate synthase from Pneumocystis carinii reveals a fungal insert important for drug design

Journal of Molecular Biology

Volumn 297, Issue 3, 2000, Pages 645-657

  Anderson, Amy C ^a   Perry, Kathy M ^a   Freymann, Douglas M ^a   Stroud, Robert M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

AIDS; Anti fungal; Crystal structure; Drug design; Thymidylate synthase

Indexed keywords

10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; ANTIPROTOZOAL AGENT; DEOXYURIDINE PHOSPHATE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR;

ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA REPLICATION; DRUG DESIGN; DRUG SPECIFICITY; DRUG TARGETING; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME CONFORMATION; NONHUMAN; PNEUMOCYSTIS CARINII; PRIORITY JOURNAL; STRUCTURE ANALYSIS;

FUNGI; PNEUMOCYSTIS CARINII;

EID: 0034737311     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1006/jmbi.2000.3544     Document Type: Article

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