Mechanism-based inactivation of thymidylate synthase by 5-(3-fluoropropyn-1-yl)-2'-deoxyuridine 5'-phosphate

Bioorganic and Medicinal Chemistry Letters

Volumn 10, Issue 4, 2000, Pages 391-394

  Kalman, Thomas I ^a   Nie, Zhe ^a   Kamat, Ashwini ^a  

^a UNIVERSITY AT BUFFALO   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 FLUOROPROPYNYL 2' DEOXYURIDINE 5' PHOSPHATE; 5 METHYLTETRAHYDROFOLIC ACID; DEOXYURIDINE PHOSPHATE; IDOXURIDINE; PALLADIUM; THYMIDYLATE SYNTHASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL MODIFICATION; CHEMICAL REACTION KINETICS; DRUG SYNTHESIS; ENZYME INACTIVATION; FLUORINATION; PROTEIN PHOSPHORYLATION; REACTION ANALYSIS;

BINDING, COMPETITIVE; DEOXYURACIL NUCLEOTIDES; DIALYSIS; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; MODELS, MOLECULAR; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE;

EID: 0034696298     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(00)00012-3     Document Type: Article

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