Thermodynamic stabilization of nucleotide binding to thymidylate synthase by a potent benzoquinazoline folate analogue inhibitor

Biochemistry

Volumn 35, Issue 26, 1996, Pages 8786-8793

  Chen, Chang Hwei ^a   Davis, R Alan ^b   Maley, Frank ^a  

^a STATE UNIVERSITY OF NEW YORK   (United States)

^b UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; DEOXYGUANOSINE PHOSPHATE; DEOXYURIDINE PHOSPHATE; FLOXURIDINE PHOSPHATE; FOLIC ACID DERIVATIVE; QUINAZOLINE DERIVATIVE; THYMIDYLATE SYNTHASE;

ARTICLE; DIFFERENTIAL SCANNING CALORIMETRY; DNA SYNTHESIS; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME SUBSTRATE; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL; PROTEIN DNA BINDING; THERMODYNAMICS;

CALORIMETRY, DIFFERENTIAL SCANNING; FOLIC ACID ANTAGONISTS; INDOLES; NUCLEOTIDES; PROTEIN DENATURATION; QUINAZOLINES; SUBSTRATE SPECIFICITY; THERMODYNAMICS; THYMIDYLATE SYNTHASE;

EID: 0030011387     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi952953t     Document Type: Article

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