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Volumn 2, Issue 2, 1996, Pages 227-243

Thymidylate synthase inhibitors

Author keywords

[No Author keywords available]

Indexed keywords

10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; 2 [5 [[(1,2 DIHYDRO 3 METHYL 1 OXOBENZO[F]QUINAZOLIN 9 YL)METHYL]AMINO] 1 OXO 2 ISOINDOLINYL]GLUTARIC ACID; ENZYME INHIBITOR; METESIND GLUCURONATE; NOLATREXED; PEMETREXED; PLEVITREXED; RALTITREXED; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

EID: 0029928146     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (126)

References (145)
  • 1
    • 0023678551 scopus 로고
    • A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells
    • Ayusawa, D., Arai, H., Wataya, Y., and Sento, T. A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells. Mutat. Res., 200: 221-230, 1988.
    • (1988) Mutat. Res. , vol.200 , pp. 221-230
    • Ayusawa, D.1    Arai, H.2    Wataya, Y.3    Sento, T.4
  • 2
    • 0002685062 scopus 로고
    • Fluorinated pyrimidines
    • B. A. Chabner and J. M. Collins (eds.), Philadelphia: J. B. Lippincott Company
    • Grem, J. L. Fluorinated pyrimidines. In: B. A. Chabner and J. M. Collins (eds.), Cancer Chemotherapy: Principles and Practice, pp. 180-224. Philadelphia: J. B. Lippincott Company, 1990.
    • (1990) Cancer Chemotherapy: Principles and Practice , pp. 180-224
    • Grem, J.L.1
  • 4
    • 0020387526 scopus 로고
    • Recent progress in the medicinal chemistry of 2,4-diaminopyridines
    • Roth, B., and Cheng, C. C. Recent progress in the medicinal chemistry of 2,4-diaminopyridines. Prog. Med. Chem., 19: 269-331, 1982.
    • (1982) Prog. Med. Chem. , vol.19 , pp. 269-331
    • Roth, B.1    Cheng, C.C.2
  • 6
    • 0345606724 scopus 로고
    • Defective transport of amethopterin (methotrexate) as a mechanism of resistance to antimetabolites in L5178Y cells
    • Fischer, G. A. Defective transport of amethopterin (methotrexate) as a mechanism of resistance to antimetabolites in L5178Y cells. Biochem. Pharmacol., 11: 1233-1234, 1962.
    • (1962) Biochem. Pharmacol. , vol.11 , pp. 1233-1234
    • Fischer, G.A.1
  • 7
    • 0015246338 scopus 로고
    • Sites of action of amethopterin in intrinsic and acquired drug resistance
    • Harrap, K. R., Hill, B. T., Furness, M. E., and Hart, L. I. Sites of action of amethopterin in intrinsic and acquired drug resistance. Ann. NY Acad. Sci., 186: 312-324, 1971.
    • (1971) Ann. NY Acad. Sci. , vol.186 , pp. 312-324
    • Harrap, K.R.1    Hill, B.T.2    Furness, M.E.3    Hart, L.I.4
  • 8
    • 0014260034 scopus 로고
    • Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response
    • Kessel, D., Hall, T. C., and Roberts, D. Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response. Cancer Res. 28: 564-570, 1968.
    • (1968) Cancer Res. , vol.28 , pp. 564-570
    • Kessel, D.1    Hall, T.C.2    Roberts, D.3
  • 9
    • 0042438137 scopus 로고
    • Chemotherapeutic agents: Folate antagonists
    • J. F. Holland, E. Frei III, R. C. Bast, Jr., D. W. Dufe, D. Morton, and R. Weichselbaum (eds.), Philadelphia: Lea & Febiger
    • Bertino, J. R., and Romanini, A. Chemotherapeutic agents: folate antagonists. In: J. F. Holland, E. Frei III, R. C. Bast, Jr., D. W. Dufe, D. Morton, and R. Weichselbaum (eds.), Cancer Medicine, Vol. 1, pp. 698-711. Philadelphia: Lea & Febiger, 1993.
    • (1993) Cancer Medicine , vol.1 , pp. 698-711
    • Bertino, J.R.1    Romanini, A.2
  • 11
    • 0014800626 scopus 로고
    • Chemical carcinogenesis, chemotherapy: Cancer's continuing core challenges - G. H. A. Clowes Memorial Lecture
    • Heidelberger, C. Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges - G. H. A. Clowes Memorial Lecture. Cancer Res., 30: 1549-1569, 1970.
    • (1970) Cancer Res. , vol.30 , pp. 1549-1569
    • Heidelberger, C.1
  • 12
    • 0021331040 scopus 로고
    • 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity
    • Schuetz, J. D., Wallace, H. J., and Diasui, R. B. 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity. Cancer Res., 44: 1358-1363, 1984.
    • (1984) Cancer Res. , vol.44 , pp. 1358-1363
    • Schuetz, J.D.1    Wallace, H.J.2    Diasui, R.B.3
  • 13
    • 0026557953 scopus 로고
    • Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin
    • Peters, J. G., van Groeningen, C. J., Van der Wilt, C., Meijer, S., Smid, K., Laurensse, E., and Pinedo, H. M. Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. Semin. Oncol , 19 (2 Suppl. 3): 26-35, 1992.
    • (1992) Semin. Oncol , vol.19 , Issue.2 SUPPL. 3 , pp. 26-35
    • Peters, J.G.1    Van Groeningen, C.J.2    Van Der Wilt, C.3    Meijer, S.4    Smid, K.5    Laurensse, E.6    Pinedo, H.M.7
  • 14
    • 0022479537 scopus 로고
    • Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells
    • Keyomarsi, K., and Moran, R. G. Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res., 46: 5229-5235, 1986.
    • (1986) Cancer Res. , vol.46 , pp. 5229-5235
    • Keyomarsi, K.1    Moran, R.G.2
  • 15
    • 0028940399 scopus 로고
    • Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
    • Johnston, P. G., Lenz, H. J., Leichman, C. G., Danenberg, K., Allegra, C. J., Danenberg, P., and Leichman, L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res., 55: 1407-1412, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 1407-1412
    • Johnston, P.G.1    Lenz, H.J.2    Leichman, C.G.3    Danenberg, K.4    Allegra, C.J.5    Danenberg, P.6    Leichman, L.7
  • 16
    • 0026795489 scopus 로고
    • The immunological quantitation of thymidylate synthase using the monoclonal antibody TS106 in 5-FU-sensitive and -resistant human cancer cell lines
    • Johnston, P. G , Drake, J. C., Trepel, J., and Allegra, C. J. The immunological quantitation of thymidylate synthase using the monoclonal antibody TS106 in 5-FU-sensitive and -resistant human cancer cell lines. Cancer Res., 52: 4302-4312, 1992.
    • (1992) Cancer Res. , vol.52 , pp. 4302-4312
    • Johnston, P.G.1    Drake, J.C.2    Trepel, J.3    Allegra, C.J.4
  • 17
    • 0028019880 scopus 로고
    • Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: Implications for treatment with fluorouracil
    • Peters, G. J., van der Wilt, C. L., van Groeningen, C. J., Smid, K., Meijer, S., and Pinedo, H. M. Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. J. Clin. Oncol., 12: 2035-2042, 1994.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 2035-2042
    • Peters, G.J.1    Van Der Wilt, C.L.2    Van Groeningen, C.J.3    Smid, K.4    Meijer, S.5    Pinedo, H.M.6
  • 18
    • 0024413739 scopus 로고
    • Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
    • Swain, S. M., Lippman, M. E., Egan, E. F., Drake, J. C., Steinberg, S. M., and Allegra, C. J. Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer. J. Clin. Oncol., 7: 890-899, 1989.
    • (1989) J. Clin. Oncol. , vol.7 , pp. 890-899
    • Swain, S.M.1    Lippman, M.E.2    Egan, E.F.3    Drake, J.C.4    Steinberg, S.M.5    Allegra, C.J.6
  • 19
    • 0028151449 scopus 로고
    • The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
    • Johnston, P. G., Fisher, E. R., Rockette, H. E., Fisher, B., Wolmark, N., Drake, J. C., Chabner, B. A., and Allegra, C. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J. Clin. Oncol., 12: 2640-2647, 1994.
    • (1994) J. Clin. Oncol. , vol.12 , pp. 2640-2647
    • Johnston, P.G.1    Fisher, E.R.2    Rockette, H.E.3    Fisher, B.4    Wolmark, N.5    Drake, J.C.6    Chabner, B.A.7    Allegra, C.8
  • 20
    • 0025016121 scopus 로고
    • Methotrexate transport in variant human ccrf-cem leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates
    • Jansen, G., Westerhof, G. R., Jarmuszewski, M. J., Kathmann, I., Rijksen, G., and Schornagel, J. H. Methotrexate transport in variant human ccrf-cem leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates. J. Biol. Chem., 265: 18272-18277, 1990.
    • (1990) J. Biol. Chem. , vol.265 , pp. 18272-18277
    • Jansen, G.1    Westerhof, G.R.2    Jarmuszewski, M.J.3    Kathmann, I.4    Rijksen, G.5    Schornagel, J.H.6
  • 21
    • 0019449889 scopus 로고
    • Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro
    • Balinska, M., Galivan, J., and Coward, J. K. Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro. Cancer Res., 41: 2751-2756, 1981.
    • (1981) Cancer Res. , vol.41 , pp. 2751-2756
    • Balinska, M.1    Galivan, J.2    Coward, J.K.3
  • 22
    • 0015827958 scopus 로고
    • Studies on the uptake of synthetic conjugated folates by human marrow cells
    • Hoffbrand, A. V., Tripp, E., Houlihan, C. M., and Scott, J. M. Studies on the uptake of synthetic conjugated folates by human marrow cells. Blood., 42: 141-146, 1973.
    • (1973) Blood. , vol.42 , pp. 141-146
    • Hoffbrand, A.V.1    Tripp, E.2    Houlihan, C.M.3    Scott, J.M.4
  • 23
    • 0002538947 scopus 로고
    • Antineoplastic agents
    • A. Goodman Gilman, T. W. Rall, A. S. Nies, and P. Taylor (eds.), New York: Pergamon Press
    • Calabresi, P., and Chabner, B. A. Antineoplastic agents. In: A. Goodman Gilman, T. W. Rall, A. S. Nies, and P. Taylor (eds.), Goodman and Gilman's The Pharmacologic Basis of Therapeutics, pp. 1223-1227. New York: Pergamon Press, 1990.
    • (1990) Goodman and Gilman's the Pharmacologic Basis of Therapeutics , pp. 1223-1227
    • Calabresi, P.1    Chabner, B.A.2
  • 25
    • 0023121146 scopus 로고
    • Atomic structure of thymidylate synthase: Target for rational drug design
    • Washington DC
    • Hardy, L. W., Finer-Moore, J. S., Montfort, W. R., Jones, M. O., Santi, D. V., and Stroud, R. M. Atomic structure of thymidylate synthase: target for rational drug design. Science (Washington DC), 235: 448-455, 1987.
    • (1987) Science , vol.235 , pp. 448-455
    • Hardy, L.W.1    Finer-Moore, J.S.2    Montfort, W.R.3    Jones, M.O.4    Santi, D.V.5    Stroud, R.M.6
  • 26
    • 0025091668 scopus 로고
    • Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2-deoxyuridylate and 5,10-methylenetetrahydrofolate
    • Matthews, D. A., Villafranca, J. E., Janson, C. A., Smith, W. W., Welsh, K., and Freer, S. Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2-deoxyuridylate and 5,10-methylenetetrahydrofolate. J. Mol. Biol., 214: 937-948, 1990.
    • (1990) J. Mol. Biol. , vol.214 , pp. 937-948
    • Matthews, D.A.1    Villafranca, J.E.2    Janson, C.A.3    Smith, W.W.4    Welsh, K.5    Freer, S.6
  • 27
    • 0025311258 scopus 로고
    • Structure, multiple site binding, and segmentai accommodation in thymidylate synthase on binding dUMP and an anti-folate
    • Montfort, W. R., Perry, K. M., Fauman, E. C., Finer-Moore, J S., Maley, G. F., Hardy, L., Maley, F., and Stroud, R. M. Structure, multiple site binding, and segmentai accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry, 29: 6964-6977, 1990.
    • (1990) Biochemistry , vol.29 , pp. 6964-6977
    • Montfort, W.R.1    Perry, K.M.2    Fauman, E.C.3    Finer-Moore, J.S.4    Maley, G.F.5    Hardy, L.6    Maley, F.7    Stroud, R.M.8
  • 28
    • 0025149019 scopus 로고
    • Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolate
    • Matthews, D. A., Appelt, K., Oatley, S. J., and Xuong, N. H. Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolate. J. Mol. Biol., 214: 923-936, 1990.
    • (1990) J. Mol. Biol. , vol.214 , pp. 923-936
    • Matthews, D.A.1    Appelt, K.2    Oatley, S.J.3    Xuong, N.H.4
  • 29
    • 0025737742 scopus 로고
    • Design of enzyme inhibitors using iterative protein crystallographic analysis
    • Appelt, K., Bacquet, F. J., Bartlett, C. A., Booth, C. L. J., and Freer, S. T. Design of enzyme inhibitors using iterative protein crystallographic analysis. J. Med. Chem., 34: 1925-1934, 1991.
    • (1991) J. Med. Chem. , vol.34 , pp. 1925-1934
    • Appelt, K.1    Bacquet, F.J.2    Bartlett, C.A.3    Booth, C.L.J.4    Freer, S.T.5
  • 30
    • 0026794266 scopus 로고
    • Structural basis for recognition of polyglutamyl folates by thymidylate synthase
    • Kamb, A., Finer-Moore, J., Calvert, H., and Stroud, R. Structural basis for recognition of polyglutamyl folates by thymidylate synthase. Biochemistry, 31: 9883-9890, 1992.
    • (1992) Biochemistry , vol.31 , pp. 9883-9890
    • Kamb, A.1    Finer-Moore, J.2    Calvert, H.3    Stroud, R.4
  • 31
    • 0027102178 scopus 로고
    • Cofactor triggers the conformational change in thymidylate synthase: Implications for an ordered binding mechanism
    • Kamb, A., Finer-Moore, J. S., and Stroud, R Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism. Biochemistry, 31: 12876-12884, 1992.
    • (1992) Biochemistry , vol.31 , pp. 12876-12884
    • Kamb, A.1    Finer-Moore, J.S.2    Stroud, R.3
  • 32
    • 0024520834 scopus 로고
    • Stacked β-bulges in thymidylate synthase account for a novel right-handed rotation between opposing β sheets
    • Matthews, D. A., Appelt, K., and Oatley, S. J. Stacked β-bulges in thymidylate synthase account for a novel right-handed rotation between opposing β sheets. J. Mol Biol., 205: 449-454, 1989.
    • (1989) J. Mol Biol. , vol.205 , pp. 449-454
    • Matthews, D.A.1    Appelt, K.2    Oatley, S.J.3
  • 33
    • 0018786751 scopus 로고
    • Evidence for a sequential interaction of the subunits of thymidylate synthetase
    • Danenberg, K. D., and Danenberg, P. V. Evidence for a sequential interaction of the subunits of thymidylate synthetase. J Biol Chem., 254: 4335-4348, 1979.
    • (1979) J Biol Chem. , vol.254 , pp. 4335-4348
    • Danenberg, K.D.1    Danenberg, P.V.2
  • 34
    • 0027151834 scopus 로고
    • Stereochemistry of a multi-step/bipartite methyl transfer reaction: Thymidylate synthase
    • Stroud, R. M., and Finer-Moore, J. S. Stereochemistry of a multi-step/bipartite methyl transfer reaction: thymidylate synthase. FASEB J., 7: 671-677, 1993.
    • (1993) FASEB J. , vol.7 , pp. 671-677
    • Stroud, R.M.1    Finer-Moore, J.S.2
  • 35
    • 0028014283 scopus 로고
    • Mode of binding of folate analogs to thymidylate synthase. Evidence of two asymmetric but interactive substrate binding sites
    • Dev, I. K., Dallas, W. S., Ferone, R., Hanlon, M., McKee, D. D., and Yates, B. B. Mode of binding of folate analogs to thymidylate synthase. Evidence of two asymmetric but interactive substrate binding sites. J. Biol. Chem., 269: 1873-1882, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 1873-1882
    • Dev, I.K.1    Dallas, W.S.2    Ferone, R.3    Hanlon, M.4    McKee, D.D.5    Yates, B.B.6
  • 36
    • 0028919297 scopus 로고
    • Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89
    • Weichsel, A., Montfort, W., Ciesla, J., and Maley, F. Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89. Proc. Natl. Acad. Sci. USA, 92: 3493-3497, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3493-3497
    • Weichsel, A.1    Montfort, W.2    Ciesla, J.3    Maley, F.4
  • 37
    • 0022518273 scopus 로고
    • Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase
    • Pogolotti, A. L. J., Danenberg, P. V., and Santi, D. V. Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. J. Med. Chem., 29: 478-482, 1986.
    • (1986) J. Med. Chem. , vol.29 , pp. 478-482
    • Pogolotti, A.L.J.1    Danenberg, P.V.2    Santi, D.V.3
  • 38
    • 0023667703 scopus 로고
    • Kinetics and thermodynamics of the interaction of 5-fluoro-2′-deoxyuridylate with thymidylate synthase
    • Santi, D. V., McHenry, C. S., Raines, R. T., and Ivanetich, K. M. Kinetics and thermodynamics of the interaction of 5-fluoro-2′-deoxyuridylate with thymidylate synthase. Biochemistry, 26: 8606-8613, 1987.
    • (1987) Biochemistry , vol.26 , pp. 8606-8613
    • Santi, D.V.1    McHenry, C.S.2    Raines, R.T.3    Ivanetich, K.M.4
  • 40
    • 0021723147 scopus 로고
    • Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver
    • Lu, Y-Z., Aiello, P. D., and Matthews, R. G. Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver. Biochemistry, 23: 6870-6876, 1984.
    • (1984) Biochemistry , vol.23 , pp. 6870-6876
    • Lu, Y.-Z.1    Aiello, P.D.2    Matthews, R.G.3
  • 41
    • 0019368721 scopus 로고
    • A potent antitumour quinazoline inhibitor of thymidylate synthase: Synthesis, biological properties and therapeutic results in mice
    • Jones, T. R., Calvert, A. H., Jackman, A. L., Brown, S. J., Jones, M., and Harrap, K. R. A potent antitumour quinazoline inhibitor of thymidylate synthase: synthesis, biological properties and therapeutic results in mice. Eur. J. Cancer, 17: 11-19, 1981.
    • (1981) Eur. J. Cancer , vol.17 , pp. 11-19
    • Jones, T.R.1    Calvert, A.H.2    Jackman, A.L.3    Brown, S.J.4    Jones, M.5    Harrap, K.R.6
  • 42
    • 0026326240 scopus 로고
    • ICI D1694, an inhibitor of thymidylate synthase for clinical study
    • R. A. Harkness, G. B. Elion, and N. Zollner (eds.), New York: Plenum Press
    • Jackman, A. L., Jodrell, D. I., Gibson, W., and Stephens, T. C. ICI D1694, an inhibitor of thymidylate synthase for clinical study. In: R. A. Harkness, G. B. Elion, and N. Zollner (eds.), Purine and Pyrimidine Metabolism in Man, Vol. VII, Part A, pp. 19-23. New York: Plenum Press, 1991.
    • (1991) Purine and Pyrimidine Metabolism in Man , vol.7 , Issue.PART A , pp. 19-23
    • Jackman, A.L.1    Jodrell, D.I.2    Gibson, W.3    Stephens, T.C.4
  • 44
    • 0021015054 scopus 로고
    • Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, CB3717, on human lymphoblastoid cells
    • Jackson, R. C., Jackman, A. L., and Calvert, A. H. Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, CB3717, on human lymphoblastoid cells. Biochem. Pharmacol., 32: 3783-3790, 1983.
    • (1983) Biochem. Pharmacol. , vol.32 , pp. 3783-3790
    • Jackson, R.C.1    Jackman, A.L.2    Calvert, A.H.3
  • 45
    • 0021222361 scopus 로고
    • Modulation of antimetabolite effects: Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB 3717
    • Jackman, A. L., Taylor, G. A., Calvert, A. H., and Harrap, K. R. Modulation of antimetabolite effects: effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB 3717. Biochem. Pharmacol., 33: 3269-3275, 1984.
    • (1984) Biochem. Pharmacol. , vol.33 , pp. 3269-3275
    • Jackman, A.L.1    Taylor, G.A.2    Calvert, A.H.3    Harrap, K.R.4
  • 52
    • 0023276902 scopus 로고
    • Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor CB 3717: A Phase II study
    • Bassendine, M. F., Curtin, N. J., Loose, H., Harris, A. L., and James, O. F. Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor CB 3717: a Phase II study. J Hepatol., 4: 349-356, 1987.
    • (1987) J Hepatol. , vol.4 , pp. 349-356
    • Bassendine, M.F.1    Curtin, N.J.2    Loose, H.3    Harris, A.L.4    James, O.F.5
  • 56
    • 0025997350 scopus 로고
    • ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L 1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
    • Jackman, A. L., Taylor, G. A., Gibson, W., Kimbell, R., Brown, M., Calvert, A. H., Judson, I. R., and Hughes, L. R. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L 1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Res., 51: 5579-5586, 1991.
    • (1991) Cancer Res. , vol.51 , pp. 5579-5586
    • Jackman, A.L.1    Taylor, G.A.2    Gibson, W.3    Kimbell, R.4    Brown, M.5    Calvert, A.H.6    Judson, I.R.7    Hughes, L.R.8
  • 57
    • 9044235902 scopus 로고
    • Biochemical effects of D1694 inhibition of thymidylate synthase in MGH-U1 bladder cancer cells
    • Erlichman, C., and Mitrovski, B. Biochemical effects of D1694 inhibition of thymidylate synthase in MGH-U1 bladder cancer cells. Proc. Am. Assoc. Cancer Res., 33: 507, 1992.
    • (1992) Proc. Am. Assoc. Cancer Res. , vol.33 , pp. 507
    • Erlichman, C.1    Mitrovski, B.2
  • 58
    • 9044239022 scopus 로고
    • Prolonged cell cycle phase perturbation induced by the quinazoline antifolate thymidylate synthase inhibitor ICI D1694
    • Arredondo, M. A., Guimaraes, M. A., Yin, M. B., Slocum, H. K., and Rustum, Y. M. Prolonged cell cycle phase perturbation induced by the quinazoline antifolate thymidylate synthase inhibitor ICI D1694. Proc. Am. Assoc. Cancer Res., 33: 428, 1992.
    • (1992) Proc. Am. Assoc. Cancer Res. , vol.33 , pp. 428
    • Arredondo, M.A.1    Guimaraes, M.A.2    Yin, M.B.3    Slocum, H.K.4    Rustum, Y.M.5
  • 59
    • 9044235716 scopus 로고
    • Cytotoxicity of ICI D 1694 and cisplatin in sensitive and acquired resistant tumor cell lines
    • Kelland, L. R., Abel, G., Brown, M., and Jackman, A. L. Cytotoxicity of ICI D 1694 and cisplatin in sensitive and acquired resistant tumor cell lines. Br J. Cancer, 65 (Suppl. 16): 64, 1992.
    • (1992) Br J. Cancer , vol.65 , Issue.16 SUPPL. , pp. 64
    • Kelland, L.R.1    Abel, G.2    Brown, M.3    Jackman, A.L.4
  • 60
    • 9044233003 scopus 로고
    • Cytotoxicity, DNA strand breaks, thymidylate synthase inhibition and methylenetetrahydrofolate pool decrease induced by ICI D 1694
    • Zhang, Z. G., Yin, M. B., and Rustum, Y. M. Cytotoxicity, DNA strand breaks, thymidylate synthase inhibition and methylenetetrahydrofolate pool decrease induced by ICI D 1694. Proc. Am. Assoc. Cancer Res., 33: 410, 1992.
    • (1992) Proc. Am. Assoc. Cancer Res. , vol.33 , pp. 410
    • Zhang, Z.G.1    Yin, M.B.2    Rustum, Y.M.3
  • 61
    • 9044226657 scopus 로고
    • Double-strand DNA damage induced by thymidylate synthase (TS) inhibitor, ZD1694, in human colon carcinoma cell, HCT-8, requires DNA replication
    • Matsui, S., Lu, K., Wrzosek, C., and Rustum, Y. Double-strand DNA damage induced by thymidylate synthase (TS) inhibitor, ZD1694, in human colon carcinoma cell, HCT-8, requires DNA replication. Proc. Am. Assoc. Cancer Res., 36: 378, 1995.
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 378
    • Matsui, S.1    Lu, K.2    Wrzosek, C.3    Rustum, Y.4
  • 63
    • 0343794762 scopus 로고
    • Pharmacokinetic and toxicity studies with the novel quinazoline thymidylate synthase (TS) inhibitor, D1694
    • Jodrell, D. I., Newell, D. R., Calvete, J A., Stephens, T. C., and Calvert, A. H. Pharmacokinetic and toxicity studies with the novel quinazoline thymidylate synthase (TS) inhibitor, D1694. Proc. Am. Assoc. Cancer Res., 31: 341, 1990.
    • (1990) Proc. Am. Assoc. Cancer Res. , vol.31 , pp. 341
    • Jodrell, D.I.1    Newell, D.R.2    Calvete, J.A.3    Stephens, T.C.4    Calvert, A.H.5
  • 64
    • 0009688297 scopus 로고
    • The thymidylate synthase (TS) inhibitor ICI D 1694 is superior to CB3717, 5-fluorouracil (5-FU) and methotrexate (MTX) against a panel of human tumor xenografts
    • Stephens, T. C., Valcaccia, B. E., Sheader, M. L., Hughes, L., and Jackman, A. L. The thymidylate synthase (TS) inhibitor ICI D 1694 is superior to CB3717, 5-fluorouracil (5-FU) and methotrexate (MTX) against a panel of human tumor xenografts. Proc. Am. Assoc. Cancer Res., 32: 328, 1991.
    • (1991) Proc. Am. Assoc. Cancer Res. , vol.32 , pp. 328
    • Stephens, T.C.1    Valcaccia, B.E.2    Sheader, M.L.3    Hughes, L.4    Jackman, A.L.5
  • 66
    • 7144261163 scopus 로고
    • ZD1694 (Tomudex) and polyglutamate levels in mouse plasma and tissues measured by radioimmunoassay (RIA) and the effect of leucovorin (LV)
    • Aherne, G. W., Farrugia, D. C , Ward, E., Sutcliffe, F., and Jackman, A. L. ZD1694 (Tomudex) and polyglutamate levels in mouse plasma and tissues measured by radioimmunoassay (RIA) and the effect of leucovorin (LV). Proc. Am. Assoc. Cancer Res., 36: 376, 1995.
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 376
    • Aherne, G.W.1    Farrugia, D.C.2    Ward, E.3    Sutcliffe, F.4    Jackman, A.L.5
  • 69
    • 0013684729 scopus 로고
    • Polyglutamation of the thymidylate synthase (TS) inhibitor, ZD1694 (Tomudex), in normal mouse tissues
    • Jackman, A. L., and Gibson, W. Polyglutamation of the thymidylate synthase (TS) inhibitor, ZD1694 (Tomudex), in normal mouse tissues. Proc. Am. Assoc. Cancer Res., 36. 377, 1995.
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 377
    • Jackman, A.L.1    Gibson, W.2
  • 74
    • 0000154770 scopus 로고
    • Phase I study of the new thymidylate synthase inhibitor "Tomudex" (ZD1694) in patients with advanced malignancy
    • Clarke, S. J., Ward, J., De Boer, M., Planting, A., Verweij, J., Sutcliffe, F., Azab, M., and Judson, I. Phase I study of the new thymidylate synthase inhibitor "Tomudex" (ZD1694) in patients with advanced malignancy. Ann. Oncol., 5 (Suppl. 5): 132, 1994.
    • (1994) Ann. Oncol. , vol.5 , Issue.5 SUPPL. , pp. 132
    • Clarke, S.J.1    Ward, J.2    De Boer, M.3    Planting, A.4    Verweij, J.5    Sutcliffe, F.6    Azab, M.7    Judson, I.8
  • 77
    • 0012523788 scopus 로고
    • Phase II study of "Tomudex" (ZD1694), a new thymidylate synthase inhibitor with antitumour activity in breast cancer
    • Gore, M., Earl, H., Cassidy, J., Tattersal, M., Mansi, J., and Azab, M. Phase II study of "Tomudex" (ZD1694), a new thymidylate synthase inhibitor with antitumour activity in breast cancer. Ann. Oncol., 5 (Suppl. 5): 132, 1994.
    • (1994) Ann. Oncol. , vol.5 , Issue.5 SUPPL. , pp. 132
    • Gore, M.1    Earl, H.2    Cassidy, J.3    Tattersal, M.4    Mansi, J.5    Azab, M.6
  • 81
    • 0005691931 scopus 로고
    • Phase II trial of "Tomudex" (ZD1694), a thymidylate synthase inhibitor in advanced pancreatic cancer
    • Pazdur, R., Casper, E. S., Meropol, N. J., Fuchs, C., and Kennealey, G. T. Phase II trial of "Tomudex" (ZD1694), a thymidylate synthase inhibitor in advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 13: 207, 1994.
    • (1994) Proc. Am. Soc. Clin. Oncol. , vol.13 , pp. 207
    • Pazdur, R.1    Casper, E.S.2    Meropol, N.J.3    Fuchs, C.4    Kennealey, G.T.5
  • 82
    • 0342433990 scopus 로고
    • Phase II study of Tomudex (ZD1694) in refractory ovarian cancer
    • Gore, M., Earl, H., Cassidy, J., Tattersal, M., Mansi, J., and Azab, M. Phase II study of Tomudex (ZD1694) in refractory ovarian cancer Ann. Oncol., 5 (Suppl 5): 133, 1994.
    • (1994) Ann. Oncol. , vol.5 , Issue.5 SUPPL. , pp. 133
    • Gore, M.1    Earl, H.2    Cassidy, J.3    Tattersal, M.4    Mansi, J.5    Azab, M.6
  • 84
    • 0009687187 scopus 로고
    • Tomudex (ZD1694). a new thymidylate synthase inhibitor with good antitumor activity in advanced colorectal cancer (ACC)
    • Cunningham, D., Zalcberg, J., Francois, E., Van Cutsem, J. H., Ellis, P., and Azab, M. Tomudex (ZD1694). a new thymidylate synthase inhibitor with good antitumor activity in advanced colorectal cancer (ACC). Proc. Am. Soc. Clin. Oncol., 13: 199, 1994.
    • (1994) Proc. Am. Soc. Clin. Oncol. , vol.13 , pp. 199
    • Cunningham, D.1    Zalcberg, J.2    Francois, E.3    Van Cutsem, J.H.4    Ellis, P.5    Azab, M.6
  • 85
    • 0026721532 scopus 로고
    • Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
    • Piedbois, P., Buyse, M., Rustum, Y , Machover, D., Erlichman, C., Carlson, R. W., Valone, F., Labianca, R , Doroshow, J. H., and Petrelli, N. for the Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J. Clin. Oncol., 10: 896-903, 1992.
    • (1992) J. Clin. Oncol. , vol.10 , pp. 896-903
    • Piedbois, P.1    Buyse, M.2    Rustum, Y.3    Machover, D.4    Erlichman, C.5    Carlson, R.W.6    Valone, F.7    Labianca, R.8    Doroshow, J.H.9    Petrelli, N.10
  • 86
  • 89
    • 0001104819 scopus 로고
    • ZD9331, a novel non-polyglutamated thymidylate synthase (TS) inhibitor: In vivo antitumor efficacy and toxicity to normal murine tissues
    • Stephens, T. C., Smith, M. N., McClockey, M. L., and Boyle, F. T. ZD9331, a novel non-polyglutamated thymidylate synthase (TS) inhibitor: in vivo antitumor efficacy and toxicity to normal murine tissues. Proc. Am. Assoc. Cancer Res., 35: 305, 1994.
    • (1994) Proc. Am. Assoc. Cancer Res. , vol.35 , pp. 305
    • Stephens, T.C.1    Smith, M.N.2    McClockey, M.L.3    Boyle, F.T.4
  • 90
    • 0027186327 scopus 로고
    • Benzoquinazoline inhibitors of thymidylate synthase: Enzyme inhibitory activity and cytotoxicity of some 3-amino and 3-methylbenzo[f]quinazolin-1(2H)-ones
    • Pendergast, W., Dickerson, S. H., Johnson, J. V., Dev, I. K., Ferone, R., Duch, D. S., Hall, W. R., Humphreys, J., Kelly, I. M., and Wilson, D. C. Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino and 3-methylbenzo[f]quinazolin-1(2H)-ones. J. Med. Chem., 36: 2279-2291, 1993.
    • (1993) J. Med. Chem. , vol.36 , pp. 2279-2291
    • Pendergast, W.1    Dickerson, S.H.2    Johnson, J.V.3    Dev, I.K.4    Ferone, R.5    Duch, D.S.6    Hall, W.R.7    Humphreys, J.8    Kelly, I.M.9    Wilson, D.C.10
  • 92
    • 0002997779 scopus 로고
    • Influence of intracellular polyglutamation on the cytotoxicity of the thymidylate synthase inhibitor 1843U89
    • Ferone, R., Hanlon, M. H., Waters, K. A., and Dev, I. K. Influence of intracellular polyglutamation on the cytotoxicity of the thymidylate synthase inhibitor 1843U89. Proc. Am. Assoc. Cancer Res., 34: 274, 1993.
    • (1993) Proc. Am. Assoc. Cancer Res. , vol.34 , pp. 274
    • Ferone, R.1    Hanlon, M.H.2    Waters, K.A.3    Dev, I.K.4
  • 95
    • 0028906786 scopus 로고
    • Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen
    • Boyd, M. R., and Paull, K. D. Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Dev. Res., 34: 91-109, 1995.
    • (1995) Drug Dev. Res. , vol.34 , pp. 91-109
    • Boyd, M.R.1    Paull, K.D.2
  • 97
    • 0026554077 scopus 로고
    • Crystal-structure-based design and synthesis of benz[od]indole-containing inhibitors of thymidylate synthase
    • Varney, M. D., Marzone, G. H. P., Palmer, C. L., Reddy, M. R., Tatlock, J., Rommes, W. H., Wu, B. W., and Musick, L. Crystal-structure-based design and synthesis of benz[od]indole-containing inhibitors of thymidylate synthase. J. Med. Chem., 35: 663-676, 1992.
    • (1992) J. Med. Chem. , vol.35 , pp. 663-676
    • Varney, M.D.1    Marzone, G.H.P.2    Palmer, C.L.3    Reddy, M.R.4    Tatlock, J.5    Rommes, W.H.6    Wu, B.W.7    Musick, L.8
  • 101
    • 9044241806 scopus 로고
    • Biochemical properties of new lipophilic thymidylate synthase inhibitors designed from the X-ray structure of the E. coli enzyme
    • Boritzki, T. J., Bartlett, C. A., Huffaker, T., Morse, C. A., Webber, S., Welsh, K., and Jackson, R. C. Biochemical properties of new lipophilic thymidylate synthase inhibitors designed from the X-ray structure of the E. coli enzyme. Proc. Am. Assoc Cancer Res., 33: 33, 1992.
    • (1992) Proc. Am. Assoc Cancer Res. , vol.33 , pp. 33
    • Boritzki, T.J.1    Bartlett, C.A.2    Huffaker, T.3    Morse, C.A.4    Webber, S.5    Welsh, K.6    Jackson, R.C.7
  • 105
    • 9044250445 scopus 로고
    • A Phase I study of the novel antifolate 3,4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by a 24 h intravenous continuous infusion
    • Rafi, I., Taylor, G. A., Balmanno, K., Calvete, J. A., Newell, D. R., Lind, M. J., and Calvert, A. H. A Phase I study of the novel antifolate 3,4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by a 24 h intravenous continuous infusion. Proc. Am. Assoc. Cancer Res., 35: 306, 1994.
    • (1994) Proc. Am. Assoc. Cancer Res. , vol.35 , pp. 306
    • Rafi, I.1    Taylor, G.A.2    Balmanno, K.3    Calvete, J.A.4    Newell, D.R.5    Lind, M.J.6    Calvert, A.H.7
  • 107
    • 0004890437 scopus 로고
    • Non-linear pharmacokinetics in cancer patients of AG337, a rationally-designed thymidylate synthase (TS) inhibitor
    • Boddy, A. V., Calvete, J. A., and Rafi, I. Non-linear pharmacokinetics in cancer patients of AG337, a rationally-designed thymidylate synthase (TS) inhibitor. Proc. Am. Assoc. Cancer Res., 36: 236, 1995.
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 236
    • Boddy, A.V.1    Calvete, J.A.2    Rafi, I.3
  • 110
    • 0028237440 scopus 로고
    • Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor
    • O'Connor, B. M., Webber, S., Jackson, R. C. Galivan, J., and Rhee, M. S. Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor. Cancer Chemother. Pharmacol., 34: 225-229, 1994.
    • (1994) Cancer Chemother. Pharmacol. , vol.34 , pp. 225-229
    • O'Connor, B.M.1    Webber, S.2    Jackson, R.C.3    Galivan, J.4    Rhee, M.S.5
  • 112
    • 2642590939 scopus 로고
    • Molecular characterisation of three cell lines selected for resistance to folate-based thymidylate synthase inhibitors
    • Freemantle, S. J., Lunec, J., Jackman, A. L., Kelland, L. R., Aherne, G W., and Calvert, A. H. Molecular characterisation of three cell lines selected for resistance to folate-based thymidylate synthase inhibitors. Br. J. Cancer, 67 (Suppl. 20): 79, 1993.
    • (1993) Br. J. Cancer , vol.67 , Issue.20 SUPPL. , pp. 79
    • Freemantle, S.J.1    Lunec, J.2    Jackman, A.L.3    Kelland, L.R.4    Aherne, G.W.5    Calvert, A.H.6
  • 113
    • 0022344622 scopus 로고
    • Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells
    • Berger, S. H., Jenh, C. H., Johnson, L. F., and Berger, F. G. Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells. Mol. Pharmacol., 28: 461-467, 1987.
    • (1987) Mol. Pharmacol. , vol.28 , pp. 461-467
    • Berger, S.H.1    Jenh, C.H.2    Johnson, L.F.3    Berger, F.G.4
  • 114
    • 0021209446 scopus 로고
    • A methotrexate-resistant human breast cancer cell line with multiple defects including diminished formation of methotrexate polyglulamates
    • Cowan, K. H., and Jolivet, J. A methotrexate-resistant human breast cancer cell line with multiple defects including diminished formation of methotrexate polyglulamates. J. Biol. Chem., 259: 10793-10800, 1984
    • (1984) J. Biol. Chem. , vol.259 , pp. 10793-10800
    • Cowan, K.H.1    Jolivet, J.2
  • 115
    • 0022382988 scopus 로고
    • Phenotypic heterogeneity in cultured human head and neck squamous cell carcinoma lines with low-level methotrexate resistance
    • Rosowsky, A., Wright, J. E., Cucchi, C. A., Lippke, J. A., Tantravahi, R., Ervin, T. J., and Frei, E. III. Phenotypic heterogeneity in cultured human head and neck squamous cell carcinoma lines with low-level methotrexate resistance. Cancer Res., 45. 6205-6212, 1985
    • (1985) Cancer Res. , vol.45 , pp. 6205-6212
    • Rosowsky, A.1    Wright, J.E.2    Cucchi, C.A.3    Lippke, J.A.4    Tantravahi, R.5    Ervin, T.J.6    Frei III, E.7
  • 123
    • 0025043811 scopus 로고
    • The interaction of interferon-γ and 5-fluorouracil in the H630 human colon carcinoma cell line
    • Chu, E., Zinn, S., Boarman, D., and Allegra, C. J. The interaction of interferon-γ and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer Res., 50: 5834-5840, 1990.
    • (1990) Cancer Res. , vol.50 , pp. 5834-5840
    • Chu, E.1    Zinn, S.2    Boarman, D.3    Allegra, C.J.4
  • 124
    • 0020056302 scopus 로고
    • In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and resistant murine colon adenocarcinomas
    • Spears, C. P., Shahinian, A. H., Moran, R. G., Heidelberger, C., and Corbett, T. H. In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and resistant murine colon adenocarcinomas. Cancer Res., 42. 450-456, 1982.
    • (1982) Cancer Res. , vol.42 , pp. 450-456
    • Spears, C.P.1    Shahinian, A.H.2    Moran, R.G.3    Heidelberger, C.4    Corbett, T.H.5
  • 125
    • 0023705723 scopus 로고
    • Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells
    • Keyomarsi, D., and Moran, R. G. Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J. Biol. Chem., 263: 14402-14409, 1988.
    • (1988) J. Biol. Chem. , vol.263 , pp. 14402-14409
    • Keyomarsi, D.1    Moran, R.G.2
  • 126
    • 0027181763 scopus 로고
    • The thymidylate synthase inhibitor ICI D 1694 overcomes translational detainment of the enzyme
    • Keyomarsi, K., Samet, J., Molnar, G., and Pardee, A. B. The thymidylate synthase inhibitor ICI D 1694 overcomes translational detainment of the enzyme. J. Biol. Chem., 268: 15132-15149, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 15132-15149
    • Keyomarsi, K.1    Samet, J.2    Molnar, G.3    Pardee, A.B.4
  • 127
    • 0006635130 scopus 로고
    • Loss of translational control of thymidylate synthase (TS) by antifolates results in the accumulation of the TS protein
    • Keyomarsi, K., Molnar, G., and Pardee, A. B. Loss of translational control of thymidylate synthase (TS) by antifolates results in the accumulation of the TS protein. Proc. Am. Assoc. Cancer Res., 34: 276, 1993.
    • (1993) Proc. Am. Assoc. Cancer Res. , vol.34 , pp. 276
    • Keyomarsi, K.1    Molnar, G.2    Pardee, A.B.3
  • 128
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 130
    • 0028149786 scopus 로고
    • Checkpoints of dueling dimers foil death wishes
    • Oltvai, Z. N., and Korsmeyer, S. J. Checkpoints of dueling dimers foil death wishes. Cell, 79: 189-192, 1994.
    • (1994) Cell , vol.79 , pp. 189-192
    • Oltvai, Z.N.1    Korsmeyer, S.J.2
  • 131
    • 0026786636 scopus 로고
    • Prognostic significance of p53 overexpression in gastric and colorectal carcinoma
    • Starzynska, T., Bromley, M., Ghosh, A., and Stern, P. L. Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br. J. Cancer, 66: 558-562, 1992.
    • (1992) Br. J. Cancer , vol.66 , pp. 558-562
    • Starzynska, T.1    Bromley, M.2    Ghosh, A.3    Stern, P.L.4
  • 132
    • 0028943734 scopus 로고
    • Apoptosis in the pathogenesis and treatment of disease
    • Washington DC
    • Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995.
    • (1995) Science , vol.267 , pp. 1456-1462
    • Thompson, C.B.1
  • 135
    • 0004342857 scopus 로고
    • Decreased c-myc protein accompanied by increased p53 and Rb is associated with thymidylate synthase inhibition and cell cycle retardation induced by D1694
    • Arredondo, M. A., Yin, M. B., Lu, K., Schöber, C., Slocum, H., and Rustum, Y. M. Decreased c-myc protein accompanied by increased p53 and Rb is associated with thymidylate synthase inhibition and cell cycle retardation induced by D1694. Proc. Am. Assoc. Cancer Res., 35: 304, 1994.
    • (1994) Proc. Am. Assoc. Cancer Res. , vol.35 , pp. 304
    • Arredondo, M.A.1    Yin, M.B.2    Lu, K.3    Schöber, C.4    Slocum, H.5    Rustum, Y.M.6
  • 136
    • 0027279128 scopus 로고
    • bcl-2 modulation of apoptosis induced by anticancer drugs: Resistance to thymidylate stress is independent of classical resistance pathways
    • Fisher, T. C., Milner, A. E., Gregory, C. D., Jackman, A. L., Aherne, G. W., Hartley, J. A., Dive, C., and Hickman, J. A. bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res., 53: 3321-3326, 1993.
    • (1993) Cancer Res. , vol.53 , pp. 3321-3326
    • Fisher, T.C.1    Milner, A.E.2    Gregory, C.D.3    Jackman, A.L.4    Aherne, G.W.5    Hartley, J.A.6    Dive, C.7    Hickman, J.A.8
  • 138
    • 9044242224 scopus 로고
    • The effect of hammerhead ribozyme against thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitor
    • Kobayashi, H., Takemura, Y., Miyachi, H., Skelton, L., and Jackman, A. L. The effect of hammerhead ribozyme against thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitor. Proc. Am. Assoc. Cancer Res., 36: 342, 1995.
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 342
    • Kobayashi, H.1    Takemura, Y.2    Miyachi, H.3    Skelton, L.4    Jackman, A.L.5
  • 139
    • 0028247776 scopus 로고
    • Targeted and non-targeted actions of anti-cancer drugs
    • Weber, G., and Prajda, N. Targeted and non-targeted actions of anti-cancer drugs. Adv. Enzyme Regul., 34: 71-89, 1994.
    • (1994) Adv. Enzyme Regul. , vol.34 , pp. 71-89
    • Weber, G.1    Prajda, N.2
  • 140
    • 0027427801 scopus 로고
    • Combination studies with 3′-azido-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects
    • Pressacco, J., and Erlichman, C. Combination studies with 3′-azido-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects. Biochem. Pharmacol., 46: 1989-1997, 1993.
    • (1993) Biochem. Pharmacol. , vol.46 , pp. 1989-1997
    • Pressacco, J.1    Erlichman, C.2
  • 141
    • 0028142050 scopus 로고
    • ICI D1694 and idoxuridine: A synergistic antitumor combination
    • Pressacco, J., Hedley, D. W , and Erlichman, C. ICI D1694 and idoxuridine: a synergistic antitumor combination. Cancer Res. 54: 3772-3778, 1994.
    • (1994) Cancer Res. , vol.54 , pp. 3772-3778
    • Pressacco, J.1    Hedley, D.W.2    Erlichman, C.3
  • 142
    • 0343739057 scopus 로고
    • Pretreatment of colon carcinoma cells to D1694 (Tomudex) markedly enhances 5-fluorouracil cytotoxicity
    • Chang, Y. M., Zielinski, Z., Izzo, J., Porubcin, M., and Bertino, J. R. Pretreatment of colon carcinoma cells to D1694 (Tomudex) markedly enhances 5-fluorouracil cytotoxicity. Proc. Am. Assoc. Cancer Res., 35: 330, 1994.
    • (1994) Proc. Am. Assoc. Cancer Res. , vol.35 , pp. 330
    • Chang, Y.M.1    Zielinski, Z.2    Izzo, J.3    Porubcin, M.4    Bertino, J.R.5
  • 143
    • 0345588453 scopus 로고
    • Molecular mechanisms of the synergistic sequential administration of D1694 (Tomudex) followed by FUra in colon carcinoma cells
    • Izzo, J., Zielinski, Z., Chang, Y. M., and Bertino, J. R. Molecular mechanisms of the synergistic sequential administration of D1694 (Tomudex) followed by FUra in colon carcinoma cells. Proc. Am. Assoc. Cancer Res., 36: 381, 1995.
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 381
    • Izzo, J.1    Zielinski, Z.2    Chang, Y.M.3    Bertino, J.R.4
  • 144
    • 0000033490 scopus 로고
    • Biochemical basis for the the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil
    • Van der Wilt, C. L., Pinedo, H. M., Kuiper, C. M., Smid, K., and Peters, G. J. Biochemical basis for the the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil. Proc. Am. Assoc. Cancer Res., 36: 379, 1995
    • (1995) Proc. Am. Assoc. Cancer Res. , vol.36 , pp. 379
    • Van Der Wilt, C.L.1    Pinedo, H.M.2    Kuiper, C.M.3    Smid, K.4    Peters, G.J.5
  • 145
    • 9044229859 scopus 로고
    • Phase I study of Tomudex in combination with 5-FU/CF/IFN-A for recurrent adult solid tumors including gastrointestinal, breast, lung, and ovarian carcinomas
    • National Cancer Institute PDQ. Phase I study of Tomudex in combination with 5-FU/CF/IFN-A for recurrent adult solid tumors including gastrointestinal, breast, lung, and ovarian carcinomas. Curr. Clin. Trials Oncol., 2: 749, 1995.
    • (1995) Curr. Clin. Trials Oncol. , vol.2 , pp. 749


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