-
1
-
-
0023678551
-
A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells
-
Ayusawa, D., Arai, H., Wataya, Y., and Sento, T. A specialized form of chromosomal DNA degradation induced by thymidylate stress in mouse FM3A cells. Mutat. Res., 200: 221-230, 1988.
-
(1988)
Mutat. Res.
, vol.200
, pp. 221-230
-
-
Ayusawa, D.1
Arai, H.2
Wataya, Y.3
Sento, T.4
-
2
-
-
0002685062
-
Fluorinated pyrimidines
-
B. A. Chabner and J. M. Collins (eds.), Philadelphia: J. B. Lippincott Company
-
Grem, J. L. Fluorinated pyrimidines. In: B. A. Chabner and J. M. Collins (eds.), Cancer Chemotherapy: Principles and Practice, pp. 180-224. Philadelphia: J. B. Lippincott Company, 1990.
-
(1990)
Cancer Chemotherapy: Principles and Practice
, pp. 180-224
-
-
Grem, J.L.1
-
3
-
-
0024841440
-
Thymidylate synthase: A target for anticancer drug design
-
Harrap, K. R., Jackman, A. L., Newell, D. R , Taylor, G. A., Hughes, L. R., and Calvert, A. H. Thymidylate synthase: a target for anticancer drug design. Adv. Enzyme Regul., 29: 161-179, 1989.
-
(1989)
Adv. Enzyme Regul.
, vol.29
, pp. 161-179
-
-
Harrap, K.R.1
Jackman, A.L.2
Newell, D.R.3
Taylor, G.A.4
Hughes, L.R.5
Calvert, A.H.6
-
4
-
-
0020387526
-
Recent progress in the medicinal chemistry of 2,4-diaminopyridines
-
Roth, B., and Cheng, C. C. Recent progress in the medicinal chemistry of 2,4-diaminopyridines. Prog. Med. Chem., 19: 269-331, 1982.
-
(1982)
Prog. Med. Chem.
, vol.19
, pp. 269-331
-
-
Roth, B.1
Cheng, C.C.2
-
5
-
-
0003892409
-
-
Cambridge: Academic Press
-
Sirotnak, F. M., Burchall, J. J., Ensminer, W. D., and Montgomery, J. A. Folate Antagonists as Therapeutic Agents, Vol. 1. Cambridge: Academic Press, 1984.
-
(1984)
Folate Antagonists as Therapeutic Agents
, vol.1
-
-
Sirotnak, F.M.1
Burchall, J.J.2
Ensminer, W.D.3
Montgomery, J.A.4
-
6
-
-
0345606724
-
Defective transport of amethopterin (methotrexate) as a mechanism of resistance to antimetabolites in L5178Y cells
-
Fischer, G. A. Defective transport of amethopterin (methotrexate) as a mechanism of resistance to antimetabolites in L5178Y cells. Biochem. Pharmacol., 11: 1233-1234, 1962.
-
(1962)
Biochem. Pharmacol.
, vol.11
, pp. 1233-1234
-
-
Fischer, G.A.1
-
7
-
-
0015246338
-
Sites of action of amethopterin in intrinsic and acquired drug resistance
-
Harrap, K. R., Hill, B. T., Furness, M. E., and Hart, L. I. Sites of action of amethopterin in intrinsic and acquired drug resistance. Ann. NY Acad. Sci., 186: 312-324, 1971.
-
(1971)
Ann. NY Acad. Sci.
, vol.186
, pp. 312-324
-
-
Harrap, K.R.1
Hill, B.T.2
Furness, M.E.3
Hart, L.I.4
-
8
-
-
0014260034
-
Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response
-
Kessel, D., Hall, T. C., and Roberts, D. Modes of uptake of methotrexate by normal and leukemic human leukocytes in vitro and their relation to drug response. Cancer Res. 28: 564-570, 1968.
-
(1968)
Cancer Res.
, vol.28
, pp. 564-570
-
-
Kessel, D.1
Hall, T.C.2
Roberts, D.3
-
9
-
-
0042438137
-
Chemotherapeutic agents: Folate antagonists
-
J. F. Holland, E. Frei III, R. C. Bast, Jr., D. W. Dufe, D. Morton, and R. Weichselbaum (eds.), Philadelphia: Lea & Febiger
-
Bertino, J. R., and Romanini, A. Chemotherapeutic agents: folate antagonists. In: J. F. Holland, E. Frei III, R. C. Bast, Jr., D. W. Dufe, D. Morton, and R. Weichselbaum (eds.), Cancer Medicine, Vol. 1, pp. 698-711. Philadelphia: Lea & Febiger, 1993.
-
(1993)
Cancer Medicine
, vol.1
, pp. 698-711
-
-
Bertino, J.R.1
Romanini, A.2
-
11
-
-
0014800626
-
Chemical carcinogenesis, chemotherapy: Cancer's continuing core challenges - G. H. A. Clowes Memorial Lecture
-
Heidelberger, C. Chemical carcinogenesis, chemotherapy: cancer's continuing core challenges - G. H. A. Clowes Memorial Lecture. Cancer Res., 30: 1549-1569, 1970.
-
(1970)
Cancer Res.
, vol.30
, pp. 1549-1569
-
-
Heidelberger, C.1
-
12
-
-
0021331040
-
5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity
-
Schuetz, J. D., Wallace, H. J., and Diasui, R. B. 5-Fluorouracil incorporation into DNA of CF-1 mouse bone marrow cells as a possible mechanism of toxicity. Cancer Res., 44: 1358-1363, 1984.
-
(1984)
Cancer Res.
, vol.44
, pp. 1358-1363
-
-
Schuetz, J.D.1
Wallace, H.J.2
Diasui, R.B.3
-
13
-
-
0026557953
-
Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin
-
Peters, J. G., van Groeningen, C. J., Van der Wilt, C., Meijer, S., Smid, K., Laurensse, E., and Pinedo, H. M. Time course of inhibition of thymidylate synthase in patients treated with fluorouracil and leucovorin. Semin. Oncol , 19 (2 Suppl. 3): 26-35, 1992.
-
(1992)
Semin. Oncol
, vol.19
, Issue.2 SUPPL. 3
, pp. 26-35
-
-
Peters, J.G.1
Van Groeningen, C.J.2
Van Der Wilt, C.3
Meijer, S.4
Smid, K.5
Laurensse, E.6
Pinedo, H.M.7
-
14
-
-
0022479537
-
Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells
-
Keyomarsi, K., and Moran, R. G. Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Res., 46: 5229-5235, 1986.
-
(1986)
Cancer Res.
, vol.46
, pp. 5229-5235
-
-
Keyomarsi, K.1
Moran, R.G.2
-
15
-
-
0028940399
-
Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors
-
Johnston, P. G., Lenz, H. J., Leichman, C. G., Danenberg, K., Allegra, C. J., Danenberg, P., and Leichman, L. Thymidylate synthase gene and protein expression correlate and are associated with response to 5-fluorouracil in human colorectal and gastric tumors. Cancer Res., 55: 1407-1412, 1995.
-
(1995)
Cancer Res.
, vol.55
, pp. 1407-1412
-
-
Johnston, P.G.1
Lenz, H.J.2
Leichman, C.G.3
Danenberg, K.4
Allegra, C.J.5
Danenberg, P.6
Leichman, L.7
-
16
-
-
0026795489
-
The immunological quantitation of thymidylate synthase using the monoclonal antibody TS106 in 5-FU-sensitive and -resistant human cancer cell lines
-
Johnston, P. G , Drake, J. C., Trepel, J., and Allegra, C. J. The immunological quantitation of thymidylate synthase using the monoclonal antibody TS106 in 5-FU-sensitive and -resistant human cancer cell lines. Cancer Res., 52: 4302-4312, 1992.
-
(1992)
Cancer Res.
, vol.52
, pp. 4302-4312
-
-
Johnston, P.G.1
Drake, J.C.2
Trepel, J.3
Allegra, C.J.4
-
17
-
-
0028019880
-
Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: Implications for treatment with fluorouracil
-
Peters, G. J., van der Wilt, C. L., van Groeningen, C. J., Smid, K., Meijer, S., and Pinedo, H. M. Thymidylate synthase inhibition after administration of fluorouracil with or without leucovorin in colon cancer patients: implications for treatment with fluorouracil. J. Clin. Oncol., 12: 2035-2042, 1994.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 2035-2042
-
-
Peters, G.J.1
Van Der Wilt, C.L.2
Van Groeningen, C.J.3
Smid, K.4
Meijer, S.5
Pinedo, H.M.6
-
18
-
-
0024413739
-
Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer
-
Swain, S. M., Lippman, M. E., Egan, E. F., Drake, J. C., Steinberg, S. M., and Allegra, C. J. Fluorouracil and high-dose leucovorin in previously treated patients with metastatic breast cancer. J. Clin. Oncol., 7: 890-899, 1989.
-
(1989)
J. Clin. Oncol.
, vol.7
, pp. 890-899
-
-
Swain, S.M.1
Lippman, M.E.2
Egan, E.F.3
Drake, J.C.4
Steinberg, S.M.5
Allegra, C.J.6
-
19
-
-
0028151449
-
The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer
-
Johnston, P. G., Fisher, E. R., Rockette, H. E., Fisher, B., Wolmark, N., Drake, J. C., Chabner, B. A., and Allegra, C. The role of thymidylate synthase expression in prognosis and outcome of adjuvant chemotherapy in patients with rectal cancer. J. Clin. Oncol., 12: 2640-2647, 1994.
-
(1994)
J. Clin. Oncol.
, vol.12
, pp. 2640-2647
-
-
Johnston, P.G.1
Fisher, E.R.2
Rockette, H.E.3
Fisher, B.4
Wolmark, N.5
Drake, J.C.6
Chabner, B.A.7
Allegra, C.8
-
20
-
-
0025016121
-
Methotrexate transport in variant human ccrf-cem leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates
-
Jansen, G., Westerhof, G. R., Jarmuszewski, M. J., Kathmann, I., Rijksen, G., and Schornagel, J. H. Methotrexate transport in variant human ccrf-cem leukemia cells with elevated levels of the reduced folate carrier. Selective effect on carrier-mediated transport of physiological concentrations of reduced folates. J. Biol. Chem., 265: 18272-18277, 1990.
-
(1990)
J. Biol. Chem.
, vol.265
, pp. 18272-18277
-
-
Jansen, G.1
Westerhof, G.R.2
Jarmuszewski, M.J.3
Kathmann, I.4
Rijksen, G.5
Schornagel, J.H.6
-
21
-
-
0019449889
-
Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro
-
Balinska, M., Galivan, J., and Coward, J. K. Efflux of methotrexate and its polyglutamate derivatives from hepatic cells in vitro. Cancer Res., 41: 2751-2756, 1981.
-
(1981)
Cancer Res.
, vol.41
, pp. 2751-2756
-
-
Balinska, M.1
Galivan, J.2
Coward, J.K.3
-
22
-
-
0015827958
-
Studies on the uptake of synthetic conjugated folates by human marrow cells
-
Hoffbrand, A. V., Tripp, E., Houlihan, C. M., and Scott, J. M. Studies on the uptake of synthetic conjugated folates by human marrow cells. Blood., 42: 141-146, 1973.
-
(1973)
Blood.
, vol.42
, pp. 141-146
-
-
Hoffbrand, A.V.1
Tripp, E.2
Houlihan, C.M.3
Scott, J.M.4
-
23
-
-
0002538947
-
Antineoplastic agents
-
A. Goodman Gilman, T. W. Rall, A. S. Nies, and P. Taylor (eds.), New York: Pergamon Press
-
Calabresi, P., and Chabner, B. A. Antineoplastic agents. In: A. Goodman Gilman, T. W. Rall, A. S. Nies, and P. Taylor (eds.), Goodman and Gilman's The Pharmacologic Basis of Therapeutics, pp. 1223-1227. New York: Pergamon Press, 1990.
-
(1990)
Goodman and Gilman's the Pharmacologic Basis of Therapeutics
, pp. 1223-1227
-
-
Calabresi, P.1
Chabner, B.A.2
-
24
-
-
0026054878
-
10-substituted-5,8-dideazafolates
-
10-substituted-5,8-dideazafolates. Adv. Enzyme Regul., 31: 13-27, 1991.
-
(1991)
Adv. Enzyme Regul.
, vol.31
, pp. 13-27
-
-
Jackman, A.L.1
Marsham, P.R.2
Moran, R.G.3
Kimbell, R.4
O'Connor, B.M.5
Hughes, L.R.6
Calvert, A.H.7
-
25
-
-
0023121146
-
Atomic structure of thymidylate synthase: Target for rational drug design
-
Washington DC
-
Hardy, L. W., Finer-Moore, J. S., Montfort, W. R., Jones, M. O., Santi, D. V., and Stroud, R. M. Atomic structure of thymidylate synthase: target for rational drug design. Science (Washington DC), 235: 448-455, 1987.
-
(1987)
Science
, vol.235
, pp. 448-455
-
-
Hardy, L.W.1
Finer-Moore, J.S.2
Montfort, W.R.3
Jones, M.O.4
Santi, D.V.5
Stroud, R.M.6
-
26
-
-
0025091668
-
Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2-deoxyuridylate and 5,10-methylenetetrahydrofolate
-
Matthews, D. A., Villafranca, J. E., Janson, C. A., Smith, W. W., Welsh, K., and Freer, S. Stereochemical mechanism of action for thymidylate synthase based on the X-ray structure of the covalent inhibitory ternary complex with 5-fluoro-2-deoxyuridylate and 5,10-methylenetetrahydrofolate. J. Mol. Biol., 214: 937-948, 1990.
-
(1990)
J. Mol. Biol.
, vol.214
, pp. 937-948
-
-
Matthews, D.A.1
Villafranca, J.E.2
Janson, C.A.3
Smith, W.W.4
Welsh, K.5
Freer, S.6
-
27
-
-
0025311258
-
Structure, multiple site binding, and segmentai accommodation in thymidylate synthase on binding dUMP and an anti-folate
-
Montfort, W. R., Perry, K. M., Fauman, E. C., Finer-Moore, J S., Maley, G. F., Hardy, L., Maley, F., and Stroud, R. M. Structure, multiple site binding, and segmentai accommodation in thymidylate synthase on binding dUMP and an anti-folate. Biochemistry, 29: 6964-6977, 1990.
-
(1990)
Biochemistry
, vol.29
, pp. 6964-6977
-
-
Montfort, W.R.1
Perry, K.M.2
Fauman, E.C.3
Finer-Moore, J.S.4
Maley, G.F.5
Hardy, L.6
Maley, F.7
Stroud, R.M.8
-
28
-
-
0025149019
-
Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolate
-
Matthews, D. A., Appelt, K., Oatley, S. J., and Xuong, N. H. Crystal structure of Escherichia coli thymidylate synthase containing bound 5-fluoro-2′-deoxyuridylate and 10-propargyl-5,8-dideazafolate. J. Mol. Biol., 214: 923-936, 1990.
-
(1990)
J. Mol. Biol.
, vol.214
, pp. 923-936
-
-
Matthews, D.A.1
Appelt, K.2
Oatley, S.J.3
Xuong, N.H.4
-
29
-
-
0025737742
-
Design of enzyme inhibitors using iterative protein crystallographic analysis
-
Appelt, K., Bacquet, F. J., Bartlett, C. A., Booth, C. L. J., and Freer, S. T. Design of enzyme inhibitors using iterative protein crystallographic analysis. J. Med. Chem., 34: 1925-1934, 1991.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1925-1934
-
-
Appelt, K.1
Bacquet, F.J.2
Bartlett, C.A.3
Booth, C.L.J.4
Freer, S.T.5
-
30
-
-
0026794266
-
Structural basis for recognition of polyglutamyl folates by thymidylate synthase
-
Kamb, A., Finer-Moore, J., Calvert, H., and Stroud, R. Structural basis for recognition of polyglutamyl folates by thymidylate synthase. Biochemistry, 31: 9883-9890, 1992.
-
(1992)
Biochemistry
, vol.31
, pp. 9883-9890
-
-
Kamb, A.1
Finer-Moore, J.2
Calvert, H.3
Stroud, R.4
-
31
-
-
0027102178
-
Cofactor triggers the conformational change in thymidylate synthase: Implications for an ordered binding mechanism
-
Kamb, A., Finer-Moore, J. S., and Stroud, R Cofactor triggers the conformational change in thymidylate synthase: implications for an ordered binding mechanism. Biochemistry, 31: 12876-12884, 1992.
-
(1992)
Biochemistry
, vol.31
, pp. 12876-12884
-
-
Kamb, A.1
Finer-Moore, J.S.2
Stroud, R.3
-
32
-
-
0024520834
-
Stacked β-bulges in thymidylate synthase account for a novel right-handed rotation between opposing β sheets
-
Matthews, D. A., Appelt, K., and Oatley, S. J. Stacked β-bulges in thymidylate synthase account for a novel right-handed rotation between opposing β sheets. J. Mol Biol., 205: 449-454, 1989.
-
(1989)
J. Mol Biol.
, vol.205
, pp. 449-454
-
-
Matthews, D.A.1
Appelt, K.2
Oatley, S.J.3
-
33
-
-
0018786751
-
Evidence for a sequential interaction of the subunits of thymidylate synthetase
-
Danenberg, K. D., and Danenberg, P. V. Evidence for a sequential interaction of the subunits of thymidylate synthetase. J Biol Chem., 254: 4335-4348, 1979.
-
(1979)
J Biol Chem.
, vol.254
, pp. 4335-4348
-
-
Danenberg, K.D.1
Danenberg, P.V.2
-
34
-
-
0027151834
-
Stereochemistry of a multi-step/bipartite methyl transfer reaction: Thymidylate synthase
-
Stroud, R. M., and Finer-Moore, J. S. Stereochemistry of a multi-step/bipartite methyl transfer reaction: thymidylate synthase. FASEB J., 7: 671-677, 1993.
-
(1993)
FASEB J.
, vol.7
, pp. 671-677
-
-
Stroud, R.M.1
Finer-Moore, J.S.2
-
35
-
-
0028014283
-
Mode of binding of folate analogs to thymidylate synthase. Evidence of two asymmetric but interactive substrate binding sites
-
Dev, I. K., Dallas, W. S., Ferone, R., Hanlon, M., McKee, D. D., and Yates, B. B. Mode of binding of folate analogs to thymidylate synthase. Evidence of two asymmetric but interactive substrate binding sites. J. Biol. Chem., 269: 1873-1882, 1994.
-
(1994)
J. Biol. Chem.
, vol.269
, pp. 1873-1882
-
-
Dev, I.K.1
Dallas, W.S.2
Ferone, R.3
Hanlon, M.4
McKee, D.D.5
Yates, B.B.6
-
36
-
-
0028919297
-
Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89
-
Weichsel, A., Montfort, W., Ciesla, J., and Maley, F. Promotion of purine nucleotide binding to thymidylate synthase by a potent folate analogue inhibitor, 1843U89. Proc. Natl. Acad. Sci. USA, 92: 3493-3497, 1995.
-
(1995)
Proc. Natl. Acad. Sci. USA
, vol.92
, pp. 3493-3497
-
-
Weichsel, A.1
Montfort, W.2
Ciesla, J.3
Maley, F.4
-
37
-
-
0022518273
-
Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase
-
Pogolotti, A. L. J., Danenberg, P. V., and Santi, D. V. Kinetics and mechanism of interaction of 10-propargyl-5,8-dideazafolate with thymidylate synthase. J. Med. Chem., 29: 478-482, 1986.
-
(1986)
J. Med. Chem.
, vol.29
, pp. 478-482
-
-
Pogolotti, A.L.J.1
Danenberg, P.V.2
Santi, D.V.3
-
38
-
-
0023667703
-
Kinetics and thermodynamics of the interaction of 5-fluoro-2′-deoxyuridylate with thymidylate synthase
-
Santi, D. V., McHenry, C. S., Raines, R. T., and Ivanetich, K. M. Kinetics and thermodynamics of the interaction of 5-fluoro-2′-deoxyuridylate with thymidylate synthase. Biochemistry, 26: 8606-8613, 1987.
-
(1987)
Biochemistry
, vol.26
, pp. 8606-8613
-
-
Santi, D.V.1
McHenry, C.S.2
Raines, R.T.3
Ivanetich, K.M.4
-
39
-
-
0023699993
-
10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro
-
10-propargyl-5,8-dideazafolic acid (CB3717) polyglutamates in L1210 cells in vitro. Biochem. Pharmacol., 37: 4047-4054, 1988.
-
(1988)
Biochem. Pharmacol.
, vol.37
, pp. 4047-4054
-
-
Sikora, E.1
Newell, D.R.2
Jackman, A.J.3
Simmons, A.J.4
Jones, T.R.5
Calvert, A.H.6
-
40
-
-
0021723147
-
Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver
-
Lu, Y-Z., Aiello, P. D., and Matthews, R. G. Studies on the polyglutamate specificity of thymidylate synthase from fetal pig liver. Biochemistry, 23: 6870-6876, 1984.
-
(1984)
Biochemistry
, vol.23
, pp. 6870-6876
-
-
Lu, Y.-Z.1
Aiello, P.D.2
Matthews, R.G.3
-
41
-
-
0019368721
-
A potent antitumour quinazoline inhibitor of thymidylate synthase: Synthesis, biological properties and therapeutic results in mice
-
Jones, T. R., Calvert, A. H., Jackman, A. L., Brown, S. J., Jones, M., and Harrap, K. R. A potent antitumour quinazoline inhibitor of thymidylate synthase: synthesis, biological properties and therapeutic results in mice. Eur. J. Cancer, 17: 11-19, 1981.
-
(1981)
Eur. J. Cancer
, vol.17
, pp. 11-19
-
-
Jones, T.R.1
Calvert, A.H.2
Jackman, A.L.3
Brown, S.J.4
Jones, M.5
Harrap, K.R.6
-
42
-
-
0026326240
-
ICI D1694, an inhibitor of thymidylate synthase for clinical study
-
R. A. Harkness, G. B. Elion, and N. Zollner (eds.), New York: Plenum Press
-
Jackman, A. L., Jodrell, D. I., Gibson, W., and Stephens, T. C. ICI D1694, an inhibitor of thymidylate synthase for clinical study. In: R. A. Harkness, G. B. Elion, and N. Zollner (eds.), Purine and Pyrimidine Metabolism in Man, Vol. VII, Part A, pp. 19-23. New York: Plenum Press, 1991.
-
(1991)
Purine and Pyrimidine Metabolism in Man
, vol.7
, Issue.PART A
, pp. 19-23
-
-
Jackman, A.L.1
Jodrell, D.I.2
Gibson, W.3
Stephens, T.C.4
-
43
-
-
0023491912
-
10-propargyl-5,8-dideazafolic Acid (CB 3717)
-
10-propargyl-5,8-dideazafolic Acid (CB 3717). Natl. Cancer Inst. Monogr., 5: 213-218, 1987.
-
(1987)
Natl. Cancer Inst. Monogr.
, vol.5
, pp. 213-218
-
-
Calvert, A.H.1
Newell, D.R.2
Jackman, A.L.3
Gumbrell, L.A.4
Sikora, E.5
Grzelakowska-Sztabert, B.6
Bishop, J.A.M.7
Judson, I.R.8
Harland, S.9
Harrap, K.R.10
-
44
-
-
0021015054
-
Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, CB3717, on human lymphoblastoid cells
-
Jackson, R. C., Jackman, A. L., and Calvert, A. H. Biochemical effects of a quinazoline inhibitor of thymidylate synthetase, CB3717, on human lymphoblastoid cells. Biochem. Pharmacol., 32: 3783-3790, 1983.
-
(1983)
Biochem. Pharmacol.
, vol.32
, pp. 3783-3790
-
-
Jackson, R.C.1
Jackman, A.L.2
Calvert, A.H.3
-
45
-
-
0021222361
-
Modulation of antimetabolite effects: Effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB 3717
-
Jackman, A. L., Taylor, G. A., Calvert, A. H., and Harrap, K. R. Modulation of antimetabolite effects: effects of thymidine on the efficacy of the quinazoline-based thymidylate synthetase inhibitor, CB 3717. Biochem. Pharmacol., 33: 3269-3275, 1984.
-
(1984)
Biochem. Pharmacol.
, vol.33
, pp. 3269-3275
-
-
Jackman, A.L.1
Taylor, G.A.2
Calvert, A.H.3
Harrap, K.R.4
-
46
-
-
0022496986
-
10-propargyl-5,8-dideazafolic acid (CB3717) in the mouse
-
10-propargyl-5,8-dideazafolic acid (CB3717) in the mouse. Cancer Treat. Rep., 70: 971-979, 1986.
-
(1986)
Cancer Treat. Rep.
, vol.70
, pp. 971-979
-
-
Newell, D.R.1
Alison, D.L.2
Calvert, A.H.3
Harrap, K.R.4
Jarman, M.J.5
Jones, T.R.6
Manteuffel-Cymborowska, M.7
O'Connor, P.8
-
47
-
-
0025925284
-
10propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue, ICI D1694, in mice
-
10propargyl-5,8-dideazafolic acid (CB3717) and a non-nephrotoxic analogue, ICI D1694, in mice. Br. J. Cancer. 64: 833-838, 1991.
-
(1991)
Br. J. Cancer.
, vol.64
, pp. 833-838
-
-
Jodrell, D.I.1
Newell, D.R.2
Morgan, S.E.3
Clinton, S.4
Bensted, J.P.M.5
Hughes, L.R.6
Calvert, A.H.7
-
48
-
-
0022894985
-
10-propargyl-5,8-dideazafolic acid, CB 3717
-
10-propargyl-5,8-dideazafolic acid, CB 3717. J. Clin. Oncol., 4: 1245-1252, 1986.
-
(1986)
J. Clin. Oncol.
, vol.4
, pp. 1245-1252
-
-
Calvert, A.H.1
Alison, D.L.2
Harland, S.J.3
Robinson, B.A.4
Jackman, A.L.5
Jones, T.R.6
Newell, D.R.7
Siddik, Z.H.8
Wiltshaw, E.9
McElwain, T.10
Smith, I.11
Harrap, K.12
-
50
-
-
0023887272
-
10-propargyl-5,8-dideazafolic acid, CB3717
-
10-propargyl-5,8-dideazafolic acid, CB3717. Eur. J. Cancer & Clin Oncol., 24: 769-775, 1988.
-
(1988)
Eur. J. Cancer & Clin Oncol.
, vol.24
, pp. 769-775
-
-
Sessa, C.1
Zucchetti, M.2
Ginier, M.3
Willems, Y.4
D'Incalci, M.5
Cavalli, F.6
-
51
-
-
0023920753
-
10-propargyl-5,8-dideazafolic acid (CB3717) in advanced breast cancer
-
10-propargyl-5,8-dideazafolic acid (CB3717) in advanced breast cancer. Eur. J Cancer & Clin. Oncol., 24. 733-736, 1988.
-
(1988)
Eur. J Cancer & Clin. Oncol.
, vol.24
, pp. 733-736
-
-
Cantwell, B.M.J.1
Macaulay, V.2
Harris, A.L.3
Kaye, S.B.4
Smith, I.E.5
Milsted, R.A.6
Calvert, A.H.7
-
52
-
-
0023276902
-
Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor CB 3717: A Phase II study
-
Bassendine, M. F., Curtin, N. J., Loose, H., Harris, A. L., and James, O. F. Induction of remission in hepatocellular carcinoma with a new thymidylate synthase inhibitor CB 3717: a Phase II study. J Hepatol., 4: 349-356, 1987.
-
(1987)
J Hepatol.
, vol.4
, pp. 349-356
-
-
Bassendine, M.F.1
Curtin, N.J.2
Loose, H.3
Harris, A.L.4
James, O.F.5
-
53
-
-
18144436567
-
Pharmacokinetics and toxicity studies with CB3717
-
Newell, D. R., Siddik, Z. H., Calvert, A. H., Jackman, A. L., Alison, D. L., McGhee, G. K., and Harrap, K. R. Pharmacokinetics and toxicity studies with CB3717 Proc. Am. Assoc. Cancer Res., 23: 181, 1982.
-
(1982)
Proc. Am. Assoc. Cancer Res.
, vol.23
, pp. 181
-
-
Newell, D.R.1
Siddik, Z.H.2
Calvert, A.H.3
Jackman, A.L.4
Alison, D.L.5
McGhee, G.K.6
Harrap, K.R.7
-
54
-
-
0025820445
-
Quinazoline antifolate thymidylate synthase inhibitors: Heterocyclic benzoyl ring modifications
-
Marsham, P. R., Hughes, L. R., Jackman, A. L., Hayter, A. J., Oldfield, J., Wardleworth, J. M., Bishop, J. A. M., O'Connor, B. M., and Calvert, A. H. Quinazoline antifolate thymidylate synthase inhibitors: heterocyclic benzoyl ring modifications. J. Med. Chem., 34: 1594-1605, 1991.
-
(1991)
J. Med. Chem.
, vol.34
, pp. 1594-1605
-
-
Marsham, P.R.1
Hughes, L.R.2
Jackman, A.L.3
Hayter, A.J.4
Oldfield, J.5
Wardleworth, J.M.6
Bishop, J.A.M.7
O'Connor, B.M.8
Calvert, A.H.9
-
55
-
-
8044225249
-
Biochemical aspects of a new thymidylate synthase inhibitor, D1694
-
Jackman, A. L., Taylor, G. A., Bishop, J. A., O'Connor, B. M., Bisset, G., Hughes, L. R , Moran, R. G., and Calvert, A. Biochemical aspects of a new thymidylate synthase inhibitor, D1694. Proc. Am. Assoc. Cancer Res., 31: 342, 1990.
-
(1990)
Proc. Am. Assoc. Cancer Res.
, vol.31
, pp. 342
-
-
Jackman, A.L.1
Taylor, G.A.2
Bishop, J.A.3
O'Connor, B.M.4
Bisset, G.5
Hughes, L.R.6
Moran, R.G.7
Calvert, A.8
-
56
-
-
0025997350
-
ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L 1210 tumor cell growth in vitro and in vivo: A new agent for clinical study
-
Jackman, A. L., Taylor, G. A., Gibson, W., Kimbell, R., Brown, M., Calvert, A. H., Judson, I. R., and Hughes, L. R. ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L 1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Res., 51: 5579-5586, 1991.
-
(1991)
Cancer Res.
, vol.51
, pp. 5579-5586
-
-
Jackman, A.L.1
Taylor, G.A.2
Gibson, W.3
Kimbell, R.4
Brown, M.5
Calvert, A.H.6
Judson, I.R.7
Hughes, L.R.8
-
57
-
-
9044235902
-
Biochemical effects of D1694 inhibition of thymidylate synthase in MGH-U1 bladder cancer cells
-
Erlichman, C., and Mitrovski, B. Biochemical effects of D1694 inhibition of thymidylate synthase in MGH-U1 bladder cancer cells. Proc. Am. Assoc. Cancer Res., 33: 507, 1992.
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 507
-
-
Erlichman, C.1
Mitrovski, B.2
-
58
-
-
9044239022
-
Prolonged cell cycle phase perturbation induced by the quinazoline antifolate thymidylate synthase inhibitor ICI D1694
-
Arredondo, M. A., Guimaraes, M. A., Yin, M. B., Slocum, H. K., and Rustum, Y. M. Prolonged cell cycle phase perturbation induced by the quinazoline antifolate thymidylate synthase inhibitor ICI D1694. Proc. Am. Assoc. Cancer Res., 33: 428, 1992.
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 428
-
-
Arredondo, M.A.1
Guimaraes, M.A.2
Yin, M.B.3
Slocum, H.K.4
Rustum, Y.M.5
-
59
-
-
9044235716
-
Cytotoxicity of ICI D 1694 and cisplatin in sensitive and acquired resistant tumor cell lines
-
Kelland, L. R., Abel, G., Brown, M., and Jackman, A. L. Cytotoxicity of ICI D 1694 and cisplatin in sensitive and acquired resistant tumor cell lines. Br J. Cancer, 65 (Suppl. 16): 64, 1992.
-
(1992)
Br J. Cancer
, vol.65
, Issue.16 SUPPL.
, pp. 64
-
-
Kelland, L.R.1
Abel, G.2
Brown, M.3
Jackman, A.L.4
-
60
-
-
9044233003
-
Cytotoxicity, DNA strand breaks, thymidylate synthase inhibition and methylenetetrahydrofolate pool decrease induced by ICI D 1694
-
Zhang, Z. G., Yin, M. B., and Rustum, Y. M. Cytotoxicity, DNA strand breaks, thymidylate synthase inhibition and methylenetetrahydrofolate pool decrease induced by ICI D 1694. Proc. Am. Assoc. Cancer Res., 33: 410, 1992.
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 410
-
-
Zhang, Z.G.1
Yin, M.B.2
Rustum, Y.M.3
-
61
-
-
9044226657
-
Double-strand DNA damage induced by thymidylate synthase (TS) inhibitor, ZD1694, in human colon carcinoma cell, HCT-8, requires DNA replication
-
Matsui, S., Lu, K., Wrzosek, C., and Rustum, Y. Double-strand DNA damage induced by thymidylate synthase (TS) inhibitor, ZD1694, in human colon carcinoma cell, HCT-8, requires DNA replication. Proc. Am. Assoc. Cancer Res., 36: 378, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 378
-
-
Matsui, S.1
Lu, K.2
Wrzosek, C.3
Rustum, Y.4
-
62
-
-
0343303553
-
Antitumor activity of a new thymidylate synthase (TS) inhibitor, D1694
-
Stephens, T. C , Calvete, J. A., Janes, D., Waterman, S. E., Valcaccia, B. E., Hughes, L. R., and Calvert, A. H. Antitumor activity of a new thymidylate synthase (TS) inhibitor, D1694. Proc. Am. Assoc. Cancer Res., 31: 342, 1990.
-
(1990)
Proc. Am. Assoc. Cancer Res.
, vol.31
, pp. 342
-
-
Stephens, T.C.1
Calvete, J.A.2
Janes, D.3
Waterman, S.E.4
Valcaccia, B.E.5
Hughes, L.R.6
Calvert, A.H.7
-
63
-
-
0343794762
-
Pharmacokinetic and toxicity studies with the novel quinazoline thymidylate synthase (TS) inhibitor, D1694
-
Jodrell, D. I., Newell, D. R., Calvete, J A., Stephens, T. C., and Calvert, A. H. Pharmacokinetic and toxicity studies with the novel quinazoline thymidylate synthase (TS) inhibitor, D1694. Proc. Am. Assoc. Cancer Res., 31: 341, 1990.
-
(1990)
Proc. Am. Assoc. Cancer Res.
, vol.31
, pp. 341
-
-
Jodrell, D.I.1
Newell, D.R.2
Calvete, J.A.3
Stephens, T.C.4
Calvert, A.H.5
-
64
-
-
0009688297
-
The thymidylate synthase (TS) inhibitor ICI D 1694 is superior to CB3717, 5-fluorouracil (5-FU) and methotrexate (MTX) against a panel of human tumor xenografts
-
Stephens, T. C., Valcaccia, B. E., Sheader, M. L., Hughes, L., and Jackman, A. L. The thymidylate synthase (TS) inhibitor ICI D 1694 is superior to CB3717, 5-fluorouracil (5-FU) and methotrexate (MTX) against a panel of human tumor xenografts. Proc. Am. Assoc. Cancer Res., 32: 328, 1991.
-
(1991)
Proc. Am. Assoc. Cancer Res.
, vol.32
, pp. 328
-
-
Stephens, T.C.1
Valcaccia, B.E.2
Sheader, M.L.3
Hughes, L.4
Jackman, A.L.5
-
65
-
-
0013684729
-
Delayed rescue of ZD1694 toxicity in BALB/c mice with thymidine (dThd) or leucovorin (LV)
-
Jackman, A. L., Farrugia, D. C., Clarke, S. J., Aherne, G. W., Boyle, F. T., Seymour, L., Azab, M., and Kennealey, G. Delayed rescue of ZD1694 toxicity in BALB/c mice with thymidine (dThd) or leucovorin (LV). Proc. Am. Assoc. Cancer Res., 36: 377, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 377
-
-
Jackman, A.L.1
Farrugia, D.C.2
Clarke, S.J.3
Aherne, G.W.4
Boyle, F.T.5
Seymour, L.6
Azab, M.7
Kennealey, G.8
-
66
-
-
7144261163
-
ZD1694 (Tomudex) and polyglutamate levels in mouse plasma and tissues measured by radioimmunoassay (RIA) and the effect of leucovorin (LV)
-
Aherne, G. W., Farrugia, D. C , Ward, E., Sutcliffe, F., and Jackman, A. L. ZD1694 (Tomudex) and polyglutamate levels in mouse plasma and tissues measured by radioimmunoassay (RIA) and the effect of leucovorin (LV). Proc. Am. Assoc. Cancer Res., 36: 376, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 376
-
-
Aherne, G.W.1
Farrugia, D.C.2
Ward, E.3
Sutcliffe, F.4
Jackman, A.L.5
-
68
-
-
0025744809
-
The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats
-
Jodrell, D. I., Newell, D. R , Gibson, W., Hughes, L. R., and Calvert, A. H. The pharmacokinetics of the quinazoline antifolate ICI D 1694 in mice and rats. Cancer Chemother. Pharmacol., 28: 331-338, 1991.
-
(1991)
Cancer Chemother. Pharmacol.
, vol.28
, pp. 331-338
-
-
Jodrell, D.I.1
Newell, D.R.2
Gibson, W.3
Hughes, L.R.4
Calvert, A.H.5
-
69
-
-
0013684729
-
Polyglutamation of the thymidylate synthase (TS) inhibitor, ZD1694 (Tomudex), in normal mouse tissues
-
Jackman, A. L., and Gibson, W. Polyglutamation of the thymidylate synthase (TS) inhibitor, ZD1694 (Tomudex), in normal mouse tissues. Proc. Am. Assoc. Cancer Res., 36. 377, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 377
-
-
Jackman, A.L.1
Gibson, W.2
-
70
-
-
0343739055
-
Pharmacokinetics of ICI D1694 following a 15-minute infusion in patients with advanced cancer
-
Judson, I., Clarke, S., Ward, J., Sutcliffe, F., Planting, A., Spiers, J., Smith, R., Verweij, J., and Judson, I. Pharmacokinetics of ICI D1694 following a 15-minute infusion in patients with advanced cancer. Proc. Am. Soc. Clin. Oncol. Annu. Meet., 11: 117, 1992.
-
(1992)
Proc. Am. Soc. Clin. Oncol. Annu. Meet.
, vol.11
, pp. 117
-
-
Judson, I.1
Clarke, S.2
Ward, J.3
Sutcliffe, F.4
Planting, A.5
Spiers, J.6
Smith, R.7
Verweij, J.8
Judson, I.9
-
71
-
-
9044238184
-
Phase I and pharmacokinetic study of ICI D1694: A folate-based thymidylate synthase (TS) inhibitor
-
Clarke, S. J., Ward, J., Tierney, K., Walker, M., Sutcliffe, F., Planting, A., Verweij, J , Spiers, J., Smith, R., and Judson, I. Phase I and pharmacokinetic study of ICI D1694: a folate-based thymidylate synthase (TS) inhibitor. Ann. Oncol., 3 (Suppl. 1): 135, 1992.
-
(1992)
Ann. Oncol.
, vol.3
, Issue.1 SUPPL.
, pp. 135
-
-
Clarke, S.J.1
Ward, J.2
Tierney, K.3
Walker, M.4
Sutcliffe, F.5
Planting, A.6
Verweij, J.7
Spiers, J.8
Smith, R.9
Judson, I.10
-
72
-
-
0039822731
-
Phase I trial of ICI D 1694: A novel thymidylate synthase inhibitor
-
Clarke, S. J., Ward, J., Planting, A., Spiers, J., Smith, R., Verweij, J., and Judson, I. Phase I trial of ICI D 1694: a novel thymidylate synthase inhibitor. Proc. Am. Assoc. Cancer Res., 33: 406, 1992.
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 406
-
-
Clarke, S.J.1
Ward, J.2
Planting, A.3
Spiers, J.4
Smith, R.5
Verweij, J.6
Judson, I.7
-
73
-
-
0027494408
-
The toxicity of ICI D1694 in man and mouse
-
Clarke, S. J., Jackman, A. L., and Judson, I. R. The toxicity of ICI D1694 in man and mouse. Adv. Exp. Med. Biol., 338: 601-604, 1993.
-
(1993)
Adv. Exp. Med. Biol.
, vol.338
, pp. 601-604
-
-
Clarke, S.J.1
Jackman, A.L.2
Judson, I.R.3
-
74
-
-
0000154770
-
Phase I study of the new thymidylate synthase inhibitor "Tomudex" (ZD1694) in patients with advanced malignancy
-
Clarke, S. J., Ward, J., De Boer, M., Planting, A., Verweij, J., Sutcliffe, F., Azab, M., and Judson, I. Phase I study of the new thymidylate synthase inhibitor "Tomudex" (ZD1694) in patients with advanced malignancy. Ann. Oncol., 5 (Suppl. 5): 132, 1994.
-
(1994)
Ann. Oncol.
, vol.5
, Issue.5 SUPPL.
, pp. 132
-
-
Clarke, S.J.1
Ward, J.2
De Boer, M.3
Planting, A.4
Verweij, J.5
Sutcliffe, F.6
Azab, M.7
Judson, I.8
-
75
-
-
0342489583
-
Phase I trial of D1694, a pure thymidylate synthase inhibitor
-
Sorensen, J. M., Jordan, D., Grem, J. L., Hamilton, J. M., Arbuck, S. G., Johnson, P., Kohler, D. R., Goldspiel, B. R., and Allegra, C. J. Phase I trial of D1694, a pure thymidylate synthase inhibitor. Proc. Am. Soc. Clin. Oncol., 12: 158, 1993.
-
(1993)
Proc. Am. Soc. Clin. Oncol.
, vol.12
, pp. 158
-
-
Sorensen, J.M.1
Jordan, D.2
Grem, J.L.3
Hamilton, J.M.4
Arbuck, S.G.5
Johnson, P.6
Kohler, D.R.7
Goldspiel, B.R.8
Allegra, C.J.9
-
76
-
-
0001139165
-
Phase I trial of ZD1694 ("Tomudex") a direct inhibitor of thymidylate synthase
-
Sorensen, J. M., Jordan, E., Grem, J. L., Arbuck, S. G., Chen, A. P., Hamilton, J. M., Johnson, P., Kohler, D., Goldspiel, B., and Allegra, C. Phase I trial of ZD1694 ("Tomudex") a direct inhibitor of thymidylate synthase. Ann. Oncol., 5 (Suppl. 5): 132, 1994.
-
(1994)
Ann. Oncol.
, vol.5
, Issue.5 SUPPL.
, pp. 132
-
-
Sorensen, J.M.1
Jordan, E.2
Grem, J.L.3
Arbuck, S.G.4
Chen, A.P.5
Hamilton, J.M.6
Johnson, P.7
Kohler, D.8
Goldspiel, B.9
Allegra, C.10
-
77
-
-
0012523788
-
Phase II study of "Tomudex" (ZD1694), a new thymidylate synthase inhibitor with antitumour activity in breast cancer
-
Gore, M., Earl, H., Cassidy, J., Tattersal, M., Mansi, J., and Azab, M. Phase II study of "Tomudex" (ZD1694), a new thymidylate synthase inhibitor with antitumour activity in breast cancer. Ann. Oncol., 5 (Suppl. 5): 132, 1994.
-
(1994)
Ann. Oncol.
, vol.5
, Issue.5 SUPPL.
, pp. 132
-
-
Gore, M.1
Earl, H.2
Cassidy, J.3
Tattersal, M.4
Mansi, J.5
Azab, M.6
-
78
-
-
0012523788
-
"Tomudex" (ZD1694), a new thymidylate synthase inhibitor ZD1694 in advanced breast cancer
-
Smith, I. E , Spielmann, M., Bonneterre, J., Namer, M., Green, M., Wander, H. E., Toussaint, C., and Azab, M. "Tomudex" (ZD1694), a new thymidylate synthase inhibitor ZD1694 in advanced breast cancer. Ann. Oncol , 5 (Suppl. 5): 132, 1994.
-
(1994)
Ann. Oncol
, vol.5
, Issue.5 SUPPL.
, pp. 132
-
-
Smith, I.E.1
Spielmann, M.2
Bonneterre, J.3
Namer, M.4
Green, M.5
Wander, H.E.6
Toussaint, C.7
Azab, M.8
-
79
-
-
9044233752
-
Antitumour activity of a new thymidylate synthase inhibitor ZD1694 in advanced breast cancer
-
Smith, I. E., Spielmann, M., Namer, M., Bonneterre, J., Wander, H. E., Green, M., Lowery, K., and Azab, M. Antitumour activity of a new thymidylate synthase inhibitor ZD1694 in advanced breast cancer. Breast Cancer Res. Treat., 27: 149, 1993.
-
(1993)
Breast Cancer Res. Treat.
, vol.27
, pp. 149
-
-
Smith, I.E.1
Spielmann, M.2
Namer, M.3
Bonneterre, J.4
Wander, H.E.5
Green, M.6
Lowery, K.7
Azab, M.8
-
80
-
-
9044246386
-
Good antitumour activity of the new thymidylate synthase inhibitor "Tomudex" (ZD1694) in colorectal cancer
-
Zalcberg, J., Cunningham, D., Banc Custsem, E., Francois, J. E., Schornagel, J. H., Adenis, A., Green, M., Starkhammer, H., and Azab, M. Good antitumour activity of the new thymidylate synthase inhibitor "Tomudex" (ZD1694) in colorectal cancer. Ann Oncol., 5 (Suppl. 5): 133, 1994.
-
(1994)
Ann Oncol.
, vol.5
, Issue.5 SUPPL.
, pp. 133
-
-
Zalcberg, J.1
Cunningham, D.2
Banc Custsem, E.3
Francois, J.E.4
Schornagel, J.H.5
Adenis, A.6
Green, M.7
Starkhammer, H.8
Azab, M.9
-
81
-
-
0005691931
-
Phase II trial of "Tomudex" (ZD1694), a thymidylate synthase inhibitor in advanced pancreatic cancer
-
Pazdur, R., Casper, E. S., Meropol, N. J., Fuchs, C., and Kennealey, G. T. Phase II trial of "Tomudex" (ZD1694), a thymidylate synthase inhibitor in advanced pancreatic cancer. Proc. Am. Soc. Clin. Oncol. 13: 207, 1994.
-
(1994)
Proc. Am. Soc. Clin. Oncol.
, vol.13
, pp. 207
-
-
Pazdur, R.1
Casper, E.S.2
Meropol, N.J.3
Fuchs, C.4
Kennealey, G.T.5
-
82
-
-
0342433990
-
Phase II study of Tomudex (ZD1694) in refractory ovarian cancer
-
Gore, M., Earl, H., Cassidy, J., Tattersal, M., Mansi, J., and Azab, M. Phase II study of Tomudex (ZD1694) in refractory ovarian cancer Ann. Oncol., 5 (Suppl 5): 133, 1994.
-
(1994)
Ann. Oncol.
, vol.5
, Issue.5 SUPPL.
, pp. 133
-
-
Gore, M.1
Earl, H.2
Cassidy, J.3
Tattersal, M.4
Mansi, J.5
Azab, M.6
-
83
-
-
0000262201
-
A Phase II trial of ZD1694, a novel thymidylate synthase inhibitor, in patients with advanced non-small cell lung cancer
-
Burris, H. I., Von Hoff, D., Bowen, K., Heaven, R., Rinaldi, D., Eckardt, J., Campbell, L., Robert, F., Patton, S., and Kennealey, G. A Phase II trial of ZD1694, a novel thymidylate synthase inhibitor, in patients with advanced non-small cell lung cancer. Ann. Oncol , 5 (Suppl. 5): 133, 1994.
-
(1994)
Ann. Oncol
, vol.5
, Issue.5 SUPPL.
, pp. 133
-
-
Burris, H.I.1
Von Hoff, D.2
Bowen, K.3
Heaven, R.4
Rinaldi, D.5
Eckardt, J.6
Campbell, L.7
Robert, F.8
Patton, S.9
Kennealey, G.10
-
84
-
-
0009687187
-
Tomudex (ZD1694). a new thymidylate synthase inhibitor with good antitumor activity in advanced colorectal cancer (ACC)
-
Cunningham, D., Zalcberg, J., Francois, E., Van Cutsem, J. H., Ellis, P., and Azab, M. Tomudex (ZD1694). a new thymidylate synthase inhibitor with good antitumor activity in advanced colorectal cancer (ACC). Proc. Am. Soc. Clin. Oncol., 13: 199, 1994.
-
(1994)
Proc. Am. Soc. Clin. Oncol.
, vol.13
, pp. 199
-
-
Cunningham, D.1
Zalcberg, J.2
Francois, E.3
Van Cutsem, J.H.4
Ellis, P.5
Azab, M.6
-
85
-
-
0026721532
-
Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: Evidence in terms of response rate
-
Piedbois, P., Buyse, M., Rustum, Y , Machover, D., Erlichman, C., Carlson, R. W., Valone, F., Labianca, R , Doroshow, J. H., and Petrelli, N. for the Advanced Colorectal Cancer Meta-Analysis Project. Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. J. Clin. Oncol., 10: 896-903, 1992.
-
(1992)
J. Clin. Oncol.
, vol.10
, pp. 896-903
-
-
Piedbois, P.1
Buyse, M.2
Rustum, Y.3
Machover, D.4
Erlichman, C.5
Carlson, R.W.6
Valone, F.7
Labianca, R.8
Doroshow, J.H.9
Petrelli, N.10
-
86
-
-
0026006962
-
Biochemical modulation of fluorouracil with leucovorin: Confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer
-
Poon, M. A., O'Connel, J. H., Wieland, H. S. Krook, J. E., Gerstner, J. B., Tschetter, L. K., Levin, R., Kardinal, C. G., and Maillard, J. A. Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. J. Clin. Oncol., 9: 1967-1972, 1991.
-
(1991)
J. Clin. Oncol.
, vol.9
, pp. 1967-1972
-
-
Poon, M.A.1
O'Connel, J.H.2
Wieland, H.S.3
Krook, J.E.4
Gerstner, J.B.5
Tschetter, L.K.6
Levin, R.7
Kardinal, C.G.8
Maillard, J.A.9
-
87
-
-
0007357121
-
ZD9331, a non-polyglutamatable quinazoline thymidylate synthase (TS) inhibitor
-
Jackman, A. L., Aherne, G., Kimbell, R., Brunton, L., Hardcastle, A., Wardleworth, J. W., Stephens, T. C., and Boyle, F. ZD9331, a non-polyglutamatable quinazoline thymidylate synthase (TS) inhibitor. Proc. Am. Assoc. Cancer Res., 35: 301, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 301
-
-
Jackman, A.L.1
Aherne, G.2
Kimbell, R.3
Brunton, L.4
Hardcastle, A.5
Wardleworth, J.W.6
Stephens, T.C.7
Boyle, F.8
-
88
-
-
0007356048
-
Pharmacokinetics of the potent non-polyglutamatable thymidylate synthase inhibitors CB30900 and ZD9331 in mice
-
Walton, M. I., Gibson, W., Aherne, L., Lawrence, N., Stephens, T., Smith, M., and Jackman, A. Pharmacokinetics of the potent non-polyglutamatable thymidylate synthase inhibitors CB30900 and ZD9331 in mice. Proc. Am. Assoc. Cancer Res., 35: 301, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 301
-
-
Walton, M.I.1
Gibson, W.2
Aherne, L.3
Lawrence, N.4
Stephens, T.5
Smith, M.6
Jackman, A.7
-
89
-
-
0001104819
-
ZD9331, a novel non-polyglutamated thymidylate synthase (TS) inhibitor: In vivo antitumor efficacy and toxicity to normal murine tissues
-
Stephens, T. C., Smith, M. N., McClockey, M. L., and Boyle, F. T. ZD9331, a novel non-polyglutamated thymidylate synthase (TS) inhibitor: in vivo antitumor efficacy and toxicity to normal murine tissues. Proc. Am. Assoc. Cancer Res., 35: 305, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 305
-
-
Stephens, T.C.1
Smith, M.N.2
McClockey, M.L.3
Boyle, F.T.4
-
90
-
-
0027186327
-
Benzoquinazoline inhibitors of thymidylate synthase: Enzyme inhibitory activity and cytotoxicity of some 3-amino and 3-methylbenzo[f]quinazolin-1(2H)-ones
-
Pendergast, W., Dickerson, S. H., Johnson, J. V., Dev, I. K., Ferone, R., Duch, D. S., Hall, W. R., Humphreys, J., Kelly, I. M., and Wilson, D. C. Benzoquinazoline inhibitors of thymidylate synthase: enzyme inhibitory activity and cytotoxicity of some 3-amino and 3-methylbenzo[f]quinazolin-1(2H)-ones. J. Med. Chem., 36: 2279-2291, 1993.
-
(1993)
J. Med. Chem.
, vol.36
, pp. 2279-2291
-
-
Pendergast, W.1
Dickerson, S.H.2
Johnson, J.V.3
Dev, I.K.4
Ferone, R.5
Duch, D.S.6
Hall, W.R.7
Humphreys, J.8
Kelly, I.M.9
Wilson, D.C.10
-
91
-
-
0027477992
-
Biochemical and cellular pharmacology of 1849U89, a novel benzoqumazoline inhibitor of thymidylate synthase
-
Duch, D. S., Banks, S., Dev, I. K., Dickerson, S. H., Ferone, R., Heath, L. S., Humphreys, J., Knick, V., Pendergast, W., Singer, S., Smith, G., Waters, K., and Wilson, R. Biochemical and cellular pharmacology of 1849U89, a novel benzoqumazoline inhibitor of thymidylate synthase. Cancer Res., 53: 810-818, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 810-818
-
-
Duch, D.S.1
Banks, S.2
Dev, I.K.3
Dickerson, S.H.4
Ferone, R.5
Heath, L.S.6
Humphreys, J.7
Knick, V.8
Pendergast, W.9
Singer, S.10
Smith, G.11
Waters, K.12
Wilson, R.13
-
92
-
-
0002997779
-
Influence of intracellular polyglutamation on the cytotoxicity of the thymidylate synthase inhibitor 1843U89
-
Ferone, R., Hanlon, M. H., Waters, K. A., and Dev, I. K. Influence of intracellular polyglutamation on the cytotoxicity of the thymidylate synthase inhibitor 1843U89. Proc. Am. Assoc. Cancer Res., 34: 274, 1993.
-
(1993)
Proc. Am. Assoc. Cancer Res.
, vol.34
, pp. 274
-
-
Ferone, R.1
Hanlon, M.H.2
Waters, K.A.3
Dev, I.K.4
-
93
-
-
0028274226
-
Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89
-
Banks, S. D., Waters, K. A., Barrett, L. L., Dickerson, S., Pendergast, W., and Smith, G. K. Destruction of WiDr multicellular tumor spheroids with the novel thymidylate synthase inhibitor 1843U89. Cancer Chemother. Pharmacol. 36: 455-459, 1994.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.36
, pp. 455-459
-
-
Banks, S.D.1
Waters, K.A.2
Barrett, L.L.3
Dickerson, S.4
Pendergast, W.5
Smith, G.K.6
-
94
-
-
0003061366
-
In vivo antitumor activity of 1843U89, a new antifolate thymidylate synthase inhibitor
-
Wilson, H. R., Heath, L S., Knick, V. C., Kszalka, G. W., and Ferone, R. In vivo antitumor activity of 1843U89, a new antifolate thymidylate synthase inhibitor. Proc. Am. Assoc. Cancer Res., 33: 407, 1992
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 407
-
-
Wilson, H.R.1
Heath, L.S.2
Knick, V.C.3
Kszalka, G.W.4
Ferone, R.5
-
95
-
-
0028906786
-
Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen
-
Boyd, M. R., and Paull, K. D. Some practical considerations and applications of the National Cancer Institute in vitro anticancer drug discovery screen. Drug Dev. Res., 34: 91-109, 1995.
-
(1995)
Drug Dev. Res.
, vol.34
, pp. 91-109
-
-
Boyd, M.R.1
Paull, K.D.2
-
96
-
-
0000714734
-
Molecular design of thymidylate synthase inhibitors
-
Jackson, R. C., Johnston, A. L., Shetty, B. V., Varney, M. D., and Webber, S. E. Molecular design of thymidylate synthase inhibitors. Proc. Am. Assoc. Cancer Res., 34: 566-567, 1993.
-
(1993)
Proc. Am. Assoc. Cancer Res.
, vol.34
, pp. 566-567
-
-
Jackson, R.C.1
Johnston, A.L.2
Shetty, B.V.3
Varney, M.D.4
Webber, S.E.5
-
97
-
-
0026554077
-
Crystal-structure-based design and synthesis of benz[od]indole-containing inhibitors of thymidylate synthase
-
Varney, M. D., Marzone, G. H. P., Palmer, C. L., Reddy, M. R., Tatlock, J., Rommes, W. H., Wu, B. W., and Musick, L. Crystal-structure-based design and synthesis of benz[od]indole-containing inhibitors of thymidylate synthase. J. Med. Chem., 35: 663-676, 1992.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 663-676
-
-
Varney, M.D.1
Marzone, G.H.P.2
Palmer, C.L.3
Reddy, M.R.4
Tatlock, J.5
Rommes, W.H.6
Wu, B.W.7
Musick, L.8
-
98
-
-
0026589385
-
Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis
-
Reich, S. H., Fuhry, M. A. M., Nguyen, D., Pino, M. J., Welsh, K. M., Webber, S., Janson, C. A., Jordan, S. R., Matthews, D. A., Smith, W., and Bartlett, C. Design and synthesis of novel 6,7-imidazotetrahydroquinoline inhibitors of thymidylate synthase using iterative protein crystal structure analysis. J. Med. Chem., 35: 847-858, 1992.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 847-858
-
-
Reich, S.H.1
Fuhry, M.A.M.2
Nguyen, D.3
Pino, M.J.4
Welsh, K.M.5
Webber, S.6
Janson, C.A.7
Jordan, S.R.8
Matthews, D.A.9
Smith, W.10
Bartlett, C.11
-
99
-
-
0013472183
-
In vitro properties and antitumor activity of AG-331, a novel lipophilic thymidylate synthase inhibitor
-
Webber, S., Shetty, B., Johnston, A., Welsh, K., Varney, M., Deal, J., Morse, C., and Soda, K. In vitro properties and antitumor activity of AG-331, a novel lipophilic thymidylate synthase inhibitor. Proc. Am. Assoc Cancer Res., 33: 413, 1992.
-
(1992)
Proc. Am. Assoc Cancer Res.
, vol.33
, pp. 413
-
-
Webber, S.1
Shetty, B.2
Johnston, A.3
Welsh, K.4
Varney, M.5
Deal, J.6
Morse, C.7
Soda, K.8
-
100
-
-
0004829272
-
Preclinical studies on AG337, a novel lipophilic thymidylate synthase inhibitor
-
Webber, S., Johnston, A., Shetty, B., Webber, S. E., Welsh, K., Hilliard, J., Kosa, M., Morse, C., and Soda, K. Preclinical studies on AG337, a novel lipophilic thymidylate synthase inhibitor. Proc. Am. Assoc. Cancer Res., 34: 273, 1993.
-
(1993)
Proc. Am. Assoc. Cancer Res.
, vol.34
, pp. 273
-
-
Webber, S.1
Johnston, A.2
Shetty, B.3
Webber, S.E.4
Welsh, K.5
Hilliard, J.6
Kosa, M.7
Morse, C.8
Soda, K.9
-
101
-
-
9044241806
-
Biochemical properties of new lipophilic thymidylate synthase inhibitors designed from the X-ray structure of the E. coli enzyme
-
Boritzki, T. J., Bartlett, C. A., Huffaker, T., Morse, C. A., Webber, S., Welsh, K., and Jackson, R. C. Biochemical properties of new lipophilic thymidylate synthase inhibitors designed from the X-ray structure of the E. coli enzyme. Proc. Am. Assoc Cancer Res., 33: 33, 1992.
-
(1992)
Proc. Am. Assoc Cancer Res.
, vol.33
, pp. 33
-
-
Boritzki, T.J.1
Bartlett, C.A.2
Huffaker, T.3
Morse, C.A.4
Webber, S.5
Welsh, K.6
Jackson, R.C.7
-
102
-
-
0008758702
-
AG-331, a "non-classical" lipophilic thymidylate synthase inhibitor for the treatment of solid tumors
-
Clendeninn, N. J., Peterkin, J. J., Webber, S., Shetty, B. V., Koda, R. T , Leichman, L., Leichman, C. G., Jeffers, S , Muggia, F., and O'Dwyer, P. AG-331, a "non-classical" lipophilic thymidylate synthase inhibitor for the treatment of solid tumors Ann. Oncol., 5 (Suppl. 5): 133, 1994.
-
(1994)
Ann. Oncol.
, vol.5
, Issue.5 SUPPL.
, pp. 133
-
-
Clendeninn, N.J.1
Peterkin, J.J.2
Webber, S.3
Shetty, B.V.4
Koda, R.T.5
Leichman, L.6
Leichman, C.G.7
Jeffers, S.8
Muggia, F.9
O'Dwyer, P.10
-
103
-
-
0008742276
-
Preclinical and clinical studies of prolonged administration of the novel thymidylate synthase inhibitor, AG337
-
Calvete, J. A., Balmanno, K., Taylor, G. A., Rafi, I., Newell, D. R., Lind, M. J., Calvert, A. H., Webber, S., and Clendeninn, N. J. Preclinical and clinical studies of prolonged administration of the novel thymidylate synthase inhibitor, AG337. Proc. Am. Assoc. Cancer Res., 35: 306, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 306
-
-
Calvete, J.A.1
Balmanno, K.2
Taylor, G.A.3
Rafi, I.4
Newell, D.R.5
Lind, M.J.6
Calvert, A.H.7
Webber, S.8
Clendeninn, N.J.9
-
104
-
-
8044245883
-
Preclinical and clinical studies of the novel thymidylate synthase inhibitor AG337, given by oral administration
-
Calvete, J. A., Balmanno, K., Rafi, I., Newell, D. R., Taylor, G. A., Boddy, A. V., Lind, M. J., Bailey, N. B., Calvert, A. H., Webber, S., and Clendeninn, N. J. Preclinical and clinical studies of the novel thymidylate synthase inhibitor AG337, given by oral administration. Proc. Am. Assoc. Cancer Res., 36: 380, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 380
-
-
Calvete, J.A.1
Balmanno, K.2
Rafi, I.3
Newell, D.R.4
Taylor, G.A.5
Boddy, A.V.6
Lind, M.J.7
Bailey, N.B.8
Calvert, A.H.9
Webber, S.10
Clendeninn, N.J.11
-
105
-
-
9044250445
-
A Phase I study of the novel antifolate 3,4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by a 24 h intravenous continuous infusion
-
Rafi, I., Taylor, G. A., Balmanno, K., Calvete, J. A., Newell, D. R., Lind, M. J., and Calvert, A. H. A Phase I study of the novel antifolate 3,4-dihydro-2-amino-6-methyl-4-oxo-5-(4-pyridylthio)-quinazolone dihydrochloride (AG337) given by a 24 h intravenous continuous infusion. Proc. Am. Assoc. Cancer Res., 35: 306, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 306
-
-
Rafi, I.1
Taylor, G.A.2
Balmanno, K.3
Calvete, J.A.4
Newell, D.R.5
Lind, M.J.6
Calvert, A.H.7
-
107
-
-
0004890437
-
Non-linear pharmacokinetics in cancer patients of AG337, a rationally-designed thymidylate synthase (TS) inhibitor
-
Boddy, A. V., Calvete, J. A., and Rafi, I. Non-linear pharmacokinetics in cancer patients of AG337, a rationally-designed thymidylate synthase (TS) inhibitor. Proc. Am. Assoc. Cancer Res., 36: 236, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 236
-
-
Boddy, A.V.1
Calvete, J.A.2
Rafi, I.3
-
108
-
-
6844236792
-
A Phase I clinical study of the novel antifolate AG337 given by a 5-day continuous infusion
-
Rafi, I., Taylor, G. A., Calvete, J. A., Balmanno, K., Boddy, A. V., Bailey, N B., Lind, M. J., Newell, D., Calvert, A. H., Johnston, A., and Clendeninn, N. J. A Phase I clinical study of the novel antifolate AG337 given by a 5-day continuous infusion. Proc. Am. Assoc. Cancer Res., 36. 240, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 240
-
-
Rafi, I.1
Taylor, G.A.2
Calvete, J.A.3
Balmanno, K.4
Boddy, A.V.5
Bailey, N.B.6
Lind, M.J.7
Newell, D.8
Calvert, A.H.9
Johnston, A.10
Clendeninn, N.J.11
-
109
-
-
8044247144
-
Pharmacokinetics of AG-331 following single escalating i.v. doses in patients with refractory solid tumors
-
Koda, R. T., Leichman, L., Webber, S., Shetty, B. V., Leichman, C. G., Jeffers, S., and Muggia, F. M. Pharmacokinetics of AG-331 following single escalating i.v. doses in patients with refractory solid tumors. Proc. Am. Assoc. Cancer Res., 35. 432, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 432
-
-
Koda, R.T.1
Leichman, L.2
Webber, S.3
Shetty, B.V.4
Leichman, C.G.5
Jeffers, S.6
Muggia, F.M.7
-
110
-
-
0028237440
-
Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor
-
O'Connor, B. M., Webber, S., Jackson, R. C. Galivan, J., and Rhee, M. S. Biological activity of a novel rationally designed lipophilic thymidylate synthase inhibitor. Cancer Chemother. Pharmacol., 34: 225-229, 1994.
-
(1994)
Cancer Chemother. Pharmacol.
, vol.34
, pp. 225-229
-
-
O'Connor, B.M.1
Webber, S.2
Jackson, R.C.3
Galivan, J.4
Rhee, M.S.5
-
111
-
-
0001625173
-
ICI D 1694 resistant cell lines
-
Jackman, A. L., Kelland, L. R., Brown, M., Gibson, W., Kimbell, R., Aherne, W., and Judson, I. R. ICI D 1694 resistant cell lines. Proc. Am. Assoc. Cancer Res., 33: 406, 1992.
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 406
-
-
Jackman, A.L.1
Kelland, L.R.2
Brown, M.3
Gibson, W.4
Kimbell, R.5
Aherne, W.6
Judson, I.R.7
-
112
-
-
2642590939
-
Molecular characterisation of three cell lines selected for resistance to folate-based thymidylate synthase inhibitors
-
Freemantle, S. J., Lunec, J., Jackman, A. L., Kelland, L. R., Aherne, G W., and Calvert, A. H. Molecular characterisation of three cell lines selected for resistance to folate-based thymidylate synthase inhibitors. Br. J. Cancer, 67 (Suppl. 20): 79, 1993.
-
(1993)
Br. J. Cancer
, vol.67
, Issue.20 SUPPL.
, pp. 79
-
-
Freemantle, S.J.1
Lunec, J.2
Jackman, A.L.3
Kelland, L.R.4
Aherne, G.W.5
Calvert, A.H.6
-
113
-
-
0022344622
-
Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells
-
Berger, S. H., Jenh, C. H., Johnson, L. F., and Berger, F. G. Thymidylate synthase overproduction and gene amplification in fluorodeoxyuridine-resistant human cells. Mol. Pharmacol., 28: 461-467, 1987.
-
(1987)
Mol. Pharmacol.
, vol.28
, pp. 461-467
-
-
Berger, S.H.1
Jenh, C.H.2
Johnson, L.F.3
Berger, F.G.4
-
114
-
-
0021209446
-
A methotrexate-resistant human breast cancer cell line with multiple defects including diminished formation of methotrexate polyglulamates
-
Cowan, K. H., and Jolivet, J. A methotrexate-resistant human breast cancer cell line with multiple defects including diminished formation of methotrexate polyglulamates. J. Biol. Chem., 259: 10793-10800, 1984
-
(1984)
J. Biol. Chem.
, vol.259
, pp. 10793-10800
-
-
Cowan, K.H.1
Jolivet, J.2
-
115
-
-
0022382988
-
Phenotypic heterogeneity in cultured human head and neck squamous cell carcinoma lines with low-level methotrexate resistance
-
Rosowsky, A., Wright, J. E., Cucchi, C. A., Lippke, J. A., Tantravahi, R., Ervin, T. J., and Frei, E. III. Phenotypic heterogeneity in cultured human head and neck squamous cell carcinoma lines with low-level methotrexate resistance. Cancer Res., 45. 6205-6212, 1985
-
(1985)
Cancer Res.
, vol.45
, pp. 6205-6212
-
-
Rosowsky, A.1
Wright, J.E.2
Cucchi, C.A.3
Lippke, J.A.4
Tantravahi, R.5
Ervin, T.J.6
Frei III, E.7
-
116
-
-
0023935785
-
Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high dose treatment with this drug
-
Pizzorno, G., Mini, E., Coronnello, M., McGuire, J. J., Moroson, J. B. A., Cashmore, A. R., Dreyer, R. N., Lin, J. T., Mazzei, T., Periti, P., and Bertino, J. Impaired polyglutamylation of methotrexate as a cause of resistance in CCRF-CEM cells after short-term, high dose treatment with this drug. Cancer Res., 48: 2149-2155, 1988.
-
(1988)
Cancer Res.
, vol.48
, pp. 2149-2155
-
-
Pizzorno, G.1
Mini, E.2
Coronnello, M.3
McGuire, J.J.4
Moroson, J.B.A.5
Cashmore, A.R.6
Dreyer, R.N.7
Lin, J.T.8
Mazzei, T.9
Periti, P.10
Bertino, J.11
-
117
-
-
0000730901
-
Structure-activity relationship studies of novel pyrrolopyrimidine antifolate LY231514
-
Shih, C., Grindey, G. B., Barnett, C. J., Pearce, H. L., Engelhardt, J. A., Todd, G. C., Rinzel, S. M , Worzalla, J F., Gossett, L. S., and Everson, T. P. Structure-activity relationship studies of novel pyrrolopyrimidine antifolate LY231514. Proc. Am. Assoc. Cancer Res., 33: 411, 1992.
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 411
-
-
Shih, C.1
Grindey, G.B.2
Barnett, C.J.3
Pearce, H.L.4
Engelhardt, J.A.5
Todd, G.C.6
Rinzel, S.M.7
Worzalla, J.F.8
Gossett, L.S.9
Everson, T.P.10
-
118
-
-
0000730899
-
LY231514, a novel pyrrolopyrimidine antifolate that inhibits thymidylate synthase (TS)
-
Grindey, G. B., Shih, C , Barnett, C. J., Pearce, H. L., Engelhardt, J A., Todd, G C., Rinzel, S. M., Worzalla, J. F., Gossett, L. S., and Everson, T. P. LY231514, a novel pyrrolopyrimidine antifolate that inhibits thymidylate synthase (TS). Proc. Am. Assoc. Cancer Res., 33: 411, 1992.
-
(1992)
Proc. Am. Assoc. Cancer Res.
, vol.33
, pp. 411
-
-
Grindey, G.B.1
Shih, C.2
Barnett, C.J.3
Pearce, H.L.4
Engelhardt, J.A.5
Todd, G.C.6
Rinzel, S.M.7
Worzalla, J.F.8
Gossett, L.S.9
Everson, T.P.10
-
119
-
-
2642641659
-
A Phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, in patients with advanced solid tumors
-
Rinaldi, D. A., Burris, H. A., Dorr, F. A., Nelson, J., Fields, S. M., Kuhn, J. G., Eckardt, J., Lu, P., Woodworth, J R., and Corso, S. W. A Phase I evaluation of the novel thymidylate synthase inhibitor, LY231514, in patients with advanced solid tumors. Proc. Am. Soc. Clin. Oncol., 13: 430, 1994.
-
(1994)
Proc. Am. Soc. Clin. Oncol.
, vol.13
, pp. 430
-
-
Rinaldi, D.A.1
Burris, H.A.2
Dorr, F.A.3
Nelson, J.4
Fields, S.M.5
Kuhn, J.G.6
Eckardt, J.7
Lu, P.8
Woodworth, J.R.9
Corso, S.W.10
-
120
-
-
0006788446
-
Preclinical and early clinical studies with the lipophilic thymidylate synthase inhibitor, AG337
-
Taylor, G. A., Rafi, I., Balmanno, K., Calvete, J. A., Newell, D. R., Webber, S., Jackson, R. C , Gumbrell, L., Chapman, F., and Oakey, A. Preclinical and early clinical studies with the lipophilic thymidylate synthase inhibitor, AG337. Br. J. Cancer., 67 (Suppl XX): 17, 1993.
-
(1993)
Br. J. Cancer.
, vol.67
, Issue.20 SUPPL.
, pp. 17
-
-
Taylor, G.A.1
Rafi, I.2
Balmanno, K.3
Calvete, J.A.4
Newell, D.R.5
Webber, S.6
Jackson, R.C.7
Gumbrell, L.8
Chapman, F.9
Oakey, A.10
-
121
-
-
0027531524
-
Identification of an RNA binding site for human thymidylate synthase
-
Chu, E., Voeller, D., Koeller, D. M., Drake, J. C., Takimoto, C. H., Maley, G., Maley, F., and Allegra, C. J. Identification of an RNA binding site for human thymidylate synthase. Proc. Natl. Acad. Sci. USA, 90: 517-521, 1993.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 517-521
-
-
Chu, E.1
Voeller, D.2
Koeller, D.M.3
Drake, J.C.4
Takimoto, C.H.5
Maley, G.6
Maley, F.7
Allegra, C.J.8
-
122
-
-
0025990937
-
Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase
-
Chu, E., Koeller, D. M., Casy, L. J., Drake, C J., Chabner, B. A., Elwood, P. C., Zinn, S., and Allegra, C. J. Autoregulation of human thymidylate synthase messenger RNA translation by thymidylate synthase. Proc. Natl. Acad. Sci. USA, 88: 8977-8981, 1991.
-
(1991)
Proc. Natl. Acad. Sci. USA
, vol.88
, pp. 8977-8981
-
-
Chu, E.1
Koeller, D.M.2
Casy, L.J.3
Drake, C.J.4
Chabner, B.A.5
Elwood, P.C.6
Zinn, S.7
Allegra, C.J.8
-
123
-
-
0025043811
-
The interaction of interferon-γ and 5-fluorouracil in the H630 human colon carcinoma cell line
-
Chu, E., Zinn, S., Boarman, D., and Allegra, C. J. The interaction of interferon-γ and 5-fluorouracil in the H630 human colon carcinoma cell line. Cancer Res., 50: 5834-5840, 1990.
-
(1990)
Cancer Res.
, vol.50
, pp. 5834-5840
-
-
Chu, E.1
Zinn, S.2
Boarman, D.3
Allegra, C.J.4
-
124
-
-
0020056302
-
In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and resistant murine colon adenocarcinomas
-
Spears, C. P., Shahinian, A. H., Moran, R. G., Heidelberger, C., and Corbett, T. H. In vivo kinetics of thymidylate synthetase inhibition of 5-fluorouracil-sensitive and resistant murine colon adenocarcinomas. Cancer Res., 42. 450-456, 1982.
-
(1982)
Cancer Res.
, vol.42
, pp. 450-456
-
-
Spears, C.P.1
Shahinian, A.H.2
Moran, R.G.3
Heidelberger, C.4
Corbett, T.H.5
-
125
-
-
0023705723
-
Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells
-
Keyomarsi, D., and Moran, R. G. Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. J. Biol. Chem., 263: 14402-14409, 1988.
-
(1988)
J. Biol. Chem.
, vol.263
, pp. 14402-14409
-
-
Keyomarsi, D.1
Moran, R.G.2
-
126
-
-
0027181763
-
The thymidylate synthase inhibitor ICI D 1694 overcomes translational detainment of the enzyme
-
Keyomarsi, K., Samet, J., Molnar, G., and Pardee, A. B. The thymidylate synthase inhibitor ICI D 1694 overcomes translational detainment of the enzyme. J. Biol. Chem., 268: 15132-15149, 1993.
-
(1993)
J. Biol. Chem.
, vol.268
, pp. 15132-15149
-
-
Keyomarsi, K.1
Samet, J.2
Molnar, G.3
Pardee, A.B.4
-
127
-
-
0006635130
-
Loss of translational control of thymidylate synthase (TS) by antifolates results in the accumulation of the TS protein
-
Keyomarsi, K., Molnar, G., and Pardee, A. B. Loss of translational control of thymidylate synthase (TS) by antifolates results in the accumulation of the TS protein. Proc. Am. Assoc. Cancer Res., 34: 276, 1993.
-
(1993)
Proc. Am. Assoc. Cancer Res.
, vol.34
, pp. 276
-
-
Keyomarsi, K.1
Molnar, G.2
Pardee, A.B.3
-
128
-
-
0027451668
-
p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
-
Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
-
(1993)
Cell
, vol.74
, pp. 957-967
-
-
Lowe, S.W.1
Ruley, H.E.2
Jacks, T.3
Housman, D.E.4
-
129
-
-
0027944206
-
p53 status and the efficacy of cancer therapy in vivo
-
Washington DC
-
Lowe, S. W , Bodis, S., McClathcey, A., Remington, L., Ruley, H. E., Fisher, D. E., Housman, D. E., and Jacks, T. p53 status and the efficacy of cancer therapy in vivo Science (Washington DC), 266: 807-810, 1994.
-
(1994)
Science
, vol.266
, pp. 807-810
-
-
Lowe, S.W.1
Bodis, S.2
McClathcey, A.3
Remington, L.4
Ruley, H.E.5
Fisher, D.E.6
Housman, D.E.7
Jacks, T.8
-
130
-
-
0028149786
-
Checkpoints of dueling dimers foil death wishes
-
Oltvai, Z. N., and Korsmeyer, S. J. Checkpoints of dueling dimers foil death wishes. Cell, 79: 189-192, 1994.
-
(1994)
Cell
, vol.79
, pp. 189-192
-
-
Oltvai, Z.N.1
Korsmeyer, S.J.2
-
131
-
-
0026786636
-
Prognostic significance of p53 overexpression in gastric and colorectal carcinoma
-
Starzynska, T., Bromley, M., Ghosh, A., and Stern, P. L. Prognostic significance of p53 overexpression in gastric and colorectal carcinoma. Br. J. Cancer, 66: 558-562, 1992.
-
(1992)
Br. J. Cancer
, vol.66
, pp. 558-562
-
-
Starzynska, T.1
Bromley, M.2
Ghosh, A.3
Stern, P.L.4
-
132
-
-
0028943734
-
Apoptosis in the pathogenesis and treatment of disease
-
Washington DC
-
Thompson, C. B. Apoptosis in the pathogenesis and treatment of disease. Science (Washington DC), 267: 1456-1462, 1995.
-
(1995)
Science
, vol.267
, pp. 1456-1462
-
-
Thompson, C.B.1
-
133
-
-
0028924738
-
Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro
-
Chu, E., Takechi, T., Jones, K. L., Voeller, D. M., Copur, S. M., Maley, G. F., Maley, F., Segal, S., and Allegra, C. J. Thymidylate synthase binds to c-myc RNA in human colon cancer cells and in vitro. Mol. Cell. Pharmacol., 15: 179-185, 1995.
-
(1995)
Mol. Cell. Pharmacol.
, vol.15
, pp. 179-185
-
-
Chu, E.1
Takechi, T.2
Jones, K.L.3
Voeller, D.M.4
Copur, S.M.5
Maley, G.F.6
Maley, F.7
Segal, S.8
Allegra, C.J.9
-
134
-
-
0009736754
-
Thymidylate synthase regulates the translation of p53 mRNA
-
Chu, E., Copur, S., Jones, K. L., Khleif, S., Voeller, D., Maley, G. F., Maley, F., and Allegra, C. J. Thymidylate synthase regulates the translation of p53 mRNA. Proc. Am. Assoc. Cancer Res., 36: 563, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 563
-
-
Chu, E.1
Copur, S.2
Jones, K.L.3
Khleif, S.4
Voeller, D.5
Maley, G.F.6
Maley, F.7
Allegra, C.J.8
-
135
-
-
0004342857
-
Decreased c-myc protein accompanied by increased p53 and Rb is associated with thymidylate synthase inhibition and cell cycle retardation induced by D1694
-
Arredondo, M. A., Yin, M. B., Lu, K., Schöber, C., Slocum, H., and Rustum, Y. M. Decreased c-myc protein accompanied by increased p53 and Rb is associated with thymidylate synthase inhibition and cell cycle retardation induced by D1694. Proc. Am. Assoc. Cancer Res., 35: 304, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 304
-
-
Arredondo, M.A.1
Yin, M.B.2
Lu, K.3
Schöber, C.4
Slocum, H.5
Rustum, Y.M.6
-
136
-
-
0027279128
-
bcl-2 modulation of apoptosis induced by anticancer drugs: Resistance to thymidylate stress is independent of classical resistance pathways
-
Fisher, T. C., Milner, A. E., Gregory, C. D., Jackman, A. L., Aherne, G. W., Hartley, J. A., Dive, C., and Hickman, J. A. bcl-2 modulation of apoptosis induced by anticancer drugs: resistance to thymidylate stress is independent of classical resistance pathways. Cancer Res., 53: 3321-3326, 1993.
-
(1993)
Cancer Res.
, vol.53
, pp. 3321-3326
-
-
Fisher, T.C.1
Milner, A.E.2
Gregory, C.D.3
Jackman, A.L.4
Aherne, G.W.5
Hartley, J.A.6
Dive, C.7
Hickman, J.A.8
-
137
-
-
9044250971
-
TS levels and p53 function predict for response to 5-fluorouracil/leucovorin in patients with advanced colon cancer
-
Lenz, H. J., Ju, J F., Danenberg, K. D., Leichman, L., Leichman, C., Haag, C., and Danenberg, P. V. TS levels and p53 function predict for response to 5-fluorouracil/leucovorin in patients with advanced colon cancer. Proc. Am. Soc. Clin. Oncol., 14: 202, 1995.
-
(1995)
Proc. Am. Soc. Clin. Oncol.
, vol.14
, pp. 202
-
-
Lenz, H.J.1
Ju, J.F.2
Danenberg, K.D.3
Leichman, L.4
Leichman, C.5
Haag, C.6
Danenberg, P.V.7
-
138
-
-
9044242224
-
The effect of hammerhead ribozyme against thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitor
-
Kobayashi, H., Takemura, Y., Miyachi, H., Skelton, L., and Jackman, A. L. The effect of hammerhead ribozyme against thymidylate synthase on the cytotoxicity of thymidylate synthase inhibitor. Proc. Am. Assoc. Cancer Res., 36: 342, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 342
-
-
Kobayashi, H.1
Takemura, Y.2
Miyachi, H.3
Skelton, L.4
Jackman, A.L.5
-
139
-
-
0028247776
-
Targeted and non-targeted actions of anti-cancer drugs
-
Weber, G., and Prajda, N. Targeted and non-targeted actions of anti-cancer drugs. Adv. Enzyme Regul., 34: 71-89, 1994.
-
(1994)
Adv. Enzyme Regul.
, vol.34
, pp. 71-89
-
-
Weber, G.1
Prajda, N.2
-
140
-
-
0027427801
-
Combination studies with 3′-azido-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects
-
Pressacco, J., and Erlichman, C. Combination studies with 3′-azido-deoxythymidine (AZT) plus ICI D1694. Cytotoxic and biochemical effects. Biochem. Pharmacol., 46: 1989-1997, 1993.
-
(1993)
Biochem. Pharmacol.
, vol.46
, pp. 1989-1997
-
-
Pressacco, J.1
Erlichman, C.2
-
141
-
-
0028142050
-
ICI D1694 and idoxuridine: A synergistic antitumor combination
-
Pressacco, J., Hedley, D. W , and Erlichman, C. ICI D1694 and idoxuridine: a synergistic antitumor combination. Cancer Res. 54: 3772-3778, 1994.
-
(1994)
Cancer Res.
, vol.54
, pp. 3772-3778
-
-
Pressacco, J.1
Hedley, D.W.2
Erlichman, C.3
-
142
-
-
0343739057
-
Pretreatment of colon carcinoma cells to D1694 (Tomudex) markedly enhances 5-fluorouracil cytotoxicity
-
Chang, Y. M., Zielinski, Z., Izzo, J., Porubcin, M., and Bertino, J. R. Pretreatment of colon carcinoma cells to D1694 (Tomudex) markedly enhances 5-fluorouracil cytotoxicity. Proc. Am. Assoc. Cancer Res., 35: 330, 1994.
-
(1994)
Proc. Am. Assoc. Cancer Res.
, vol.35
, pp. 330
-
-
Chang, Y.M.1
Zielinski, Z.2
Izzo, J.3
Porubcin, M.4
Bertino, J.R.5
-
143
-
-
0345588453
-
Molecular mechanisms of the synergistic sequential administration of D1694 (Tomudex) followed by FUra in colon carcinoma cells
-
Izzo, J., Zielinski, Z., Chang, Y. M., and Bertino, J. R. Molecular mechanisms of the synergistic sequential administration of D1694 (Tomudex) followed by FUra in colon carcinoma cells. Proc. Am. Assoc. Cancer Res., 36: 381, 1995.
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 381
-
-
Izzo, J.1
Zielinski, Z.2
Chang, Y.M.3
Bertino, J.R.4
-
144
-
-
0000033490
-
Biochemical basis for the the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil
-
Van der Wilt, C. L., Pinedo, H. M., Kuiper, C. M., Smid, K., and Peters, G. J. Biochemical basis for the the combined antiproliferative effect of AG337 or ZD1694 and 5-fluorouracil. Proc. Am. Assoc. Cancer Res., 36: 379, 1995
-
(1995)
Proc. Am. Assoc. Cancer Res.
, vol.36
, pp. 379
-
-
Van Der Wilt, C.L.1
Pinedo, H.M.2
Kuiper, C.M.3
Smid, K.4
Peters, G.J.5
-
145
-
-
9044229859
-
Phase I study of Tomudex in combination with 5-FU/CF/IFN-A for recurrent adult solid tumors including gastrointestinal, breast, lung, and ovarian carcinomas
-
National Cancer Institute PDQ. Phase I study of Tomudex in combination with 5-FU/CF/IFN-A for recurrent adult solid tumors including gastrointestinal, breast, lung, and ovarian carcinomas. Curr. Clin. Trials Oncol., 2: 749, 1995.
-
(1995)
Curr. Clin. Trials Oncol.
, vol.2
, pp. 749
-
-
|