Thymidylate synthase: Structure, inhibition, and strained conformations during catalysis

Pharmacology and Therapeutics

Volumn 76, Issue 1-3, 1997, Pages 29-43

  Montfort, William R ^a   Weichsel, Andrzej ^a  

^a University of Arizona   (United States)

Author keywords

5 fluoro dUMP; 5 nitro dUMP; Antifolate; Conformational change; Enzyme mechanism; Thymidylate synthase

Indexed keywords

10 PROPARGYL 5,8 DIDEAZAFOLIC ACID; BW 1843; DEOXYURIDINE PHOSPHATE; FLOXURIDINE PHOSPHATE; FOLIC ACID ANTAGONIST; METHYLENETETRAHYDROFOLIC ACID; NOLATREXED; NUCLEOTIDE DERIVATIVE; RALTITREXED; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; CANCER; CATALYSIS; CLINICAL TRIAL; CONFORMATIONAL TRANSITION; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME INHIBITOR COMPLEX; HUMAN; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; ENZYME INHIBITORS; HUMANS; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THYMIDYLATE SYNTHASE;

EID: 0031278012     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(97)00099-5     Document Type: Review

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