Catalytic cysteine of thymidylate synthase is activated upon substrate binding

Biochemistry

Volumn 39, Issue 23, 2000, Pages 6969-6978

  Phan, Jason ^a   Mahdavian, Elahe ^a   Nivens, Michael C ^a   Minor, Wladek ^b   Berger, Sondra ^a   Spencer, H Trent ^a   Dunlap, R Bruce ^a   Lebioda, Lukasz ^a  

^a UNIVERSITY OF SOUTH CAROLINA   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYSTEINE; THYMIDYLATE SYNTHASE;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL MODIFICATION; COMPLEX FORMATION; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME BINDING; ENZYME KINETICS; ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; CYSTEINE; DEOXYURACIL NUCLEOTIDES; ESCHERICHIA COLI; KINETICS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; PROTEIN BINDING; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATES; THYMIDYLATE SYNTHASE;

BACTERIA (MICROORGANISMS); ESCHERICHIA COLI; FELIS CATUS; NEGIBACTERIA;

EID: 0034643812     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi000367g     Document Type: Article

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