Crystal structures of 5-fluoro-dUrd and its 2 and/or 4-thio analogues: Models of substituted dUMP pyrimidine ring interacting with thymidylate synthase

Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology

Volumn 1382, Issue 2, 1998, Pages 277-286

  Jarmuła, Adam ^a   Anulewicz, Romana ^b   Leś, Andrzej ^b   Cyrański, Michał K ^b   Adamowicz, Ludwik ^c   Bretner, Maria ^d   Felczak, Krzysztof ^d   Kulikowski, Tadeusz ^d   Krygowski, Tadeusz M ^b   Rode, Wojciech ^a  

^a NENCKI INSTITUTE OF EXPERIMENTAL BIOLOGY   (Poland)

^b UNIVERSITY OF WARSAW   (Poland)

^c University of Arizona   (United States)

^d INSTITUTE OF BIOCHEMISTRY AND BIOPHYSICS   (Poland)

Author keywords

Aromaticity; DUMP analogue; Thymidylate synthase; Walsh Bent rule; X ray diffraction

Indexed keywords

2' DEOXY 2 THIO 5 FLUOROURIDINE; 2' DEOXY 2,4 DITHIO 5 FLUOROURIDINE; 2' DEOXY 4 THIO 5 FLUOROURIDINE; FLOXURIDINE; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE INHIBITOR; UNCLASSIFIED DRUG; URIDINE DERIVATIVE;

ARTICLE; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME BINDING; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; THEORY; X RAY DIFFRACTION;

BINDING SITES; CRYSTALLOGRAPHY, X-RAY; DEOXYURACIL NUCLEOTIDES; FLOXURIDINE; HYDROGEN BONDING; MOLECULAR STRUCTURE; SULFHYDRYL COMPOUNDS; THYMIDYLATE SYNTHASE;

EID: 0032539584     PISSN: 01674838     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0167-4838(97)00169-6     Document Type: Article

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