Tyrosine 146 of thymidylate synthase assists proton abstraction from the 5-position of 2'-deoxyuridine 5'-monophosphate

Biochemistry

Volumn 38, Issue 2, 1999, Pages 848-852

  Liu, Yaoquan ^a   Barrett, Jeannie E ^b   Schultz, Peter G ^b   Santi, Daniel V ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYURIDINE PHOSPHATE; THYMIDYLATE SYNTHASE;

AMINO ACID SEQUENCE; ARTICLE; ENZYME KINETICS; ESCHERICHIA COLI; METHYLATION; NONHUMAN; PRIORITY JOURNAL; PROTON TRANSPORT; PYRIMIDINE SYNTHESIS; REDUCTION;

BINDING SITES; CATALYSIS; DEOXYURACIL NUCLEOTIDES; ESCHERICHIA COLI; MODELS, CHEMICAL; MODELS, MOLECULAR; MUTAGENESIS, INSERTIONAL; PROTONS; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THYMIDYLATE SYNTHASE; TYROSINE;

ESCHERICHIA COLI; FELIS CATUS;

EID: 0033547816     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi9822877     Document Type: Article

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