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Volumn 569, Issue 1-2, 2005, Pages 87-100

Cellular reaction to hypoxia: Sensing and responding to an adverse environment

Author keywords

Apoptosis; Cell cycle; Microenvironment; Pathophysiologic; Solid tumor

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1; PROTEIN BCL 2; PROTEIN P53;

EID: 10444280004     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2004.06.054     Document Type: Review
Times cited : (63)

References (113)
  • 2
    • 1642546291 scopus 로고    scopus 로고
    • Oxygen-sensing pathways and the development of mammalian gas exchange
    • S.C. Land Oxygen-sensing pathways and the development of mammalian gas exchange Redox. Rep. 8 2003 325 340
    • (2003) Redox. Rep. , vol.8 , pp. 325-340
    • Land, S.C.1
  • 5
    • 0842270041 scopus 로고    scopus 로고
    • Hypoxia and lung branching morphogenesis
    • S.A. Gebb, and P.L. Jones Hypoxia and lung branching morphogenesis Adv. Exp. Med. Biol. 543 2003 117 125
    • (2003) Adv. Exp. Med. Biol. , vol.543 , pp. 117-125
    • Gebb, S.A.1    Jones, P.L.2
  • 6
  • 7
    • 0344197968 scopus 로고    scopus 로고
    • Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a
    • L.B. Gardner, F. Li, X. Yang, and C.V. Dang Anoxic fibroblasts activate a replication checkpoint that is bypassed by E1a Mol. Cell Biol. 23 2003 9032 9045
    • (2003) Mol. Cell Biol. , vol.23 , pp. 9032-9045
    • Gardner, L.B.1    Li, F.2    Yang, X.3    Dang, C.V.4
  • 9
    • 0035925098 scopus 로고    scopus 로고
    • Tumor hypoxia: Definitions and current clinical, biologic, and molecular aspects
    • M. Hockel, and P. Vaupel Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects J. Natl. Cancer Inst. 93 2001 266 276
    • (2001) J. Natl. Cancer Inst. , vol.93 , pp. 266-276
    • Hockel, M.1    Vaupel, P.2
  • 11
    • 0033924882 scopus 로고    scopus 로고
    • Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor
    • K.R. Laderoute, R.M. Alarcon, M.D. Brody, J.M. Calaoagan, E.Y. Chen, A.M. Knapp, Z. Yun, N.C. Denko, and A.J. Giaccia Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor Clin. Cancer Res. 6 2000 2941 2950
    • (2000) Clin. Cancer Res. , vol.6 , pp. 2941-2950
    • Laderoute, K.R.1    Alarcon, R.M.2    Brody, M.D.3    Calaoagan, J.M.4    Chen, E.Y.5    Knapp, A.M.6    Yun, Z.7    Denko, N.C.8    Giaccia, A.J.9
  • 13
    • 0035145591 scopus 로고    scopus 로고
    • P21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest
    • S.L. Green, R.A. Freiberg, and A.J. Giaccia p21(Cip1) and p27(Kip1) regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest Mol. Cell Biol. 21 2001 1196 1206
    • (2001) Mol. Cell Biol. , vol.21 , pp. 1196-1206
    • Green, S.L.1    Freiberg, R.A.2    Giaccia, A.J.3
  • 14
    • 0142166332 scopus 로고    scopus 로고
    • Targeting HIF-1 for cancer therapy
    • G.L. Semenza Targeting HIF-1 for cancer therapy Nat. Rev. Cancer 3 2003 721 732
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 721-732
    • Semenza, G.L.1
  • 18
    • 0035859692 scopus 로고    scopus 로고
    • HIF-1-alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation
    • F. Yu, S.B. White, Q. Zhao, and F.S. Lee HIF-1-alpha binding to VHL is regulated by stimulus-sensitive proline hydroxylation Proc. Natl. Acad. Sci. U.S.A. 98 2001 9630 9635
    • (2001) Proc. Natl. Acad. Sci. U.S.A. , vol.98 , pp. 9630-9635
    • Yu, F.1    White, S.B.2    Zhao, Q.3    Lee, F.S.4
  • 19
    • 0037035851 scopus 로고    scopus 로고
    • Structure of an HIF-1-alpha pVHL complex: Hydroxyproline recognition in signaling
    • J.H. Min, H. Yang, M. Ivan, F. Gertler, W.G. Kaelin Jr., and N.P. Pavletich Structure of an HIF-1-alpha pVHL complex: hydroxyproline recognition in signaling Science 296 2002 1886 1889
    • (2002) Science , vol.296 , pp. 1886-1889
    • Min, J.H.1    Yang, H.2    Ivan, M.3    Gertler, F.4    Kaelin Jr., W.G.5    Pavletich, N.P.6
  • 20
  • 21
    • 0037131271 scopus 로고    scopus 로고
    • Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1-alpha
    • D.A. Chan, P.D. Sutphin, N.C. Denko, and A.J. Giaccia Role of prolyl hydroxylation in oncogenically stabilized hypoxia-inducible factor-1-alpha J. Biol. Chem. 277 2002 40112 40117
    • (2002) J. Biol. Chem. , vol.277 , pp. 40112-40117
    • Chan, D.A.1    Sutphin, P.D.2    Denko, N.C.3    Giaccia, A.J.4
  • 23
    • 0035405351 scopus 로고    scopus 로고
    • Gene microarray analysis reveals a novel hypoxia signal transduction pathway in human hepatocellular carcinoma cells
    • A.B. Scandurro, C.W. Weldon, Y.G. Figueroa, J. Alam, and B.S. Beckman Gene microarray analysis reveals a novel hypoxia signal transduction pathway in human hepatocellular carcinoma cells Int. J. Oncol. 19 2001 129 135
    • (2001) Int. J. Oncol. , vol.19 , pp. 129-135
    • Scandurro, A.B.1    Weldon, C.W.2    Figueroa, Y.G.3    Alam, J.4    Beckman, B.S.5
  • 24
    • 0027458517 scopus 로고
    • In vivo and in vitro regulation of erythropoietin mRNA: Measurement by competitive polymerase chain reaction
    • J. Fandrey, and H.F. Bunn In vivo and in vitro regulation of erythropoietin mRNA: measurement by competitive polymerase chain reaction Blood 81 1993 617 623
    • (1993) Blood , vol.81 , pp. 617-623
    • Fandrey, J.1    Bunn, H.F.2
  • 26
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1 alpha is required for solid tumor formation and embryonic vascularization
    • H.E. Ryan, J. Lo, and R.S. Johnson HIF-1 alpha is required for solid tumor formation and embryonic vascularization EMBO J. 17 1998 3005 3015
    • (1998) EMBO J. , vol.17 , pp. 3005-3015
    • Ryan, H.E.1    Lo, J.2    Johnson, R.S.3
  • 29
    • 0034682513 scopus 로고    scopus 로고
    • The transcription factor EPAS-1/hypoxia-inducible factor 2 alpha plays an important role in vascular remodeling
    • J. Peng, L. Zhang, L. Drysdale, and G.H. Fong The transcription factor EPAS-1/hypoxia-inducible factor 2 alpha plays an important role in vascular remodeling Proc. Natl. Acad. Sci. U.S.A. 97 2000 8386 8391
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 8386-8391
    • Peng, J.1    Zhang, L.2    Drysdale, L.3    Fong, G.H.4
  • 30
    • 0032213236 scopus 로고    scopus 로고
    • The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development
    • H. Tian, R.E. Hammer, A.M. Matsumoto, D.W. Russell, and S.L. McKnight The hypoxia-responsive transcription factor EPAS1 is essential for catecholamine homeostasis and protection against heart failure during embryonic development Genes Dev. 12 1998 3320 3324
    • (1998) Genes Dev. , vol.12 , pp. 3320-3324
    • Tian, H.1    Hammer, R.E.2    Matsumoto, A.M.3    Russell, D.W.4    McKnight, S.L.5
  • 32
    • 0345491599 scopus 로고    scopus 로고
    • Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation
    • C.J. Hu, L.Y. Wang, L.A. Chodosh, B. Keith, and M.C. Simon Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation Mol. Cell Biol. 23 2003 9361 9374
    • (2003) Mol. Cell Biol. , vol.23 , pp. 9361-9374
    • Hu, C.J.1    Wang, L.Y.2    Chodosh, L.A.3    Keith, B.4    Simon, M.C.5
  • 33
    • 0035914436 scopus 로고    scopus 로고
    • Hypoxia-inducible factor-2 alpha (HIF-2 alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia
    • K. Brusselmans, F. Bono, P. Maxwell, Y. Dor, M. Dewerchin, D. Collen, J.M. Herbert, and P. Carmeliet Hypoxia-inducible factor-2 alpha (HIF-2 alpha) is involved in the apoptotic response to hypoglycemia but not to hypoxia J. Biol. Chem. 276 2001 39192 39196
    • (2001) J. Biol. Chem. , vol.276 , pp. 39192-39196
    • Brusselmans, K.1    Bono, F.2    Maxwell, P.3    Dor, Y.4    Dewerchin, M.5    Collen, D.6    Herbert, J.M.7    Carmeliet, P.8
  • 34
    • 0038788826 scopus 로고    scopus 로고
    • Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): Role of cytoplasmic trapping of HIF-2 alpha
    • S.K. Park, A.M. Dadak, V.H. Haase, L. Fontana, A.J. Giaccia, and R.S. Johnson Hypoxia-induced gene expression occurs solely through the action of hypoxia-inducible factor 1 alpha (HIF-1 alpha): role of cytoplasmic trapping of HIF-2 alpha Mol. Cell Biol. 23 2003 4959 4971
    • (2003) Mol. Cell Biol. , vol.23 , pp. 4959-4971
    • Park, S.K.1    Dadak, A.M.2    Haase, V.H.3    Fontana, L.4    Giaccia, A.J.5    Johnson, R.S.6
  • 35
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element
    • N.M. Mazure, E.Y. Chen, K.R. Laderoute, and A.J. Giaccia Induction of vascular endothelial growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia inducible factor-1 transcriptional element Blood 90 1997 3322 3331
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3    Giaccia, A.J.4
  • 36
    • 0026482290 scopus 로고
    • Cytogenetic and molecular correlates between rodent and human renal cell carcinoma
    • C. Walker, L. Recio, K. Funaki, and J. Everitt Cytogenetic and molecular correlates between rodent and human renal cell carcinoma Progr. Clin. Biol. Res. 376 1992 289 302
    • (1992) Progr. Clin. Biol. Res. , vol.376 , pp. 289-302
    • Walker, C.1    Recio, L.2    Funaki, K.3    Everitt, J.4
  • 37
    • 0037842275 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factor 2 alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene
    • M.Y. Liu, L. Poellinger, and C.L. Walker Up-regulation of hypoxia-inducible factor 2 alpha in renal cell carcinoma associated with loss of Tsc-2 tumor suppressor gene Cancer Res. 63 2003 2675 2680
    • (2003) Cancer Res. , vol.63 , pp. 2675-2680
    • Liu, M.Y.1    Poellinger, L.2    Walker, C.L.3
  • 39
    • 0032535077 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factor-1 alpha is not sufficient for hypoxic/anoxic p53 induction
    • R.H. Wenger, G. Camenisch, I. Desbaillets, D. Chilov, and M. Gassmann Up-regulation of hypoxia-inducible factor-1 alpha is not sufficient for hypoxic/anoxic p53 induction Cancer Res. 58 1998 5678 5680
    • (1998) Cancer Res. , vol.58 , pp. 5678-5680
    • Wenger, R.H.1    Camenisch, G.2    Desbaillets, I.3    Chilov, D.4    Gassmann, M.5
  • 42
    • 0037008770 scopus 로고    scopus 로고
    • Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway
    • C. Treins, S. Giorgetti-Peraldi, J. Murdaca, G.L. Semenza, E. Van, and Obberghen Insulin stimulates hypoxia-inducible factor 1 through a phosphatidylinositol 3-kinase/target of rapamycin-dependent signaling pathway J. Biol. Chem. 277 2002 27975 27981
    • (2002) J. Biol. Chem. , vol.277 , pp. 27975-27981
    • Treins, C.1    Giorgetti-Peraldi, S.2    Murdaca, J.3    Semenza, G.L.4    Van, E.5    Obberghen6
  • 43
    • 0035955663 scopus 로고    scopus 로고
    • Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide
    • K.B. Sandau, J. Zhou, T. Kietzmann, and B. Brune Regulation of the hypoxia-inducible factor 1alpha by the inflammatory mediators nitric oxide and tumor necrosis factor-alpha in contrast to desferroxamine and phenylarsine oxide J. Biol. Chem. 276 2001 39805 39811
    • (2001) J. Biol. Chem. , vol.276 , pp. 39805-39811
    • Sandau, K.B.1    Zhou, J.2    Kietzmann, T.3    Brune, B.4
  • 44
    • 0037134442 scopus 로고    scopus 로고
    • Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension
    • M. Alvarez-Tejado, A. Alfranca, J. Aragones, A. Vara, M.O. Landazuri, L. del, and Peso Lack of evidence for the involvement of the phosphoinositide 3-kinase/Akt pathway in the activation of hypoxia-inducible factors by low oxygen tension J. Biol. Chem. 277 2002 13508 13517
    • (2002) J. Biol. Chem. , vol.277 , pp. 13508-13517
    • Alvarez-Tejado, M.1    Alfranca, A.2    Aragones, J.3    Vara, A.4    Landazuri, M.O.5    Del Peso, L.6
  • 45
    • 0037177867 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription
    • A.M. Arsham, D.R. Plas, C.B. Thompson, and M.C. Simon Phosphatidylinositol 3-kinase/Akt signaling is neither required for hypoxic stabilization of HIF-1 alpha nor sufficient for HIF-1-dependent target gene transcription J. Biol. Chem. 277 2002 15162 15170
    • (2002) J. Biol. Chem. , vol.277 , pp. 15162-15170
    • Arsham, A.M.1    Plas, D.R.2    Thompson, C.B.3    Simon, M.C.4
  • 46
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • B.H. Jiang, F. Agani, A. Passaniti, and G.L. Semenza V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression Cancer Res. 57 1997 5328 5335
    • (1997) Cancer Res. , vol.57 , pp. 5328-5335
    • Jiang, B.H.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 48
    • 0030866226 scopus 로고    scopus 로고
    • Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway
    • J.M. Muller, B. Krauss, C. Kaltschmidt, P.A. Baeuerle, and R.A. Rupec Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway J. Biol. Chem. 272 1997 23435 23439
    • (1997) J. Biol. Chem. , vol.272 , pp. 23435-23439
    • Muller, J.M.1    Krauss, B.2    Kaltschmidt, C.3    Baeuerle, P.A.4    Rupec, R.A.5
  • 51
    • 0028841622 scopus 로고
    • The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-κB
    • R.A. Rupec, and P.A. Baeuerle The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-κB Eur. J. Biochem. 234 1995 632 640
    • (1995) Eur. J. Biochem. , vol.234 , pp. 632-640
    • Rupec, R.A.1    Baeuerle, P.A.2
  • 52
    • 0028268629 scopus 로고
    • Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues
    • A.C. Koong, E.Y. Chen, and A.J. Giaccia Hypoxia causes the activation of nuclear factor kappa B through the phosphorylation of I kappa B alpha on tyrosine residues Cancer Res. 54 1994 1425 1430
    • (1994) Cancer Res. , vol.54 , pp. 1425-1430
    • Koong, A.C.1    Chen, E.Y.2    Giaccia, A.J.3
  • 54
    • 0031034814 scopus 로고    scopus 로고
    • Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells
    • J.F. Schmedtje Jr., Y.S. Ji, W.L. Liu, R.N. DuBois, and M.S. Runge Hypoxia induces cyclooxygenase-2 via the NF-κB p65 transcription factor in human vascular endothelial cells J. Biol. Chem. 272 1997 601 608
    • (1997) J. Biol. Chem. , vol.272 , pp. 601-608
    • Schmedtje Jr., J.F.1    Ji, Y.S.2    Liu, W.L.3    Dubois, R.N.4    Runge, M.S.5
  • 55
    • 0030713446 scopus 로고    scopus 로고
    • Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1- mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells
    • A. Damert, E. Ikeda, and W. Risau Activator-protein-1 binding potentiates the hypoxia-induciblefactor-1-mediated hypoxia-induced transcriptional activation of vascular-endothelial growth factor expression in C6 glioma cells Biochem. J. 327 Pt 2 1997 419 423
    • (1997) Biochem. J. , vol.327 , Issue.2 , pp. 419-423
    • Damert, A.1    Ikeda, E.2    Risau, W.3
  • 56
    • 0028859483 scopus 로고
    • Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene
    • M.L. Norris, and D.E. Millhorn Hypoxia-induced protein binding to O2-responsive sequences on the tyrosine hydroxylase gene J. Biol. Chem. 270 1995 23774 23779
    • (1995) J. Biol. Chem. , vol.270 , pp. 23774-23779
    • Norris, M.L.1    Millhorn, D.E.2
  • 57
    • 0028807821 scopus 로고
    • Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types
    • R.S. Bandyopadhyay, M. Phelan, and D.V. Faller Hypoxia induces AP-1-regulated genes and AP-1 transcription factor binding in human endothelial and other cell types Biochim. Biophys. Acta 1264 1995 72 78
    • (1995) Biochim. Biophys. Acta , vol.1264 , pp. 72-78
    • Bandyopadhyay, R.S.1    Phelan, M.2    Faller, D.V.3
  • 58
    • 0035918213 scopus 로고    scopus 로고
    • Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, and p300/CBP
    • K. Yamashita, D.J. Discher, J. Hu, N.H. Bishopric, and K.A. Webster Molecular regulation of the endothelin-1 gene by hypoxia. Contributions of hypoxia-inducible factor-1, activator protein-1, GATA-2, AND p300/CBP J. Biol. Chem. 276 2001 12645 12653
    • (2001) J. Biol. Chem. , vol.276 , pp. 12645-12653
    • Yamashita, K.1    Discher, D.J.2    Hu, J.3    Bishopric, N.H.4    Webster, K.A.5
  • 59
    • 0036132872 scopus 로고    scopus 로고
    • C-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription
    • A. Alfranca, M.D. Gutierrez, A. Vara, J. Aragones, F. Vidal, and M.O. Landazuri c-Jun and hypoxia-inducible factor 1 functionally cooperate in hypoxia-induced gene transcription Mol. Cell Biol. 22 2002 12 22
    • (2002) Mol. Cell Biol. , vol.22 , pp. 12-22
    • Alfranca, A.1    Gutierrez, M.D.2    Vara, A.3    Aragones, J.4    Vidal, F.5    Landazuri, M.O.6
  • 62
    • 1242272854 scopus 로고    scopus 로고
    • Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors
    • D. Mukhopadhyay, and K. Datta Multiple regulatory pathways of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) expression in tumors Semin. Cancer Biol. 14 2004 123 130
    • (2004) Semin. Cancer Biol. , vol.14 , pp. 123-130
    • Mukhopadhyay, D.1    Datta, K.2
  • 63
    • 0029039195 scopus 로고
    • Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia
    • A.P. Levy, N.S. Levy, S. Wegner, and M.A. Goldberg Transcriptional regulation of the rat vascular endothelial growth factor gene by hypoxia J. Biol. Chem. 270 1995 13333 13340
    • (1995) J. Biol. Chem. , vol.270 , pp. 13333-13340
    • Levy, A.P.1    Levy, N.S.2    Wegner, S.3    Goldberg, M.A.4
  • 65
    • 0032941747 scopus 로고    scopus 로고
    • Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements
    • J.A. Dibbens, D.L. Miller, A. Damert, W. Risau, M.A. Vadas, and G.J. Goodall Hypoxic regulation of vascular endothelial growth factor mRNA stability requires the cooperation of multiple RNA elements Mol. Biol. Cell 10 1999 907 919
    • (1999) Mol. Biol. Cell , vol.10 , pp. 907-919
    • Dibbens, J.A.1    Miller, D.L.2    Damert, A.3    Risau, W.4    Vadas, M.A.5    Goodall, G.J.6
  • 66
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • A.P. Levy, N.S. Levy, and M.A. Goldberg Post-transcriptional regulation of vascular endothelial growth factor by hypoxia J. Biol. Chem. 271 1996 2746 2753
    • (1996) J. Biol. Chem. , vol.271 , pp. 2746-2753
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 67
    • 0033555522 scopus 로고    scopus 로고
    • Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L
    • S.C. Shih, and K.P. Claffey Regulation of human vascular endothelial growth factor mRNA stability in hypoxia by heterogeneous nuclear ribonucleoprotein L J. Biol. Chem. 274 1999 1359 1365
    • (1999) J. Biol. Chem. , vol.274 , pp. 1359-1365
    • Shih, S.C.1    Claffey, K.P.2
  • 68
    • 0037134484 scopus 로고    scopus 로고
    • A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR
    • I. Goldberg-Cohen, H. Furneauxb, and A.P. Levy A 40-bp RNA element that mediates stabilization of vascular endothelial growth factor mRNA by HuR J. Biol. Chem. 277 2002 13635 13640
    • (2002) J. Biol. Chem. , vol.277 , pp. 13635-13640
    • Goldberg-Cohen, I.1    Furneauxb, H.2    Levy, A.P.3
  • 69
    • 0028284559 scopus 로고
    • Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3′-untranslated region of rat tyrosine hydroxylase mRNA
    • M.F. Czyzyk-Krzeska, Z. Dominski, R. Kole, and D.E. Millhorn Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine-rich sequence in the 3′-untranslated region of rat tyrosine hydroxylase mRNA J. Biol. Chem. 269 1994 9940 9945
    • (1994) J. Biol. Chem. , vol.269 , pp. 9940-9945
    • Czyzyk-Krzeska, M.F.1    Dominski, Z.2    Kole, R.3    Millhorn, D.E.4
  • 70
    • 0033559760 scopus 로고    scopus 로고
    • Identification of the poly(C) binding protein in the complex associated with the 3′-untranslated region of erythropoietin messenger RNA
    • M.F. Czyzyk-Krzeska, and A.C. Bendixen Identification of the poly(C) binding protein in the complex associated with the 3′-untranslated region of erythropoietin messenger RNA Blood 93 1999 2111 2120
    • (1999) Blood , vol.93 , pp. 2111-2120
    • Czyzyk-Krzeska, M.F.1    Bendixen, A.C.2
  • 71
    • 0029907837 scopus 로고    scopus 로고
    • Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae
    • A. Goppelt, and M. Meisterernst Characterization of the basal inhibitor of class II transcription NC2 from Saccharomyces cerevisiae Nucl. Acids Res. 24 1996 4450 4455
    • (1996) Nucl. Acids Res. , vol.24 , pp. 4450-4455
    • Goppelt, A.1    Meisterernst, M.2
  • 72
    • 0025988495 scopus 로고
    • Activation of class II gene transcription by regulatory factors is potentiated by a novel activity
    • M. Meisterernst, A.L. Roy, H.M. Lieu, and R.G. Roeder Activation of class II gene transcription by regulatory factors is potentiated by a novel activity Cell 66 1991 981 993
    • (1991) Cell , vol.66 , pp. 981-993
    • Meisterernst, M.1    Roy, A.L.2    Lieu, H.M.3    Roeder, R.G.4
  • 73
    • 0026742095 scopus 로고
    • Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription
    • J.A. Inostroza, F.H. Mermelstein, I. Ha, W.S. Lane, and D. Reinberg Dr1, a TATA-binding protein-associated phosphoprotein and inhibitor of class II gene transcription Cell 70 1992 477 489
    • (1992) Cell , vol.70 , pp. 477-489
    • Inostroza, J.A.1    Mermelstein, F.H.2    Ha, I.3    Lane, W.S.4    Reinberg, D.5
  • 75
    • 0037458545 scopus 로고    scopus 로고
    • Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly
    • N. Denko, K. Wernke-Dollries, A.B. Johnson, E. Hammond, C.M. Chiang, and M.C. Barton Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly J. Biol. Chem. 278 2003 5744 5749
    • (2003) J. Biol. Chem. , vol.278 , pp. 5744-5749
    • Denko, N.1    Wernke-Dollries, K.2    Johnson, A.B.3    Hammond, E.4    Chiang, C.M.5    Barton, M.C.6
  • 76
    • 0037195939 scopus 로고    scopus 로고
    • Stra13 homodimers repress transcription through class B E-box elements
    • B. St-Pierre, G. Flock, E. Zacksenhaus, and S.E. Egan Stra13 homodimers repress transcription through class B E-box elements J. Biol. Chem. 277 2002 46544 46551
    • (2002) J. Biol. Chem. , vol.277 , pp. 46544-46551
    • St-Pierre, B.1    Flock, G.2    Zacksenhaus, E.3    Egan, S.E.4
  • 79
    • 0036198010 scopus 로고    scopus 로고
    • Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia
    • Z. Yun, H.L. Maecker, R.S. Johnson, and A.J. Giaccia Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia Dev. Cell 2 2002 331 341
    • (2002) Dev. Cell , vol.2 , pp. 331-341
    • Yun, Z.1    Maecker, H.L.2    Johnson, R.S.3    Giaccia, A.J.4
  • 81
    • 0034632052 scopus 로고    scopus 로고
    • P53 checkpoint-defective cells are sensitive to X rays, but not hypoxia
    • N.C. Denko, S.L. Green, D. Edwards, and A.J. Giaccia p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia Exp. Cell Res. 258 2000 82 91
    • (2000) Exp. Cell Res. , vol.258 , pp. 82-91
    • Denko, N.C.1    Green, S.L.2    Edwards, D.3    Giaccia, A.J.4
  • 83
    • 0033215387 scopus 로고    scopus 로고
    • Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a
    • M. Murphy, J. Ahn, K.K. Walker, W.H. Hoffman, R.M. Evans, A.J. Levine, and D.L. George Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a Genes Dev. 13 1999 2490 2501
    • (1999) Genes Dev. , vol.13 , pp. 2490-2501
    • Murphy, M.1    Ahn, J.2    Walker, K.K.3    Hoffman, W.H.4    Evans, R.M.5    Levine, A.J.6    George, D.L.7
  • 85
    • 0036837864 scopus 로고    scopus 로고
    • Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2 alpha
    • C. Koumenis, C. Naczki, M. Koritzinsky, S. Rastani, A. Diehl, N. Sonenberg, A. Koromilas, and B.G. Wouters Regulation of protein synthesis by hypoxia via activation of the endoplasmic reticulum kinase PERK and phosphorylation of the translation initiation factor eIF2 alpha Mol. Cell Biol. 22 2002 7405 7416
    • (2002) Mol. Cell Biol. , vol.22 , pp. 7405-7416
    • Koumenis, C.1    Naczki, C.2    Koritzinsky, M.3    Rastani, S.4    Diehl, A.5    Sonenberg, N.6    Koromilas, A.7    Wouters, B.G.8
  • 87
    • 0037404443 scopus 로고    scopus 로고
    • Genetic models in applied physiology: Invited review: Effect of oxygen deprivation on cell cycle activity: A profile of delay and arrest
    • R.M. Douglas, and G.G. Haddad Genetic models in applied physiology: invited review: effect of oxygen deprivation on cell cycle activity: a profile of delay and arrest J. Appl. Physiol. 94 2003 2068 2083 (discussion 2084)
    • (2003) J. Appl. Physiol. , vol.94 , pp. 2068-2083
    • Douglas, R.M.1    Haddad, G.G.2
  • 88
    • 0031964536 scopus 로고    scopus 로고
    • Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo
    • L. Webster, R.J. Hodgkiss, and G.D. Wilson Cell cycle distribution of hypoxia and progression of hypoxic tumour cells in vivo Br. J. Cancer 77 1998 227 234
    • (1998) Br. J. Cancer , vol.77 , pp. 227-234
    • Webster, L.1    Hodgkiss, R.J.2    Wilson, G.D.3
  • 90
    • 0028110809 scopus 로고
    • Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status
    • T.G. Graeber, J.F. Peterson, M. Tsai, K. Monica, A.J. Fornace Jr., and A.J. Giaccia Hypoxia induces accumulation of p53 protein, but activation of a G1-phase checkpoint by low-oxygen conditions is independent of p53 status Mol. Cell Biol. 14 1994 6264 6277
    • (1994) Mol. Cell Biol. , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Peterson, J.F.2    Tsai, M.3    Monica, K.4    Fornace Jr., A.J.5    Giaccia, A.J.6
  • 91
    • 0028849274 scopus 로고
    • P21 is necessary for the p53-mediated G1 arrest in human cancer cells
    • T. Waldman, K.W. Kinzler, and B. Vogelstein p21 is necessary for the p53-mediated G1 arrest in human cancer cells Cancer Res. 55 1995 5187 5190
    • (1995) Cancer Res. , vol.55 , pp. 5187-5190
    • Waldman, T.1    Kinzler, K.W.2    Vogelstein, B.3
  • 92
    • 0033401439 scopus 로고    scopus 로고
    • Fast control of DNA replication in response to hypoxia and to inhibited protein synthesis in CCRF-CEM and HeLa cells
    • G. Probst, H.J. Riedinger, P. Martin, M. Engelcke, and H. Probst Fast control of DNA replication in response to hypoxia and to inhibited protein synthesis in CCRF-CEM and HeLa cells Biol. Chem. 380 1999 1371 1382
    • (1999) Biol. Chem. , vol.380 , pp. 1371-1382
    • Probst, G.1    Riedinger, H.J.2    Martin, P.3    Engelcke, M.4    Probst, H.5
  • 93
    • 0345708265 scopus 로고    scopus 로고
    • Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest
    • E.M. Hammond, S.L. Green, and A.J. Giaccia Comparison of hypoxia-induced replication arrest with hydroxyurea and aphidicolin-induced arrest Mut. Res. 532 2003 205 213
    • (2003) Mut. Res. , vol.532 , pp. 205-213
    • Hammond, E.M.1    Green, S.L.2    Giaccia, A.J.3
  • 94
    • 0038146962 scopus 로고    scopus 로고
    • ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation
    • E.M. Hammond, M.J. Dorie, and A.J. Giaccia ATR/ATM targets are phosphorylated by ATR in response to hypoxia and ATM in response to reoxygenation J. Biol. Chem. 278 2003 12207 12213
    • (2003) J. Biol. Chem. , vol.278 , pp. 12207-12213
    • Hammond, E.M.1    Dorie, M.J.2    Giaccia, A.J.3
  • 95
    • 0033572417 scopus 로고    scopus 로고
    • Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation
    • R. Alarcon, C. Koumenis, R.K. Geyer, C.G. Maki, and A.J. Giaccia Hypoxia induces p53 accumulation through MDM2 down-regulation and inhibition of E6-mediated degradation Cancer Res. 59 1999 6046 6051
    • (1999) Cancer Res. , vol.59 , pp. 6046-6051
    • Alarcon, R.1    Koumenis, C.2    Geyer, R.K.3    Maki, C.G.4    Giaccia, A.J.5
  • 97
    • 0035237410 scopus 로고    scopus 로고
    • Genetic determinants that influence hypoxia-induced apoptosis
    • R.M. Alarcon, N.C. Denko, and A.J. Giaccia Genetic determinants that influence hypoxia-induced apoptosis Novartis Found Sym. 240 2001 115 128 (discussion 128-132)
    • (2001) Novartis Found Sym. , vol.240 , pp. 115-128
    • Alarcon, R.M.1    Denko, N.C.2    Giaccia, A.J.3
  • 103
    • 0346655211 scopus 로고    scopus 로고
    • BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor-1 {alpha}
    • J.Y. Kim, H.J. Ahn, J.H. Ryu, K. Suk, and J.H. Park BH3-only protein Noxa is a mediator of hypoxic cell death induced by hypoxia-inducible factor-1 {alpha} J. Exp. Med. 199 2004 113 124
    • (2004) J. Exp. Med. , vol.199 , pp. 113-124
    • Kim, J.Y.1    Ahn, H.J.2    Ryu, J.H.3    Suk, K.4    Park, J.H.5
  • 104
    • 0034255036 scopus 로고    scopus 로고
    • Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia
    • R.K. Bruick Expression of the gene encoding the proapoptotic Nip3 protein is induced by hypoxia Proc. Natl. Acad. Sci. U.S.A. 97 2000 9082 9087
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 9082-9087
    • Bruick, R.K.1
  • 106
    • 0033549869 scopus 로고    scopus 로고
    • Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability
    • T. Imazu, S. Shimizu, S. Tagami, M. Matsushima, Y. Nakamura, T. Miki, A. Okuyama, and Y. Tsujimoto Bcl-2/E1B 19 kDa-interacting protein 3-like protein (Bnip3L) interacts with bcl-2/Bcl-xL and induces apoptosis by altering mitochondrial membrane permeability Oncogene 18 1999 4523 4529
    • (1999) Oncogene , vol.18 , pp. 4523-4529
    • Imazu, T.1    Shimizu, S.2    Tagami, S.3    Matsushima, M.4    Nakamura, Y.5    Miki, T.6    Okuyama, A.7    Tsujimoto, Y.8
  • 107
    • 0033984094 scopus 로고    scopus 로고
    • BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites
    • R. Ray, G. Chen, C. Vande Velde, J. Cizeau, J.H. Park, J.C. Reed, R.D. Gietz, and A.H. Greenberg BNIP3 heterodimerizes with Bcl-2/Bcl-X(L) and induces cell death independent of a Bcl-2 homology 3 (BH3) domain at both mitochondrial and nonmitochondrial sites J. Biol. Chem. 275 2000 1439 1448
    • (2000) J. Biol. Chem. , vol.275 , pp. 1439-1448
    • Ray, R.1    Chen, G.2    Vande Velde, C.3    Cizeau, J.4    Park, J.H.5    Reed, J.C.6    Gietz, R.D.7    Greenberg, A.H.8
  • 110


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