Gene expression profile and histopathology of experimental bronchopulmonary dysplasia induced by prolonged oxidative stress

Free Radical Biology and Medicine

Volumn 36, Issue 6, 2004, Pages 782-801

  Wagenaar, Gerry T M ^a   Ter Horst, Simone A J ^a   Van Gastelen, Margôt A ^a   Leijser, Lara M ^a   Mauad, Thais ^a   Van Der Velden, Pieter A ^a   De Heer, Emile ^a   Hiemstra, Pieter S ^a   Poorthuis, Ben J H M ^a   Walther, Frans J ^a,b  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^b HARBOR UCLA MEDICAL CENTER   (United States)

Author keywords

Activator protein 1; Alveolar enlargement; AP 1; BPD; Bronchopulmonary dysplasia; cDNA array; Chemokine induced neutrophilic chemoattractant 1; CINC 1; Coagulation; FGFR; Fibroblast growth factor receptor; Flk 1; Free radicals; Hyperoxia; Inflammation; Rat

Indexed keywords

AMPHIREGULIN; CHEMOATTRACTANT; CHEMOKINE; FIBRIN; FIBROBLAST GROWTH FACTOR RECEPTOR 4; HEME OXYGENASE; MACROPHAGE ELASTASE; METALLOTHIONEIN; MONOCYTE CHEMOTACTIC PROTEIN 1; PLASMINOGEN ACTIVATOR INHIBITOR 1; PROTEIN P21; SECRETORY LEUKOCYTE PROTEINASE INHIBITOR; VASCULOTROPIN RECEPTOR 2;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CLOTTING; CELL CYCLE; CONTROLLED STUDY; DEVELOPMENTAL STAGE; DNA MICROARRAY; DOWN REGULATION; EXTRACELLULAR MATRIX; FEMALE; FIBRIN DEPOSITION; FIBRINOLYSIS; GENE EXPRESSION PROFILING; HISTOPATHOLOGY; HYPEROXIA; INFLAMMATION; LUNG ALVEOLUS; LUNG DEVELOPMENT; LUNG DYSPLASIA; NEWBORN; NEWBORN INTENSIVE CARE; NONHUMAN; OXIDATIVE STRESS; PREMATURITY; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; UPREGULATION; WESTERN BLOTTING;

EID: 10744227545     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2003.12.007     Document Type: Article

References (56)

1. Lemons J.A., Bauer C.R., Oh W., Korones S.B., Papile L.A., Stoll B.J., Verter J., Temprosa M., Wright L.L., Ehrenkranz R.A., Fanaroff A.A., Stark A., Carlo W., Tyson J.E., Donovan E.F., Shankaran S., Stevenson D.K. Very low birth weight outcomes of the National Institute of Child Health and Human Development neonatal research network, January 1995 through December 1996. NICHD Neonatal Research Network. Pediatrics. 107:2001;E1.
2. Jobe A.H. The new BPD: an arrest of lung development. Pediatr. Res. 46:1999;641-643.
3. Bancalari E., Gonzalez A. Clinical course and lung function abnormalities during development of neonatal chronic lung disease. Bland R.D., Coalson J.J. Chronic lung disease in early infancy. 2000;Marcel Dekker, New York.
4. Jobe A.H., Bancalari E. Bronchopulmonary dysplasia. Am. J. Respir. Crit. Care Med. 163:2001;1723-1729.
5. Coalson J.J. Experimental models of bronchopulmonary dysplasia. Biol. Neonate. 71:1997;35-38.
6. 2 exposure on the lungs of new born mice. Lab. Invest. 32:1975;619-635.
7. Warner B.B., Stuart L.A., Papes R.A., Wispé J.R. Functional and pathological effects of prolonged hyperoxia in neonatal mice. Am. J. Physiol. 275:1998;L110-L117.
8. Roberts R.J., Weesner K.M., Bucher J.R. Oxygen-induced alterations in lung vascular development in the newborn rat. Pediatr. Res. 17:1983;368-375.
9. Han R.N.N., Buch S., Tseu I., Youngh J., Christie N.A., Frndova H., Lye S.J., Post M., Tanswell A.K. Changes in structure, mechanics and insulin-like growth factor-related gene expression in the lungs of newborn rats exposed to air or 60% oxygen. Pediatr. Res. 39:1996;921-929.
10. Chen Y., Martinez M.A., Frank L. Prenatal dexamethasone administration to premature rats exposed to prolonged hyperoxia: a new rat model of pulmonary fibrosis (bronchopulmonary dysplasia). J. Pediatr. 130:1997;409-416.
11. Dijkstra C.D., Dopp E.A., Joling P., Kraal G. The heterogeneity of mononuclear phagocytes in lymphoid organs: distinct macrophage subpopulations in the rat recognized by monoclonal antibodies ED1, ED2, and ED3. Immunology. 54:1985;589-599.
12. Margraf L.R., Tomashefski J.F. Jr., Bruce M.C., Dahms B.B. Morphometric analysis of the lung in bronchopulmonary dysplasia. Am. Rev. Respir. Dis. 143:1991;391-400.
13. Weiler-Guettler H., Christie P.D., Beeler D.L., Healy A.M., Hancock W.W., Rayburn H., Edelberg J.M., Rosenberg R.D. A targeted point mutation in thrombomodulin generates viable mice with a prethrombotic state. J. Clin. Invest. 101:1998;1983-1991.
14. Hui K.Y., Haber E., Matsueda G.R. Monoclonal antibodies to a synthetic fibrin-like peptide bind to human fibrin but not fibrinogen. Science. 222:1983;1129-1132.
15. Pfaffl M.W. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res. 29:2001;E45.
16. Idell S., James K.K., Levin E.G., Schwartz S., Marchanda N., Maunder R.J., Martin T.R., McLarty J., Fair D.S. Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J. Clin. Invest. 84:1989;695-705.
17. Idell S., Koenig K.B., Flair D.S., Martin T.R., McLarty J., Maunder R.J. Serial abnormalities of fibrin turnover in evolving adult respiratory distress syndrome. Am. J. Physiol. 261:1991;L240-L248.
18. Perkowski S., Sun J., Singhal S., Santiago J., Leikauf G.D., Albelda S.M. Gene expression profiling of the early pulmonary response to hyperoxia in mice. Am. J. Respir. Cell Mol. Biol. 28:2003;682-696.
19. Lander H.M. An essential role for free radicals and derived species in signal transduction. FASEB J. 11:1997;118-124.
20. Blackwell T.S., Christman J.W. The role of nuclear factor-κB in cytokine gene regulation. Am. J. Respir. Cell Mol. Biol. 17:1997;3-9.
21. Roebuck K.A., Carpenter L.R., Lakshminarayanan V., Page S.M., Moy J.N., Thomas L.L. Stimulus-specific regulation of chemokine expression involves differential activation of the redox-responsive transcription factors AP-1 and NF-κB. J. Leukoc. Biol. 65:1999;291-298.
22. Fan J., Ye R.D., Malik A.B. Transcriptional mechanisms of acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol. 281:2001;L1037-L1050.
23. Weinstein M., Xu X., Ohyama K., Deng C. FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development. 125:1998;3615-3623.
24. Hosford G.E., Olson D.M. Effects of hyperoxia on VEGF, its receptors and HIF-2α in the newborn rat lung. Am. J. Physiol. Lung Cell. Mol. Physiol. 285:2003;L161-L168.
25. Kasahara Y., Tuder D.M., Taraseviciene-Stewart L., Le Cras T.D., Abman S., Hirth P.K., Waltenberger J., Voelkel N.F. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106:2000;1311-1319.
26. Mariani T.J., Reed J.J., Shapiro S.D. Expression profiling of the developing mouse lung. Insights into the establishment of the extracellular matrix. Am. J. Respir. Cell Mol. Biol. 26:2002;541-548.
27. Gyetko M.R., Sud S., Kendall T., Fuller J.A., Newstead M.W., Standiford T.J. Urokinase deficient mice have impaired neutrophil recruitment in response to pulmonary Pseudomonas aeruginosa infection. J. Immunol. 165:2000;1513-1519.
28. Gyetko M.R., Dud S., Sonstein J., Polak T., Sud A., Curtis J.L. Antigen-driven lymphocyte recruitment to the lung is diminished in the absence of urokinase-type plasminogen activator (uPA) receptor, but is independent of uPA. J. Immunol. 167:2001;5539-5542.
29. Rijneveld A.W., Levi M., Florquin S., Speelman P., Carmeliet P., van der Poll T. Urokinase receptor is necessary for adequate host defense against pneumococcal pneumonia. J. Immunol. 168:2002;3507-3511.
30. Deng H., Mason S.N., Auten R.L. Jr. Lung inflammation in hyperoxia can be prevented by antichemokine treatment in new born rats. Am. J. Respir. Crit. Care Med. 162:2000;2316-2323.
31. Auten R.L., Richardson R.M., White J.R., Mason S.N., Vozzell M.A., Whorton M.H. Nonpeptide CXCR2 antagonist prevents neutrophil accumulation in hyperoxia-exposed newborn rats. J. Pharmacol. Exp. Ther. 299:2001;90-95.
32. Coalson J.J., Kuehl T.J., Escobedo M.B., Hilliard J.L., Smith F., Meredith K., Null D.M. Jr., Walsh W., Johnson D., Robotham J.L. A baboon model of bronchopulmonary dysplasia II. Pathologic features. Exp. Mol. Pathol. 37:1982;335-350.
33. Barazzone C., Belin D., Piguet P.F., Vassalli J.P., Sappino A.P. Plasminogen activator inhibitor-1 in acute hyperoxic mouse lung injury. J. Clin. Invest. 98:1996;2666-2673.
34. Carraway M.S., Welty-Wolf K.E., Miller D.L., Ortel T.L., Idell S., Ghio A.J., Petersen L.C., Piantadosi C.A. Blockade of tissue factor: treatment for organ injury in established sepsis. Am. J. Respir. Crit. Care Med. 167:2003;1200-1209.
35. Altieri D.C., Agbanyo F.R., Plescia J., Ginsberg M.H., Edgington T.S., Plow E.F. A unique recognition site mediates the interaction of fibrinogen with the leukocyte integrin Mac-1 (CD11b/CD18). J. Biol. Chem. 265:1990;12119-12122.
36. Fan S.T., Edgington T. Integrin regulation of leukocyte inflammatory functions: CD11b/CD18 enhancement of the tumor necrosis factor-α responses of monocytes. J. Immunol. 150:1993;2972-2980.
37. Sitrin R.G., Pan P.M., Srikanth S., Tod R.F. III Fibrinogen activates NF-κB transcription factors in mononuclear phagocytes. J. Immunol. 161:1998;1462-1470.
38. Seeger W., Stohr G., Wolf H.R., Neuhof H. Alteration of surfactant function due to protein leakage: special interaction with fibrin monomer. J. Appl. Phys. 58:1985;326-338.
39. Seeger W., Grube C., Gunther A. Proteolytic cleavage of fibrinogen: amplification of its surfactant inhibitory capacity. Am. J. Respir. Cell Mol. Biol. 9:1993;239-247.
40. Gupta M., Hernandez-Juviel J.M., Waring A.J., Bruni R., Walther F.J. Comparison of functional efficacy of surfactant protein B analogues in lavaged rats. Eur. Respir. J. 16:2000;1129-1133.
41. Birkedal-Hansen H. Proteolytic remodelling of extracellular matrix. Curr. Opin. Cell. Biol. 7:1995;728-735.
42. Nagase H., Woessner J.F. Jr. Matrix metalloproteinasesx. J. Biol. Chem. 274:1999;21491-21494.
43. Pardo A., Selman M., Ridge K., Barrios R., Sznajder J.I. Increased expression of gelatinases and collagenases in rat lungs exposed to 100% oxygen. Am. J. Respir. Crit. Care Med. 154:1996;1067-1075.
44. Pardo A., Barrios R., Maldonado V., Melendez J., Perez J., Ruiz V., Segura-Valdez L., Sznajder J.I., Selman M. Gelatinases A and B are up-regulated in rat lungs by subacute hyperoxia. Am. J. Pathol. 153:1998;833-844.
45. Radomski A., Sawicki G., Olson D.M., Radomski M.W. The role of nitric oxide and metalloproteinases in the pathogenesis of hyperoxia-induced lung injury in newborn rats. Br. J. Pharmacol. 125:1998;1455-1462.
46. Gipson T.S., Bless N.M., Shanley T.P., Crouch L.D., Bleavins M.R., Younkin E.M., Sarma V., Gibbs D.F., Tefera W., McConnell P.C., Mueller W.T., Johnson K.J., Ward P.A. Regulatory effects of endogenous protease inhibitors in acute lung inflammatory injury. J. Immunol. 162:1999;3653-3662.
47. Yoneda K., Peck K., Mann-Jong M., Chmiel K., Sher Y.-P., Chen J., Yang P.-C., Chen Y., Wu R. Development of high-density DNA microarray membrane for profiling smoke- and hydrogen peroxide-induced genes in a human bronchial epithelial cell line. Am. J. Respir. Crit. Care Med. 164:2001;S85-S89.
48. Sveger T., Ohlsson K., Polberger S., Noack G., Morse H., Laurin S. Tracheobronchial aspirate fluid neutrophil lipocalin, elastase- and neutrophil protease-4-α1-antitrypsin complexes, protease inhibitors and free proteolytic activity in respiratory distress syndrome. Acta Paediatr. 91:2002;934-937.
49. Devoogdt N., Hassanzadeh Ghassabeh G., Zhang J., Brys L., De Baetselier P., Revets H. Secretory leukocyte protease inhibitor promotes the tumorigenic and metastatic potential of cancer cells. Proc. Natl. Acad. Sci. USA. 100:2003;5778-5782.
50. Warner R.L., Beltran L., Younkin E.M., Lewis C.S., Weiss S.J., Varani J., Johnson K.J. Role of stromelysin 1 and gelatinase B in experimental acute lung injury. Am. J. Respir. Cell Mol. Biol. 24:2001;537-544.
51. Warner R.L., Lewis C.S., Beltran L., Younkin E.M., Varani J., Johnson K.J. The role of metalloelastase in immune complex-induced acute lung injury. Am. J. Pathol. 158:2001;2139-2144.
52. Leco K.J., Waterhouse P., Sanchez O.H., Gowing K.L.M., Poole A.R., Wakeman A., Mak T.W., Khokha R. Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP3). J. Clin. Invest. 108:2001;817-829.
53. Hautamaki R.D., Kobayashi D.K., Senior R.M., Shapiro S.D. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science. 277:1997;2002-2004.
54. Kaminski N., Allard J.D., Pittet J.F., Zuo F., Griffiths M.J.D., Morris D., Huang X., Sheppard D., Heller R.A. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc. Natl. Acad. Sci. USA. 97:2000;1778-1783.
55. Eitzman D.T., McCoy R.D., Zheng X., Fay W.P., Shen T., Ginsburg D., Simon R.H. Bleomycin-induced pulmonary fibrosis in transgenic mice that either lack or overexpress the murine plasminogen activator inhibitor-1 gene. J. Clin. Invest. 97:1996;232-237.
56. D'Angio C.T., Maniscalco W.M. The role of vascular growth factors in hyperoxia-induced injury to the developing lung. Front. Biosci. 7:2002;d1609-d1623.