Identification of the poly(C) binding protein in the complex associated with the 3' untranslated region of erythropoietin messenger RNA

Blood

Volumn 93, Issue 6, 1999, Pages 2111-2120

  Czyzyk Krzeska, Maria F ^a   Bendixen, Amy C ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BINDING PROTEIN; CYTIDINE; ERYTHROPOIETIN; MESSENGER RNA; TYROSINE 3 MONOOXYGENASE;

AMINO ACID SEQUENCE; ARTICLE; CELL STRAIN; CELL STRAIN HEPG2; GENE EXPRESSION REGULATION; HYPOXIA; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN PROTEIN INTERACTION; PROTEIN STABILITY; RNA CONFORMATION; SEQUENCE ANALYSIS;

EID: 0033559760     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v93.6.2111.406k24_2111_2120     Document Type: Article

References (27)

1. Jelkmann W: Erythropoietin: Structure, control of production, and function. Physiol Rev 72:449, 1992
2. Eckardt KU, Koury ST, Tan CC, Schuster SJ, Kaissling B, Ratcliffe PJ, Kurtz A: Distribution of erythropoietin producing cells in rat kidneys during hypoxic hypoxia. Kidney Int 43:815, 1993
3. Goldberg MA, Glass GA, Cunningham JM, Bunn HF: The regulated expression of erythropoietin by two human hepatoma cell lines. Proc Natl Acad Sci USA, 84:7972, 1987
4. Bunn HF, Poyton RO: Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76:839, 1996
5. Goldberg MA, Gout CC, Bunn, HF: Erythropoietin mRNA levels are governed by both the rate of gene transcription and posttranscriptional events. Blood 77:271, 1991
6. Bunn HF, Poyton RO: Oxygen sensing and molecular adaptation to hypoxia. Physiol Rev 76:839,1996
7. Ho V, Acquaviva A, Duh E, Bunn HF: Use of a marked erythropoietin gene for investigation of its cis-acting elements. J Biol Chem 270:10084, 1995
8. McGary EC, Rondon IJ, Beckman BS: Post-transcriptional regulation of erythropoietin mRNA stability by erythropoietin mRNA-binding protein. J Biol Chem 272:8628, 1997
9. Rondon IJ, MacMillan LA, Beckman BS, Goldberg MA, Schneider T, Bunn HF, Malter JS: Hypoxia up-regulates the activity of a novel erythropoietin mRNA binding protein. J Biol Chem 266:16594, 1991
10. Rondon IJ, Scadurro AB, Wilson RB, Beckman, BS: Changes in redox affect the activity of erythropoietin RNA binding protein. FEBS Lett 359: 267, 1995
11. Czyzyk-Krzeska MF, Furnuri BA, Lawson EE, Millhorn DE: Hypoxia increases rate of transcription and stability of tyrosine hydroxylase mRNA in pheochromocytoma (PC12) cells. J Biol Chem 269:760, 1994
12. Czyzyk-Krzeska MF, Dominski Z, Kole R, Millhorn DE: Hypoxia stimulates binding of a cytoplasmic protein to a pyrimidine rich sequence in the 3′ untranslated region of rat tyrosine hydroxylase mRNA. J Biol Chem 269:9940, 1994
13. Czyzyk-Krzeska MF, Beresh JE : Characterization of the hypoxia inducible protein binding site within the pyrimidine rich tract in the 3′ untranslated region of the tyrosine hydroxylase mRNA. J Biol Chem 271:3293, 1996
14. Czyzyk-Krzeska MF, Paulding WR, Beresh JE, Kroll, SL: Post-transcriptional regulation of tyrosine hydroxylase gene expression by oxygen in PC12 cells. Kidney Int 51:585-590, 1997
15. Paulding WR, Czyzyk-Krzeska MF: Regulation of tyrosine hydroxylase mRNA stability by protein-binding, pyrimidine-rich sequence in the 3′ untranslated region. J Biol Chem 274:2532, 1999
16. Wang X, Kiledjian M, Weiss IM, Liebhaber SA: Detection and characterization of a 3′ untranslated region ribonucleoprotein complex associated with human α-globin mRNA stability. Mol Cell Biol 15:1769, 1995
17. Kiledjian M, Wang X, Liebhaber SA: Identification of two KH domain proteins in the α-globin mRNP stability complex. EMBO J 14:4357, 1995
18. 2-globin 3′ nontranslated region. Mol Cell Biol 15:2457, 1995
19. Holcik M, Liebhaber SA: Four highly stable eukaryotic mRNAs assemble 3′ untranslated region RNA-protein complexes sharing cis and trans components. Proc Natl Acad Sci USA 94:2410, 1997
20. Stefanovic B, Hellerbrand C, Holcik M, Briendl M, Liebhaber SA, Brenner DA: Posttranscriptional regulation of collagen a1(I) mRNA in hepatic stellate cells. Mol Cell Biol 17:5201, 1997
21. Levy AP, Levy NS, Goldberg MA: Posttranscriptional regulation of vascular endothelial growth factor by hypoxia. J Biol Chem 271:2746, 1996
22. Levy AP, Levy NS, Goldberg MA: Hypoxia-inducible protein binding to vascular endothelial growth factor mRNA and its modulation by the von Hippel-Lindau protein. J Biol Chem 271:25492, 1996
23. Czyzyk-Krzeska MF, Bayliss DA, Lawson EE, Millhorn DE: Regulation of tyrosine hydroxylase gene expression in the rat carotid body by hypoxia. J Neurochem 58:1538, 1992
24. Czyzyk-Krzeska MF: Molecular aspects of oxygen sensing in physiological adaptation to hypoxia. Respir Physiol 110:99, 1997
25. Wang GL, Semenza GL: Characterization of hypoxia-inducible factor 1 and regulation of DNA binding activity by hypoxia. J Biol Chem 268:21513, 1993
26. 2-responsive sequences on the tyrosine hydroxylase gene. J Biol Chem 270:23774, 1995
27. Scandurro AB, Rondon IJ, Wilson RB, Tennenbaum SA, Garry RF, Beckman BS: Interaction of erythropoietin RNA binding protein with erythropoietin RNA requires an association with heat shock protein 70. Kidney Int 51:579, 1997