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Volumn 6, Issue 7, 2000, Pages 2941-2950

Opposing effects of hypoxia on expression of the angiogenic inhibitor thrombospondin 1 and the angiogenic inducer vascular endothelial growth factor

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53; THROMBOSPONDIN 1; VASCULOTROPIN;

EID: 0033924882     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (97)

References (76)
  • 1
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: A review
    • Vaupel, P., Kallinowski, F., and Okunieff, P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res., 49: 6449-6465, 1989.
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 2
    • 0032053823 scopus 로고    scopus 로고
    • The unique physiology of solid tumors: Opportunities (and problems) for cancer therapy
    • Brown, J. M., and Giaccia, A. J. The unique physiology of solid tumors: opportunities (and problems) for cancer therapy. Cancer Res., 58: 1408-1416, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 1408-1416
    • Brown, J.M.1    Giaccia, A.J.2
  • 3
    • 0030025773 scopus 로고    scopus 로고
    • Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors
    • Graeber, T., Osmanian, C., Jacks, T., Housman, D., Koch, C., Lowe, S., and Giaccia, A. Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumors. Nature (Lond.), 379: 88-91, 1996.
    • (1996) Nature (Lond.) , vol.379 , pp. 88-91
    • Graeber, T.1    Osmanian, C.2    Jacks, T.3    Housman, D.4    Koch, C.5    Lowe, S.6    Giaccia, A.7
  • 5
    • 0030866226 scopus 로고    scopus 로고
    • Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway
    • Müller, J. M., Krauss, B., Kaltschmidt, C., Baeuerle, P. A., and Rupec, R. A. Hypoxia induces c-fos transcription via a mitogen-activated protein kinase-dependent pathway. J. Biol. Chem., 272: 23435-23439, 1997.
    • (1997) J. Biol. Chem. , vol.272 , pp. 23435-23439
    • Müller, J.M.1    Krauss, B.2    Kaltschmidt, C.3    Baeuerle, P.A.4    Rupec, R.A.5
  • 6
    • 0033617186 scopus 로고    scopus 로고
    • Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. a candidate MKP for the inactivation of hypoxia-inducible SAPK/JNK activity
    • Laderoute, K. R., Mendonca, H. L., Calaoagan, J. M., Knapp, A. M., Giaccia, A. J., and Stork, P. J. S. Mitogen-activated protein kinase phosphatase-1 (MKP-1) expression is induced by low oxygen conditions found in solid tumor microenvironments. A candidate MKP for the inactivation of hypoxia-inducible SAPK/JNK activity. J. Biol. Chem., 274: 12890-12897, 1999.
    • (1999) J. Biol. Chem. , vol.274 , pp. 12890-12897
    • Laderoute, K.R.1    Mendonca, H.L.2    Calaoagan, J.M.3    Knapp, A.M.4    Giaccia, A.J.5    Stork, P.J.S.6
  • 7
    • 0029753768 scopus 로고    scopus 로고
    • Genetic instability induced by the tumor microenvironment
    • Reynolds, T. Y., Rockwell, S., and Glazer, P. M. Genetic instability induced by the tumor microenvironment. Cancer Res., 56: 5754-5757, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 5754-5757
    • Reynolds, T.Y.1    Rockwell, S.2    Glazer, P.M.3
  • 8
    • 0032132806 scopus 로고    scopus 로고
    • A new role for hypoxia in tumor progression: Induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs
    • Coquelle, A., Toledo, F., Stern, S., Bieth, A., and Debatisse, M. A new role for hypoxia in tumor progression: induction of fragile site triggering genomic rearrangements and formation of complex DMs and HSRs. Mol. Cell, 2: 259-265, 1998.
    • (1998) Mol. Cell , vol.2 , pp. 259-265
    • Coquelle, A.1    Toledo, F.2    Stern, S.3    Bieth, A.4    Debatisse, M.5
  • 9
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan, D., and Folkman, J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell, 86: 353-364, 1996.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 10
    • 0029681850 scopus 로고    scopus 로고
    • Oncogenic transformation and hypoxia synergistically act to modulate VEGF expression
    • Mazure, N. M., Chen, E. Y., Yeh, P., Mivechi, N., Laderoute, K. R., and Giaccia, A. J. Oncogenic transformation and hypoxia synergistically act to modulate VEGF expression. Cancer Res., 56: 3436-3440, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 3436-3440
    • Mazure, N.M.1    Chen, E.Y.2    Yeh, P.3    Mivechi, N.4    Laderoute, K.R.5    Giaccia, A.J.6
  • 11
    • 0029833679 scopus 로고    scopus 로고
    • The rise and fall of apoptosis during multistage tumorigenesis: Down-modulation contributes to tumor progression from angiogenic progenitors
    • Naik, P., Karrim, J., and Hanahan, D. The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors. Genes Dev., 10: 2105-2116, 1996.
    • (1996) Genes Dev. , vol.10 , pp. 2105-2116
    • Naik, P.1    Karrim, J.2    Hanahan, D.3
  • 12
    • 0028955022 scopus 로고
    • Thrombospondins
    • E. Ruoslahti and E. Engvall (eds.), San Diego, CA: Academic Press
    • Bornstein, P., and Sage, E. H. Thrombospondins. In: E. Ruoslahti and E. Engvall (eds.), Extracellular Matrix Components, pp. 62-85. San Diego, CA: Academic Press, 1994.
    • (1994) Extracellular Matrix Components , pp. 62-85
    • Bornstein, P.1    Sage, E.H.2
  • 13
    • 0028114985 scopus 로고
    • The implications of angiogenesis for the biology and therapy of cancer metastasis
    • Fidler, I. J., and Ellis, L. M. The implications of angiogenesis for the biology and therapy of cancer metastasis. Cell, 79: 185-188, 1994.
    • (1994) Cell , vol.79 , pp. 185-188
    • Fidler, I.J.1    Ellis, L.M.2
  • 15
    • 0029128416 scopus 로고
    • The modulation of thrombospondin and other naturally occurring inhibitors of angiogenesis during tumor progression
    • Volpert, O. V., Stellmach, V., and Bouck, N. The modulation of thrombospondin and other naturally occurring inhibitors of angiogenesis during tumor progression. Breast Cancer Res. Treat., 36: 119-126, 1995.
    • (1995) Breast Cancer Res. Treat. , vol.36 , pp. 119-126
    • Volpert, O.V.1    Stellmach, V.2    Bouck, N.3
  • 16
    • 0031469819 scopus 로고    scopus 로고
    • Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance
    • Boehm, T., Folkman, J., Browder, T., and O'Reilly, M. S. Antiangiogenic therapy of experimental cancer does not induce acquired drug resistance. Nature (Lond.), 390: 404-407, 1997.
    • (1997) Nature (Lond.) , vol.390 , pp. 404-407
    • Boehm, T.1    Folkman, J.2    Browder, T.3    O'Reilly, M.S.4
  • 17
    • 0030893967 scopus 로고    scopus 로고
    • Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity
    • Volpert, O. V., Dameron, K. M., and Bouck, N. Sequential development of an angiogenic phenotype by human fibroblasts progressing to tumorigenicity. Oncogene, 14: 1495-1502, 1997.
    • (1997) Oncogene , vol.14 , pp. 1495-1502
    • Volpert, O.V.1    Dameron, K.M.2    Bouck, N.3
  • 18
    • 0032521539 scopus 로고    scopus 로고
    • Molecular mediators of angiogenesis in bladder cancer
    • Campbell, S. C., Volpert, O. V., Ivanovich, M., and Bouck, N. P. Molecular mediators of angiogenesis in bladder cancer. Cancer Res., 58: 1298-1304, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 1298-1304
    • Campbell, S.C.1    Volpert, O.V.2    Ivanovich, M.3    Bouck, N.P.4
  • 19
    • 0032568607 scopus 로고    scopus 로고
    • A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1
    • Volpert, O. V., Lawler, J., and Bouck, N. P. A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1. Proc. Natl. Acad. Sci. USA, 95: 6343-6348, 1998.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 6343-6348
    • Volpert, O.V.1    Lawler, J.2    Bouck, N.P.3
  • 20
    • 0030040976 scopus 로고    scopus 로고
    • The role of thrombospondin-1 in tumor progression and angiogenesis
    • Tuszynski, G. P., and Nicosia, R. F. The role of thrombospondin-1 in tumor progression and angiogenesis. Bioessays, 18: 71-76, 1996.
    • (1996) Bioessays , vol.18 , pp. 71-76
    • Tuszynski, G.P.1    Nicosia, R.F.2
  • 22
    • 0029347102 scopus 로고
    • Diversity of function is inherent in matricellular proteins: An appraisal of thrombospondin 1
    • Bernstein, P. Diversity of function is inherent in matricellular proteins: an appraisal of thrombospondin 1. J. Cell Biol., 130: 503-506, 1995.
    • (1995) J. Cell Biol. , vol.130 , pp. 503-506
    • Bernstein, P.1
  • 23
    • 0029797025 scopus 로고    scopus 로고
    • Regulation of tumor growth and metastasis by thrombospondin-1
    • Roberts, D. D. Regulation of tumor growth and metastasis by thrombospondin-1. FASEB J., 10: 1183-1191, 1996.
    • (1996) FASEB J. , vol.10 , pp. 1183-1191
    • Roberts, D.D.1
  • 24
    • 0028060380 scopus 로고
    • Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1
    • Washington, DC
    • Dameron, K. M., Volpert, O. V., Tainsky, M. A., and Bouck, N. Control of angiogenesis in fibroblasts by p53 regulation of thrombospondin-1. Science (Washington, DC), 265: 1582-1584, 1994.
    • (1994) Science , vol.265 , pp. 1582-1584
    • Dameron, K.M.1    Volpert, O.V.2    Tainsky, M.A.3    Bouck, N.4
  • 25
    • 0033514927 scopus 로고    scopus 로고
    • Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization
    • Bleuel, K., Popp, S., Fusenig, N. E., Stanbridge, E. J., and Boukamp, P. Tumor suppression in human skin carcinoma cells by chromosome 15 transfer or thrombospondin-1 overexpression through halted tumor vascularization. Proc. Natl. Acad. Sci. USA, 96: 2065-2070, 1999.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2065-2070
    • Bleuel, K.1    Popp, S.2    Fusenig, N.E.3    Stanbridge, E.J.4    Boukamp, P.5
  • 26
    • 0032770860 scopus 로고    scopus 로고
    • Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas
    • Streit, M., Velasco, P., Brown, L. F., Skobe, M., Richard, L., Riccardi, L., Lawler, J., and Detmar, M. Overexpression of thrombospondin-1 decreases angiogenesis and inhibits the growth of human cutaneous squamous cell carcinomas. Am. J. Pathol., 155: 441-452, 1999.
    • (1999) Am. J. Pathol. , vol.155 , pp. 441-452
    • Streit, M.1    Velasco, P.2    Brown, L.F.3    Skobe, M.4    Richard, L.5    Riccardi, L.6    Lawler, J.7    Detmar, M.8
  • 28
    • 0028037536 scopus 로고
    • Transformation by v-src causes transient induction followed by repression of mouse thrombospondin-1
    • Slack, J. L., and Bornstein, P. Transformation by v-src causes transient induction followed by repression of mouse thrombospondin-1. Cell Growth Differ., 5: 1373-1380, 1994.
    • (1994) Cell Growth Differ. , vol.5 , pp. 1373-1380
    • Slack, J.L.1    Bornstein, P.2
  • 29
    • 10544235440 scopus 로고    scopus 로고
    • Viral Myc oncoproteins in infected fibroblasts down-modulate thrombospondin-1. A possible tumor suppressor gene
    • Tikhonenko, A. T., Black, D. J., and Linial, M. L. Viral Myc oncoproteins in infected fibroblasts down-modulate thrombospondin-1. a possible tumor suppressor gene. J. Biol. Chem., 271: 30741-30747, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 30741-30747
    • Tikhonenko, A.T.1    Black, D.J.2    Linial, M.L.3
  • 30
    • 0033609371 scopus 로고    scopus 로고
    • Methylation and silencing of the thrombospondin-1 promoter in human cancer
    • Li, Q., Ahuja, N., Burger, P. C., and Issa, J. P. Methylation and silencing of the thrombospondin-1 promoter in human cancer. Oncogene, 18: 3284-3289, 1999.
    • (1999) Oncogene , vol.18 , pp. 3284-3289
    • Li, Q.1    Ahuja, N.2    Burger, P.C.3    Issa, J.P.4
  • 31
    • 0028110809 scopus 로고
    • 1 phase checkpoint by low oxygen conditions is independent of p53 status
    • 1 phase checkpoint by low oxygen conditions is independent of p53 status. Mol. Cell. Biol., 14: 6264-6277, 1994.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 6264-6277
    • Graeber, T.G.1    Koong, A.C.2    Giaccia, A.J.3
  • 32
    • 0029068339 scopus 로고
    • Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation
    • Mukhopadhyay, D., Tsiokas, L., Zhou, X-M., Foster, D., Brugge, J. S., and Sukhatme, V. P. Hypoxic induction of human vascular endothelial growth factor expression through c-Src activation. Nature (Lond.), 375: 577-581, 1995.
    • (1995) Nature (Lond.) , vol.375 , pp. 577-581
    • Mukhopadhyay, D.1    Tsiokas, L.2    Zhou, X.-M.3    Foster, D.4    Brugge, J.S.5    Sukhatme, V.P.6
  • 33
    • 0030044039 scopus 로고    scopus 로고
    • Post-transcriptional regulation of vascular endothelial growth factor by hypoxia
    • Levy, A. P., Levy, N. S., and Goldberg, M. A. Post-transcriptional regulation of vascular endothelial growth factor by hypoxia. J. Biol. Chem., 271: 2746-2753, 1996.
    • (1996) J. Biol. Chem. , vol.271 , pp. 2746-2753
    • Levy, A.P.1    Levy, N.S.2    Goldberg, M.A.3
  • 34
    • 0030869787 scopus 로고    scopus 로고
    • Induction of vascular endothelial cell growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia-inducible factor-1 transcriptional element
    • Mazure, N. M., Chen, E. Y., Laderoute, K. R., and Giaccia, A. J. Induction of vascular endothelial cell growth factor by hypoxia is modulated by a phosphatidylinositol 3-kinase/Akt signaling pathway in Ha-ras-transformed cells through a hypoxia-inducible factor-1 transcriptional element. Blood, 90: 3322-3331, 1997.
    • (1997) Blood , vol.90 , pp. 3322-3331
    • Mazure, N.M.1    Chen, E.Y.2    Laderoute, K.R.3    Giaccia, A.J.4
  • 35
    • 0031869662 scopus 로고    scopus 로고
    • Translation of vascular endothelial growth factor mRNA by internal ribosome entry: Implications for translation under hypoxia
    • Stein, I., Itin, A., Einat, P., Skaliter, R., Grossman, Z., and Keshet, E. Translation of vascular endothelial growth factor mRNA by internal ribosome entry: implications for translation under hypoxia. Mol. Cell. Biol., 18: 3112-3119, 1998.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 3112-3119
    • Stein, I.1    Itin, A.2    Einat, P.3    Skaliter, R.4    Grossman, Z.5    Keshet, E.6
  • 36
    • 0028864565 scopus 로고
    • Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker
    • Waleh, N. S., Brody, M. D., Knapp, A. M., Mendonca, H. L., Lord, E. M., Koch, C. J., Laderoute, K. R., and Sutherland, R. M. Mapping of the vascular endothelial growth factor-producing hypoxic cells in multicellular tumor spheroids using a hypoxia-specific marker. Cancer Res., 55: 6222-6226, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 6222-6226
    • Waleh, N.S.1    Brody, M.D.2    Knapp, A.M.3    Mendonca, H.L.4    Lord, E.M.5    Koch, C.J.6    Laderoute, K.R.7    Sutherland, R.M.8
  • 37
    • 0028822834 scopus 로고
    • Mutant ras oncogenes upregulate VEGF/VPF expression: Implications for induction and inhibition of tumor angiogenesis
    • Rak, J., Mitsuhashi, Y., Bayko, L., Filmus, J., Shirsawa, S., Sasazuki, T., and Kerbel, R. S. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis. Cancer Res., 55: 4575-4580, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 4575-4580
    • Rak, J.1    Mitsuhashi, Y.2    Bayko, L.3    Filmus, J.4    Shirsawa, S.5    Sasazuki, T.6    Kerbel, R.S.7
  • 38
  • 39
    • 0029761644 scopus 로고    scopus 로고
    • Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1
    • Forsythe, J. A., Jiang, B. H., Iyer, N. V., Agani, F., Leung, S. W., Koos, R. D., and Semenza, G. L. Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1. Mol. Cell. Biol., 16: 4604-4613, 1996.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 4604-4613
    • Forsythe, J.A.1    Jiang, B.H.2    Iyer, N.V.3    Agani, F.4    Leung, S.W.5    Koos, R.D.6    Semenza, G.L.7
  • 42
    • 0027451668 scopus 로고
    • p53-dependent apoptosis modulates the cytotoxicity of anticancer agents
    • Lowe, S. W., Ruley, H. E., Jacks, T., and Housman, D. E. p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell, 74: 957-967, 1993.
    • (1993) Cell , vol.74 , pp. 957-967
    • Lowe, S.W.1    Ruley, H.E.2    Jacks, T.3    Housman, D.E.4
  • 45
    • 0027945376 scopus 로고
    • Modified indirect immunodetection allows study of murine tissue with mouse monoclonal antibodies
    • Hierck, B. P., Iperen, L. V., Gittenberger-De Groot, A. C., and Poelmann, R. E. Modified indirect immunodetection allows study of murine tissue with mouse monoclonal antibodies. J. Histochem. Cytochem., 42: 1499-1502, 1994.
    • (1994) J. Histochem. Cytochem. , vol.42 , pp. 1499-1502
    • Hierck, B.P.1    Iperen, L.V.2    Gittenberger-De Groot, A.C.3    Poelmann, R.E.4
  • 46
    • 0039529940 scopus 로고
    • Enhancement of epidermal growth factor receptor synthesis in A431 human squamous carcinoma cells exposed to low levels of oxygen
    • Laderoute, K. R., Grant, T. D., Murphy, B. J., and Sutherland, R. M. Enhancement of epidermal growth factor receptor synthesis in A431 human squamous carcinoma cells exposed to low levels of oxygen. Int. J. Cancer, 42: 1-5, 1992.
    • (1992) Int. J. Cancer , vol.42 , pp. 1-5
    • Laderoute, K.R.1    Grant, T.D.2    Murphy, B.J.3    Sutherland, R.M.4
  • 47
    • 0027415654 scopus 로고
    • A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene
    • Framson, P., and Bornstein, P. A serum response element and a binding site for NF-Y mediate the serum response of the human thrombospondin 1 gene. J. Biol. Chem., 268: 4989-4996, 1993.
    • (1993) J. Biol. Chem. , vol.268 , pp. 4989-4996
    • Framson, P.1    Bornstein, P.2
  • 49
    • 0028089956 scopus 로고
    • Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines
    • Zabrenetzky, V., Harris, C. C., Steeg, P. S., and Roberts, D. D. Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines. Int. J. Cancer, 59: 191-195, 1994.
    • (1994) Int. J. Cancer , vol.59 , pp. 191-195
    • Zabrenetzky, V.1    Harris, C.C.2    Steeg, P.S.3    Roberts, D.D.4
  • 52
    • 0030032543 scopus 로고    scopus 로고
    • 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors
    • Evans, S. M., Jenkins, W. T., Joiner, B., Lord, E. M., and Koch, C. J. 2-Nitroimidazole (EF5) binding predicts radiation resistance in individual 9L s.c. tumors. Cancer Res., 56: 405-411, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 405-411
    • Evans, S.M.1    Jenkins, W.T.2    Joiner, B.3    Lord, E.M.4    Koch, C.J.5
  • 53
    • 0343530603 scopus 로고    scopus 로고
    • Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts
    • Lee, J., Siemann, D. W., Koch, C. J., and Lord, E. M. Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts. Int. J. Cancer, 67: 372-378, 1996.
    • (1996) Int. J. Cancer , vol.67 , pp. 372-378
    • Lee, J.1    Siemann, D.W.2    Koch, C.J.3    Lord, E.M.4
  • 54
    • 0028559569 scopus 로고
    • Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene
    • Shingu, T., and Bornstein, P. Overlapping Egr-1 and Sp1 sites function in the regulation of transcription of the mouse thrombospondin 1 gene. J. Biol. Chem., 269: 32551-32557, 1994.
    • (1994) J. Biol. Chem. , vol.269 , pp. 32551-32557
    • Shingu, T.1    Bornstein, P.2
  • 55
    • 0032387693 scopus 로고    scopus 로고
    • Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells
    • Phelan, M. W., Forman, L. W., Perrine, S. P., and Faller, D. V. Hypoxia increases thrombospondin-1 transcript and protein in cultured endothelial cells. J. Lab. Clin. Med., 132: 519-529, 1998.
    • (1998) J. Lab. Clin. Med. , vol.132 , pp. 519-529
    • Phelan, M.W.1    Forman, L.W.2    Perrine, S.P.3    Faller, D.V.4
  • 56
    • 0015251378 scopus 로고
    • A new human cell line (FaDu) from a hypopharyngeal carcinoma
    • Phila.
    • Rangan, S. R. A new human cell line (FaDu) from a hypopharyngeal carcinoma. Cancer (Phila.), 29: 117-121, 1972.
    • (1972) Cancer , vol.29 , pp. 117-121
    • Rangan, S.R.1
  • 58
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel, M., Schlenger, K., Aral, B., Mitze, M., Schaffer, U., and Vaupel, P. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res., 56: 4509-4515, 1996.
    • (1996) Cancer Res. , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3    Mitze, M.4    Schaffer, U.5    Vaupel, P.6
  • 59
    • 0029955072 scopus 로고    scopus 로고
    • Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck
    • Nordsmark, M., Overgaard, M., and Overgaard, J. Pretreatment oxygenation predicts radiation response in advanced squamous cell carcinoma of the head and neck. Radiother. Oncol., 41: 31-39, 1996.
    • (1996) Radiother. Oncol. , vol.41 , pp. 31-39
    • Nordsmark, M.1    Overgaard, M.2    Overgaard, J.3
  • 60
    • 0028841622 scopus 로고
    • The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-κB
    • Rupec, R. A., and Baeuerle, P. A. The genomic response of tumor cells to hypoxia and reoxygenation. Differential activation of transcription factors AP-1 and NF-κB. Eur. J. Biochem., 234: 632-640, 1995.
    • (1995) Eur. J. Biochem. , vol.234 , pp. 632-640
    • Rupec, R.A.1    Baeuerle, P.A.2
  • 61
    • 0030659531 scopus 로고    scopus 로고
    • V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: Involvement of HIF-1 in tumor progression
    • Jiang, B., Agani, F., Passaniti, A., and Semenza, G. L. V-SRC induces expression of hypoxia-inducible factor 1 (HIF-1) and transcription of genes encoding vascular endothelial growth factor and enolase 1: involvement of HIF-1 in tumor progression. Cancer Res., 57: 5328-5335, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 5328-5335
    • Jiang, B.1    Agani, F.2    Passaniti, A.3    Semenza, G.L.4
  • 62
    • 1842416574 scopus 로고    scopus 로고
    • Oxygen(es) and the hypoxia-inducible factor-1
    • Wenger, R. H., and Gassmann, M. Oxygen(es) and the hypoxia-inducible factor-1. Biol. Chem., 378: 609-616, 1997.
    • (1997) Biol. Chem. , vol.378 , pp. 609-616
    • Wenger, R.H.1    Gassmann, M.2
  • 66
    • 0032100732 scopus 로고    scopus 로고
    • HIF-1α is required for solid tumor formation and embryonic vascularization
    • Ryan, H., Lo, J., and Johnson, R. S. HIF-1α is required for solid tumor formation and embryonic vascularization. EMBO J., 17: 3005-3015, 1998.
    • (1998) EMBO J. , vol.17 , pp. 3005-3015
    • Ryan, H.1    Lo, J.2    Johnson, R.S.3
  • 67
    • 0029970981 scopus 로고    scopus 로고
    • p53 and angiogenesis
    • Bouck, N. p53 and angiogenesis. Biochim. Biophys. Acta, 1287: 63-66, 1996.
    • (1996) Biochim. Biophys. Acta , vol.1287 , pp. 63-66
    • Bouck, N.1
  • 68
    • 0028865988 scopus 로고
    • Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression
    • Mukhopadhyay, D., Tsiokas, L., and Sukhatme, V. P. Wild-type p53 and v-Src exert opposing influences on human vascular endothelial growth factor gene expression. Cancer Res., 55: 6161-6165, 1995.
    • (1995) Cancer Res. , vol.55 , pp. 6161-6165
    • Mukhopadhyay, D.1    Tsiokas, L.2    Sukhatme, V.P.3
  • 69
    • 0030767287 scopus 로고    scopus 로고
    • p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene
    • Agani, F., Kirsch, D. G., Friedman, S. L., Kastan, M. B., and Semenza, G. L. p53 does not repress hypoxia-induced transcription of the vascular endothelial growth factor gene. Cancer Res., 57: 4474-4477, 1997.
    • (1997) Cancer Res. , vol.57 , pp. 4474-4477
    • Agani, F.1    Kirsch, D.G.2    Friedman, S.L.3    Kastan, M.B.4    Semenza, G.L.5
  • 70
    • 0032535077 scopus 로고    scopus 로고
    • Up-regulation of hypoxia-inducible factor-1α is not sufficient for hypoxic/anoxic p53 induction
    • Wenger, R. H., Camenisch, G., Desbaillets, I., Chilov, D., and Gassmann, M. Up-regulation of hypoxia-inducible factor-1α is not sufficient for hypoxic/anoxic p53 induction. Cancer Res., 58: 5678-5680, 1998.
    • (1998) Cancer Res. , vol.58 , pp. 5678-5680
    • Wenger, R.H.1    Camenisch, G.2    Desbaillets, I.3    Chilov, D.4    Gassmann, M.5
  • 71
    • 0025293207 scopus 로고
    • Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism
    • Heacock, C. S., and Sutherland, R. M. Enhanced synthesis of stress proteins caused by hypoxia and relation to altered cell growth and metabolism. Br. J. Cancer, 62: 217-225, 1990.
    • (1990) Br. J. Cancer , vol.62 , pp. 217-225
    • Heacock, C.S.1    Sutherland, R.M.2
  • 72
    • 0029074864 scopus 로고
    • Regulation of protein synthesis in human cells exposed to extreme hypoxia
    • Kraggerud, S. M., Sandvik, J. A., and Pettersen, E. O. Regulation of protein synthesis in human cells exposed to extreme hypoxia. Anticancer Res., 15: 683-686, 1995.
    • (1995) Anticancer Res. , vol.15 , pp. 683-686
    • Kraggerud, S.M.1    Sandvik, J.A.2    Pettersen, E.O.3
  • 73
    • 0032516886 scopus 로고    scopus 로고
    • Myb-dependent regulation of thrombospondin 2 expression. Role of mRNA stability
    • Bein, K., Ware, J. A., and Simons, M. Myb-dependent regulation of thrombospondin 2 expression. Role of mRNA stability. J. Biol. Chem., 272: 21423-21429, 1998.
    • (1998) J. Biol. Chem. , vol.272 , pp. 21423-21429
    • Bein, K.1    Ware, J.A.2    Simons, M.3
  • 74
    • 0030272798 scopus 로고    scopus 로고
    • Repression of thrombospondin-1 expression, a natural inhibitor of angiogenesis, in polyoma middle T transformed NIH3T3 cells
    • Sheibani, N., and Frazier, W. A. Repression of thrombospondin-1 expression, a natural inhibitor of angiogenesis, in polyoma middle T transformed NIH3T3 cells. Cancer Lett., 107: 45-52, 1996.
    • (1996) Cancer Lett. , vol.107 , pp. 45-52
    • Sheibani, N.1    Frazier, W.A.2
  • 75
    • 0031728635 scopus 로고    scopus 로고
    • Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes
    • Fusenig, N. E., and Boukamp, P. Multiple stages and genetic alterations in immortalization, malignant transformation, and tumor progression of human skin keratinocytes. Mol. Carcinog., 23: 144-158, 1998.
    • (1998) Mol. Carcinog. , vol.23 , pp. 144-158
    • Fusenig, N.E.1    Boukamp, P.2
  • 76
    • 0033587012 scopus 로고    scopus 로고
    • The Wilms' tumor gene product represses the transcription of thrombospondin 1 in response to overexpression of c-Jun
    • Dejong, V., Degeorges, A., Filleur, S., Ait-Si-Ali, S., Mettouchi, A., Bornstein, P., Binétruy, B., and Cabon, F. The Wilms' tumor gene product represses the transcription of thrombospondin 1 in response to overexpression of c-Jun. Oncogene, 18: 3143-3151, 1999.
    • (1999) Oncogene , vol.18 , pp. 3143-3151
    • Dejong, V.1    Degeorges, A.2    Filleur, S.3    Ait-Si-Ali, S.4    Mettouchi, A.5    Bornstein, P.6    Binétruy, B.7    Cabon, F.8


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