p21Cip1 and p27Kip1 regulate cell cycle reentry after hypoxic stress but are not necessary for hypoxia-induced arrest

Molecular and Cellular Biology

Volumn 21, Issue 4, 2001, Pages 1196-1206

  Green, S L ^a   Freiberg, R A ^a   Giaccia, A J ^a  

^a STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BROXURIDINE; CYCLIN DEPENDENT KINASE; CYCLIN DEPENDENT KINASE 2; PROTEIN P21; PROTEIN P27; RETINOBLASTOMA PROTEIN;

ANIMAL CELL; ARTICLE; CELL CYCLE; CELL CYCLE S PHASE; CONTROLLED STUDY; DEPHOSPHORYLATION; DNA REPLICATION; DNA SYNTHESIS; FIBROBLAST; FLOW CYTOMETRY; HYPOXIA; NONHUMAN; NULL CELL; OXYGEN TENSION; PRIORITY JOURNAL; REGULATORY MECHANISM; REOXYGENATION;

ANIMALS; CDC2-CDC28 KINASES; CELL CYCLE; CELL CYCLE PROTEINS; CELL HYPOXIA; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE 2; CYCLIN-DEPENDENT KINASE INHIBITOR P21; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLIN-DEPENDENT KINASES; CYCLINS; DNA; MICE; MICE, KNOCKOUT; MICROTUBULE-ASSOCIATED PROTEINS; PHOSPHORYLATION; PROTEIN-SERINE-THREONINE KINASES; RETINOBLASTOMA PROTEIN; TUMOR SUPPRESSOR PROTEINS;

EID: 0035145591     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.21.4.1196-1206.2001     Document Type: Article

References (39)

1. The retinoblastoma protein-associated cell cycle arrest in S-phase under moderate hypoxia is disrupted in cells expressing HPV18 E7 oncoprotein
2. 2 phases during hypoxic stress
3. Oxygen modulates growth of human cells at physiologic partial pressures
4. 1 arrest after gamma-irradiation
5. Role of HIF-1alpha in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
6. Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle
7. A new pathway for mitogen-dependent cdk2 regulation uncovered in p27(Kip1)-deficient cells
8. 1/S-phase and late S-phase checkpoints with regulation of cyclin-dependent kinases in Chinese hamster ovary cells
9. CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control
10. p53 checkpoint-defective cells are sensitive to X rays, but not hypoxia
11. Selective and synchronous activation of early-S-phase replicons of Ehrlich ascites cells
12. 1-phase checkpoint by low-oxygen conditions is independent of p53 status
13. Tumor hypoxia and the cell cycle: Implications for malignant progression and response to therapy
14. Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15
15. 2-histography
16. Hypoxia-induced pRB hypophosphorylation results from downregulation of CDK and upregulation of PP1 activities
17. Molecular analysis of selected cell cycle regulatory proteins during aerobic and hypoxic maintenance of human ovarian carcinoma cells
18. Hypoxia arrests ovarian carcinoma cell cycle progression, but invasion is unaffected
19. A reversible, p53-dependent G0/G1 cell cycle arrest induced by ribonucleotide depletion in the absence of detectable DNA damage
20. Characterization of the deoxynucleoside-dependent reversal of hypoxia-induced inhibition of cell cycle progression in Ehrlich ascites tumor cells
21. 2-dependence of pyrimidine(deoxy)nucleotide biosynthesis relevant for cell proliferation
22. Restimulation of cell cycle progression by hypoxic tumour cells with deoxynucleosides requires ppm oxygen tension
23. Dihydroorotatubiquinone oxidoreductase links mitochondria in the biosynthesis of pyrimidine nucleotides
24. Hypoxic stress induces reversible hypophosphorylation of pRB and reduction in cyclin A abundance independent of cell cycle progression
25. Cyclin-dependent kinase 2 (Cdk2) is required for centrosome duplication in mammalian cells
26. Induction of p21WAF/CIP1 during hyperoxia
27. 1-to-S phase transition
28. Redistribution of the CDK inhibitor p27 between different cyclin-CDK complexes in the mouse fibroblast cell cycle and in cells arrested with lovastatin or ultraviolet irradiation
29. Fast control of DNA replication in response to hypoxia and to inhibited protein synthesis in CCRF-CEM and HeLa cells
30. Oxygen dependent regulation of DNA synthesis and growth of Ehrlich ascites tumor cells in vitro and in vivo
31. Oxygen-dependent regulation of mammalian ribonucleotide reductase in vivo and possible significance for replicon initiation
32. Reversible shutdown of replicon initiation by transient hypoxia in Ehrlich ascites cells. Dependence of initiation on short-lived protein
33. Transforming growth factor-beta1 up-regulates p15, p21 and p27 and blocks cell cycling in G1 in human prostate epithelium
34. Cdc25M2 activation of cyclin-dependent kinases by dephosphorylation of threonine-14 and tyrosine-15
35. Continual presence of oxygen and iron required for mammalian ribonucleotide reduction: Possible regulation mechanism
36. 2 tension measurements
37. Changes in growth characteristics and macromolecular synthesis on recovery from severe hypoxia
38. Mitochondrial DNA damage is more extensive and persists longer than nuclear DNA damage in human cells following oxidative stress