Neurotrophic factors in Huntington's disease

Progress in Brain Research

Volumn 146, Issue , 2004, Pages 197-229

  Alberch, Jordi ^a   Pérez Navarro, Esther ^a   Canals, Josep M ^a  

^a UNIVERSITY OF BARCELONA   (Spain)

Author keywords

Basal ganglia; CNTF; Excitotoxicity; GDNF; Huntington's disease; Neuroprotection; Neurotrophins; Striatum

Indexed keywords

ARTEMIN; CILIARY NEUROTROPHIC FACTOR; GLIAL CELL LINE DERIVED NEUROTROPHIC FACTOR; HUNTINGTIN; NERVE GROWTH FACTOR; NEUROTROPHIC FACTOR; NEUROTROPHIN; NEUROTROPHIN RECEPTOR; NEURTURIN; PERSEPHIN;

BASAL GANGLION; BRAIN CELL; CELL DEATH; CONFERENCE PAPER; DEGENERATIVE DISEASE; DRUG ACTIVITY; DRUG ISOLATION; GENE; GENE MUTATION; HUMAN; HUNTINGTON CHOREA; NERVE DEGENERATION; NERVE FUNCTION; NERVE GROWTH; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION;

EID: 0348110426     PISSN: 00796123     EISSN: None     Source Type: Book Series    
DOI: 10.1016/s0079-6123(03)46014-7     Document Type: Conference Paper

References (328)

1. Abiru, Y., Nishio, C. and Hatanaka, H. (1996) The survival of striatal cholinergic neurons cultured from postnatal 2-week-old rats is promoted by neurotrophins. Dev. Brain Res., 91: 260-267.
2. Adler, R., Landa, K.B., Manthorpe, M. and Varon, S. (1979) Cholinergic neuronotrophic factors: intraocular distribution of trophic activity for ciliary neurons. Science, 204: 1434-1436.
3. Airaksinen, M.S. and Saarma, M. (2002) The GDNF family: signalling, biological functions and therapeutic value. Nat. Rev. Neurosci., 3: 383-394.
4. Akerud, P., Alberch, J., Eketjall, S., Wagner, J. and Arenas, E. (1999) Differential effects of glial cell line-derived neurotrophic factor and neurturin on developing and adult substantia nigra dopaminergic neurons. J. Neurochem., 73: 70-78.
5. Akerud, P., Canals, J.M., Snyder, E.Y. and Arenas, E. (2001) Neuroprotection through delivery of glial cell line-derived neurotrophic factor by neural stem cells in a mouse model of Parkinson's disease. J. Neurosci., 21: 8108-8118.
6. Akerud, P., Holm, P.C., Castelo-Branco, G., Sousa, K., Rodriguez, F.J. and Arenas, E. (2002) Persephin-overexpressing neural stem cells regulate the function of nigral dopaminergic neurons and prevent their degeneration in a model of Parkinson's disease. Mol. Cell. Neurosci., 21: 205-222.
7. Akkina, S.K., Patterson, C.L. and Wright, D.E. (2001) GDNF rescues nonpeptidergic unmyelinated primary afferents in streptozotocin-treated diabetic mice. Exp. Neurol., 167: 173-182.
8. Alberch, J., Perez-Navarro, E. and Canals, J.M. (2002) Neuroprotection by neurotrophins and GDNF family members in the excitotoxic model of Huntington's disease. Brain Res. Bull., 57: 817-822.
9. Alexi, T., Venero, J.L. and Hefti, F. (1997) Protective effects of neurotrophin-4/5 and transforming growth factor-alpha on striatal neuronal phenotypic degeneration after excitotoxic lesioning with quinolinic acid. Neuroscience, 78: 73-86.
10. Alexi, T., Borlongan, C.V., Faull, R.L., Williams, C.E., Clark, R.G., Gluckman, P.D. and Hughes, P.E. (2000) Neuroprotective strategies for basal ganglia degeneration: Parkinson's and Huntington's diseases. Prog. Neurobiol., 60: 409-470.
11. Altar, C.A., Armanini, M., Dugich-Djordjevic, M., Bennett, G.L., Williams, R., Feinglass, S., Anicetti, V., Sinicropi, D. and Bakhit, C. (1992) Recovery of cholinergic phenotype in the injured rat neostriatum: roles for endogenous and exogenous nerve growth factor. J. Neurochem., 59: 2167-2177.
12. Altar, C.A., Cai, N., Bliven, T., Juhasz, M., Conner, J.M., Acheson, A.L., Lindsay, R.M. and Wiegand, S.J. (1997) Anterograde transport of brain-derived neurotrophic factor and its role in the brain. Nature, 389: 856-860.
13. Anderson, K.D., Panayotatos, N., Corcoran, T.L., Lindsay, R.M. and Wiegand, S.J. (1996) Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease. Proc. Natl. Acad. Sci. USA, 93: 7346-7351.
14. Aoki, C., Wu, K., Elste, A., Len, G., Lin, S., McAuliffe, G. and Black, I.B. (2000) Localization of brain-derived neurotrophic factor and TrkB receptors to postsynaptic densities of adult rat cerebral cortex. J. Neurosci. Res., 59: 454-463.
15. Apfel, S.C. (1996) Neurotrophic factors in the treatment of neurotoxicity: an overview. Neurotoxicology, 17: 839-844.
16. Apfel, S.C. (1999) Neurotrophic factors and diabetic peripheral neuropathy. Eur. Neurol., 41 (Suppl. 1): 27-34.
17. Apfel, S.C. (2002) Is the therapeutic application of neurotrophic factors dead?. Ann. Neurol., 51: 8-11.
18. Arakawa, Y., Sendtner, M. and Thoenen, H. (1990) Survival effect of ciliary neurotrophic factor (CNTF) on chick embryonic motoneurons in culture: comparison with other neurotrophic factors and cytokines. J. Neurosci., 10: 3507-3515.
19. Araujo, D.M. and Hilt, D.C. (1997) Glial cell line-derived neurotrophic factor attenuates the excitotoxin-induced behavioral and neurochemical deficits in a rodent model of Huntington's disease. Neuroscience, 81: 1099-1110.
20. Araujo, D.M. and Hilt, D.C. (1998) Glial cell line-derived neurotrophic factor attenuates the locomotor hypofunction and striatonigral neurochemical deficits induced by chronic systemic administration of the mitochondrial toxin 3-nitropropionic acid. Neuroscience, 82: 117-127.
21. Asada, H., Ip, N.Y., Pan, L., Razack, N., Parfitt, M.M. and Plunkett, R.J. (1995) Time course of ciliary neurotrophic factor mRNA expression is coincident with the presence of protoplasmic astrocytes in traumatized rat striatum. J. Neurosci. Res., 40: 22-30.
22. Bachoud-Levi, A.C., Deglon, N., Nguyen, J.P., Bloch, J., Bourdet, C., Winkel, L., Remy, P., Goddard, M., Lefaucheur, J.P., Brugieres, P., Baudic, S., Cesaro, P., Peschanski, M. and Aebischer, P. (2000) Neuroprotective gene therapy for Huntington's disease using a polymer encapsulated BHK cell line engineered to secrete human CNTF. Hum. Gene Ther., 11: 1723-1729.
23. Baloh, R.H., Tansey, M.G., Golden, J.P., Creedon, D.J., Heuckeroth, R.O., Keck, C.L., Zimonjic, D.B., Popescu, N.C., Johnson, E.M.J. and Milbrandt, J. (1997) TrnR2, a novel receptor that mediates neurturin and GDNF signaling through Ret. Neuron, 18: 793-802.
24. Baloh, R.H., Gorodinsky, A., Golden, J.P., Tansey, M.G., Keck, C.L., Popescu, N.C., Johnson, E.M.J. and Milbrandt, J. (1998a) GFRα3 is an orphan member of the GDNF/neurturin/persephin receptor family. Proc. Natl. Acad. Sci. USA, 95: 5801-5806.
25. Baloh, R.H., Tansey, M.G., Lampe, P.A., Fahrner, T.J., Enomoto, H., Simburger, K.S., Leitner, M.L., Araki, T., Johnson, E.M.J. and Milbrandt, J. (1998b) Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRα3-RET receptor complex. Neuron, 21: 1291-1302.
26. Baloh, R.H., Enomoto, H., Johnson, E.M.J. and Milbrandt, J. (2000) The GDNF family ligands and receptors-implications for neural development. Curr. Opin. Neurobiol., 10: 103-110.
27. Barbacid, M. (1994) The Trk family of neurotrophin receptors. J. Neurobiol., 25: 1386-1403.
28. Barbin, G., Manthorpe, M. and Varon, S. (1984) Purification of the chick eye ciliary neuronotrophic factor. J. Neurochem., 43: 1468-1478.
29. Barde, Y.A., Edgar, D. and Thoenen, H. (1982) Purification of a new neurotrophic factor from mammalian brain. EMBO J., 1: 549-553.
30. Barker, P.A., Lomen-Hoerth, C., Gensch, E.M., Meakin, S.O., Glass, D.J. and Shooter, E.M. (1993) Tissue-specific alternative splicing generates two isoforms of the trkA receptor. J. Biol. Chem., 268: 15150-15157.
31. Baxter, G.T., Radeke, M.J., Kuo, R.C., Makrides, V., Hinkle, B., Hoang, R., Medina-Selby, A., Coit, D. and Valenzuela, P. (1997) Signal transduction mediated by the truncated trkB receptor isoforms, trkB.T1 and trkB.T2. J. Neurosci., 17: 2683-2690.
32. Beal, M.F., Kowall, N.W., Ellison, D.W., Mazurek, M.F., Swartz, K.J. and Martin, J.B. (1986) Replication of the neurochemical characteristics of Huntington's disease by quinolinic acid. Nature, 321: 168-171.
33. Beal, M.F., Brouillet, E., Jenkins, B.G., Ferrante, R.J., Kowall, N.W., Miller, J.M., Storey, E., Srivastava, R., Rosen, B.R. and Hyman, B.T. (1993) Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitocondrial toxin 3-nitropropionic acid. J. Neurosci., 13: 4181-4192.
34. Beal, M.F. (1994) Neurochemistry and toxin models in Huntington's disease. Curr. Opin. Neurol., 7: 542-547.
35. Beck, K.D., Lamballe, F., Klein, R., Barbacid, M., Schauwecker, P.E., McNeill, T.H., Finch, C.E., Hefti, F. and Day, J.R. (1993) Induction of noncatalytic TrkB neurotrophin receptors during axonal sprouting in the adult hippocampus. J. Neurosci., 13: 4001-4014.
36. Bemelmans, A.P., Horellou, P., Pradier, L., Brunet, I., Colin, P. and Mallet, J. (1999) Brain-derived neurotrophic factor-mediated protection of striatal neurons in an excitotoxic rat model of Huntington's disease, as demonstrated by adenoviral gene transfer. Hum. Gene Ther., 10: 2987-2997.
37. Benedetti, M., Levi, A. and Chao, M.V. (1993) Differential expression of nerve growth factor receptors leads to altered binding affinity and neurotrophin responsiveness. Proc. Natl. Acad. Sci. USA, 90: 7859-7863.
38. Berkemeier, L.R., Winslow, J.W., Kaplan, D.R., Nikolics, K., Goeddel, D.V. and Rosenthal, A. (1991) Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron, 7: 857-866.
39. Bibel, M., Hoppe, E. and Barde, Y.A. (1999) Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J., 18: 616-622.
40. Bilak, M.M., Shifrin, D.A., Corse, A.M., Bilak, S.R. and Kuncl, R.W. (1999) Neuroprotective utility and neurotrophic action of neurturin in postnatal motor neurons: comparison with GDNF and persephin. Mol. Cell. Neurosci., 13: 326-336.
41. Bizon, J.L., Lauterborn, J.C. and Gall, C.M. (1999) Subpopulations of striatal interneurons can be distinguished on the basis of neurotrophic factor expression. J. Comp. Neurol., 408: 283-298.
42. Blesch, A. and Tuszynski, M.H. (2002) Spontaneous and neurotrophin-induced axonal plasticity after spinal cord injury. Prog. Brain Res., 137: 415-423.
43. Blochl, A. and Sirrenberg, C. (1996) Neurotrophins stimulate the release of dopamine from rat mesencephalic neurons via Trk and p75LNTR receptors. J. Biol. Chem., 271: 21100-21107.
44. Blottner, D., Bruggemann, W. and Unsicker, K. (1989) Ciliary neurotrophic factor supports target-deprived preganglionic sympathetic spinal cord neurons. Neurosci. Lett., 105: 316-320.
45. Boulton, T.G., Stahl, N. and Yancopoulos, G.D. (1994) Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/ oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem., 269: 11648-11655.
46. Bourque, M.J. and Trudeau, L.E. (2000) GDNF enhances the synaptic efficacy of dopaminergic neurons in culture. Eur. J. Neurosci., 12: 3172-3180.
47. Bresjanac, M. and Antauer, G. (2000) Reactive astrocytes of the quinolinic acid-lesioned rat striatum express GFRα1 as well as GDNF in vivo. Exp. Neurol., 164: 53-59.
48. Brouillet, E., Conde, F., Beal, M.F. and Hantraye, P. (1999) Replicating Huntington's disease phenotype in experimental animals. Prog. Neurobiol., 59: 427-468.
49. Brunet, A., Datta, S.R. and Greenberg, M.E. (2001) Transcription-dependent and -independent control of neuronal survival by the PI3K-Akt signaling pathway. Curr. Opin. Neurobiol., 11: 297-305.
50. Buj-Bello, A., Adu, J., Pinon, L.G., Horton, A., Thompson, J., Rosenthal, A., Chinchetru, M., Buchman, V.L. and Davies, A.M. (1997) Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase. Nature, 387: 721-724.
51. Burazin, T.C. and Gundlach, A.L. (1999) Localization of GDNF/neurturin receptor (c-ret, GFRα1 and α-2) mRNAs in postnatal rat brain: differential regional and temporal expression in hippocampus, cortex and cerebellum. Mol. Brain Res., 73: 151-171.
52. Cacalano, G., Fariñas, I., Wang, L.C., Hagler, K., Forgie, A., Moore, M., Armanini, M., Phillips, H., Ryan, A.M., Reichardt, L.F., Hynes, M., Davies, A., Rosenthal, A. (1998) GFRα1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron, 21: 53-62.
53. Canals, J.M., Marco, S., Checa, N., Michels, A., Pérez-Navarro, E., Arenas, E. and Alberch, J. (1998) Differential regulation of the expression of NGF, BDNF and NT-3 after excitotoxicity in a rat model of Huntington's disease. Neurobiol. Dis., 5: 357-364.
54. Canals, J.M., Checa, N., Marco, S., Michels, A., Pérez-Navarro, E. and Alberch, J. (1999) The neurotrophin receptors trkA, trkB and trkC are differentially regulated after excitotoxic lesion in rat striatum. Mol. Brain Res., 69: 242-248.
55. Canals, J.M., Checa, N., Marco, S., Åkerud, P., Michels, A., Pérez-Navarro, E., Tolosa, E., Arenas, E. and Alberch, J. (2001) Expression of brain-derived neurotrophic factor in cortical neurons is regulated by striatal target area. J. Neurosci., 21: 117-124.
56. Casaccia-Bonnefil, P., Gu, C., Khursigara, G. and Chao, M.V. (1999) p75 neurotrophin receptor as a modulator of survival and death decisions. Microsc. Res. Tech., 45: 217-224.
57. Castellani, V. and Bolz, J. (1999) Opposite roles for neurotrophin-3 in targeting and collateral formation of distinct sets of developing cortical neurons. Development, 126: 3335-3345.
58. Cattaneo, E., Rigamonti, D., Goffredo, D., Zuccato, C., Squitieri, F. and Sipione, S. (2001) Loss of normal huntingtin function: new developments in Huntington's disease research. Trends Neurosci., 24: 182-188.
59. Cellerino, A., Maffei, L. and Domenici, L. (1996) The distribution of brain-derived neurotrophic factor and its receptor trkB in parvalbumin-containing neurons of the rat visual cortex. Eur. J. Neurosci., 8: 1190-1197.
60. Chao, M.V. (1994) The p75 neurotrophin receptor. J. Neurobiol., 25: 1373-1385.
61. Checa, N., Canals, J.M. and Alberch, J. (2000) Developmental regulation of BDNF and NT-3 expression by quinolinic acid in the striatum and its main connections. Exp. Neurol., 165: 118-124.
62. Checa, N., Canals, J.M., Gratacos, E. and Alberch, J. (2001) TrkB and TrkC are differentially regulated by excitotoxicity during development of the basal ganglia. Exp. Neuroi., 172: 282-292.
63. Chen, Q., Veenman, C.L. and Reiner, A. (1996) Cellular expression of ionotropic glutamate receptors subunits on specific striatal neuron types and its implications for striatal vulnerability in glutamate receptor-mediated excitotoxicity. Neuroscience, 73: 715-731.
64. Clary, D.O. and Reichardt, L.F. (1994) An alternatively spliced form of the nerve growth factor receptor TrkA confers an enhanced response to neurotrophin 3. Proc. Natl. Acad. Sci. USA, 91: 11133-11137.
65. Clatterbuck, R.E., Price, D.L. and Koliatsos, V.E. (1993) Ciliary neurotrophic factor prevents retrograde neuronal death in the adult central nervous system. Proc. Natl. Acad. Sci. USA, 90: 2222-2226.
66. Conneally, P.M. (1984) Huntington disease: genetics and epidemiology. Am. J. Hum. Genet., 36: 506-526.
67. Conner, J.M. and Varon, S. (1996) Maintenance of sympathetic innervation into the hippocampal formation requires a continuous local availability of nerve growth factor. Neuroscience, 72: 933-945.
68. Cooper, J.D., Skepper, J.N., Berzaghi, M.D., Lindholm, D. and Sofroniew, M.V. (1996) Delayed death of septal cholinergic neurons after excitotoxic ablation of hippocampal neurons during early postnatal development in the rat. Exp. Neurol., 139: 143-155.
69. Cordon-Cardo, C., Tapley, P., Jing, S.Q., Nanduri, V., O'Rourke, E., Lamballe, F., Kovary, K., Klein, R., Jones, K.R. and Reichardt, L.F. (1991) The trk tyrosine protein kinase mediates the mitogenic properties of nerve growth factor and neurotrophin-3. Cell, 66: 173-183.
70. Corse, A.M., Bilak, M.M., Bilak, S.R., Lehar, M., Rothstein, J.D. and Kuncl, R.W. (1999) Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degeneration. Neurobiol. Dis., 6: 335-346.
71. Costantini, L.C., Feinstein, S.C., Radeke, M.J. and Snyder-Keller, A. (1999) Compartmental expression of trkB receptor protein in the developing striatum. Neuroscience, 89: 505-513.
72. Coulpier, M., Anders, J. and Ibanez, C.F. (2002) Coordinated activation of autophosphorylation sites in the RET receptor tyrosine kinase: importance of tyrosine 1062 for GDNF mediated neuronal differentiation and survival. J. Biol. Chem., 277: 1991-1999.
73. Coyle, J.T. and Puttfarcken, P. (1993) Oxidative stress, glutamate, and neurodegenerative disorders. Science, 262: 689-695.
74. Crowley, C., Spencer, S.D., Nishimura, M.C., Chen, K.S., Pitts-Meek, S., Armanini, M.P., Ling, L.H., MacMahon, S.B., Shelton, D.L. and Levinson, A.D. (1994) Mice lacking nerve growth factor display perinatal loss of sensory and sympathetic neurons yet develop basal forebrain cholinergic neurons. Cell, 76: 1001-1011.
75. Cruz-Aguado, R., Turner, L.F., Diaz, C.M. and Pinero, J. (2000) Nerve growth factor and striatal glutathione metabolism in a rat model of Huntington's disease. Restor. Neurol. Neurosci., 17: 217-221.
76. Cudkowicz, M. and Kowall, N.W. (1990) Degeneration of pyramidal projection neurons in Huntington's disease cortex. Ann. Neurol., 27: 200-204.
77. Davies, S.W. and Beardsall, K. (1992) Nerve growth factor selectively prevents excitotoxin induced degeneration of striatal cholinergic neurons. Neurosci. Lett., 140: 161-164.
78. Davis, S., Aldrich, T.H., Valenzuela, D.M., Wong, V.V., Furth, M.E., Squinto, S.P. and Yancopoulos, G.D. (1991) The receptor for ciliary neurotrophic factor. Science, 253: 59-63.
79. Davis, S., Aldrich, T.H., Ip, N.Y., Stahl, N., Scherer, S., Farruggella, T., DiStefano, P.S., Curtis, R., Panayotatos, N., Gascan, H. (1993) Released form of CNTF receptor α component as a soluble mediator of CNTF responses. Science, 259: 1736-1739.
80. Davis, S. and Yancopoulos, G.D. (1993) The molecular biology of the CNTF receptor. Curr. Opin. Cell. Biol., 5: 281-285.
81. Dawbarn, D., D. Quidt, M.E. and Emson, P.C. (1985) Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's disease, Brain Res., 340: 251-260.
82. DeChiara, T.M., Vejsada, R., Poueymirou, W.T., Acheson, A., Suri, C., Conover, J.C., Friedman, B., McClain, J., Pan, L. and Stahl, N. (1995) Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell, 83: 313-322.
83. DiFiglia, M., Sapp, E., Chase, K.O., Davies, S.W., Bates, G.P., Vonsattel, J.P. and Aronin, N. (1997) Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain. Science, 277: 1990-1993.
84. Dluzen, D.E., Gao, X., Story, G.M., Anderson, L.I., Kucera, J. and Walro, J.M. (2001) Evaluation of nigrostriatal dopaminergic function in adult +/+ and +/- BDNF mutant mice. Exp. Neurol., 170: 121-128.
85. Dluzen, D.E., Anderson, L.I., McDermott, J.L., Kucera, J. and Walro, J.M. (2002) Striatal dopamine output is compromised within +/- BDNF mice. Synapse, 43: 112-117.
86. Duyao, M.P., Auerbach, A.B., Ryan, A., Persichetti, F., Barnes, G.T., McNeil, S.M., Ge, P., Vonsattel, J.P., Gusella, J.F. and Joyner, A.L. (1995) Inactivation of the mouse Huntington's disease gene homolog Hdh. Science, 269: 407-410.
87. Eide, F.F., Vining, E.R., Eide, B.L., Zang, K. and Reichardt, L.F. (1996) Naturally occurring truncated trkB receptors have dominant inhibitory effects on brain-derived neurotrophic factor signaling. J. Neurosci., 16: 3123-3129.
88. Emerich, D.F., Lindner, M.D., Winn, S.R., Chen, E.Y., Frydel, B.R. and Kordower, J.H. (1996) Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J. Neurosci., 16: 5168-5181.
89. Emerich, D.F., Cain, C.K., Greco, C., Saydoff, J.A., Hu, Z.Y., Liu, H. and Lindner, M.D. (1997a) Cellular delivery of human CNTF prevents motor and cognitive dysfunction in a rodent model of Huntington's disease. Cell Transplant., 6: 249-266.
90. Emerich, D.F., Winn, S.R., Hantraye, P.M., Peschanskl, M., Chen, E.-Y., Chu, Y., McDermott, P., Baetge, E.E. and Kordower, J.H. (1997b) Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature, 386: 395-399.
91. Enokido, Y., de Sauvage, F., Hongo, J.A., Ninkina, N., Rosenthal, A., Buchman, V.L. and Davies, A.M. (1998) GFR α-4 and the tyrosine kinase Ret form a functional receptor complex for persephin. Curr. Biol., 8: 1019-1022.
92. Enomoto, H., Crawford, P.A., Gorodinsky, A., Heuckeroth, R.O., Johnson, E.M.J. and Milbrandt, J. (2001) RET signaling is essential for migration, axonal growth and axon guidance of developing sympathetic neurons. Development, 128: 3963-3974.
93. Ernfors, P., Hallbook, F., Ebendal, T., Shooter, E.M., Radeke, M.J., Misko, T.P. and Persson, H. (1988) Developmental and regional expression of beta-nerve growth factor receptor mRNA in the chick and rat. Neuron, 1: 983-996.
94. Ernfors, P., Wetmore, C., Olson, L. and Persson, H. (1990) Identification of cells in rat brain and peripheral tissues expressing mRNA for members of the nerve growth factor family. Neuron, 5: 511-526.
95. Ernsberger, U., Sendtner, M. and Rohrer, H. (1989) Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor. Neuron, 2: 1275-1284.
96. Fagan, A.M., Garber, M., Barbacid, M., Silos-Santiago, I. and Holtzman, D.M. (1997) A role for TrkA during maturation of striatal and basal forebrain cholinergic neurons in vivo. J. Neurosci., 17: 7644-7654.
97. Farkas, L.M., Suter-Crazzolara, C. and Unsicker, K. (1997) GDNF induces the calretinin phenotype in cultures of embryonic striatal neurons. J. Neurosci. Res., 50: 361-372.
98. Ferrante, R.J., Kowall, N.W., Beal, M.F., Richardson, E.P.J., Bird, E.D. and Martin, J.B. (1985) Selective sparing of a class of striatal neurons in Huntington's disease. Science, 230: 561-563.
99. Ferrer, I., Goutan, E., Marin, C., Rey, M.J. and Ribalta, T. (2000) Brain-derived neurotrophic factor in Huntington's disease. Brain Res., 866: 257-261.
100. Fischer, W., Wictorin, K., Bjorklund, A., Williams, L.R., Varon, S. and Gage, F.H. (1987) Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature, 329: 65-68.
101. Fiumelli, H., Kiraly, M., Ambrus, A., Magistretti, P.J. and Martin, J.L. (2000) Opposite regulation of calbindin and calretinin expression by brain-derived neurotrophic factor in cortical neurons. J. Neurochem., 74: 1870-1877.
102. Friden, P.M., Walus, L.R., Watson, P., Doctrow, S.R., Kozarich, J.W., Backman, C., Bergman, H., Hoffer, B., Bloom, F. and Granholm, A.C. (1993) Blood-brain barrier penetration and in vivo activity of an NGF conjugate. Science, 259: 373-377.
103. Friedman, W.J., Olson, L. and Persson, H. (1991) Cells that express brain-derived neurotrophic factor mRNA in the developing postnatal rat brain. Eur. J. Neurosci., 3: 688-697.
104. Friedman, W.J., Black, I.B. and Kaplan, D.R. (1998) Distribution of the neurotrophins brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 in the postnatal rat brain: an immunocytochemical study. Neuroscience, 84: 101-114.
105. Frim, D.M., Uhler, T.A., Short, M.P., Ezzedine, Z.D., Klagsbrum, M., Breackfield, X.O. and Isacson, O. (1993) Effects of biologically delivered NGF, BDNF and bFGF on striatal excitotoxic lesions. NeuroReport, 4: 367-370.
106. Fukuda, T., Kiuchi, K. and Takahashi, M. (2002) Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase, J. Biol. Chem., 277: 19114-19121.
107. Galpern, W.R., Matthews, R.T., Beal, M.F. and Isacson, O. (1996) NGF attenuates 3-nitrotyrosine formation in a 3-NP model of Huntington's disease. NeuroReport, 7: 2639-2642.
108. Gerfen, C.R. (1992) The neostriatal mosaic: multiple levels of compartmental organization in the basal ganglia. Annu. Rev. Neurosci., 15: 285-320.
109. Gervais, F.G., Singaraja, R., Xanthoudakis, S., Gutekunst, C.A., Leavitt, B.R., Metzler, M., Hackam, A.S., Tam, J., Vaillancourt, J.P., Houtzager, V., Rasper, D.M., Roy, S., Hayden, M.R. and Nicholson, D.W. (2002) Recruitment and activation of caspase-8 by the Huntingtin-interacting protein Hip-1 and a novel partner Hippi. Nat. Cell Biol., 4: 95-105.
110. Ghosh, A., Carnahan, J. and Greenberg, M.E. (1994) Requirement for BDNF in activity-dependent survival of cortical neurons. Science, 263: 1618-1623.
111. Glazner, G.W., Mu, X. and Springer, J.E. (1998) Localization of glial cell line-derived neurotrophic factor receptor alpha and c-ret mRNA in rat central nervous system. J. Comp. Neurol., 391: 42-49.
112. Gloaguen, I., Costa, P., Demartis, A., Lazzaro, D., Di Marco, A., Graziani, R., Paonessa, G., Chen, F., Rosenblum, C.I., Van der Ploeg, L.H., Cortese, R., Ciliberto, G. and Laufer, R. (1997) Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc. Natl. Acad. Sci. USA, 94: 6456-6461.
113. Golden, J.P., Baloh, R.H., Kotzbauer, P.T., Lampe, P.A., Osborne, P.A., Milbrandt, J. and Johnson, E.M., Jr. (1998) Expression of neurturin, GDNF, and their receptors in the adult mouse CNS. J. Comp. Neurol., 398: 139-150.
114. Golden, J.P., DeMaro, J.A., Osborne, P.A., Milbrandt, J. and Johnson, E.M.J. (1999) Expression of neurturin, GDNF, and GDNF family-receptor mRNA in the developing and mature mouse. Exp. Neurol., 158: 504-528.
115. Gotz, T., Kraushaar, U., Geiger, J., Lubke, J., Berger, T. and Jonas, P. (1997) Functional properties of AMPA and NMDA receptors expressed in identified types of basal ganglia neurons. J. Neurosci., 17: 204-215.
116. Gouhier, C., Chalon, S., Venier-Julienne, M.C., Bodard, S., Benoit, J., Besnard, J. and Guilloteau, D. (2000) Neuroprotection of nerve growth factor-loaded microspheres on the D2 dopaminergic receptor positive-striatal neurones in quinolinic acid-lesioned rats: a quantitative autoradiographic assessment with iodobenzamide. Neurosci. Lett., 288: 71-75.
117. Gratacos, E., Checa, N., Pérez-Navarro, E. and Alberch, J. (2001a) Brain-derived neurotrophic factor (BDNF) mediates bone morphogenetic protein-2 (BMP-2) effects on cultured striatal neurones. J. Neurochem., 79: 747-755.
118. Gratacos, E., Pérez-Navarro, E., Tolosa, E., Arenas, E. and Alberch, J. (2001b) Neuroprotection of striatal neurons against kainate excitotoxicity by neurotrophins and GDNF family members. J. Neurochem., 78: 1287-1296.
119. Graybiel, A.M. (2000) The basal ganglia. Curr. Biol., 10: R509-R511.
120. Greenamyre, J.T. and Shoulson, I. (1994) Huntington's Disease, WB Saunders, Philadelphia, pp. 685-704.
121. Grill, R., Murai, K., Blesch, A., Gage, F.H. and Tuszynski, M.H. (1997) Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J. Neurosci., 17: 5560-5572.
122. Guiton, M., Gunn-Moore, F.J., Glass, D.J., Geis, D.R., Yancopoulos, G.D. and Tavare, J.M. (1995) Naturally occurring tyrosine kinase inserts block high affinity binding of phospholipase C gamma and Shc to TrkC and neurotrophin-3 signaling. J. Biol. Chem., 270: 20384-20390.
123. Gusella, J.F. and MacDonald, M.E. (1998) Huntingtin: a single bait hooks many species. Curr. Opin. Neurobiol., 8: 425-430.
124. Ha, D.H., Robertson, R.T., Ribak, C.E. and Weiss, J.H. (1996) Cultured basal forebrain cholinergic neurons in contact with cortical cells display synapses, enhanced morphological features, and decreased dependence on nerve growth factor. J. Comp. Neurol., 373: 451-465.
125. Hagg, T., Hagg, F., Vahlsing, H.L., Manthorpe, M. and Varon, S. (1989) Nerve growth factor effects on cholinergic neurons of neostriatum and nucleus accumbens in the adult rat. Neuroscience, 30: 95-103.
126. Hagg, T., Quon, D., Higaki, J. and Varon, S. (1992) Ciliary neurotrophic factor prevents neuronal degeneration and promotes low affinity NGF receptor expression in the adult rat CNS. Neuron, 8: 145-158.
127. Hagg, T. and Varon, S. (1993) Ciliary neurotrophic factor prevents degeneration of adult rat substantia nigra dopaminergic neurons in vivo. Proc. Natl. Acad. Sci. USA, 90: 6315-6319.
128. Hapner, S.J., Boeshore, K.L., Large, T.H. and Lefcort, F. (1998) Neural differentiation promoted by truncated trkC receptors in collaboration with p75(NTR). Dev. Biol., 201: 90-100.
129. Harper, P.S. (1992) The epidemiology of Huntington's disease. Hum. Genet., 89: 365-376.
130. Hebert, M.A., Van Horne, C.G., Hoffer, B.J. and Gerhardt, G.A. (1996) Functional effects of GDNF in normal rat striatum: presynaptic studies using in vivo electrochemistry and microdialysis. J. Pharmacol. Exp. Ther., 279: 1181-1190.
131. Hefti, F. (1994) Development of effective therapy for Alzheimer's disease based on neurotrophic factors. Neurobiol. Aging, 15 (Suppl 2): S193-S194.
132. Hempstead, B.L., Martin-Zanca, D., Kaplan, D.R., Parada, L.F. and Chao, M.V. (1991) High-affinity NGF binding requires coexpression of the trk proto-oncogene and the low-affinity NGF receptor. Nature, 350: 678-683.
133. Henderson, C.E., Phillips, H.S., Pollock, R.A., Davies, A.M., Lemeulle, C., Armanini, M., Simpson, L.C., Moffet, B., Vandlen, R.A., Koliatsos, V.E. and Rosenthal, A. (1994) GDNF: A potent survival factor motoneurons present in peripheral nerve and muscle. Science, 266: 1062-1064.
134. Hirano, T., Nakajima, K. and Hibi, M. (1997) Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev., 8: 241-252.
135. Hodgson, J.G., Agopyan, N., Gutekunst, C.A., Leavitt, B.R., LePiane, F., Singaraja, R., Smith, D.J., Bissada, N., McCutcheon, K., Nasir, J., Jamot, L., Li, X.J., Stevens, M.E., Rosemond, E., Roder, J.C., Phillips, A.G., Rubin, E.M., Hersch, S.M. and Hayden, M.R. (1999) A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. Neuron, 23: 181-192.
136. Hofer, M., Pagliusi, S.R., Hohn, A., Leibrock, J. and Barde, Y.A. (1990) Regional distribution of brain-derived neurotrophic factor mRNA in the adult mouse brain. EMBO J., 9: 2459-2464.
137. Hoglinger, G.U., Sautter, J., Meyer, M., Spenger, C., Seiler, R.W., Oertel, W.H. and Widmer, H.R. (1998) Rat fetal ventral mesencephalon grown as solid tissue cultures: influence of culture time and BDNF treatment on dopamine neuron survival and function. Brain Res., 813: 313-322.
138. Hohn, A., Leibrock, J., Bailey, K. and Barde, Y.-A. (1990) Identification and characterization of a novel member of the nerve growth factor/brain-derived neurotrophic factor family. Nature, 344: 339-341.
139. Holm, P.C., Akerud, P., Wagner, J. and Arenas, E. (2002) Neurturin is a neuritogenic but not a survival factor for developing and adult central noradrenergic neurons. J. Neurochem., 81: 1318-1327.
140. Holtzman, D.M., Li, Y., Parada, L.F., Kinsman, S., Chen, C.-K., Valletta, J.S., Zhou, J., Long, J.B. and Mobley, W.C. (1992) p140trk mRNA marks NGF-responsive forebrain neurons: Evidence that trk gene expression is induced by NGF. Neuron, 9: 465-478.
141. Holtzman, D.M., Sheldon, R.A., Jaffe, W., Cheng, Y. and Ferriero, D.M. (1996) Nerve growth factor protects the neonatal brain against hypoxic-ischemic injury. Ann. Neurol., 39: 114-122.
142. Horch, H.W., Krüttgen, A., Portbury, S.D. and Katz, L.C. (1999) Destabilization of cortical dendrites and spines by BDNF. Neuron, 23: 353-364.
143. Horger, B.A., Nishimura, M.C., Armanini, M.P., Wang, L.C., Poulsen, K.T., Rosenblad, C., Kirik, D., Moffat, B., Simmons, L., Johnson, E., Jr., et al. (1998) Neurturin exerts potent actions on survival and function of midbrain dopaminergic neurons. J. Neurosci., 18: 4929-4937.
144. Huang, E.J. and Reichardt, L.F. (2001) Neurotrophins: roles in neuronai development and function. Annu. Rev. Neurosci., 24: 677-736.
145. Humpel, C., Marksteiner, J. and Saria, A. (1996) Glial-cell-line-derived neurotrophic factor enhances biosynthesis of substance P in striatal neurons in vitro. Cell Tissue Res., 286: 249-255.
146. Hyman, C., Hofer, M., Barde, Y.A., Juhasz, M., Yancopoulos, G.D., Squinto, S.P. and Lindsay, R.M. (1991) BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature, 350: 230-232.
147. Hyman, C., Juhasz, M., Jackson, C., Wright, P., Ip, N.Y. and Lindsay, R.M. (1994) Overlapping and distinct actions of the neurotrophins BDNF, NT-3, and NT-4/5 on cultured dopaminergic and GABAergic neurons of the ventral mesencephalon. J. Neurosci., 14: 335-347.
148. Ibañez, C.F. (1996) Neurotrophin-4: the odd one out in the neurotrophin family. Neurochem. Res., 21: 787-793.
149. Ip, N.Y., Ibañez, C.F., Nye, S.H., McClain, J., Jones, P.F., Gies, D.R., Belluscio, L., Le Beau, M.M., Espinosa, R. and Squinto, S.P. (1992) Mammalian neurotrophin-4: structure, chromosomal localization, tissue distribution, and receptor specificity. Proc. Natl. Acad. Sci. USA, 89: 3060-3064.
150. Ip, N.Y., Li, Y., Yancopoulos, G.D. and Lindsay, R.M. (1993a) Cultured hippocampal neurons show responses to BDNF, NT-3, and NT-4, but not NGF. J. Neurosci., 13: 3394-3405.
151. Ip, N.Y., Stitt, T.N., Tapley, P., Klein, R., Glass, D.J., Fandl, J., Greene, L.A., Barbacid, M. and Yancopoulos, G.D. (1993b) Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. Neuron, 10: 137-149.
152. Ip, N.Y., Wiegand, S.J., Morse, J. and Rudge, J.S. (1993c) Injury-induced regulation of ciliary neurotrophic factor mRNA in the adult rat brain. Eur. J. Neurosci., 5: 25-33.
153. Ip, N.Y. and Yancopoulos, G.D. (1996) The neurotrophins and CNTF: two families of collaborative neurotrophic factors. Annu. Rev. Neurosci., 19: 491-515.
154. Itami, C., Mizuno, K., Kohno, T. and Nakamura, S. (2000) Brain-derived neurotrophic factor requirement for activity-dependent maturation of glutamatergic synapse in developing mouse somatosensory cortex. Brain Res., 857: 141-150.
155. Ivkovic, S., Polonskaia, O., Fariñas, I. and Ehrlich, M.E. (1997) Brain-derived neurotrophic factor regulates maturation of the DARPP-32 phenotype in striatal medium spiny neurons: studies in vivo and in vitro. Neuroscience, 79: 509-516.
156. Ivkovic, S. and Ehrlich, M.E. (1999) Expression of the striatal DARPP-32/ARPP-21 phenotype in GABAergic neurons requires neurotrophins in vivo and in vitro. J. Neurosci., 19:5409-5419.
157. Jaszai, J., Farkas, L., Galter, D., Reuss, B., Strelau, J., Unsicker, K. and Kriegistein, K. (1998) GDNF-related factor persephin is widely distributed throughout the nervous system. J. Neurosci. Res., 53: 494-501.
158. Jing, S., Wen, D., Yu, Y., Holst, P.L., Luo, Y., Fang, M., Tamir, R., Antonio, L., Hu, Z., Cupples, R., Louis, J.C., Hu, S., Altrock, B.W. and Fox, G.M. (1996) GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-α, a novel receptor for GDNF. Cell, 85: 1113-1124.
159. Jones, K.R., Fariñas, I., Backus, C. and Reichardt, L.F. (1994) Target disruption of the BDNF gene perturbs brain and sensory neuron development but not motor neuron development. Cell, 76: 989-999.
160. Jung, A.B. and Bennett, J.P.J. (1996) Development of striatal dopaminergic function. III: Pre- and postnatal development of striatal and cortical mRNAs for the neurotrophin receptors trkBTK+ and trkC and their regulation by synaptic dopamine. Dev. Brain Res., 94: 133-143.
161. Kaplan, D.R., Hempstead, B.L., Martin-Zanca, D., Chao, M.V. and Parada, L.F. (1991) The trk proto-oncogene product: a signal transducing receptor for nerve growth factor. Science, 252: 554-558.
162. Kaplan, D.R. and Miller, F.D. (2000) Neurotrophin signal transduction in the nervous system. Curr. Opin. Neurobiol., 10: 381-391.
163. Katoh-Semba, R., Semba, R., Takeuchi, I.K. and Kato, K. (1998) Age-related changes in levels of brain-derived neurotrophic factor in selected brain regions of rats, normal mice and senescence-accelerated mice: a comparison to those of nerve growth factor and neurotrophin-3. Neurosci. Res., 31: 227-234.
164. Kawamoto, Y., Nakamura, S., Nakano, S., Oka, N., Akiguchi, I. and Kimura, J. (1996) Immunohistochemical localization of brain-derived neurotrophic factor in adult rat brain. Neuroscience, 74: 1209-1226.
165. Kawamoto, Y., Nakamura, S., Kawamata, T., Akiguchi, I. and Kimura, J. (1999) Cellular localization of brain-derived neurotrophic factor-like immunoreactivity in adult monkey brain. Brain Res., 821: 341-349.
166. Kawamoto, Y., Nakamura, S., Matsuo, A., Akiguchi, I. and Shibasaki, H. (2000) Immunohistochemical localization of glial cell line-derived neurotrophic factor in the human central nervous system. Neuroscience, 100: 701-712.
167. Klein, R., Conway, D., Parada, L.F. and Barbacid, M. (1990a) The trkB tyrosine protein kinase gene codes for a second neurogenic receptor that lacks the catalytic kinase domain. Cell, 61: 647-656.
168. Klein, R., Martin-Zanca, D., Barbacid, M. and Parada, L.F. (1990b) Expression of the tyrosine kinase receptor gene trkB is confined to the murine embryonic and adult nervous system. Development, 109: 845-850.
169. Klein, R., Jing, S.Q., Nanduri, V., O'Rourke, E. and Barbacid, M. (1991a) The trk proto-oncogene encodes a receptor for nerve growth factor. Cell, 65: 189-197.
170. Klein, R., Nanduri, V., Jing, S.A., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K.R., Reichardt, L.F. and Barbacid, M. (1991b) The trkB tyrosine protein kinase is a receptor for brain-derived neurotrophic factor and neurotrophin-3. Cell, 66: 395-403.
171. Klein, R., Lamballe, F., Bryant, S. and Barbacid, M. (1992) The trkB tyrosine protein kinase is a receptor for neurotrophin-4. Neuron, 8: 947-956.
172. Klein, R.D., Sherman, D., Ho, W.H., Stone, D., Bennett, G.L., Moffat, B., Vandlen, R., Simmons, L., Gu, Q., Hongo, J.A., Devaux, B., Poulsen, K., Armanini, M., Nozaki, C., Asai, N., Goddard, A., Phillips, H., Henderson, C.E., Takahashi, M. and Rosenthal, A. (1997) A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor. Nature, 387: 717-721.
173. Koh, S. and Higgins, G.A. (1991) Differential regulation of the low-affinity nerve growth factor receptor during postnatal development of the rat brain. J. Comp. Neurol., 313: 494-508.
174. Kordower, J.H., Charles, V., Bayer, R., Bartus, R.T., Putney, S., Walus, L.R. and Friden, P.M. (1994) Intravenous administration of a transferrin receptor antibody-nerve growth factor conjugate prevents the degeneration of cholinergic striatal neurons in a model of Huntington disease. Proc. Natl. Acad. Sci. USA, 91: 9077-9080.
175. Kordower, J.H., Isacson, O. and Emerich, D.F. (1999) Cellular delivery of trophic factors for the treatment of Huntington's disease: is neuroprotection possible?. Exp. Neurol., 159: 4-20.
176. Kordower, J.H., Emborg, M.E., Bloch, J., Ma, S.Y., Chu, Y., Leventhal, L., McBride, J., Chen, E.Y., Palfi, S., Roitberg, B.Z., Brown, W.D., Holden, J.E., Pyzalski, R., Taylor, M.D., Carvey, P., Ling, Z., Trono, D., Hantraye, P., Deglon, N. and Aebischer, P. (2000) Neurodegeneration prevented by lentiviral vector delivery of GDNF in primate models of Parkinson's disease. Science, 290: 767-773.
177. Kotzbauer, P.T., Lampe, P.A., Heuckeroth, R.O., Golden, J.P., Creedon, D.J., Johnson, E.M.J. and Milbrandt, J. (1996) Neurturin, a relative of glial-cell-line-derived neurotrophic factor. Nature, 384: 467-470.
178. Laforet, G.A., Sapp, E., Chase, K., McIntyre, C., Boyce, F.M., Campbell, M., Cadigan, B.A., Warzecki, L., Tagle, D.A., Reddy, P.H., Cepeda, C., Calvert, C.R., Jokel, E.S., Klapstein, G.J., Ariano, M.A., Levine, M.S., DiFiglia, M. and Aronin, N. (2001) Changes in cortical and striatal neurons predict behavioral and electrophysiological abnormalities in a transgenic murine model of Huntington's disease. J. Neurosci., 21: 9112-9123.
179. Lamballe, F., Klein, R. and Barbacid, M. (1991) trkC, a new member of the trk family of tyrosine protein kinases, is a receptor for neurotrophin-3. Cell, 66: 967-979.
180. Lamballe, F., Smeyne, R.J. and Barbacid, M. (1994) Developmental expression of trkC, the neurotrophin-3 receptor, in the mammalian nervous system. J. Neurosci., 14: 14-28.
181. Landwehrmeyer, G.B., Standaert, D.G., Testa, C.M., Penney, J.B.J. and Young, A.B. (1995) NMDA receptor subunit mRNA expression by projection neurons and interneurons in rat striatum. J. Neurosci., 15: 5297-5307.
182. Large, T.H., Bodary, S.C., Clegg, D.O., Weskamp, G., Otten, U. and Reichardt, L.F. (1986) Nerve growth factor gene expression in the developing rat brain. Science, 234: 352-355.
183. Lee, F.S., Kim, A.H., Khursigara, G. and Chao, M.V. (2001) The uniqueness of being a neurotrophin receptor. Curr. Opin. Neurobiol., 11: 281-286.
184. Lesser, S.S. and Lo, D.C. (1995) Regulation of voltage-gated ion channels by NGF and ciliary neurotrophic factor in SK-N-SH neuroblastoma cells. J. Neurosci., 15: 253-261.
185. Levi-Montalcini, R. (1987) The nerve growth factor 35 years later. Science, 237: 1154-1162.
186. Li, M., Sendtner, M. and Smith, A. (1995) Essential function of LIF receptor in motor neurons. Nature, 378: 724-727.
187. Lin, L.F., Mismer, D., Lile, J.D., Armes, L.G., Butler, E.T., Vannice, J.L. and Collins, F. (1989) Purification, cloning, and expression of ciliary neurotrophic factor (CNTF). Science, 246: 1023-1025.
188. Lin, L.-F.H., Doherty, D., Lile, J., Bektesh, S. and Collins, F. (1993) GDNF: a glial cell line-derived neurotrophic factor for midbrain dopaminergic neurons. Science, 260: 1130-1132.
189. Linker, R.A., Maurer, M., Gaupp, S., Martini, R., Holtmann, B., Giess, R., Rieckmann, P., Lassmann, H., Toyka, K.V., Sendtner, M. and Gold, R. (2002) CNTF is a major protective factor in demyelinating CNS disease: a neurotrophic cytokine as modulator in neuroinflammation. Nat. Med., 8: 620-624.
190. Lisovoski, F., Akli, S., Peltekian, E., Vigne, E., Haase, G., Perricaudet, M., Dreyfus, P.A., Kahn, A. and Peschanski, M. (1997) Phenotypic alteration of astrocytes induced by ciliary neurotrophic factor in the intact adult brain, as revealed by adenovirus-mediated gene transfer. J. Neurosci., 17: 7228-7236.
191. Lopez-Martin, E., Caruncho, H.J., Rodriguez-Pallares, J., Guerra, M.J. and Labandeira-Garcia, J.L. (1999) Striatal dopaminergic afferents concentrate in GDNF-positive patches during development and in developing intrastriatal striatal grafts. J. Comp. Neurol., 406: 199-206.
192. MacDonald, V. and Halliday, G. (2002) Pyramidal cell loss in motor cortices in Huntington's disease. Neurobiol. Dis., 10: 378-386.
193. Maisonpierre, P.C., Belluscio, L., Squinto, S., Ip, N.Y., Furth, M.E., Lindsay, R.M. and Yancopoulos, G.D. (1990) Neurotrophin-3: a neurotrophic factor related to NGF and BDNF. Science, 247: 1446-1451.
194. Maksimovic, I.D., Jovanovic, M.D., Malicevic, Z., Colic, M. and Ninkovic, M. (2002) Effects of nerve and fibroblast growth factors on the production of nitric oxide in experimental model of Huntington's disease. Vojnosanit. Pregl., 59: 119-123.
195. Mangiarini, L., Sathasivam, K., Seller, M., Cozens, B., Harper, A., Hetherington, C., Lawton, M., Trottier, Y., Lehrach, H., Davies, S.W., Bates, G.P. (1996) Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice. Cell, 87: 493-506.
196. Manthorpe, M., Hagg, T. and Varon, S. (1992) Ciliary neurotrophic factor. In: Fallon J.A. and Loughlin S.E. (Eds.), Neurotrophic Factors. Academic Press, New York, pp. 443-473.
197. Marco, S., Canudas, A.M., Canals, J.M., Gavalda, N., Perez-Navarro, E. and Alberch, J. (2002a) Excitatory amino acids differentially regulate the expression of GDNF, neurturin, and their receptors in the adult rat striatum. Exp. Neurol., 174: 243-252.
198. Marco, S., Perez-Navarro, E., Tolosa, E., Arenas, E. and Alberch, J. (2002b) Striatopallidal neurons are selectively protected by neurturin in an excitotoxic model of Huntington's disease. J. Neurobiol., 50: 323-332.
199. Marco, S., Saura, J., Perez-Navarro, E., Jose, M.M., Tolosa, E. and Alberch, J. (2002c) Regulation of c-Ret, GFRα1, and GFRα2 in the substantia nigra pars compacta in a rat model of Parkinson's disease. J. Neurobiol., 52: 343-351.
200. Martin-Zanca, D., Hughes, S.H. and Barbacid, M. (1986) A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences. Nature, 319: 743-748.
201. Martin-Zanca, D., Barbacid, M. and Parada, L.F. (1990) Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development. Genes Dev., 4: 683-694.
202. Martin, J.B. and Gusella, J.F. (1986) Huntington's disease. Pathogenesis and management. N. Engl. J. Med., 315: 1267-1276.
203. Martinez, H.J., Dreyfus, C.F., Jonakait, G.M. and Black, I.B. (1985) Nerve growth factor promotes cholinergic development in brain striatal cultures. Proc. Natl. Acad. Sci. USA, 82: 7777-7781.
204. Martinez-Serrano, A. and Björklund, A. (1996) Protection of the neostriatum against excitotoxic damage by neurotrophin-producing, genetically modified neural stem cells. J. Neurosci., 16: 4604-4616.
205. Marty, S., Berzaghi, M.P. and Berninger, B. (1997) Neurotrophins and activity-dependent plasticity of cortical interneurons. Trends Neurosci., 20: 198-202.
206. Masu, Y., Wolf, E., Holtmann, B., Sendtner, M., Brem, G. and Thoenen, H. (1993) Disruption of the CNTF gene results in motor neuron degeneration. Nature, 365: 27-32.
207. Masure, S., Cik, M., Pangalos, M.N., Bonaventure, P., Verhasselt, P., Lesage, A.S., Leysen, J.E. and Gordon, R.D. (1998) Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor α-3 (GFRα-3). Eur. J. Biochem., 251: 622-630.
208. Masure, S., Cik, M., Hoefnagel, E., Nosrat, C.A., Van, D.L.I, Scott, R., Van Gompel, P., Lesage, A.S., Verhasselt, P., Ibanez, C.F. and Gordon, R.D. (2000) Mammalian GFR?-4, a divergent member of the GFRα family of coreceptors for glial cell line-derived neurotrophic factor family ligands, is a receptor for the neurotrophic factor persephin. J. Biol. Chem., 275: 39427-39434.
209. McAllister, A.K., Lo, D.C. and Katz, L.C. (1995) Neurotrophins regulate dentritic growth in developing visual cortex. Neuron, 15: 791-803.
210. McAllister, A.K., Katz, L.C. and Lo, D.C. (1997) Opposing roles for endogenous BDNF and NT-3 in regulating cortical dentritic growth. Neuron, 18: 767-778.
211. McMurray, C.T. (2001) Huntington's disease: new hope for therapeutics. Trends Neurosci., 24: S32-S38.
212. Meakin, S.O., Gryz, E.A. and MacDonald, J.I. (1997) A kinase insert isoform of rat TrkA supports nerve growth factor-dependent cell survival but not neurite outgrowth. J. Neurochem., 69: 954-967.
213. Menei, P., Pean, J.M., Nerriere-Daguin, V., Jollivet, C., Brachet, P. and Benoit, J.P. (2000) Intracerebral implantation of NGF-releasing biodegradable microspheres protects striatum against excitotoxic damage. Exp. Neurol., 161: 259-272.
214. Menn, B., Timsit, S., Represa, A., Mateos, S., Calothy, G. and Lamballe, F. (2000) Spatiotemporal expression of noncatalytic TrkC NC2 isoform during early and late CNS neurogenesis: a comparative study with TrkC catalytic and p75NTR receptors. Eur. J. Neurosci., 12: 3211-3223.
215. Merlio, J.P., Ernfors, P., Jaber, M. and Persson, H. (1992) Molecular cloning of rat trkC and distribution of cells expressing messenger RNA for members of the trk family in the rat central nervous system. Neuroscience, 51: 513-532.
216. Middlemas, D.S., Lindberg, R.A. and Hunter, T. (1991) trkB, a neural receptor protein-Tyrosine Kinase: evidence for a full-length and two truncated receptors. Mol. Cell. Biol., 11: 143-153.
217. Milbrandt, J., de Sauvage, F.J., Fahrner, T.J., Baloh, R.H., Leitner, M.L., Tansey, M.G., Lampe, P.A., Heuckeroth, R.O., Kotzbauer, P.T., Simburger, K.S., Golden, J.P., Davies, J.A., Vejsada, R., Kato, A.C., Hynes, M., Sherman, D., Nishimura, M., Wang, L.C., Vandlen, R., Moffat, B., Klein, R.D., Poulsen, K., Gray, C., Garces, A. and Johnson, E.M.J. (1998) Persephin, a novel neurotrophic factor related to GDNF and neurturin. Neuron, 20: 245-253.
218. Mitsumoto, H., Ikeda, K., Klinkosz, B., Cedarbaum, J.M., Wong, V. and Lindsay, R.M. (1994) Arrest of motor neuron disease in wobbler mice cotreated with CNTF and BDNF. Science, 265: 1107-1110.
219. Mittoux, V., Joseph, J.M., Conde, F., Palfi, S., Dautry, C., Poyot, T., Bloch, J., Deglon, N., Ouary, S., Nimchinsky, E.A., Brouillet, E., Hof, P.R., Peschanski, M., Aebischer, P. and Hantraye, P. (2000) Restoration of cognitive and motor functions by ciliary neurotrophic factor in a primate model of Huntington's disease. Hum. Gene Ther., 11: 1177-1187.
220. Mittoux, V., Ouary, S., Monville, C., Lisovoski, F., Poyot, T., Conde, F., Escartin, C., Robichon, R., Brouillet, E., Peschanski, M. and Hantraye, P. (2002) Corticostriatopallidal neuroprotection by adenovirus-mediated ciliary neurotrophic factor gene transfer in a rat model of progressive striatal degeneration. J. Neurosci., 22: 4478-4486.
221. Mizuno, K., Carnahan, J. and Nawa, H. (1994) Brain-derived neurotrophic factor promotes differentiation of striatal GABA-ergic neurons. Dev. Biol., 165: 243-256.
222. Mobley, W.C., Rutkowski, J.L., Tennekoon, G.I., Buchanan, K. and Johnston, M.V. (1985) Choline acetyltransferase activity in striatum of neonatal rats increased by nerve growth factor. Science, 229: 284-287.
223. Mobley, W.C., Woo, J.E., Edwwards, R.H., Riopelle, R.J., Longo, F.M., Weskamp, G., Otten, U., Valletta, J.S. and Johnston, M.V. (1989) Development regulation of nerve growth factor and its receptor in the rat caudate-putamen. Neuron, 3: 655-664.
224. Morrison, R.S. and de Vellis, J. (1981) Growth of purified astrocytes in a chemically defined medium. Proc. Natl. Acad. Sci. USA, 78: 7205-7209.
225. Mount, H.T.J., Dean, D.O., Alberch, J., Dreyfus, C.F. and Black, J.B. (1995) Glial cell line-derived neurotrophic factor promotes the survival and morphological differentiation of Purkinge cells. Proc. Natl. Acad. Sci. USA, 92: 9092-9096.
226. Mufson, E.J., Kroin, J.S., Sobreviela, T., Burke, M.A., Kordower, J.H., Penn, R.D. and Miller, J.A. (1994) Intrastriatal infusions of brain-derived neurotrophic factor: retrograde transport and colocalization with dopamine containing substantia nigra neurons in rat. Exp. Neurol., 129: 15-26.
227. Mufson, E.J., Kroin, J.S., Liu, Y.T., Sobreviela, T., Penn, R.D., Miller, J.A. and Kordower, J.H. (1996) Intrastriatal and intraventricular infusion of brain-derived neurotrophic factor in the cynomologous monkey: distribution, retrograde transport and co-localization with substantia nigra dopamine-containing neurons. Neuroscience, 71: 179-191.
228. Nakao, N., Kokaia, Z., Odin, P. and Lindvall, O. (1995) Protective effects of BDNF and NT-3 but not PDGF against hypoglycemic injury to cultured striatal neurons. Exp. Neurol., 131: 1-10.
229. Nakao, N., Odin, P., Lindvall, O. and Brundin, P. (1996) Differential trophic effects of basic fibroblast growth factor, insulin-like growth factor-1, and neurotrophin-3 on striatal neurons in culture. Exp. Neurol., 138: 144-157.
230. Nasir, J., Floresco, S.B., O'Kusky, J.R., Diewert, V.M., Richman, J.M., Zeisler, J., Borowski, A., Marth, J.D., Phillips, A.G. and Hayden, M.R. (1995) Targeted disruption of the Huntington's disease gene results in embryonic lethality and behavioral and morphological changes in heterozygotes. Cell, 81: 811-823.
231. Naveilhan, P., Baudet, C., Mikaels, A., Shen, L., Westphal, H. and Ernfors, P. (1998) Expression and regulation of GFRα3, a glial cell line-derived neurotrophic factor family receptor. Proc. Natl. Acad. Sci. USA, 95: 1295-1300.
232. Nishi, R. and Berg, D.K. (1981) Two components from eye tissue that differentially stimulate the growth and development of ciliary ganglion neurons in cell culture. J. Neurosci., 1: 505-513.
233. Nosrat, C.A., Tomac, A., Lindqvist, E., Lindskog, S., Humpel, C., Stromberg, I., Ebendal, T., Hoffer, B.J. and Olson, L. (1996) Cellular expression of GDNF mRNA suggests multiple functions inside and outside the nervous system. Cell Tissue Res., 286: 191-207.
234. Nosrat, C.A., Tomac, A., Hoffer, B.J. and Olson, L. (1997) Cellular and developmental patterns of expression of Ret and glial cell line-derived neurotrophic factor receptor alpha mRNAs. Exp. Brain Res., 115: 410-422.
235. Oppenheim, R.W., Prevette, D., Yin, Q.W., Collins, F. and MacDonald, J. (1991) Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science, 251: 1616-1618.
236. Oppenheim, R.W., Houenou, L.J., Johnson, J.E., Lin, L.F., Li, L., Lo, A.C., Newsome, A.L., Prevette, D.M. and Wang, S. (1995) Developing motor neurons rescued from programmed and axotomy-induced cell death by GDNF. Nature, 373: 344-346,
237. Paratcha, G., Ledda, F., Baars, L., Coulpier, M., Besset, V., Anders, J., Scott, R. and Ibanez, C. F. (2001) Released GFRα potentiates downstream signaling, neuronal survival, and differentiation via a novel mechanism of recruitment of c-Ret to lipid rafts. Neuron, 29: 171-184.
238. Park, C.K., Ju, W.K., Hofmann, H.D., Kirsch, M., Ki, K.J., Chun, M.H. and Lee, M.Y. (2000) Differential regulation of ciliary neurotrophic factor and its receptor in the rat hippocampus following transient global ischemia. Brain. Res., 861: 345-353.
239. Patapoutian, A. and Reichardt, L.F. (2001) Trk receptors: mediators of neurotrophin action. Curr. Opin. Neurobiol., 11: 272-280.
240. Pelicci, G., Troglio, F., Bodini, A., Melillo, R.M., Pettirossi, V., Coda, L., De Giuseppe, A., Santoro, M. and Pelicci, P.G. (2002) The neuron-specific Rai (ShcC) adaptor protein inhibits apoptosis by coupling Ret to the phosphatidylinositol 3-kinase/Akt signaling pathway. Mol. Cell. Biol., 22: 7351-7363.
241. Pereira de Almeida, L., Zala, D., Aebischer, P. and Deglon, N. (2001) Neuroprotective effect of a CNTF-expressing lentiviral vector in the quinolinic acid rat model of Huntington's disease. Neurobiol. Dis., 8: 433-446.
242. Pérez-Navarro, E., Alberch, J., Arenas, E., Calvo, N. and Marsal, J. (1994) Nerve growth factor and basic fibroblast growth factor protect cholinergic neurons against quinolinic acid excitotoxicity in rat neostriatum. Eur. J. Neurosci., 6: 706-711.
243. Pérez-Navarro, E. and Alberch, J. (1995) Protective role of Nerve growth factor against excitatory amino acids injury during neostriatal cholinergic neurons postnatal development. Exp. Neurol., 135: 146-152.
244. Pérez-Navarro, E., Arenas, E., Reiriz, J., Calvo, N. and Alberch, J. (1996) Glial cell line-derived neurotrophic factor protects striatal calbindin-immunoreactive neurons from excitotoxic damage. Neuroscience, 75: 345-352.
245. Pérez-Navarro, E., Alberch, J., Neveu, I. and Arenas, E. (1999a) BDNF, NT-3 and NT-4/5 differentially regulate the phenotype and prevent degenerative changes of striatal projection neurons after excitotoxicity in vivo. Neuroscience, 91: 1257-1264.
246. Pérez-Navarro, E., Arenas, E., Marco, S. and Alberch, J. (1999b) Intrastriatal grafting of a GDNF-producing cell line protects striatonigralneurons from quinolinic acid excitotoxicity in vivo. Eur. J. Neurosci., 11: 241-249.
247. Pérez-Navarro, E., Akerud, P., Marco, S., Canals, J.M., Tolosa, E., Arenas, E. and Alberch, J. (2000a) Neurturin protects striatal projection neurons but not interneurons in a rat model of Huntington's disease. Neuroscience, 98: 89-96.
248. Pérez-Navarro, E., Canudas, A.M., Akerund, P., Alberch, J. and Arenas, E. (2000b) Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4/5 prevent the death of striatal projection neurons in a rodent model of Huntington's disease. J. Neurochem., 75: 2190-2199.
249. Petersen, A., Mani, K. and Brundin, P. (1999) Recent advances on the pathogenesis of Huntington's disease. Exp. Neurol., 157: 1-18.
250. Pitts, A.F. and Miller, M.W. (2000) Expression of nerve growth factor, brain-derived neurotrophic factor, and neurotrophin-3 in the somatosensory cortex of the mature rat: coexpression with high affinity neurotrophin receptor. J. Comp. Neurol., 418: 241-254.
251. Pochon, N.A., Menoud, A., Tseng, J.L., Zurn, A.D. and Aebischer, P. (1997) Neuronal GDNF expression in the adult rat nervous system identified by in situ hybridization. Eur. J. Neurosci., 9: 463-471.
252. Pong, K., Xu, R.Y., Baron, W.F., Louis, J.C. and Beck, K.D. (1998) Inhibition of phosphatidylinositol 3-kinase activity blocks cellular differentiation mediated by glial cell line-derived neurotrophic factor in dopaminergic neurons. J. Neurochem., 71: 1912-1919.
253. Poteryaev, D., Titievsky, A., Sun, Y.F., Thomas-Crusells, J., Lindahl, M., Billaud, M., Arumae, U. and Saarma, M. (1999) GDNF triggers a novel ret-independent Src kinase family-coupled signaling via a GPI-linked GDNF receptor alpha1. FEBS Lett., 463: 63-66.
254. Price, M.L., Hoffer, B.J. and Granholm, A.C. (1996) Effects of GDNF on fetal septal forebrain transplants in oculo. Exp. Neurol., 141: 181-189.
255. Rao, M.S., Tyrrell, S., Landis, S.C. and Patterson, P.H. (1992) Effects of ciliary neurotrophic factor (CNTF) and depolarization on neuropeptide expression in cultured sympathetic neurons. Dev. Biol., 150: 281-293.
256. Reddy, P.H., Williams, M. and Tagle, D.A. (1999) Recent advances in understanding the pathogenesis of Huntington's disease. Trends Neurosci., 22: 248-255.
257. Reiner, A., Albin, R.L., Anderson, K.D., D'Amato, C.J., Penney, J.B. and Young, A.B. (1988) Differential loss of striatal projection neurons in Huntington disease. Proc. Natl. Acad. Sci. USA, 85: 5733-5737.
258. Richfield, E.K., Maguire-Zeiss, K.A., Vonkeman, H.E. and Voorn, P. (1995) Preferential loss of preproenkephalin versus preprotachykinin neurons from the striatum of Huntington's disease patients. Ann. Neurol., 38: 852-861.
259. Rigamonti, D., Bauer, J.H., De-Fraja, C., Conti, L., Sipione, S., Sciorati, C., Clementi, E., Hackam, A., Hayden, M.R., Li, Y., Cooper, J.K., Ross, C.A., Govoni, S., Vincenz, C. and Cattaneo, E. (2000) Wild-type huntingtin protects from apoptosis upstream of caspase-3. J. Neurosci., 20: 3705-3713.
260. Ringstedt, T., Lagercrantz, H. and Persson, H. (1993) Expression of members of the trk family in the developing postnatal rat brain. Dev. Brain Res., 72: 119-131.
261. Rosenblad, C., Gronborg, M., Hansen, C., Blom, N., Meyer, M., Johansen, J., Dago, L., Kirik, D., Patel, U.A., Lundberg, C., Trono, D., Bjorklund, A. and Johansen, T.E. (2000) In vivo protection of nigral dopamine neurons by lentiviral gene transfer of the novel GDNF-family member neublastin/artemin. Mol. Cell. Neurosci., 15: 199-214.
262. Ross, C.A. (2002) Polyglutamine pathogenesis: emergence of unifying mechanisms for Huntington's disease and related disorders. Neuron, 35: 819-822.
263. Roux, P.P. and Barker, P.A. (2002) Neurotrophin signaling through the p75 neurotrophin receptor. Prog. Neurobiol., 67: 203-233.
264. Rudge, J.S., Pasnikowski, E.M., Holst, P. and Lindsay, R.M. (1995) Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid. J. Neurosci., 15: 6856-6867.
265. Saadat, S., Sendtner, M. and Rohrer, H. (1989) Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture. J. Cell Biol., 108: 1807-1816.
266. Salin, T., Mudò, G., Jiang, X.H., Timmusk, T., Metsis, M. and Belluardo, N. (1995) Up-regulation of trkB mRNA expression in the rat striatum after seizures. Neurosci. Lett., 194: 181-184.
267. Sarabi, A., Hoffer, B.J., Olson, L. and Morales, M. (2001) GFRα-1 mRNA in dopaminergic and nondopaminergic neurons in the substantia nigra and ventral tegmental area. J. Comp. Neurol., 441: 106-117.
268. Sarabi, A., Hoffer, B.J., Olson, L. and Morales, M. (2003) Glial cell line neurotrophic factor-family receptor a-1 is present in central neurons with distinct phenotypes, Neuroscience, 116: 261-271.
269. Saudou, F., Finkbeiner, S., Devys, D. and Greenberg, M.E. (1998) Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. Cell, 95: 55-66.
270. Schumacher, J.M., Short, M.P., Hyman, B.T., Breakefield, X.O. and Isacson, O. (1991) Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids. Neuroscience, 45: 561-570.
271. Scott, R.P. and Ibañez, C.F. (2001) Determinants of ligand binding specificity in the glial cell line-derived neurotrophic factor family receptor as. J. Biol. Chem., 276: 1450-1458.
272. Segal, R.A. and Greenberg, M.E. (1996) Intracellular signaling pathways activated by neurotrophic factors. Annu. Rev. Neurosci., 19: 463-489.
273. Sendtner, M., Carroll, P., Holtmann, B., Hughes, R.A. and Thoenen, H. (1994) Ciliary neurotrophic factor. J. Neurobiol., 25: 1436-1453.
274. Sendtner, M., Gotz, R., Holtmann, B., Escary, J.L., Masu, Y., Carroll, P., Wolf, E., Brem, G., Brulet, P. and Thoenen, H. (1996) Cryptic physiological trophic support of motoneurons by LIF revealed by double gene targeting of CNTF and LIF. Curr. Biol., 6: 686-694.
275. Sendtner, M., Gotz, R., Holtmann, B. and Thoenen, H. (1997) Endogenous ciliary neurotrophic factor is a lesion factor for axotomized motoneurons in adult mice. J. Neurosci., 17: 6999-7006.
276. Shelton, D.L., Sutherland, J., Gripp, J., Camerato, T., Armanini, M.P., Phillips, H.S., Carroll, K., Spencer, S.D. and Levinson, A.D. (1995) Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. J. Neurosci., 15: 477-491.
277. Shoulson, I. (1998) Experimental therapeutics of neurodegenerative disorders: unmet needs. Science, 282: 1072-1074.
278. Sleeman, M.W., Anderson, K.D., Lambert, P.D., Yancopoulos, G.D. and Wiegand, S.J. (2000) The ciliary neurotrophic factor and its receptor, CNTFR α. Pharm. Acta Helv., 74: 265-272.
279. Smeyne, R.J., Klein, R., Schnapp, A., Long, L.K., Bryant, S., Lewin, A., Lira, S.A. and Barbacid, M. (1994) Severe sensory and sympathetic neuropathies in mice carrying a disrupted Trk/NGF receptor gene. Nature, 368: 246-249.
280. Snider, W.D. (1994) Functions of the neurotrophins during nervous system development: what the knockouts are teaching us. Cell, 77: 627-638.
281. Sobreviela, T., Pagcatipunan, M., Kroin, J.S. and Mufson, E.J. (1996) Retrograde transport of BDNF following infusion in neo- and limbic cortex in rat: relationship to BDNF mRNA expressing neurons. J. Comp. Neurol., 375: 417-444.
282. Sofroniew, M.V., Galletly, N.P., Isacson, O. and Svendsen, C.N. (1990) Survival of adult basal forebrain cholinergic neurons after loss of target neurons. Science, 247: 338-342.
283. Soler, R.M., Dolcet, X., Encinas, M., Egea, J., Bayascas, J.R. and Comella, J.X. (1999) Receptors of the glial cell line-derived neurotrophic factor family of neurotrophic factors signal cell survival through the phosphatidylinositol 3-kinase pathway in spinal cord motoneurons. J. Neurosci., 19: 9160-9169.
284. Soppet, D., Escandon, E., Maragos, J., Middlemas, D.S., Reid, S.W., Blair, J., Burton, L.E., Stanton, B.R., Kaplan, D.R. and Hunter, T. (1991) The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. Cell, 65: 895-903.
285. Spenger, C., Hyman, C., Studer, L., Egli, M., Evtouchenko, L., Jackson, C., Dahl-Jorgensen, A., Lindsay, R.M. and Seiler, R.W. (1995) Effects of BDNF on dopaminergic, serotonergic, and GABAergic neurons in cultures of human fetal ventral mesencephalon. Exp. Neurol., 133: 50-63.
286. Squinto, S.P., Stitt, T.N., Aldrich, T.H., Davis, S., Bianco, S.M., Radziejewski, C., Glass, D.J., Masiakowski, P., Furth, M.E. and Valenzuela, D.M. (1991) trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. Cell, 65: 885-893.
287. Stahl, N. and Yancopoulos, G.D. (1994) The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines. J. Neurobiol., 25: 1454-1466.
288. Stahl, N., Farruggella, T.J., Boulton, T.G., Zhong, Z., Darnell, J.E.J. and Yancopoulos, G.D. (1995) Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science, 267: 1349-1353.
289. Stankoff, B., Aigrot, M.S., Noel, F., Wattilliaux, A., Zalc, B. and Lubetzki, C. (2002) Ciliary neurotrophic factor (CNTF) enhances myelin formation: a novel role for CNTF and CNTF-related molecules. J. Neurosci., 22: 9221-9227.
290. Steininger, T.L., Wainer, B.H., Klein, R., Barbacid, M. and Palfrey, H.C. (1993) High-affinity nerve growth factor receptor (Trk) immunoreactivity is localized in cholinergic neurons of the basal forebrain and striatum in the adult rat brain. Brain Res., 612: 330-335.
291. Stockli, K.A., Lottspeich, F., Sendtner, M., Masiakowski, P., Carroll, P., Gotz, R., Lindholm, D. and Thoenen, H. (1989) Molecular cloning, expression and regional distribution of rat ciliary neurotrophic factor. Nature, 342: 920-923.
292. Stoop, R. and Poo, M.M. (1995) Potentiation of transmitter release by ciliary neurotrophic factor requires somatic signaling. Science, 267: 695-699.
293. Strauss, S., Otten, U., Joggerst, B., Plüss, K. and Volk, B. (1994) Increased levels of nerve growth factor (NGF) protein and mRNA and reactive gliosis following kainic acid injection ibto the striatum. Neurosci. Lett., 168: 193-196.
294. Strohmaier, C., Carter, B.D., Urfer, R., Barde, Y.A. and Dechant, G. (1996) A splice variant of the neurotrophin receptor trkB with increased specificity for brain-derived neurotrophic factor. EMBO J., 15: 3332-3337.
295. Symes, A.J., Rao, M.S., Lewis, S.E., Landis, S.C., Hyman, S.E. and Fink, J.S. (1993) Ciliary neurotrophic factor coordinately activates transcription of neuropeptide genes in a neuroblastoma cell line. Proc. Natl. Acad. Sci. USA, 90: 572-576.
296. Tessarollo, L., Tsoulfas, P., Martin-Zanca, D., Gilbert, D.J., Jenkins, N.A., Copeland, N.G. and Parada, L.F. (1993) TrkC, a receptor for neurotrophin-3, is widely expressed in the developing nervous system and in non-neuronal tissues. Development, 118: 463-475.
297. The Huntington's Disease Collaborative Research Group (1993) A novel gene containing a trinucleotide repeat that is expanded and unstable on Huntington's disease chromosomes. Cell, 72: 971-983.
298. Thoenen, H. and Sendtner, M. (2002) Neurotrophins: from enthusiastic expectations through sobering experiences to rational therapeutic approaches, Nat. Neurosci., 5 Suppl: 1046-1050.
299. Thompson, J., Doxakis, E., Pinon, L.G., Strachan, P., Buj-Bello, A., Wyatt, S., Buchman, V.L. and Davies, A.M. (1998) GFRα-4, a new GDNF family receptor. Mol. Cell. Neurosci., 11: 117-126.
300. Timmusk, T., Belluardo, N., Metsis, M. and Persson, H. (1993) Widespread and developmentally regulated expression of neurotrophin-4 mRNA in rat brain and peripheral tissues. Eur. J. Neurosci., 5: 605-613.
301. Tomac, A.C., Agulnick, A.D., Haughey, N., Chang, C.F., Zhang, Y., Backman, C., Morales, M., Mattson, M.P., Wang, Y., Westphal, H. and Hoffer, B.J. (2002) Effects of cerebral ischemia in mice deficient in Persephin. Proc. Natl. Acad. Sci. USA, 99: 9521-9526.
302. Treanor, J.J., Goodman, L., de Sauvage, F., Stone, D.M., Poulsen, K.T., Beck, C.D., Gray, C., Armanini, M.P., Pollock, R.A., Hefti, F., Phillips, H.S., Goddard, A., Moore, M.W., Buj-Bello, A., Davies, A.M., Asai, N., Takahashi, M., Vandlen, R., Henderson, C.E. and Rosenthal, A. (1996) Characterization of a multicomponent receptor for GDNF. Nature, 382: 80-83.
303. Trupp, M., Arenas, E., Fainzilber, M., Nilsson, A.S., Sieber, B.A., Grigoriou, M., Kilkenny, C., Salazar-Grueso, E., Pachnis, V. and Arumae, U. (1996) Functional receptor for GDNF encoded by the c-ret proto-oncogene. Nature, 381: 785-789.
304. Trupp, M., Belluardo, N., Funakoshi, H. and Ibañez, C.F. (1997) Complementary and overlapping expression of glial cell line-derived neurotrophic factor (GDNF), c-ret protooncogene, and GDNF receptor-α indicates multiple mechanisms of trophic actions in the adult rat CNS. J. Neurosci., 1715:3527-3554.
305. Trupp, M., Scott, R., Whittemore, S.R. and Ibañez, C.F. (1999) Ret-dependent and -independent mechanisms of glial cell line-derived neurotrophic factor signaling in neuronal cells. J. Biol. Chem., 274: 20885-20894.
306. Vahlsing, H.L., Hagg, T., Spencer, M., Conner, J.M., Manthorpe, M. and Varon, S. (1991) Dose-dependent responses to nerve growth factor by adult rat cholinergic medial septum and neostriatum neurons. Brain Res., 552: 320-329.
307. Van der Zee, C.E., Ross, G.M., Riopelle, R.J. and Hagg, T. (1996) Survival of cholinergic forebrain neurons in developing p75NGFR-deficient mice. Science, 274: 1729-1732.
308. Van Vulpen, E.H. and Van D. Kooy, D. (1999) NGF facilitates the developmental maturation of the previously committed cholinergic interneurons in the striatal matrix. J. Comp. Neurol., 411: 87-96.
309. Van Weering, D.H., de Rooij, J., Marte, B., Downward, J., Bos, J.L. and Burgering, B.M. (1998) Protein kinase B activation and lamellipodium formation are independent phosphoinositide 3-kinase-mediated events differentially regulated by endogenous Ras. Mol. Cell, Biol., 18: 1802-1811.
310. Venero, J.L., Knüsel, B., Beck, K.D. and Hefti, F. (1994) Expression of neurotrophin and trk receptor genes in adult rats with fimbria transections: effect of intraventricular nerve growth factor and brain-derived neurotrophic factor administration. Neuroscience, 59: 797-815.
311. Ventimiglia, R., Mather, P.E., Jones, B.E. and Lindsay, R.M. (1995) The neurotrophins BDNF, NT-3 and NT-4/5 promote survival and morphological and biochemical differentiation of striatal neurons. Eur. J. Neurosci., 7: 213-222.
312. Wang, C.Y., Ni, J., Jiang, H., Hsu, T.A., Dugich-Djordjevic, M., Feng, L., Zhang, M., Mei, L., Gentz, R. and Lu, B. (1998) Cloning and characterization of glial cell line-derived neurotrophic factor receptor-B: a novel receptor for members of glial cell line-derived neurotrophic factor family of neurotrophic factors. Neuroscience, 83: 7-14.
313. Wang, L.C., Shih, A., Hongo, J., Devaux, B. and Hynes, M. (2000) Broad specificity of GDNF family receptors GFRα1 and GFRα2 for GDNF and NTN in neurons and transfected cells. J. Neurosci. Res., 61: 1-9.
314. Ward, N.L. and Hagg, T. (2000) BDNF is needed for postnatal maturation of basal forebrain and neostriatum cholinergic neurons in vivo. Exp. Neurol., 162: 297-310.
315. Ware, C.B., Horowitz, M.C., Renshaw, B.R., Hunt, J.S., Liggitt, D., Koblar, S.A., Gliniak, B.C., McKenna, H.J., Papayannopoulou, T. and Thoma, B. (1995) Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development, 121: 1283-1299.
316. Widenfalk, J., Nosrat, C., Tomac, A., Westphal, H., Hoffer, B. and Olson, L. (1997) Neurturin and glial cell line-derived neurotrophic factor receptor-β (GDNFR-β), novel proteins related to GDNF and GDNFR-α with specific cellular patterns of expression suggesting roles in the developing and adult nervous system and in the peripheral organs. J. Neurosci., 17: 8506-8519.
317. Widmer, H.R. and Hefti, F. (1994) Stimulation of GABAergic neuron differentiation by NT-4/5 in cultures of rat cerebral cortex. Dev. Brain Res., 80: 279-284.
318. Wong, J.Y., Liberatore, G.T., Donnan, G.A. and Howells, D.W. (1997) Expression of brain-derived neurotrophic factor and TrkB neurotrophin receptors after striatal injury in the mouse. Exp. Neurol., 148: 83-91.
319. Worby, C.A., Vega, Q.C., Chao, H.H., Seasholtz, A.F., Thompson, R.C. and Dixon, J.E. (1998) Identification and characterization of GFRα-3, a novel Co-receptor belonging to the glial cell line-derived neurotrophic receptor family. J. Biol. Chem., 273: 3502-3508.
320. Xu, B., Zang, H., Ruff, N.L., Zhang, Y.A., McConnell, S.K., Stryker, M.P. and Reichardt, L.F. (2000) Cortical degeneration in the absence of neurotrophin signaling: dendritic retraction and neuronal loss after removal of the receptor TrkB. Neuron, 26: 233-245.
321. Yacoubian, T.A. and Lo, D.C. (2000) Truncated and full-length TrkB receptors regulate distinct modes of dendritic growth. Nat. Neurosci., 3: 342-349.
322. Yamamoto, A., Lucas, J.J. and Hen, R. (2000) Reversal of neuropathology and motor dysfunction in a conditional model of Huntington's disease. Cell, 101: 57-66.
323. Yan, Q., Radeka, M.J., Matheson, C.R., Talvenheimo, J., Welcher, A.A. and Feinstein, S.C. (1997a) Immunocytochemical localization of TrkB in the central nervous system of the adult rat. J. Comp. Neurol., 378: 135-157.
324. Yan, Q., Rosenfeld, R.D., Matheson, C.R., Hawkins, N., Lopez, O.T., Bennet, L. and Welcher, A.A. (1997b) Expression of brain-derived neurotrophic factor protein in the adult rat central nervous system. Neuroscience, 78: 431-448.
325. Yu, T., Scully, S., Yu, Y., Fox, G.M., Jing, S. and Zhou, R. (1998) Expression of GDNF family receptor components during development: implications in the mechanisms of interaction. J. Neurosci., 18: 4684-4696.
326. Yurek, D.M. and Fletcher-Turner, A. (2001) Differential expression of GDNF, BDNF, and NT-3 in the aging nigrostriatal system following a neurotoxic lesion. Brain Res., 891: 228-235.
327. Zeron, M.M., Hansson, O., Chen, N., Wellington, C.L., Leavitt, B.R., Brundin, P., Hayden, M.R. and Raymond, L.A. (2002) Increased sensitivity to N-methyl-d-aspartate receptor-mediated excitotoxicity in a mouse model of Huntington's disease. Neuron, 33: 849-860.
328. Zuccato, C., Ciammola, A., Rigamonti, D., Leavitt, B.R., Goffredo, D., Conti, L., MacDonald, M.E., Friedlander, R.M., Silani, V., Hayden, M.R., Timmusk, T., Sipione, S. and Cattaneo, E. (2001) Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease. Science, 293: 493-498.