The ciliary neurotrophic factor and its receptor, CNTFRα

Pharmaceutica Acta Helvetiae

Volumn 74, Issue 2-3, 2000, Pages 265-272

  Sleeman, Mark W ^a   Anderson, Keith D ^a   Lambert, Philip D ^a   Yancopoulos, George D ^a   Wiegand, Stanley J ^a  

^a REGENERON PHARMACEUTICALS INC   (United States)

Author keywords

Body weight; Ciliary neurotrophic factor; Obesity; STAT

Indexed keywords

CILIARY NEUROTROPHIC FACTOR; CILIARY NEUROTROPHIC FACTOR ALPHA; MEMBRANE PROTEIN; NEUROTROPHIN RECEPTOR; RECEPTOR SUBUNIT; STAT PROTEIN; UNCLASSIFIED DRUG;

CELL DIFFERENTIATION; CELL VIABILITY; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; FOOD INTAKE; GLIA CELL; HISTOCHEMISTRY; HUMAN; MOTOR PERFORMANCE; NONHUMAN; OBESITY; OLIGODENDROGLIA; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; SEQUENCE ANALYSIS;

ANIMALS; CILIARY NEUROTROPHIC FACTOR; HUMANS; LIGANDS; MICE; OBESITY; RECEPTOR, CILIARY NEUROTROPHIC FACTOR;

EID: 0034080807     PISSN: 00316865     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0031-6865(99)00050-3     Document Type: Conference Paper

References (62)

1. Adler R., Landa K.B., Manthorpe M., Varon S. Cholinergic neuronotrophic factors. Intraocular distribution of soluble trophic activity for ciliary neurons. Science. 204:1979;143-1436.
2. ALS CNTF Treatment Study Group, 1996. Neurology 46, 1244-1249.
3. Anderson K.D., Panayotatos N., Corcoran T.L., Lindsay R.M., Wiegand S.J. Ciliary neurotrophic factor protects striatal output neurons in an animal model of Huntington disease. Proc. Natl. Acad. Sci. U. S. A. 93:1996;7346-7351.
4. Anderson K.D., Wong V., Corcoran T.L., Murray J.D., Wang Q., Nelson G.et al. Weight-loss effects of central and peripheral administration of Axokine (an analogue of ciliary neurotrophic factor) and leptin. Soc. Neurosci. Abs. 24:1998;621.
5. Bjørbæk C., Elmquist J.K., El-Haschimi K., Kelly J., Ahima R.S., Hileman S., Flier J.S. Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology. 140(5):1999;2035-2043.
6. Boulton T.G., Stahl N., Yancopoulos G.D. Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors. J. Biol. Chem. 269(15):1994;11648-11655.
7. Clatterbuck R.E., Price D.L., Koliatsos V.E. Ciliary neurotrophic factor stimulates the expression of glial fibrillary acidic protein by brain astrocytes in vivo. J. Comp. Neurol. 369(4):1996;543-551.
8. Conover J.C., Ip N.Y., Poueymirou W.T., Bates B., Goldfarb M.P., DeChiara T.M., Yancopoulos G.D. Ciliary neurotrophic factor maintains the pluripotentiality of embryonic stem cells. Development. 119(3):1993;559-565.
9. Curtis R., Adryan K.M., Zhu Y., Harkness P.J., Lindsay R.M., DiStefano P.S. Retrograde axonal transport of ciliary neurotrophic factor is increased by peripheral nerve injury. Nature. 365(6443):1993;253-255.
10. Davis S., Aldrich T.H., Valenzuela D.M., Wong V., Furth M.E., Squinto S.P., Yancopoulos G.D. The receptor for ciliary neurotrophic factor. Science. 253:1991;59-63.
11. Davis S., Aldrich T.H., Ip N.Y., Stahl N., Scherer S., Farruggella T., DiStefan P.S., Curtis R., Panayotatos N., Gascan H., Chevalier S., Yancopoulos G.D. Released form of CNTF receptor alpha component as a soluble mediator of CNTF responses. Science. 259(5102):1993;1736-1739.
12. DeChiara T.M., Vejsada R., Poueymirou W.T., Acheson A., Suri C., Conover J.C., Friedman B., McClain J., Pan L., Stahl N., Ip N.Y., Kato A., Yancopoulos G.D. Mice lacking the CNTF receptor, unlike mice lacking CNTF, exhibit profound motor neuron deficits at birth. Cell. 83(2):1995;313-322.
13. De Serio A., Graziani R., Laufer R., Ciliberto G., Paonessa G. In vitro binding of ciliary neurotrophic factor to its receptors: evidence for the formation of an IL-6-type hexameric complex. J. Mol. Biol. 254(5):1995;795-800.
14. Di Marco A., Gloaguen I., Graziani R., Paonessa G., Saggio I., Hudson K.R., Laufer R. Identification of ciliary neurotrophic factor (CNTF) residues essential for leukemia inhibitory factor receptor binding and generation of CNTF receptor antagonists. Proc. Natl. Acad. Sci. U. S. A. 93(17):1996;9247-9252.
15. DiStefano P.S., Boulton T.G., Stark J.L., Zhu Y., Adryan K.M., Ryan T.E., Lindsay R.M. Ciliary neurotrophic factor induces down-regulation of its receptor and desensitization of signal transduction pathways in vivo: non-equivalence with pharmacological activity. J. Biol. Chem. 271(37):1996;22839-22846.
16. Emerich D.F., Lindner M.D., Winn S.R., Chen E.-Y., Frydel B.R., Kordower J.H. Implants of encapsulated human CNTF-producing fibroblasts prevent behavioral deficits and striatal degeneration in a rodent model of Huntington's disease. J. Neurosci. 16:1996;5168-5181.
17. Emerich D.F., Winn S.R., Hantraye P.M., Peschanski M., Chen E.Y., Chu Y., McDermott P., Baetge E.E., Kordower J.H. Protective effect of encapsulated cells producing neurotrophic factor CNTF in a monkey model of Huntington's disease. Nature. 386:1997;395-399.
18. Ernsberger U., Sendtner M., Rohrer H. Proliferation and differentiation of embryonic chick sympathetic neurons: effects of ciliary neurotrophic factor. Neuron. 2(3):1989;1275-1284.
19. Espat N.J., Auffenberg T., Rosenberg J.J., Rogy M., Martin C.H., Hasselgren P.O., Copeland E.M., Moldawer L.L. Ciliary neurotrophic factor is catabolic and shares with IL-6 the capacity to induce an acute phase response. Am. J. Physiol. 271:1996;R185-R190.
20. Fantuzzi G., Benigni F., Sironi M., Conni M., Carelli M., Cantoni L., Shapiro L., Dinarello C.A., Sipe J.D., Ghezzi P. Ciliary neurotrophic factor (CNTF) induces serum amyloid A, hypoglycaemia and anorexia, and potentiates IL-1 induced corticosterone and IL-6 production in mice. Cytokine. 7(2):1995;150-156.
21. Friedman B., Scherer S.S., Rudge J.S., Helgren M., Morrisey D., McClain J., Wang D.Y., Wiegand S.J., Furth M.E., Lindsay R.M., Ip N.Y. Regulation of ciliary neurotrophic factor expression in myelin-related Schwann cells in vivo. Neuron. 9:1992;295-305.
22. Gloaguen I., Costa P., Demartis A., Lazzaro D., Marco A.D., Graziani R., Paonessa G., Chen F., Rosenblum C.I., Ploeg L.H.T.v.d., Cortese R., Ciliberto G., Laufer R. Ciliary neurotrophic factor corrects obesity and diabetes associated with leptin deficiency and resistance. Proc. Natl. Acad. Sci. U. S. A. 94:1997;6456-6461.
23. Helgren M.E., Squinto S.P., Davis H.L., Parry D.J., Boulton T.G., Heck C.S., Zhu Y., Yancopoulos G.D., Lindsay R.M., DiStefano P.S. Trophic effect of ciliary neurotrophic factor on denervated skeletal muscle. Cell. 76(3):1994;493-504.
24. Hirano T., Nakajima K., Hibi M. Signaling mechanisms through gp130: a model of the cytokine system. Cytokine Growth Factor Rev. 8(4):1997;241-252.
25. Hughes S.M., Lillien L.E., Raff M.C., Rohrer H., Sendtner M. Ciliary neurotrophic factor induces type-2 astrocyte differentiation in culture. Nature. 335(6185):1988;70-73.
26. Ip N.Y., Li Y.P., van de Stadt I., Panayotatos N., Alderson R.F., Lindsay R.M. Ciliary neurotrophic factor enhances neuronal survival in embryonic rat hippocampal cultures. J. Neurosci. 11(10):1991;3124-3134.
27. Ip N.Y., Nye S.H., Boulton T.G., Davis S., Taga T., Li Y., Birren S.J., Yasukawa K., Kishimoto T., Anderson D.J., Stahl N., Yancopoulos G.D. CNTF and LIF act on neuronal cells via shared signaling pathways that involve the IL-6 signal transducing receptor component gp130. Cell. 69(7):1992;1121-1132.
28. Ip N.Y., McClain J., Barrezueta N.X., Aldrich T.H., Pan L., Li Y., Wiegand S.J., Friedman B., Davis S., Yancopoulos G.D. The α component of the CNTF receptor is required for signaling and defines potential CNTF targets in the adult and during development. Neuron. 10:1993;89-102.
29. Kallen K.J., Grotzinger J., Lelievre E., Vollmer P., Aasland D., Renne C., Mullberg J., Myer zum Buschenfelde K.H., Gascan H., Rose-John S. Receptor recognition sites of cytokines are organized as exchangeable modules. Transfer of the leukemia inhibitory factor receptor-binding site from ciliary neurotrophic factor to interleukin-6. J. Biol. Chem. 274(17):1999;11859-11867.
30. Larkfors L., Lindsay R.M., Alderson R.F. Ciliary neurotrophic factor enhances the survival of Purkinje cells in vitro. Eur. J. Neurosci. 6(6):1994;1015-1025.
31. Li M., Sendtner M., Smith A. Essential function of LIF receptor in motor neurons. Nature. 378(6558):1995;724-727.
32. Lillien L.E., Sendtner M., Rohrer H., Hughes S.M., Raff M.C. Type-2 astrocyte development in rat brain cultures is initiated by a CNTF-like protein produced by type-1 astrocytes. Neuron. 1(6):1988;485-494.
33. Lin F.-L.H., Mismer D., Lile J.D., Armes L.G., Butler E.T., Vannice J.L., Collins F. Purification, cloning and expression of ciliary neurotrophic factor (CNTF). Science. 246:1989;1023-1025.
34. Lindsay R.M. Trophic protection of motor neurons: clinical potential in motor neuron diseases. J. Neurol. 242(1):1994;S8-S11. Suppl. 1.
35. Louis J.C., Magal E., Takayama S., Varon S. CNTF protection of oligodendrocytes against natural and tumor necrosis factor-induced death. Science. 259(5095):1993;689-692.
36. Marsh D.J., Hollopeter G., Huszar D., Laufer R., Yagaloff K.A., Fisher S.L., Burn P., Palmiter R.D. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat. Genet. 21(1):1999;119-122.
37. Masu Y., Wolf E., Holtmann B., Sendtner M., Brem G., Thoenen H. Disruption of the CNTF gene results in motor neuron degeneration. Nature. 365(6441):1993;27-32.
38. Matthys P., Billiau A. Cytokines and cachexia. Nutrition. 13:1997;763-770.
39. McDonald N.Q., Panayotatos N., Hendrickson W.A. Crystal structure of dimeric human ciliary neurotrophic factor determined by MAD phasing. EMBO J. 14(12):1995;2689-2699.
40. Miller, R.G., Petajan, J.H., Bryan, W.W., Armon, C., Barohn, R.J., Goodpasture, J.C., Hoagland, R.J., Parry, G.J., Ross, M.A., Stromatt, S.C., rhCNTF ALS Study Group, 1996. A placebo-controlled trial of recombinant human ciliary neurotrophic (rhCNTF) factor in Amyotrophic Lateral Sclerosis. Ann. Neurol. 39, 256-260.
41. Nesbitt J.E., Fuentes N.L., Fuller G.M. Ciliary neurotrophic factor regulates fibrinogen gene expression in hepatocytes by binding to the interleukin-6 receptor. Biochem. Biophys. Res. Commun. 190:1993;544-550.
42. Nonogaki K., Pan X.M., Moser A.H., Shigenaga J., Staprans I., Sakamoto N., Grunfeld C., Feingold K.R. LIF and CNTF, which share the gp130 transduction system, stimulate hepatic lipid metabolism in rats. Am. J. Physiol. 271(3):1996;E521-E528. Pt. 1.
43. Oppenheim R.W., Prevette D., Yin Q.W., Collins F., MacDonald J. Control of embryonic motoneuron survival in vivo by ciliary neurotrophic factor. Science. 251(5001):1991;1616-1618.
44. Panayotatos N., Radziejewska E., Acheson A., Pearsall D., Thadani A., Wong V. Exchange of a single amino acid interconverts the specific activity and gel mobility of human and rat ciliary neurotrophic factors. J. Biol. Chem. 268:1993;19000-19003.
45. Panayotatos N., Radziejewska E., Acheson A., Somogyi R., Thadani A., Hendrickson W.A., McDonald N.Q. Localization of functional receptor epitopes on the structure of ciliary neurotrophic factor indicates a conserved, function-related epitope topography among helical cytokines. J. Biol. Chem. 270(23):1995;14007-14014.
46. Rudge J.S., Pasnikowski E.M., Holst P., Lindsay R.M. Changes in neurotrophic factor expression and receptor activation following exposure of hippocampal neuron/astrocyte cocultures to kainic acid. J. Neurosci. 15(10):1995;6856-6867.
47. Saadat S., Sendtner M., Rohrer H. Ciliary neurotrophic factor induces cholinergic differentiation of rat sympathetic neurons in culture. J. Cell Biol. 108(5):1989;1807-1816.
48. Saggio I., Gloaguen I., Poiana G., Laufer R. CNTF variants with increased biological potency and receptor selectivity define a functional site of receptor interaction. EMBO J. 14(13):1995;3045-3054.
49. Sendtner M., Schmalbruch H., Stöckli K.A., Carroll P., Kreutzberg G.W., Thoenen H. Ciliary neurotrophic factor prevents degeneration of motor neurons in mouse mutant progressive motor neuronopathy. Nature. 358:1992;502-504.
50. Shapiro L., Zhang X., Rupp R.G., Wolff S.M., Dinarello C.A. Ciliary neurotrophic factor is an endogenous pyrogen. Proc. Natl. Acad. Sci. U. S. A. 90:1993;8614-8618.
51. Skaper S.D., Montz H.P., Varon S. Control of Na+, K+-pump activity in dorsal root ganglionic neurons by different neuronotrophic agents. Brain Res. 386(1-2):1986;130-135.
52. Stahl N., Yancopoulos G.D. The tripartite CNTF receptor complex: activation and signaling involves components shared with other cytokines. J. Neurobiol. 25:1994;1454-1466.
53. Stahl N., Farruggella T.J., Boulton T.G., Zhong Z., Darnell J.E. Jr., Yancopoulos G.D. Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science. 267(5202):1995;1349-1353.
54. Stöckli K.A., Lottspeich F., Sendtner M., Masiakowski P., Carroll P., Götz R., Lindholm D., Thoenen H. Molecular cloning, expression, regional distribution of rat ciliary neurotrophic factor. Nature. 342:1989;920-923.
55. Takahashi R., Yokoji H., Misawa H., Hayashi M., Hu J., Deguchi T. A null mutation in the human CNTF gene is not causally related to neurological diseases. Nat. Genet. 1:1994;79-84.
56. Ware C.B., Horowitz M.C., Renshaw B.R., Hunt J.S., Liggitt D., Koblar S.A., Gliniak B.C., McKenna H.J., Papayannopoulou T. Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death. Development. 121(5):1995;1283-1299.
57. Winter C.G., Saotome Y., Levison S.W., Hirsh D. A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury. Proc. Natl. Acad. Sci. U. S. A. 92(13):1995;5865-5869.
58. Wong V., Arriaga R., Ip N.Y., Lindsay R.M. The neurotrophins BDNF, NT-3 and NT-4/5, but not NGF, up-regulate the cholinergic phenotype of developing motor neurons. Eur. J. Neurosci. 5(5):1993;466-474.
59. Xu B., Kalra P.S., Moldawer L.L., Kalra S.P. Increased appetite augments hypothalamic NPY Y1 receptor gene expression: effects of anorexigenic ciliary neurotropic factor. Regul. Pept. 75-76:1998;391-395.
60. Yoshida T., Satoh M., Nakagaito Y., Kuno H., Takeuchi M. Cytokines affecting survival and differentiation of an astrocyte progenitor cell line. Brain. Res. Dev. Brain Res. 76(1):1993;147-150.
61. Yoshimura A. The CIS family: negative regulators of JAK-STAT signaling. Cytokine Growth Factor Rev. 9(3-4):1998;197-204.
62. Zhang J.G., Zhang Y., Owczarek C.M., Ward L.D., Moritz R.L., Simpson R.J., Yasukawa K., Nicola N.A. Identification and characterization of two distinct truncated forms of gp130 and a soluble form of leukemia inhibitory factor receptor alpha-chain in normal human urine and plasma. J. Biol. Chem. 273(17):1998;10798-10805.